Emerging TACnology: Heterobifunctional Small Molecule Inducers of Targeted Posttranslational Protein Modifications
出版年份 2023 全文链接
标题
Emerging TACnology: Heterobifunctional Small Molecule Inducers of Targeted Posttranslational Protein Modifications
作者
关键词
-
出版物
MOLECULES
Volume 28, Issue 2, Pages 690
出版商
MDPI AG
发表日期
2023-01-11
DOI
10.3390/molecules28020690
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- PROTAC targeted protein degraders: the past is prologue
- (2022) Miklós Békés et al. NATURE REVIEWS DRUG DISCOVERY
- Deubiquitinase-targeting chimeras for targeted protein stabilization
- (2022) Nathaniel J. Henning et al. Nature Chemical Biology
- TF-DUBTACs Stabilize Tumor Suppressor Transcription Factors
- (2022) Jing Liu et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Radiotherapy-Triggered Proteolysis Targeting Chimera Prodrug Activation in Tumors
- (2022) Chunrong Yang et al. Journal of the American Chemical Society
- Degradation of lipid droplets by chimeric autophagy-tethering compounds
- (2021) Yuhua Fu et al. CELL RESEARCH
- Targeted Protein Acetylation in Cells Using Heterobifunctional Molecules
- (2021) Wesley W. Wang et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Optical Control of Small Molecule-Induced Protein Degradation
- (2020) Yuta Naro et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Light-induced control of protein destruction by opto-PROTAC
- (2020) Jing Liu et al. Science Advances
- PHOTACs enable optical control of protein degradation
- (2020) Martin Reynders et al. Science Advances
- Azo-PROTAC: Novel Light-Controlled Small-Molecule Tool for Protein Knockdown
- (2020) Yu-Hui Jin et al. JOURNAL OF MEDICINAL CHEMISTRY
- Optimising proteolysis-targeting chimeras (PROTACs) for oral drug delivery: a drug metabolism and pharmacokinetics perspective
- (2020) Andy Pike et al. DRUG DISCOVERY TODAY
- Phosphorylation-Inducing Chimeric Small Molecules
- (2020) Sachini U. Siriwardena et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Lysosome-targeting chimaeras for degradation of extracellular proteins
- (2020) Steven M. Banik et al. NATURE
- First orally bioavailable prodrug of proteolysis targeting chimera (PROTAC) degrades cyclin-dependent kinases 2/4/6 in vivo
- (2020) Mingming Wei et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Solution Conformations Shed Light on PROTAC Cell Permeability
- (2020) Yoseph Atilaw et al. ACS Medicinal Chemistry Letters
- The PROTAC technology in drug development
- (2019) Yutian Zou et al. CELL BIOCHEMISTRY AND FUNCTION
- Visualization and Analysis of Epiproteome Dynamics
- (2019) Sandeep Kaur et al. JOURNAL OF MOLECULAR BIOLOGY
- Rapid and Reversible Knockdown of Endogenously Tagged Endosomal Proteins via an Optimized HaloPROTAC Degrader
- (2019) Hannah Tovell et al. ACS Chemical Biology
- Targeted Protein Internalization and Degradation by ENDosome TArgeting Chimeras (ENDTACs)
- (2019) Dhanusha A. Nalawansha et al. ACS Central Science
- Simple Structural Modifications Converting a Bona Fide MDM2 PROTAC Degrader into a Molecular Glue Molecule: A Cautionary Tale in the Design of PROTAC Degraders
- (2019) Jiuling Yang et al. JOURNAL OF MEDICINAL CHEMISTRY
- Reversible Spatiotemporal Control of Induced Protein Degradation by Bistable PhotoPROTACs
- (2019) Patrick Pfaff et al. ACS Central Science
- Degradation of proteins by PROTACs and other strategies
- (2019) Yang Wang et al. Acta Pharmaceutica Sinica B
- Bifunctional chemical probes inducing protein–protein interactions
- (2019) Chiara Maniaci et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- Light-Induced Protein Degradation with Photocaged PROTACs
- (2019) Gang Xue et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Heterobifunctional Molecules Induce Dephosphorylation of Kinases–A Proof of Concept Study
- (2019) Sayumi Yamazoe et al. JOURNAL OF MEDICINAL CHEMISTRY
- AUTACs: Cargo-Specific Degraders Using Selective Autophagy
- (2019) Daiki Takahashi et al. MOLECULAR CELL
- A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity
- (2019) Sajid Khan et al. NATURE MEDICINE
- PROTACs: An Emerging Targeting Technique for Protein Degradation in Drug Discovery
- (2018) Shanshan Gu et al. BIOESSAYS
- Cargo recognition and degradation by selective autophagy
- (2018) Damián Gatica et al. NATURE CELL BIOLOGY
- PTMD: A Database of Human Disease-associated Post-translational Modifications
