期刊
IMMUNOLOGIC RESEARCH
卷 59, 期 1-3, 页码 23-34出版社
HUMANA PRESS INC
DOI: 10.1007/s12026-014-8527-y
关键词
T cells; FAK; Pyk2; Signal transduction; Csk; Cytoskeletal rearrangement
类别
资金
- American Heart Association [11PRE7390070, 0830244N]
- National Institutes of Health [T32 AI008595, ROI CA136729]
T cells control the focus and extent of adaptive immunity in infectious and pathological diseases. The activation of T cells occurs when the T cell antigen receptor (TCR) and costimulatory and/or adhesion receptors are engaged by their ligands. This process drives signaling that promotes cytoskeletal rearrangement and transcription factor activation, both of which regulate the quality and magnitude of the T cell response. However, it is not fully understood how different receptor-induced signals combine to alter T cell activation. The related non-receptor tyrosine kinases focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (Pyk2) are phosphorylated downstream of the TCR and several costimulatory and adhesion receptors. FAK family proteins integrate receptor-mediated signals that influence actin cytoskeletal rearrangement and effector T cell responses. In this review, we summarize the receptor-specific roles that FAK and Pyk2 control to influence T cell development and activation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据