4.3 Article

Inhibition of Colorectal Cancer Cell Proliferation by Treatment with Itadori Leaf Extract

期刊

JOURNAL OF OLEO SCIENCE
卷 72, 期 2, 页码 199-209

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JAPAN OIL CHEMISTS SOC
DOI: 10.5650/jos.ess22245

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functional food; itadori; polyphenol; anti-tumor effects

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Research has shown that treatment with itadori extract can inhibit the growth of mouse colon cancer cells and induce apoptosis. Itadori extracts are rich in polyphenols such as neochlorogenic acid, rutin, quercetin, and piceatannol, which are thought to be responsible for the observed effects. This suggests that the leaf of itadori has potential as a novel anti-tumor therapeutic.
Treatment with itadori extract inhibited the growth of mouse colon cancer cells (Colon-26) in mice. In addition, it induced DNA fragmentation and caspase 3/7 activation in Colon-26 cells, suggesting potent induction of apoptosis. Itadori extracts are rich in neochlorogenic acid and rutin and also contain quercetin and piceatannol. These polyphenols are thought to be involved in the observed DNA fragmentation and caspase 3/7 activation in colon cancer cells and may thus have anticancer effects. There is hence scope for development of the leaf of itadori, which currently has only a few known uses, as a novel anti-tumor therapeutic.

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