Peptides from human BNIP5 and PXT1 and non-native binders of pro-apoptotic BAK can directly activate or inhibit BAK-mediated membrane permeabilization

Structural basis of BAK activation in mitochondrial apoptosis initiation

(2022) Geetika Singh et al.   Nature Communications

Native proline-rich motifs exploit sequence context to target actin-remodeling Ena/VASP protein ENAH

(2022) Theresa Hwang et al.   eLife

Structure of the BAK-activating antibody 7D10 bound to BAK reveals an unexpected role for the α1-α2 loop in BAK activation

(2022) Adeline Y. Robin et al.   CELL DEATH AND DIFFERENTIATION

Tertiary motifs as building blocks for the design of protein‐binding peptides

(2022) Sebastian Swanson et al.   PROTEIN SCIENCE

Structural and biochemical analyses of Bcl-xL in complex with the BH3 domain of peroxisomal testis-specific 1

(2022) Dahwan Lim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Small molecule SJ572946 activates BAK to initiate apoptosis

(2022) Giridhar Sekar et al.   iScience

Structure of detergent-activated BAK dimers derived from the inert monomer

(2021) Richard W. Birkinshaw et al.   MOLECULAR CELL

High‐resolution analysis of the conformational transition of pro‐apoptotic Bak at the lipid membrane

(2021) Laura E Sperl et al.   EMBO JOURNAL

Dynamic reconfiguration of pro‐apoptotic BAK on membranes

(2021) Jarrod J Sandow et al.   EMBO JOURNAL

Highly accurate protein structure prediction for the human proteome

(2021) Kathryn Tunyasuvunakool et al.   NATURE

A general-purpose protein design framework based on mining sequence–structure relationships in known protein structures

(2020) Jianfu Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A reference map of the human binary protein interactome

(2020) Katja Luck et al.   NATURE

Robust autoactivation for apoptosis by BAK but not BAX highlights BAK as an important therapeutic target

(2020) Sweta Iyer et al.   Cell Death & Disease

Biophysical Characterization of Pro-apoptotic BimBH3 Peptides Reveals an Unexpected Capacity for Self-Association

(2020) Tufa E. Assafa et al.   STRUCTURE

Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins

(2019) Rumani Singh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Tertiary Structural Motif Sequence Statistics Enable Facile Prediction and Design of Peptides that Bind Anti-apoptotic Bfl-1 and Mcl-1

(2019) Vincent Frappier et al.   STRUCTURE

BAX, BAK, and BOK: A Coming of Age for the BCL-2 Family Effector Proteins

(2019) Tudor Moldoveanu et al.   Cold Spring Harbor Perspectives in Biology

Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix

(2019) Dorothee Liebschner et al.   Acta Crystallographica Section D-Structural Biology

A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis

(2019) Mark F. van Delft et al.   Nature Chemical Biology

Contact prediction is hardest for the most informative contacts, but improves with the incorporation of contact potentials

(2018) Jack Holland et al.   PLoS One

Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design

(2017) Jason M. Brouwer et al.   MOLECULAR CELL

Allosteric sensitization of proapoptotic BAX

(2017) Jonathan R Pritz et al.   Nature Chemical Biology

High-resolution global peptide-protein docking using fragments-based PIPER-FlexPepDock

(2017) Nawsad Alam et al.   PLoS Computational Biology

Epistatic mutations in PUMA BH3 drive an alternate binding mode to potently and selectively inhibit anti-apoptotic Bfl-1

(2017) Justin M Jenson et al.   eLife

Disordered clusters of Bak dimers rupture mitochondria during apoptosis

(2017) Rachel T Uren et al.   eLife

Rapid Optimization of Mcl-1 Inhibitors using Stapled Peptide Libraries Including Non-Natural Side Chains

(2016) Raheleh Rezaei Araghi et al.   ACS Chemical Biology

Coiled-coils: The long and short of it

(2016) Linda Truebestein et al.   BIOESSAYS

Inactivation of prosurvival Bcl-2 proteins activates Bax/Bak through the outer mitochondrial membrane

(2016) Katelyn L. O'Neill et al.   GENES & DEVELOPMENT

Identification of an activation site in Bak and mitochondrial Bax triggered by antibodies

(2016) Sweta Iyer et al.   Nature Communications

Potent and Specific Peptide Inhibitors of Human Pro-Survival Protein Bcl-x L

(2015) Sanjib Dutta et al.   JOURNAL OF MOLECULAR BIOLOGY

Bid chimeras indicate that most BH3-only proteins can directly activate Bak and Bax and show no preference for Bak versus Bax

(2015) C Hockings et al.   Cell Death & Disease

Bak Core and Latch Domains Separate during Activation, and Freed Core Domains Form Symmetric Homodimers

(2014) Jason M. Brouwer et al.   MOLECULAR CELL

Rapid search for tertiary fragments reveals protein sequence-structure relationships

(2014) Jianfu Zhou et al.   PROTEIN SCIENCE

Genome-Wide Prediction and Validation of Peptides That Bind Human Prosurvival Bcl-2 Proteins

(2014) Joe DeBartolo et al.   PLoS Computational Biology

Bax Crystal Structures Reveal How BH3 Domains Activate Bax and Nucleate Its Oligomerization to Induce Apoptosis

(2013) Peter E. Czabotar et al.   CELL

Evaluation of the BH3-only Protein Puma as a Direct Bak Activator

(2013) Haiming Dai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BH3 profiling in whole cells by fluorimeter or FACS

(2013) Jeremy Ryan et al.   METHODS

BID Preferentially Activates BAK while BIM Preferentially Activates BAX, Affecting Chemotherapy Response

(2013) Kristopher A. Sarosiek et al.   MOLECULAR CELL

BID-induced structural changes in BAK promote apoptosis

(2013) Tudor Moldoveanu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A Pareto-Optimal Refinement Method for Protein Design Scaffolds

(2013) Lucas Gregorio Nivón et al.   PLoS One

Direct activation of full-length proapoptotic BAK

(2013) Elizaveta S. Leshchiner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evolution of Bcl-2 homology motifs: homology versus homoplasy

(2012) Abdel Aouacheria et al.   TRENDS IN CELL BIOLOGY

Overexpression of peroxisomal testis-specific 1 protein induces germ cell apoptosis and leads to infertility in male mice

(2011) Karina Kaczmarek et al.   MOLECULAR BIOLOGY OF THE CELL

A Unified Model of Mammalian BCL-2 Protein Family Interactions at the Mitochondria

(2011) Fabien Llambi et al.   MOLECULAR CELL

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Mitochondria and cell death: outer membrane permeabilization and beyond

(2010) Stephen W. G. Tait et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A survey of the anti-apoptotic Bcl-2 subfamily expression in cancer types provides a platform to predict the efficacy of Bcl-2 antagonists in cancer therapy

(2010) W J Placzek et al.   Cell Death & Disease

Fpocket: An open source platform for ligand pocket detection

(2009) Vincent Le Guilloux et al.   BMC BIOINFORMATICS

Stepwise Activation of BAX and BAK by tBID, BIM, and PUMA Initiates Mitochondrial Apoptosis

(2009) Hyungjin Kim et al.   MOLECULAR CELL

Differential Regulation of Bax and Bak by Anti-apoptotic Bcl-2 Family Proteins Bcl-B and Mcl-1

(2008) Dayong Zhai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BAX activation is initiated at a novel interaction site

(2008) Evripidis Gavathiotis et al.   NATURE