Article
Engineering, Chemical
Seyede Elaheh Ghafouri, Seyed Rasoul Mousavi, Maliheh Khakestani, Shahla Mozaffari, Narges Ajami, Hossein Ali Khonakdar
Summary: This study investigates the release of levetiracetam using poly(lactic acid), poly(epsilon-caprolactone), and their blend electrospun nanofibers as novel systems. Scanning electron microscopy confirms the smooth and beads-free morphology of the samples. With increasing levetiracetam content, the average diameters of the nanofibers also increase. FTIR spectroscopy is used for structural confirmation and observation of functional groups. X-ray diffraction reveals a decrease in crystallinity and different drug release kinetics are evaluated using various models.
POLYMER ENGINEERING AND SCIENCE
(2022)
Article
Chemistry, Physical
Leila Yavari Maroufi, Marjan Ghorbani, Maryam Mohammadi, Akram Pezeshki
Summary: This study successfully prepared PLA/GG nanofibers containing thyme essential oil, which displayed smooth morphology and desirable biocompatibility, suitable for food packaging applications.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Article
Chemistry, Multidisciplinary
Mingchao Sun, Shaojuan Chen, Peixue Ling, Jianwei Ma, Shaohua Wu
Summary: This study successfully fabricated methacrylated gelatin/poly(L-lactic acid) hybrid nanofiber mats and demonstrated their excellent hydrophilic properties and high water absorption capacity. The UV crosslinking process significantly improved the structural stability and mechanical properties of the nanofiber mats. Crosslinked nanofiber mats with higher MeGel content showed enhanced attachment, growth, and proliferation of human dermal fibroblasts.
Article
Polymer Science
Youngchae Cho, Heeseok Jeong, Baeyeon Kim, Juwoong Jang, Yo-Seung Song, Deuk Yong Lee
Summary: By adjusting the content of PLLA and gelatin, the mechanical properties, water absorption capacity, degradation rate, and cell compatibility of the polymer membranes can be modified. High PLLA content improves the strength of the membranes and reduces their water absorption, while high gelatin content enhances both strength and water absorption.
Article
Chemistry, Physical
Constantinos Voniatis, Kenigen Manikion, Gergo Gyulai, Angela Jedlovszky-Hajdu
Summary: Tissue integration is a major challenge in tissue engineering and tissue scaffold development. This study explores the use of blend and composite materials to improve tissue integration. Poly(lactic acid) PLA and polysuccinimide (PSI) are used as the polymer components. The results show that the blend-electrospun meshes have a pronounced 3D structure and increased hydrophilicity. However, the blend meshes performed poorly in terms of degradation.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Materials Science, Multidisciplinary
Fanfan Du, Irene Bonadies, Alessandra Longo, Harald Rupp, Maria Laura Di Lorenzo, Renei Androsch
Summary: Fibers consisting of PLLA and mosquito-repellent IR3535 were successfully prepared by solution electrospinning. The incorporation of more than 40 m% of IR3535 into PLLA fibers was achieved. IR3535 facilitated the crystallization of PLLA and had a plasticizing effect on PLLA, leading to a decrease in the glass transition temperature. The slow release of IR3535 from PLLA/IR3535 fibers suggests their potential use as a long-lasting repellent-delivery system for combating diseases caused by mosquito bites.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Engineering, Biomedical
Susan Bayati, Parmida Harirchi, Payam Zahedi, Abdolmajid Bayandori Moghaddam
Summary: This study aimed to develop a new bioactive wound dressing based on electrospun nanofibers containing Lawsonia inermis for burn wounds. The results showed that the dressing had a positive influence on wound closure and exhibited antibacterial properties.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2023)
Article
Engineering, Biomedical
Zhe Wang, Yili Zhao, Mingwu Shen, Helena Tomas, Benqing Zhou, Xiangyang Shi
Summary: In this study, we developed a method to fabricate electrospun drug-loaded organic/inorganic hybrid nanofibrous system for antitumor therapy applications. The rod-like attapulgite (ATT) was utilized to load the anticancer drug doxorubicin (DOX), and mixed with poly(lactic-co-glycolic acid) (PLGA) to form electrospun hybrid nanofibers. The ATT/DOX/PLGA nanofibers showed sustained release of DOX under neutral and acidic pH conditions, significantly inhibiting tumor cell growth. These organic/inorganic hybrid nanofibers hold great promise as a nanoplatform for enhanced local tumor therapy.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Zeyu Fu, Dejian Li, Kaili Lin, Bin Zhao, Xudong Wang
Summary: Bone defects cause significant physical and economic burden, but the use of artificially bone repairing materials shows promise. Electrospinning is a popular technique to fabricate fibers for scaffold structures that mimic the extracellular matrix and promote cell attachment and migration. Research has demonstrated the benefits of bioactive ions and physical cues in bone regeneration. In this study, electrospun scaffolds made of calcium silicate and poly (L-lactic acid) were prepared, and the ones with aligned structure exhibited improved physical properties and enhanced cell adhesion and osteogenic gene expression. These findings suggest that the prepared scaffolds have potential for bone regeneration.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Applied
Mohammad Tajul Islam, Raechel M. Laing, Cheryl A. Wilson, Michelle McConnell, M. Azam Ali
Summary: Novel nanofibrous PVA/keratin/chitosan 3DENS with relatively uniform fibrous structure, suitable porosity, swelling properties, and degradation potential for biomedical applications were fabricated through electrospinning technique. The physiochemical properties of the polymer solutions, such as viscosity and conductivity, were investigated to demonstrate the potential of these 3DENS. The study showed that the properties of the 3DENS were affected by the mass ratio of keratin and chitosan to PVA, indicating the potential for tailored biomedical applications.
