Exome Sequencing of Fresh-frozen or Formalin-fixed Paraffin-embedded B6C3F1/N Mouse Hepatocellular Carcinomas Arising Either Spontaneously or due to Chronic Chemical Exposure

Formalin fixation increases deamination mutation signature but should not lead to false positive mutations in clinical practice

(2018) Leah M. Prentice et al.   PLoS One

Epigenetic dysregulation of the erythropoietic transcription factor KLF1 and the β-like globin locus in juvenile myelomonocytic leukemia

(2017) Silvia Fluhr et al.   Epigenetics

Mutational spectra of aflatoxin B1in vivo establish biomarkers of exposure for human hepatocellular carcinoma

(2017) Supawadee Chawanthayatham et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-years for 32 Cancer Groups, 1990 to 2015

(2017) et al.   JAMA Oncology

Sanger Confirmation Is Required to Achieve Optimal Sensitivity and Specificity in Next-Generation Sequencing Panel Testing

(2016) Wenbo Mu et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

COSMIC: somatic cancer genetics at high-resolution

(2016) Simon A. Forbes et al.   NUCLEIC ACIDS RESEARCH

Distinct response of the hepatic transcriptome to Aflatoxin B1 induced hepatocellular carcinogenesis and resistance in rats

(2016) Jiejun Shi et al.   Scientific Reports

Key Characteristics of Carcinogens as a Basis for Organizing Data on Mechanisms of Carcinogenesis

(2015) Martyn T. Smith et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Essential role of constitutive androstane receptor in Ginkgo biloba extract induced liver hypertrophy and hepatocarcinogenesis

(2015) Jun Maeda et al.   FOOD AND CHEMICAL TOXICOLOGY

The Role of Autophagy in Hepatocellular Carcinoma

(2015) Yoo Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets

(2015) Kornelius Schulze et al.   NATURE GENETICS

Toxic Phytochemicals and Their Potential Risks for Human Cancer

(2014) A. M. Bode et al.   Cancer Prevention Research

Sequence Artifacts in DNA from Formalin-Fixed Tissues: Causes and Strategies for Minimization

(2014) H. Do et al.   CLINICAL CHEMISTRY

Exome-wide mutation profile in benzo[a]pyrene-derived post-stasis and immortal human mammary epithelial cells

(2014) Paul L. Severson et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

The mutational landscapes of genetic and chemical models of Kras-driven lung cancer

(2014) Peter M. K. Westcott et al.   NATURE

Mechanisms underlying mutational signatures in human cancers

(2014) Thomas Helleday et al.   NATURE REVIEWS GENETICS

Next-Generation Sequencing of RNA and DNA Isolated from Paired Fresh-Frozen and Formalin-Fixed Paraffin-Embedded Samples of Human Cancer and Normal Tissue

(2014) Jakob Hedegaard et al.   PLoS One

In Vivo Genotoxicity of Ginkgo Biloba Extract in gpt Delta Mice and Constitutive Androstane Receptor Knockout Mice

(2014) Jun Maeda et al.   TOXICOLOGICAL SCIENCES

Modelling mutational landscapes of human cancers in vitro

(2014) Magali Olivier et al.   Scientific Reports

α-Actinin1 and 4 tyrosine phosphorylation is critical for stress fiber establishment, maintenance and focal adhesion maturation

(2013) Yunfeng Feng et al.   EXPERIMENTAL CELL RESEARCH

Human hepatocyte carcinogenesis

(2013) HIDENORI SHIRAHA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Signatures of mutational processes in human cancer

(2013) Ludmil B. Alexandrov et al.   NATURE

Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples

(2013) Kristian Cibulskis et al.   NATURE BIOTECHNOLOGY

IntOGen-mutations identifies cancer drivers across tumor types

(2013) Abel Gonzalez-Perez et al.   NATURE METHODS

A program for annotating and predicting the effects of single nucleotide polymorphisms, SnpEff

(2012) Pablo Cingolani et al.   FLY

Hepatocellular Carcinomas in B6C3F1 Mice Treated with Ginkgo biloba Extract for Two Years Differ from Spontaneous Liver Tumors in Cancer Gene Mutations and Genomic Pathways

(2012) Mark J. Hoenerhoff et al.   TOXICOLOGIC PATHOLOGY

Dietary modulation of the biotransformation and genotoxicity of aflatoxin B1

(2012) Kerstin Gross-Steinmeyer et al.   TOXICOLOGY

GNAS-activating mutations define a rare subgroup of inflammatory liver tumors characterized by STAT3 activation

(2011) Jean Charles Nault et al.   JOURNAL OF HEPATOLOGY

Overexpression of engulfment and cell motility 1 promotes cell invasion and migration of hepatocellular carcinoma

(2011) JIARUI JIANG et al.   Experimental and Therapeutic Medicine

The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data

(2010) A. McKenna et al.   GENOME RESEARCH

Commentary: Update on Animal Models for NTP Studies

(2009) Angela P. King-Herbert et al.   TOXICOLOGIC PATHOLOGY

Bioactive Terpenoids and Flavonoids from Ginkgo Biloba Extract Induce the Expression of Hepatic Drug-Metabolizing Enzymes Through Pregnane X Receptor, Constitutive Androstane Receptor, and Aryl hydrocarbon Receptor-Mediated Pathways

(2008) Linhao Li et al.   PHARMACEUTICAL RESEARCH