Article
Biotechnology & Applied Microbiology
Xinwei Jiang, Boxuan Zhang, Fangren Lan, Conghao Zhong, Jiaming Jin, Xiaochang Li, Qianqian Zhou, Junying Li, Ning Yang, Chaoliang Wen, Congjiao Sun
Summary: Blood biochemical indicators are regulated by both host genetics and gut microbiota, and their interrelationships can affect growth traits in chickens. The heritability and microbiability of these indicators vary, and several candidate genes and microbial species have been identified as potentially involved in their regulation.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Review
Gastroenterology & Hepatology
Hyoann Choi, Mrinalini C. Rao, Eugene B. Chang
Summary: This review explores the role of gut microbiota as a driver and regulator of host circadian rhythms and metabolism, emphasizing its unique role in transducing dietary cues. It discusses key determinants of microbial oscillations and insights into microbial control of chronometabolism. Certain members of the gut microbiota exhibit diurnal variations in abundance and function to serve as non-canonical drivers of host circadian rhythms and metabolism.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2021)
Review
Food Science & Technology
Chen Wang, Junying Bai, Xiaoyong Chen, Jiajia Song, Yu Zhang, Hongwei Wang, Huayi Suo
Summary: Host health and disease are affected by changes in intestinal flora. Strategies such as probiotics, prebiotics, diet, fecal microbiota transplantation, antibiotics, and phages can regulate the structure and abundance of microflora. Diets and prebiotics have reduced risk and high security, while phages have high specificity for targeted regulation. Individual variability in microflora and metabolic response should be considered, and future studies should use artificial intelligence and multi-omics to develop personalized intervention strategies.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Gastroenterology & Hepatology
Yuanyuan Deng, Manfei Zhou, Junfeng Wang, Jiaxi Yao, Jing Yu, Wenwei Liu, Linlin Wu, Jun Wang, Rong Gao
Summary: The research found that long-term stress disrupts Kyn metabolism and endocrine function, accompanied by disrupted homeostasis of certain microbiota, collectively contributing to the development of depression-like behavior.
Review
Microbiology
Hui Han, Bao Yi, Ruqing Zhong, Mengyu Wang, Shunfen Zhang, Jie Ma, Yulong Yin, Jie Yin, Liang Chen, Hongfu Zhang
Summary: Feelings of hunger and satiety play crucial roles in maintaining life; gut microbiota have been implicated in appetite control, potentially affecting host metabolic health and leading to various metabolic disorders.
Review
Biochemistry & Molecular Biology
Salma Sultan, Walid Mottawea, JuDong Yeo, Riadh Hammami
Summary: Dysbiosis of gut microbiota has been linked to various health disorders over the past decade, but the detailed mechanism of this correlation remains unclear. Recently, microbiota-released extracellular vesicles (MEVs) have emerged as significant mediators in intercellular signaling, potentially playing an integral role in microbiota-host communications. MEVs are small membrane-bound vesicles that carry a wide range of biologically active compounds, facilitating the horizontal transfer of their cargo across intra- and intercellular space.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Paola Cuomo, Rosanna Capparelli, Marco Alifano, Antonio Iannelli, Domenico Iannelli
Summary: Metabolites from gut microbiota are crucial for various functions in the body, such as immune system development, pathogen interception, and nutritional enrichment. Alteration of gut microbiota is connected to gastrointestinal infection, obesity, diabetes, inflammatory bowel disease, colorectal cancer, and lung cancer. Diet changes and antibiotics have a significant impact on gut microbiota. Further research is needed to understand the interaction between host genes, microbiota, and the environment, and longitudinal studies on patients undergoing therapy could provide valuable insights for improving treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Ben A. Kappel, Lorenzo De Angelis, Andreas Puetz, Marta Ballanti, Rossella Menghini, Nikolaus Marx, Massimo Federici
Summary: There is a link between gut microbiota and host cholesterol metabolism, and changes in gut microbiota may contribute to hypercholesterolemia. Treatment with antibiotics can increase serum cholesterol levels and potentially impact cardiovascular disease.