CARBOHYDRATE POLYMERS
(2022)
Article
Nanoscience & Nanotechnology
Nur Setiawan Suroto, Asra Al Fauzi, Prihartini Widiyanti, Fitria Renata Bella
Summary: Stroke is the second leading cause of death, disability, morbidity, and mortality worldwide. Carotid stenosis is one of the main causes of ischemic stroke. This study used the electrospinning process to create a biomaterial using PLLA as a base material and adding chitosan and heparin to improve biocompatibility. The results showed that the biomaterial had strong physical properties and could modify the inflammatory response.
JOURNAL OF SCIENCE-ADVANCED MATERIALS AND DEVICES
(2023)
Article
Pharmacology & Pharmacy
Amalia Mira, Marta Rubio-Camacho, David Alarcon, Enrique Rodriguez-Canas, Asia Fernandez-Carvajal, Alberto Falco, Ricardo Mallavia
Summary: Electrospun fibers from PMVEMA and menthol solutions were characterized, showing higher encapsulation efficiency and stability of menthol in P139 fibers compared to P119 fibers. The morphology and size of the fibers were analyzed, and in vitro biological assays demonstrated no cytotoxicity induction.
Article
Polymer Science
Alexis Theodorou, Vasilios Raptis, Chrissie Isabella Maria Baltzaki, Thrassyvoulos Manios, Vagelis Harmandaris, Kelly Velonia
Summary: In this study, we performed synthetic experiments and kinetic modeling calculations to investigate the polycondensation process of lactic acid and the formation of poly(lactic acid) (PLA). The results showed that under optimized conditions, PLLA with a weight-average molecular weight of 161 kDa could be obtained. The kinetic parameters obtained from the optimization accurately reproduced the experimental data.
Article
Nanoscience & Nanotechnology
Fatemeh Nikbakhtnasrabadi, Ensieh S. Hosseini, Saoirse Dervin, Dhayalan Shakthivel, Ravinder Dahiya
Summary: This article presents a wireless pressure sensor based on a flexible and piezoelectric substrate, which can be used for real-time health monitoring. The sensor exhibits high sensitivity, excellent durability, and potential use in online monitoring of sub-bandage pressure to facilitate wound healing.
ADVANCED ELECTRONIC MATERIALS
(2022)
Article
Biophysics
Zhigang Zhang, Long Zhu, Wanjun Hu, Jidong Dai, Pengfei Ren, Xiangyu Shao, Bo Xiong, Tianzhu Zhang, Zhenling Ji
Summary: This study developed a novel composite material combining polypropylene (PP) mesh and poly (L-lactic acid) (PLA) electrospun nanofibers for repairing abdominal wall defects. In vivo experiments showed that this composite material had good anti-adhesion and anti-inflammatory properties, and was able to integrate completely with the abdominal wall with sufficient mechanical strength.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Engineering, Biomedical
Liliana Liverani, Anna Liguori, Paola Zezza, Chiara Gualandi, Maurizio Toselli, Aldo R. Boccaccini, Maria Letizia Focarete
Summary: This study presents electrospun fibers loaded with bioactive glasses (BG) as well as unloaded fibers for comparison. It is proposed that the interaction between triethoxysilane groups and silanol groups at the BG particle surface leads to additional crosslinking points, enhancing the shape memory properties of the fibers. The presence of BG particles not only confers bioactivity to the fibers but also promotes the precipitation of hydroxycarbonate apatite on the fiber surface. Preliminary cytocompatibility tests show that adding BG particles does not inhibit cell viability. This novel approach expands the versatility and suitability of PCL-based composite fibers for various biomedical applications.
