Article
Gastroenterology & Hepatology
Mirae Lee, Eugene B. Chang
Summary: Inflammatory bowel diseases (IBD) result from the interaction of environmental, microbial, immunological, and genetic factors, with alterations in the gut microbiota playing a role in their development and progression. The use of microbiome-based therapies can potentially prevent, manage, and cure IBD, bridging the gap between basic sciences and clinical application through research findings.
Article
Cell Biology
Lejla Gul, Dezso Modos, Sonia Fonseca, Matthew Madgwick, John P. Thomas, Padhmanand Sudhakar, Catherine Booth, Regis Stentz, Simon R. Carding, Tamas Korcsmaros
Summary: The gastrointestinal tract houses a complex microbial community that plays a crucial role in maintaining gut health. This study investigates the interactions between bacterial extracellular vesicles (BEVs) released by a gut commensal bacterium and host immune cells, revealing that the communication between BEVs and the host is influenced by both cell type and health status. The findings provide insights into potential BEV-based therapies for treating inflammatory bowel disease.
JOURNAL OF EXTRACELLULAR VESICLES
(2022)
Review
Immunology
Boris Vidal-Veuthey, Damariz Gonzalez, Juan P. Cardenas
Summary: This article reviews the literature on the functions of secreted proteins from the gut microbiota and discusses their impact on host physiology and health, as well as how these effects can be utilized for the development of postbiotic products.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Infectious Diseases
Sara Federici, Denise Kviatcovsky, Rafael Valdes-Mas, Eran Elinav
Summary: Inflammatory bowel disease (IBD) is a group of auto-inflammatory disorders affecting the gastrointestinal tract and other organs. The gut microbiome and specifically bacteriophages, which can infect bacteria, play a role in IBD pathology. Phage therapy shows potential in eradicating pathobionts associated with IBD, but further research is needed.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Review
Microbiology
Sean L. Carlson, Liya Mathew, Michael Savage, Klaartje Kok, James O. Lindsay, Carol A. Munro, Neil E. Mccarthy
Summary: The gut microbiome, consisting of bacteria, viruses, and fungi, plays a crucial role in the development of inflammatory bowel disease. Candida albicans, a common gut commensal and pathogenic fungus, has been extensively studied for its impact on the pathophysiology of IBD.
Review
Gastroenterology & Hepatology
Alexa N. Sasson, Ashwin N. Ananthakrishnan, Maitreyi Raman
Summary: The global incidence of inflammatory bowel diseases (IBDs) has increased significantly in the past few decades, with genetic and environmental factors playing a role in the pathogenesis. Diet is a potentially modifiable environmental risk factor for IBD, as it can promote intestinal inflammation through various mechanisms such as dysregulating the immune system and altering intestinal permeability. Dietary changes may be integrated into therapeutic strategies for IBD treatment.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Marie Vibeke Vestergaard, Kristine H. Allin, Carsten Eriksen, Oliwia Zakerska-Banaszak, Ramesh P. Arasaradnam, Mohammad T. Alam, Karsten Kristiansen, Susanne Brix, Tine Jess
Summary: This study re-analyzed fecal microbiota data from 45 cohorts of inflammatory bowel disease (IBD) patients. The analysis identified a large number of genera associated with IBD, providing potential new treatment targets.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2023)
Review
Nutrition & Dietetics
Xue Guo, Chen Huang, Jing Xu, Haoming Xu, Le Liu, Hailan Zhao, Jiaqi Wang, Wenqi Huang, Wu Peng, Ye Chen, Yuqiang Nie, Yongjian Zhou, Youlian Zhou
Summary: Inflammatory bowel disease (IBD) is characterized by relapse and remission, making it challenging to diagnose and assess disease activity. Traditional biomarkers from plasma and stool lack specificity, while changes in gut microbiota are closely associated with IBD etiology and pathogenesis.
FRONTIERS IN NUTRITION
(2022)
Article
Gastroenterology & Hepatology
John Gubatan, Derek R. Holman, Christopher J. Puntasecca, Danielle Polevoi, Samuel J. S. Rubin, Stephan Rogalla
Summary: Antimicrobial peptides play crucial roles in maintaining tolerance to gut microbiota and protecting against infections in the gastrointestinal tract, and are increasingly recognized as potential biomarkers and novel therapeutic targets in the pathogenesis of inflammatory bowel disease.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Microbiology
Laila Aldars-Garcia, Maria Chaparro, Javier P. Gisbert
Summary: IBD is a chronic relapsing-remitting systemic disease of the gastrointestinal tract, and the gut microbiome plays a crucial role in its pathogenesis by showing reduced species richness, diversity, and temporal stability. Changes in the gut microbiome are pivotal in determining the onset of IBD, with certain microbial taxa identified as diagnostic biomarkers.
Article
Microbiology
Clayton M. Small, Emily A. Beck, Mark C. Currey, Hannah F. Tavalire, Susan Bassham, William A. Cresko
Summary: This study demonstrates a positive association between host genetic dissimilarity and microbiome dissimilarity in stickleback fish. The findings provide insight into the genomic architecture of gut microbiome variation and highlight the influence of host genome on microbiome diversity.