PHARMACOLOGICAL RESEARCH
(2023)
Review
Gastroenterology & Hepatology
Marica Colella, Ioannis Alexandros Charitos, Andrea Ballini, Concetta Cafiero, Skender Topi, Raffaele Palmirotta, Luigi Santacroce
Summary: The human intestine is a complex and dynamic ecosystem of microorganisms called microbiota, which interact with the host and play a crucial role in maintaining host homeostasis. The composition of the microbiota can have both protective and harmful effects on the host health, and dysbiosis can lead to various diseases such as autoimmune diseases, chronic intestinal inflammation, diabetes mellitus, obesity, atherosclerosis, neurological disorders, and colorectal cancer.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Medicine, Research & Experimental
Cheng Li
Summary: Human responses to the same diets vary due to complex diet-host-microbiota interactions. Recent advances show that quantifying this interaction could lead to personalized nutrition strategies for improving individual health. The gut microbiome, compared to host related factors, can be easily modulated by dietary exposures and plays a crucial role in human health. However, limitations in processing and analyzing 'big-data' on the human microbiome hinder the translation of diet-host-microbiota interactions into tools for personalized health improvement. This review aims to summarize recent advances in understanding diet-host-microbiota interactions to aid in the development of personalized nutrition strategies.
Article
Immunology
Li-Fang Yeo, Soo Ching Lee, Uma Devi Palanisamy, BAK. Khalid, Qasim Ayub, Shu Yong Lim, Yvonne AL. Lim, Maude Elvira Phipps
Summary: This study assessed the cardiometabolic health of the Orang Asli (OA) communities in Malaysia and characterized their oral and gut microbiomes. The urban Temuan had worse cardiometabolic health, while the rural OA communities were undergoing epidemiological transition. The OA oral microbiota were unexpectedly homogenous, with low alpha diversity. The rural communities had uncharacterized bacteria in their oral microbiota, indicating potential for discoveries. The study also highlighted the importance of including under-represented populations in large cohort studies and provided insights into the health trends and microbiome composition of these indigenous populations.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Microbiology
Kunling Teng, Fuqing Huang, Yayong Liu, Yudong Wang, Tianqi Xia, Fangfei Yun, Jin Zhong
Summary: Gut microbes and their interactions with the host have an impact on human health and diseases. Bacteriocins, produced by gut commensals and food-originated bacteria, can inhibit pathogens and modulate gut microbiota. They are potential candidates for precision therapy of gut disorders. Lactic acid bacteria, including many probiotics, are the main producers of bacteriocins. Bacteriocin production is considered a probiotic trait that provides a competitive advantage to bacteria in colonizing the human gut and mediating interactions with the host ecosystem.
CRITICAL REVIEWS IN MICROBIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Xinzhou Wang, Peng Zhang, Xin Zhang
Summary: Probiotics are beneficial microorganisms that colonize the human intestines and can change gut flora composition, which in turn enhances host immunity. By regulating gut microbiome with probiotics, it is an effective way to improve human immunity and quality of life.
Article
Microbiology
Pil Soo Kim, Na-Ri Shin, Jae-Bong Lee, Min-Soo Kim, Tae Woong Whon, Dong-Wook Hyun, Ji-Hyun Yun, Mi-Ja Jung, Joon Yong Kim, Jin-Woo Bae
Summary: This study comprehensively characterized gut bacterial communities in fish, revealing that the dominant phyla were Proteobacteria and Firmicutes. The gut microbiota in fish was more strongly influenced by host habitat than by host taxonomy or trophic level.
Article
Multidisciplinary Sciences
Anna S. Weiss, Lisa S. Niedermeier, Alexandra von Strempel, Anna G. Burrichter, Diana Ring, Chen Meng, Karin Kleigrewe, Chiara Lincetto, Johannes Huebner, Baerbel Stecher
Summary: By characterizing a synthetic gut bacterial community, the authors challenge the concept of universal keystone species in the gastrointestinal ecosystem, revealing a context dependency of keystone functions and bacterial interaction networks.
NATURE COMMUNICATIONS
(2023)
Review
Microbiology
Livia H. Morais, Henry L. Schreiber, Sarkis K. Mazmanian
Summary: This Review discusses the intricate and potentially important connections between the gut microbiota and the brain, involving bidirectional communication along the gut-brain axis. Emerging evidence suggests that disruptions in microbial communities may be implicated in neurological disorders, with animal models providing valuable insights into the pathways linking the gut and the brain which could have tangible impacts on human health.