BIOACTIVE MATERIALS
(2022)
Review
Polymer Science
Anna Liguori, Stefano Pandini, Chiara Rinoldi, Nelsi Zaccheroni, Filippo Pierini, Maria Letizia Focarete, Chiara Gualandi
Summary: The recent surge in research on smart materials indicates a growing interest in this field from the scientific community, industry, and society. The development of stimuli-responsive materials with the help of new manufacturing technologies such as electrospinning has opened up new possibilities. This article provides a systematic review of the current advancements in thermoactive electrospun fibers and textiles, categorizing them based on their response to thermal stimulus. Different platforms including thermoresponsive systems, shape memory polymers, thermo-optically responsive systems, and more are discussed, emphasizing the diversity and potential of temperature stimulus. Novel thermoactive materials are also highlighted for their promising achievements.
MACROMOLECULAR RAPID COMMUNICATIONS
(2022)
Article
Physics, Applied
Alina Bisag, Pasquale Isabelli, Giulia Laghi, Romolo Laurita, Giorgio Dirani, Francesca Taddei, Cristiana Bucci, Filippo Capelli, Matteo Gherardi, Alessandro Paglianti, Vittorio Sambri, Vittorio Colombo
Summary: This study demonstrates the potential use of cold atmospheric pressure plasma (CAP) for controlling the diffusion of SARS-CoV-2 through bioaerosols by effectively inactivating the virus contained in bioaerosols using CAP generated in air.
PLASMA PROCESSES AND POLYMERS
(2022)
Article
Chemistry, Multidisciplinary
Nora Bloise, Lorenzo Fassina, Maria Letizia Focarete, Nadia Lotti, Livia Visai
Summary: Haralick's texture features of electrospun nanomaterials were extracted using a computer vision approach to predict the proliferative behavior of cells seeded onto the nanosurfaces.
NANOSCALE ADVANCES
(2022)
Article
Biochemistry & Molecular Biology
Anna Liguori, Alessandro De Vita, Giulia Rossi, Luisa Stella Dolci, Silvia Panzavolta, Chiara Gualandi, Laura Mercatali, Toni Ibrahim, Maria Letizia Focarete
Summary: This study presents a composite hydrogel-electrospun nanofiber scaffold for the local therapy and post-surgical treatment of solid soft tumors. The scaffold showed modulate architecture and controlled release kinetics for two pharmaceutics. In vitro analyses confirmed the non-toxicity of the scaffold and demonstrated its role in tissue repair. Furthermore, in silico analysis supported the negative prognostic role of IL-10 in solid tumors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Materials Science, Multidisciplinary
Giacomo Selleri, Maria Elena Gino, Tommaso Maria Brugo, Riccardo D'Anniballe, Johnnidel Tabucol, Maria Letizia Focarete, Raffaella Carloni, Davide Fabiani, Andrea Zucchelli
Summary: This study fabricates a self-sensing composite material by embedding PVDF-TrFE nanofibers in a polymeric elastic matrix and carbon black-based electrodes. The sensor can measure impulsive loads and low-frequency loads. A piezoelectric model is proposed and validated, and the sensor is applied in a prosthetic carbon fiber sole. This research is significant for the development of self-sensing smart composites.
MATERIALS & DESIGN
(2022)
Article
Chemistry, Multidisciplinary
Alexander Cordoba, Cesar Saldias, Marcela Urzua, Marco Montalti, Moreno Guernelli, Maria Letizia Focarete, Angel Leiva
Summary: This translation excerpt introduces various materials, strategies, and methods proposed to tackle wastewater pollution. It emphasizes the innovative approach of using hybrid materials made of polymeric nanofibers and photocatalytic nanoparticles. The crucial role of polymeric nanofibers and their versatility in pollutant degradation processes is highlighted.
Article
Physics, Applied
Giulia Laghi, Domenico Franco, Guglielmo Guido Condorelli, Riccardo Gallerani, Salvatore Guglielmino, Romolo Laurita, Dario Morganti, Francesco Traina, Sabrina Conoci, Matteo Gherardi
Summary: The validity of the Yasuda parameter W/FM as a controlling parameter for plasma polymerization is demonstrated using an atmospheric pressure single electrode plasma jet. Thin films deposited under different W/FM values exhibit different chemical and physical properties. Coatings with similar characteristics can be obtained regardless of the power and feed rate values adopted. Preliminary results show that the deposited coatings have antiadhesive activity against Pseudomonas aeruginosa and Staphylococcus aureus.
