p53 triggers mitochondrial apoptosis following DNA damage-dependent replication stress by the hepatotoxin methyleugenol

Mutational signature analysis reveals widespread contribution of pyrrolizidine alkaloid exposure to human liver cancer

(2021) Yisheng He et al.   HEPATOLOGY

The Mitochondrial Disruptor Devimistat (CPI-613) Synergizes with Genotoxic Anticancer Drugs in Colorectal Cancer Therapy in a Bim-Dependent Manner

(2021) Carina Arnold et al.   MOLECULAR CANCER THERAPEUTICS

Global Burden of 5 Major Types Of Gastrointestinal Cancer

(2020) Melina Arnold et al.   GASTROENTEROLOGY

Heme oxygenase 1 protects human colonocytes against ROS formation, oxidative DNA damage and cytotoxicity induced by heme iron, but not inorganic iron

(2020) Nina Seiwert et al.   Cell Death & Disease

Defective mitosis-linked DNA damage response and chromosomal instability in liver cancer

(2019) Maryam Tahmasebi Birgani et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Impact of p53 function on the sulfotransferase‐mediated bioactivation of the alkylated polycyclic aromatic hydrocarbon 1‐hydroxymethylpyrene in vitro

(2019) Laura E. Wohak et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

A global view of hepatocellular carcinoma: trends, risk, prevention and management

(2019) Ju Dong Yang et al.   Nature Reviews Gastroenterology & Hepatology

Sensitive CometChip assay for screening potentially carcinogenic DNA adducts by trapping DNA repair intermediates

(2019) Le P Ngo et al.   NUCLEIC ACIDS RESEARCH

Formation and fate of DNA adducts of alpha- and beta-asarone in rat hepatocytes

(2018) Simone Stegmüller et al.   FOOD AND CHEMICAL TOXICOLOGY

Exome Sequencing of Fresh-frozen or Formalin-fixed Paraffin-embedded B6C3F1/N Mouse Hepatocellular Carcinomas Arising Either Spontaneously or due to Chronic Chemical Exposure

(2018) Scott S. Auerbach et al.   TOXICOLOGIC PATHOLOGY

Methyleugenol and selected oxidative metabolites affect DNA-Damage signalling pathways and induce apoptosis in human colon tumour HT29 cells

(2017) Isabel Anna Maria Groh et al.   FOOD AND CHEMICAL TOXICOLOGY

Impact of DNA repair on the dose-response of colorectal cancer formation induced by dietary carcinogens

(2017) Jörg Fahrer et al.   FOOD AND CHEMICAL TOXICOLOGY

Mutational spectra of aflatoxin B1in vivo establish biomarkers of exposure for human hepatocellular carcinoma

(2017) Supawadee Chawanthayatham et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AKT2 suppresses pro-survival autophagy triggered by DNA double-strand breaks in colorectal cancer cells

(2017) Nina Seiwert et al.   Cell Death & Disease

Phenylpropenes: Occurrence, Distribution, and Biosynthesis in Fruit

(2016) Ross G. Atkinson   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Targeting Homologous Recombination by Pharmacological Inhibitors Enhances the Killing Response of Glioblastoma Cells Treated with Alkylating Drugs

(2016) N. Berte et al.   MOLECULAR CANCER THERAPEUTICS

DNA damage response curtails detrimental replication stress and chromosomal instability induced by the dietary carcinogen PhIP

(2016) Maximilian Mimmler et al.   NUCLEIC ACIDS RESEARCH

Adaptive upregulation of DNA repair genes following benzo(a)pyrene diol epoxide protects against cell death at the expense of mutations

(2016) Markus Christmann et al.   NUCLEIC ACIDS RESEARCH

Genetic alterations in hepatocellular carcinoma: An update

(2016) Zhao-Shan Niu et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Methyleugenol and oxidative metabolites induce DNA damage and interact with human topoisomerases

(2015) Isabel Anna Maria Groh et al.   ARCHIVES OF TOXICOLOGY

Simultaneous Detection of Multiple DNA Adducts in Human Lung Samples by Isotope-Dilution UPLC-MS/MS

(2014) Bernhard H. Monien et al.   ANALYTICAL CHEMISTRY

Lipoic acid induces p53-independent cell death in colorectal cancer cells and potentiates the cytotoxicity of 5-fluorouracil

(2014) Bastian Dörsam et al.   ARCHIVES OF TOXICOLOGY

The eucalyptus oil ingredient 1,8-cineol induces oxidative DNA damage

(2014) Bastian Dörsam et al.   ARCHIVES OF TOXICOLOGY

Toxic Phytochemicals and Their Potential Risks for Human Cancer

(2014) A. M. Bode et al.   Cancer Prevention Research

Cytolethal distending toxin (CDT) is a radiomimetic agent and induces persistent levels of DNA double-strand breaks in human fibroblasts

(2014) Jörg Fahrer et al.   DNA REPAIR

DNA polymerase IV mediates efficient and quick recovery of replication forks stalled at N2-dG adducts

(2014) Mio Ikeda et al.   NUCLEIC ACIDS RESEARCH

C2-Streptavidin Mediates the Delivery of Biotin-Conjugated Tumor Suppressor Protein P53 into Tumor Cells

(2013) Jörg Fahrer et al.   BIOCONJUGATE CHEMISTRY

Abundance of DNA adducts of methyleugenol, a rodent hepatocarcinogen, in human liver samples

(2013) Kristin Herrmann et al.   CARCINOGENESIS

Formation of hepatic DNA adducts by methyleugenol in mouse models: drastic decrease by Sult1a1 knockout and strong increase by transgenic human SULT1A1/2

(2013) Kristin Herrmann et al.   CARCINOGENESIS

Causes and consequences of replication stress

(2013) Michelle K. Zeman et al.   NATURE CELL BIOLOGY

Optimized enzymatic hydrolysis of DNA for LC–MS/MS analyses of adducts of 1-methoxy-3-indolylmethyl glucosinolate and methyleugenol

(2012) Fabian Schumacher et al.   ANALYTICAL BIOCHEMISTRY

Identification of human and murine sulfotransferases able to activate hydroxylated metabolites of methyleugenol to mutagens in Salmonella typhimurium and detection of associated DNA adducts using UPLC-MS/MS methods

(2012) K. Herrmann et al.   MUTAGENESIS

Metabolism of Methyleugenol in Liver Microsomes and Primary Hepatocytes: Pattern of Metabolites, Cytotoxicity, and DNA-Adduct Formation

(2012) Alexander T. Cartus et al.   TOXICOLOGICAL SCIENCES

Methyleugenol Genotoxicity in the Fischer 344 Rat Using the Comet Assay and Pathway-Focused Gene Expression Profiling

(2011) Wei Ding et al.   TOXICOLOGICAL SCIENCES

Application of the margin of exposure (MoE) approach to substances in food that are genotoxic and carcinogenic

(2010) Benjamin Smith et al.   FOOD AND CHEMICAL TOXICOLOGY

TP53 Mutations in Human Cancers: Origins, Consequences, and Clinical Use

(2009) M. Olivier et al.   Cold Spring Harbor Perspectives in Biology