NATURE REVIEWS MICROBIOLOGY
(2021)
Article
Microbiology
Michael LaPelusa, Dorit Donoviel, Sergio E. Branzini, Paul E. Carlson, Stephanie Culler, Amrita K. Cheema, Rima Kaddurah-Daouk, Denise Kelly, Isabelle de Cremoux, Rob Knight, Rosa Krajmalnik-Brown, Stephen L. Mayo, Sarkis K. Mazmanian, Emeran A. Mayer, Joseph F. Petrosino, Keith Garrison
Summary: The inaugural Microbiome for Mars virtual workshop gathered leaders in microbiome research and development to discuss their work and its potential relevance to long-duration human space travel. The conference focused on current microbiome research, future endeavors, and how this field could impact human health and space exploration on a broad scale.
Article
Multidisciplinary Sciences
Wei-Li Wu, Mark D. Adame, Chia-Wei Liou, Jacob T. Barlow, Tzu-Ting Lai, Gil Sharon, Catherine E. Schretter, Brittany D. Needham, Madelyn Wang, Weiyi Tang, James Ousey, Yuan-Yuan Lin, Tzu-Hsuan Yao, Reem Abdel-Haq, Keith Beadle, Viviana Gradinaru, Rustem F. Ismagilov, Sarkis K. Mazmanian
Summary: The study demonstrates that microbiome modulates neuronal activity in specific brain regions of male mice to regulate stress responses and social behaviors. Social deviations in germ-free or antibiotic-treated mice are associated with elevated corticosterone levels, primarily produced by activation of the hypothalamus-pituitary-adrenal (HPA) axis.
Article
Multidisciplinary Sciences
Brittany D. Needham, Masanori Funabashi, Mark D. Adame, Zhuo Wang, Joseph C. Boktor, Jillian Haney, Wei-Li Wu, Claire Rabut, Mark S. Ladinsky, Son-Jong Hwang, Yumei Guo, Qiyun Zhu, Jessica A. Griffiths, Rob Knight, Pamela J. Bjorkman, Mikhail G. Shapiro, Daniel H. Geschwind, Daniel P. Holschneider, Michael A. Fischbach, Sarkis K. Mazmanian
Summary: The integration of sensory and molecular inputs from the environment has a strong impact on animal behavior. This study focuses on the role of the gastrointestinal tract as a major site of exposure to environmental molecules. The gut microbiota plays a crucial role in behavior, neurotransmitter production, brain development, and myelination patterns in mice. The researchers identified specific genes in the gut microbiome that are responsible for the conversion of dietary tyrosine to a microbial metabolite called 4-ethylphenyl sulfate (4EPS). By engineering gut bacteria, they were able to selectively produce 4EPS in mice. The presence of 4EPS in the brain was associated with changes in activity and functional connectivity in specific brain regions. Furthermore, 4EPS impaired oligodendrocyte maturation in mice, leading to decreased myelination of neuronal axons and anxiety-like behaviors. The behavioral effects of 4EPS were prevented by promoting oligodendrocyte differentiation with pharmacological treatments. This study highlights the influence of a gut-derived molecule on complex behaviors through its effects on oligodendrocyte function and myelin patterning in the brain.
Editorial Material
Multidisciplinary Sciences
Aubrey M. Schonhoff, Sarkis K. Mazmanian
Summary: Research shows that lung bacteria can modulate the activity of immune cells in the central nervous system in a rodent model of autoimmunity, which may provide insights into the neuroinflammation associated with multiple sclerosis.
Article
Biochemistry & Molecular Biology
A. Stewart Campbell, Brittany D. Needham, Christopher R. Meyer, Joanna Tan, Mary Conrad, Gregory M. Preston, Federico Bolognani, Srinivas G. Rao, Helen Heussler, Rebecca Griffith, Adam J. Guastella, Amy C. Janes, Blaise Frederick, David H. Donabedian, Sarkis K. Mazmanian
Summary: The study on an oral absorbent for adolescents with autism spectrum disorder shows significant improvements in symptoms, particularly in anxiety and irritability. The clinical trial results support the use of oral adsorbents to target gut-derived metabolites as a safe and tolerable approach to addressing symptoms associated with ASD.
Review
Immunology
John W. Bostick, Aubrey M. Schonhoff, Sarkis K. Mazmanian
Summary: The intestinal microbiome influences neuroinflammatory diseases through multiple communication pathways with the brain, involving the production of metabolites, modulation of inflammatory tone, and affecting immune cell trafficking.