- (2018) Haodong Xu et al. GENOMICS PROTEOMICS & BIOINFORMATICS
- Selective Degradation of Polo-like Kinase 1 by a Hydrophobically Tagged Inhibitor of the Polo-Box Domain
- (2018) Stefan Rubner et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Structural basis of PROTAC cooperative recognition for selective protein degradation
- (2017) Morgan S Gadd et al. Nature Chemical Biology
- DrugBank 5.0: a major update to the DrugBank database for 2018
- (2017) David S Wishart et al. NUCLEIC ACIDS RESEARCH
- Targeted protein degradation by PROTACs
- (2017) Taavi K. Neklesa et al. PHARMACOLOGY & THERAPEUTICS
- Boc3Arg-Linked Ligands Induce Degradation by Localizing Target Proteins to the 20S Proteasome
- (2016) Yuntao Shi et al. ACS Chemical Biology
- Efficient protein knockdown of HaloTag-fused proteins using hybrid molecules consisting of IAP antagonist and HaloTag ligand
- (2016) Shusuke Tomoshige et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Induced protein degradation: an emerging drug discovery paradigm
- (2016) Ashton C. Lai et al. NATURE REVIEWS DRUG DISCOVERY
- UniProt: the universal protein knowledgebase
- (2016) NUCLEIC ACIDS RESEARCH
- PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer
- (2016) Kanak Raina et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Protein Degradation by In-Cell Self-Assembly of Proteolysis Targeting Chimeras
- (2016) Honorine Lebraud et al. ACS Central Science
- HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins
- (2015) Dennis L. Buckley et al. ACS Chemical Biology
- Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4
- (2015) Michael Zengerle et al. ACS Chemical Biology
- Small-Molecule-Mediated Degradation of the Androgen Receptor through Hydrophobic Tagging
- (2015) Jeffrey L. Gustafson et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- HaloTag Technology: A Versatile Platform for Biomedical Applications
- (2015) Christopher G. England et al. BIOCONJUGATE CHEMISTRY
- Development of small molecules targeting the pseudokinase Her3
- (2015) Sang Min Lim et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Oral Selective Estrogen Receptor Downregulators (SERDs), a Breakthrough Endocrine Therapy for Breast Cancer
- (2015) Donald P. McDonnell et al. JOURNAL OF MEDICINAL CHEMISTRY
- Degradation of HaloTag-fused nuclear proteins using bestatin-HaloTag ligand hybrid molecules
- (2015) Shusuke Tomoshige et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- Phthalimide conjugation as a strategy for in vivo target protein degradation
- (2015) G. E. Winter et al. SCIENCE
- Pharmacological targeting of the pseudokinase Her3
- (2014) Ting Xie et al. Nature Chemical Biology
- Non-histone protein methylation as a regulator of cellular signalling and function
- (2014) Kyle K. Biggar et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Emerging Principles for the Therapeutic Exploitation of Glycosylation
- (2014) Martin Dalziel et al. SCIENCE
- Cullin-RING Ligases as Attractive Anti-cancer Targets
- (2013) Yongchao Zhao et al. CURRENT PHARMACEUTICAL DESIGN
- Posttranslational protein knockdown coupled to receptor tyrosine kinase activation with phosphoPROTACs
- (2013) J. Hines et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
- (2012) Christopher A. Lipinski et al. ADVANCED DRUG DELIVERY REVIEWS
- Identification of Hydrophobic Tags for the Degradation of Stabilized Proteins
- (2012) Hyun Seop Tae et al. CHEMBIOCHEM
- Inhibitor Mediated Protein Degradation
- (2012) Marcus J.C. Long et al. CHEMISTRY & BIOLOGY
- Deciphering a global network of functionally associated post-translational modifications
- (2012) Pablo Minguez et al. Molecular Systems Biology
- Post-translational modification: nature's escape from genetic imprisonment and the basis for dynamic information encoding
- (2012) Sudhakaran Prabakaran et al. Wiley Interdisciplinary Reviews-Systems Biology and Medicine
- Small-molecule hydrophobic tagging–induced degradation of HaloTag fusion proteins
- (2011) Taavi K Neklesa et al. Nature Chemical Biology
- Targeting the Undruggable Proteome: The Small Molecules of My Dreams
- (2010) Craig M. Crews CHEMISTRY & BIOLOGY
- HaloTag7: A genetically engineered tag that enhances bacterial expression of soluble proteins and improves protein purification
- (2009) Rachel Friedman Ohana et al. PROTEIN EXPRESSION AND PURIFICATION
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started