An αvβ3 integrin checkpoint is critical for efficient TH2 cell cytokine polarization and potentiation of antigen-specific immunity

Emerging functions of cytoskeletal proteins in immune diseases

(2021) Sara Tur-Gracia et al.   JOURNAL OF CELL SCIENCE

ZINC40099027 activates human focal adhesion kinase by accelerating the enzymatic activity of the FAK kinase domain

(2021) Rashmi et al.   Pharmacology Research & Perspectives

EGFR-HIF1α signaling positively regulates the differentiation of IL-9 producing T helper cells

(2021) Suyasha Roy et al.   Nature Communications

RUNX1/EGFR pathway contributes to STAT3 activation and tumor growth caused by hyperactivated mTORC1

(2021) Wei Lin et al.   Molecular Therapy-Oncolytics

Quorum Regulation via Nested Antagonistic Feedback Circuits Mediated by the Receptors CD28 and CTLA-4 Confers Robustness to T Cell Population Dynamics

(2020) Simon Zenke et al.   IMMUNITY

Genome-wide analysis highlights contribution of immune system pathways to the genetic architecture of asthma

(2020) Yi Han et al.   Nature Communications

Genome-wide CRISPR Screens in T Helper Cells Reveal Pervasive Crosstalk between Activation and Differentiation

(2019) Johan Henriksson et al.   CELL

Pivotal role for αVintegrins in sustained Tfh support of the germinal center response for long-lived plasma cell generation

(2019) Dillon C. Schrock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The transcription factor CBFB suppresses breast cancer through orchestrating translation and transcription

(2019) Navdeep Malik et al.   Nature Communications

BET Bromodomain Inhibitor iBET151 Impedes Human ILC2 Activation and Prevents Experimental Allergic Lung Inflammation

(2019) Bernhard Kerscher et al.   Frontiers in Immunology

Programming of Distinct Chemokine-Dependent and -Independent Search Strategies for Th1 and Th2 Cells Optimizes Function at Inflamed Sites

(2019) Alison Gaylo-Moynihan et al.   IMMUNITY

Small molecule FAK activator promotes human intestinal epithelial monolayer wound closure and mouse ulcer healing

(2019) Qinggang Wang et al.   Scientific Reports

Signaling and Function of Interleukin-2 in T Lymphocytes

(2018) Sarah H. Ross et al.   Annual Review of Immunology

Integrin activation by talin, kindlin and mechanical forces

(2018) Zhiqi Sun et al.   NATURE CELL BIOLOGY

Epidermal Growth Factor Receptor Expression Licenses Type-2 Helper T Cells to Function in a T Cell Receptor-Independent Fashion

(2017) Carlos M. Minutti et al.   IMMUNITY

Monocyte chemotactic protein–induced protein 1 controls allergic airway inflammation by suppressing IL-5–producing T H 2 cells through the Notch/Gata3 pathway

(2017) Hui Peng et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Wnt/β-Catenin Signaling Induces Integrin α4β1 in T Cells and Promotes a Progressive Neuroinflammatory Disease in Mice

(2017) Daniele Sorcini et al.   JOURNAL OF IMMUNOLOGY

LFA-1/ICAM-1 Ligation in Human T Cells Promotes Th1 Polarization through a GSK3β Signaling–Dependent Notch Pathway

(2016) Navin K. Verma et al.   JOURNAL OF IMMUNOLOGY

Phosphatidylinositol 3-Kinase/Akt Mediates Integrin Signaling To Control RNA Polymerase I Transcriptional Activity

(2016) Chuanyue Wu et al.   MOLECULAR AND CELLULAR BIOLOGY

Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9

(2016) John G Doench et al.   NATURE BIOTECHNOLOGY

Efficient CRISPR-mediated mutagenesis in primary immune cells using CrispRGold and a C57BL/6 Cas9 transgenic mouse line

(2016) Van Trung Chu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism

(2016) M. Peng et al.   SCIENCE

A Genome-wide CRISPR Screen in Primary Immune Cells to Dissect Regulatory Networks

(2015) Oren Parnas et al.   CELL

Group 2 innate lymphoid cells license dendritic cells to potentiate memory TH2 cell responses

(2015) Timotheus Y F Halim et al.   NATURE IMMUNOLOGY

ChIPmentation: fast, robust, low-input ChIP-seq for histones and transcription factors

(2015) Christian Schmidl et al.   NATURE METHODS

The Nuclear Receptor Nr4a1 Controls CD8 T Cell Development Through Transcriptional Suppression of Runx3

(2015) Heba N. Nowyhed et al.   Scientific Reports

CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling

(2014) Randall J. Platt et al.   CELL

T-Cell-Receptor-Dependent Signal Intensity Dominantly Controls CD4+ T Cell Polarization In Vivo

(2014) Nicholas van Panhuys et al.   IMMUNITY

Functions of the FAK family kinases in T cells: beyond actin cytoskeletal rearrangement

(2014) Nicole M. Chapman et al.   IMMUNOLOGIC RESEARCH

Periostin in Allergic Inflammation

(2014) Kenji Izuhara et al.   ALLERGOLOGY INTERNATIONAL

Inflammation-induced interstitial migration of effector CD4+ T cells is dependent on integrin αV

(2013) Michael G Overstreet et al.   NATURE IMMUNOLOGY

Generation of CD4CreERT2transgenic mice to study development of peripheral CD4-T-cells

(2012) Katayoun Aghajani et al.   GENESIS

Selective inhibition of CD4+ T-cell cytokine production and autoimmunity by BET protein and c-Myc inhibitors

(2012) H. S. Bandukwala et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PI3K-Akt-mTORC1-S6K1/2 Axis Controls Th17 Differentiation by Regulating Gfi1 Expression and Nuclear Translocation of RORγ

(2012) Yutaka Kurebayashi et al.   Cell Reports

Mold allergen sensitization in adult asthma according to integrin β3 polymorphisms and Toll-like receptor 2/+596 genotype

(2011) Lidwien A.M. Smit et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Innate IL-13–producing nuocytes arise during allergic lung inflammation and contribute to airways hyperreactivity

(2011) Jillian L. Barlow et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Peripheral CD4+ T-cell differentiation regulated by networks of cytokines and transcription factors

(2010) Jinfang Zhu et al.   IMMUNOLOGICAL REVIEWS

Transcriptional regulation of Th2 cell differentiation

(2010) Jinfang Zhu   IMMUNOLOGY AND CELL BIOLOGY

Activating and inhibitory functions for the histone lysine methyltransferase G9a in T helper cell differentiation and function

(2010) Bernhard Lehnertz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dissection of platelet and myeloid cell defects by conditional targeting of the β3-integrin subunit

(2009) Elizabeth A. Morgan et al.   FASEB JOURNAL

Early Growth Response Protein-1 (Egr-1) Is Preferentially Expressed in T Helper Type 2 (Th2) Cells and Is Involved in Acute Transcription of the Th2 Cytokine Interleukin-4

(2009) Michael Lohoff et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Runx3 Transcription Factor Augments Th1 and Down-Modulates Th2 Phenotypes by Interacting with and Attenuating GATA3

(2009) K. Kohu et al.   JOURNAL OF IMMUNOLOGY

ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation

(2009) K. E. Wellen et al.   SCIENCE

A Synaptic Basis for Paracrine Interleukin-2 Signaling during Homotypic T Cell Interaction

(2008) Catherine A. Sabatos et al.   IMMUNITY

The Early Growth Response Factor-1 Contributes to Interleukin-13 Production by Mast Cells in Response to Stem Cell Factor Stimulation

(2008) Bo Li et al.   Journal of Immunotoxicology