CURRENT OPINION IN IMMUNOLOGY
(2022)
Editorial Material
Neurosciences
John W. Bostick, Sarkis K. Mazmanian
NATURE NEUROSCIENCE
(2022)
Article
Neurosciences
Xinhong Chen, Sripriya Ravindra Kumar, Cameron D. Adams, Daping Yang, Tongtong Wang, Damien A. Wolfe, Cynthia M. Arokiaraj, Victoria Ngo, Lillian J. Campos, Jessica A. Griffiths, Takako Ichiki, Sarkis K. Mazmanian, Peregrine B. Osborne, Janet R. Keast, Cory T. Miller, Andrew S. Fox, Isaac M. Chiu, Viviana Gradinaru
Summary: Gene therapy shows promise in treating neuropathologies of the central and peripheral nervous systems. Researchers have developed and validated two gene delivery vectors, AAV-MaCPNS1 and AAV-MaCPNS2, in rodents and non-human primates. These vectors efficiently transduced the nervous systems of these species and demonstrated their functional utility through experiments in mice.
Editorial Material
Multidisciplinary Sciences
Ohn F. Cryan, Sarkis K. Mazmanian
Article
Biochemistry & Molecular Biology
Joseph C. Boktor, Mark D. Adame, Destanie R. Rose, Cynthia M. Schumann, Karl D. Murray, Melissa D. Bauman, Milo Careaga, Sarkis K. Mazmanian, Paul Ashwood, Brittany D. Needham
Summary: This study explored the metabolic profiles of rhesus monkeys exposed to maternal immune activation (MIA) as a model for neurodevelopmental disorders. The results revealed differences in lipid, amino acid, and nucleotide metabolism between MIA-exposed offspring and control samples, with correlations to behavior scores and cytokine levels. Modest changes in fecal and intestinal microbial profiles were also observed, along with differential metabolomic profiles within males and females.
MOLECULAR PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
James Ousey, Joseph C. Boktor, Sarkis K. Mazmanian
Summary: This study explores the influence of gut microbiota on the consumption of palatable foods, finding that the absence of gut bacteria leads to overconsumption of tasty foods and increased motivation for high-sucrose rewards in mice. Certain types of gut bacteria are able to suppress overconsumption, highlighting the significant impact of gut microbiota on behavioral responses in mice.
Article
Clinical Neurology
Joseph C. C. Boktor, Gil Sharon, Leo A. A. Verhagen Metman, Deborah A. A. Hall, Phillip A. A. Engen, Zoe Zreloff, Daniel J. J. Hakim, John W. W. Bostick, James Ousey, Danielle Lange, Gregory Humphrey, Gail Ackermann, Martha Carlin, Rob Knight, Ali Keshavarzian, Sarkis K. Mazmanian
Summary: This study analyzes the gut microbiome of patients with Parkinson's disease (PD) and controls, and finds significant alterations in microbial composition, taxon abundance, metabolic pathways, and microbial gene products in PD patients. These changes may be related to disease progression.
MOVEMENT DISORDERS
(2023)
Article
Biology
Reem Abdel-Haq, Johannes C. M. Schlachetzki, Joseph C. Boktor, Thaisa M. Cantu-Jungles, Taren Thron, Mengying Zhang, John W. Bostick, Tahmineh Khazaei, Sujatha Chilakala, Livia H. Morais, Greg Humphrey, Ali Keshavarzian, Jonathan E. Katz, Matthew Thomson, Rob Knight, Viviana Gradinaru, Bruce R. Hamaker, Christopher K. Glass, Sarkis K. Mazmanian
Summary: Parkinson's disease is a movement disorder characterized by neuroinflammation, alpha-synuclein pathology, and neurodegeneration. The gut microbiome, which is altered in PD, may impact motor and GI symptoms. Feeding a prebiotic high-fiber diet can improve motor deficits and reduce alpha-synuclein aggregation in PD-like mice, potentially through its effects on the gut microbiome and microglial activation.
Meeting Abstract
Biotechnology & Applied Microbiology
Xinhong Chen, Sripriya Ravindra Kumar, Cameron D. Adams, Daping Yang, Tongtong Wang, Damien A. Wolfe, Cynthia M. Arokiaraj, Victoria Ngo, Lillian J. Campos, Jessica A. Griffith, Takako Ichiki, Sarkis K. Mazmanian, Peregrine B. Osborne, Janet R. Keast, Cory T. Miller, Andrew S. Fox, Isaac M. Chiu, Viviana Gradinaru