PLASMA PROCESSES AND POLYMERS
(2023)
Article
Engineering, Biomedical
Valentina Giraldi, Maria Letizia Focarete, Daria Giacomini
Summary: In this study, Laccase from Trametes versicolor (LTv) was immobilized on poly-L-lactic acid (PLLA) nanofibers and used in LMS oxidation reactions. The PLLA-LTv catalysts were successfully produced by electrospinning and thoroughly characterized. Different enzyme loadings and potential enzyme leaching were evaluated. The PLLA-LTv mats were successfully applied in the oxidation reactions of catechol and amines using LMS.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Correction
Engineering, Biomedical
Gina Prado-Prone, Masoomeh Bazzar, Maria Letizia Focarete, Jorge A. Garcia-Macedo, Javier Perez-Orive, Clemente Ibarra, Cristina Velasquillo, Phaedra Silva-Bermudez
BIOMEDICAL MATERIALS
(2023)
Article
Cell Biology
Agnese Stanzani, Anna Sansone, Cinzia Brenna, Vito Antonio Baldassarro, Giuseppe Alastra, Luca Lorenzini, Chryssostomos Chatgilialoglu, Ilaria Laface, Carla Ferreri, Luca Maria Neri, Laura Calza
Summary: The study analyzed changes in lipid composition due to inflammatory conditions. The fatty acid composition was measured in erythrocytes and spinal cord tissue of mice affected by experimental allergic encephalomyelitis (EAE). The results showed a decrease in PUFAs and an increase in SFAs in the membrane during the acute phase of EAE, while PUFAs decreased in the spinal cord tissue.
Article
Cell Biology
Marzia Moretti, Riccardo Caraffi, Luca Lorenzini, Ilaria Ottonelli, Michele Sannia, Giuseppe Alastra, Vito Antonio Baldassarro, Alessandro Giuliani, Jason Thomas Duskey, Maura Cescatti, Barbara Ruozi, Luigi Aloe, Maria Angela Vandelli, Luciana Giardino, Giovanni Tosi, Laura Calza
Summary: Spinal cord injury (SCI) causes sensory and motor disabilities without any cure. To improve myelin repair and limit degeneration, a multitherapy using nanomedicines loaded with T3, ibuprofen, and mNGF was developed. In vitro experiments confirmed the efficacy of T3-NMeds in promoting oligodendrocyte precursor cell differentiation. In vivo rat experiments showed short-term anti-inflammatory effects and long-term improvements in myelination, suggesting the potential effectiveness of this multiple treatment for SCIs.
Article
Food Science & Technology
Lorenzo Siroli, Virginia Glicerina, Filippo Capelli, Francesca Patrignani, Maurizio Fiorini, Vincenza Andrisano, Matteo Minelli, Matteo Gherardi, Rosalba Lanciotti, Vittorio Colombo, Santina Romani
Summary: This study evaluated the effects of HPH treatment and PLA packaging activated with lysozyme on a smoothie made with apple, carrot, and rice beverage. The results showed that HPH treatment effectively reduced the initial cell load of various bacteria and yeast. When combined with lysozyme activated packaging, the antimicrobial effect against bacteria was further increased. The use of active packaging also improved color retention. Overall, the combination of HPH treatment and active packaging could enhance the safety and shelf-life of vegetable smoothies.
FOOD PACKAGING AND SHELF LIFE
(2023)
Article
Physics, Applied
Giulia Laghi, Sean Watson, Stephan Reuter, Matteo Gherardi, Michael R. Wertheimer
Summary: This article reports on a methodology for measuring the energy dissipated per AC high voltage cycle in a cold atmospheric pressure plasma jet (CAPJet). The method was adapted from previous research and found to be consistent with previous results. It provides a successful approach for obtaining realistic energy values.
PLASMA PROCESSES AND POLYMERS
(2023)
Article
Materials Science, Multidisciplinary
Giorgia Pagnotta, Maila Becconi, Marco Malferrari, Donatella Aiello, Anna Napoli, Luana Di Lisa, Stefano Grilli, Stefania Rapino, Maria Letizia Focarete
Summary: 3D bioprinting is a promising technology to replicate the complex characteristics of real tissues in vitro. Researchers developed a green synthetic route to create bioink formulations using HeLa cells, achieving good cellular viability and tunable mechanical properties. A systematic study was conducted to investigate the effects of the photoinitiator concentration, crosslinking process, and mechanical properties on cell viability.
MATERIALS ADVANCES
(2023)