Article
Microbiology
Ben O. Oyserman, Viviane Cordovez, Stalin Sarango Flores, Marcio F. A. Leite, Harm Nijveen, Marnix H. Medema, Jos M. Raaijmakers
Summary: The phenotype of an organism is determined by its genotype, environment, and their interactions. The traditional model does not account for the contribution of the microbiome to the host phenotype, leading to the development of the GEM model as an expansion. The GEM model captures the nuanced ecological interactions between host, environment, and microbiome.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Medicine, General & Internal
Claudia Cantoni, Qingqi Lin, Yair Dorsett, Laura Ghezzi, Zhongmao Liu, Yeming Pan, Kun Chen, Yanhui Han, Zhengze Li, Hang Xiao, Matthew Gormley, Yue Liu, Suresh Bokoliya, Hunter Panier, Cassandra Suther, Emily Evans, Li Deng, Alberto Locca, Robert Mikesell, Kathleen Obert, Pamela Newland, Yufeng Wu, Amber Salter, Anne H. Cross, Phillip Tarr, Amy Lovett-Racke, Laura Piccio, Yanjiao Zhou
Summary: This study conducted a six-month longitudinal multi-omics study on multiple sclerosis (MS) patients and healthy controls, revealing multi-system alterations in gut microbiota, immune system, and blood metabolome. The study demonstrated the interactions between gut microbiome and host immune system, metabolism, and diet, and identified microbiome and metabolome features related to the degree of disability in MS patients. Furthermore, a correlation network linking meat intake with gut microbiota and blood metabolites was discovered.
Article
Gastroenterology & Hepatology
Ishan Manandhar, Ahmad Alimadadi, Sachin Aryal, Patricia B. Munroe, Bina Joe, Xi Cheng
Summary: Despite frequent misdiagnosis of inflammatory bowel diseases (IBD), this study shows promising potential of using supervised machine learning modeling to predictively diagnose different types of IBD using fecal gut microbiome data.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2021)
Review
Nutrition & Dietetics
Hala Elzayat, Ghaidaa Mesto, Farah Al-Marzooq
Summary: Inflammatory bowel disease (IBD) is a complex disorder characterized by chronic inflammation of the gastrointestinal tract (GIT). Recent research has shown the significant role of the oral and gut microbiome in the development and progression of IBD and their impact on overall gut health. The interconnected oral and gut microbiome, as complex microbial communities, are implicated in IBD pathogenesis, and understanding their relationship can provide insights into disease management and prevention strategies.
Article
Biotechnology & Applied Microbiology
Hao Zhou, Wenjie Gu, Wen Sun, Anthony G. Hay
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2018)
Article
Engineering, Environmental
Hao Zhou, Xiaolong Wang, Zhaohuan Li, Yu Kuang, Daqing Mao, Yi Luo
ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS
(2018)
Article
Multidisciplinary Sciences
Matthew J. Mosquera, Sungwoong Kim, Hao Zhou, Tina T. Jing, Marysol Luna, Jason D. Guss, Pooja Reddy, Kristine Lai, Cynthia A. Leifer, Ilana L. Brito, Christopher J. Hernandez, Ankur Singh
Article
Chemistry, Multidisciplinary
Bibudlia Parasar, Hao Zhou, Xieyue Xiao, Quojuan Shi, Ilana L. Brito, Pamela Chang
ACS CENTRAL SCIENCE
(2019)
Article
Biophysics
Nirrit Cohen, Hao Zhou, Anthony G. Hay, Adi Radian
COLLOIDS AND SURFACES B-BIOINTERFACES
(2019)
Review
Microbiology
Ana Maria Porras, Ilana Lauren Brito
CURRENT OPINION IN MICROBIOLOGY
(2019)
Article
Environmental Sciences
Haiyan Hu, Hao Zhou, Shixiong Zhou, Zhaojun Li, Chaojun Wei, Yong Yu, Anthony G. Hay
ENVIRONMENTAL POLLUTION
(2019)
Editorial Material
Nanoscience & Nanotechnology
Brian A. Aguado, Ana M. Porras
NATURE REVIEWS MATERIALS
(2020)
Article
Cell Biology
Ana Maria Porras, Qiaojuan Shi, Hao Zhou, Rowan Callahan, Gabriella Montenegro-Bethancourt, Noel Solomons, Ilana Lauren Brito
Summary: Large-scale studies of human gut microbiomes have shown broad differences in composition across geographically distinct populations, which may lead to varying levels of resistance to specific diseases. Experimenting with microbiome samples from donors representing different countries, researchers observed geographic differences in susceptibility of mice to specific bacterial infections. Further findings suggest that cohabitation of susceptible and resistant mice can enhance immunity to bacterial infections.
Article
Cardiac & Cardiovascular Systems
Ashley J. Scott, LaTonya R. Simon, Heather N. Hutson, Ana M. Porras, Kristyn S. Masters
Summary: This review discusses the changes in extracellular matrix during aortic valve disease progression and highlights the potential of ECM-based scaffolds in therapies. Additionally, it summarizes the applications and future prospects of bottom-up tissue engineering strategies.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2021)
Article
Multidisciplinary Sciences
Hao Zhou, Juan Felipe Beltran, Ilana Lauren Brito
Summary: The study used machine learning algorithms to analyze bacterial genomes, finding that functional content accurately predicts HGT events, especially for transfers involving antibiotic resistance genes. High-probability but not-yet detected ARG transfer events are mainly exclusive to human-associated bacteria in the future.
Article
Biotechnology & Applied Microbiology
Hao Zhou, Juan Felipe Beltran, Ilana Lauren Brito
Summary: This study explores the potential mechanisms through which human-associated bacteria affect host health, with a focus on diseases such as IBD, CRC, obesity, and T2D. By leveraging publicly available data and analyzing metagenomic studies, the researchers identify differential targeting of bacterial genes that interact with human proteins involved in immune, oncogenic, apoptotic, and endocrine signaling pathways. This host-centric analysis provides valuable insights into the role of the microbiome in disease development.