Identification and Optimization of a Ligand-Efficient Benzoazepinone Bromodomain and Extra Terminal (BET) Family Acetyl-Lysine Mimetic into the Oral Candidate Quality Molecule I-BET432
出版年份 2022 全文链接
标题
Identification and Optimization of a Ligand-Efficient Benzoazepinone Bromodomain and Extra Terminal (BET) Family Acetyl-Lysine Mimetic into the Oral Candidate Quality Molecule I-BET432
作者
关键词
-
出版物
Journal of Medicinal Chemistry
Volume 65, Issue 22, Pages 15174-15207
出版商
American Chemical Society (ACS)
发表日期
2022-11-16
DOI
10.1021/acs.jmedchem.2c01102
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Design, Synthesis, and Characterization of I-BET567, a Pan-Bromodomain and Extra Terminal (BET) Bromodomain Oral Candidate
- (2022) Philip G. Humphreys et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery, X-ray Crystallography, and Anti-inflammatory Activity of Bromodomain-containing Protein 4 (BRD4) BD1 Inhibitors Targeting a Distinct New Binding Site
- (2022) Zhiqing Liu et al. JOURNAL OF MEDICINAL CHEMISTRY
- Achieving clinical success with BET inhibitors as anti-cancer agents
- (2021) Tatiana Shorstova et al. BRITISH JOURNAL OF CANCER
- Target-Based Evaluation of “Drug-Like” Properties and Ligand Efficiencies
- (2021) Paul D. Leeson et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of a Novel Bromodomain and Extra Terminal Domain (BET) Protein Inhibitor, I-BET282E, Suitable for Clinical Progression
- (2021) Katherine L. Jones et al. JOURNAL OF MEDICINAL CHEMISTRY
- Progress in the development of domain selective inhibitors of the bromo and extra terminal domain family (BET) proteins
- (2021) Yuantao Fu et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- From Hit Seeking to Magic Bullets: The Successful Union of Epigenetic and Fragment Based Drug Discovery (EPIDD + FBDD)
- (2021) Miguel M. Vaidergorn et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of a Bromodomain and Extraterminal Inhibitor with a Low Predicted Human Dose through Synergistic Use of Encoded Library Technology and Fragment Screening
- (2020) Christopher R. Wellaway et al. JOURNAL OF MEDICINAL CHEMISTRY
- Dose Predictions for Drug Design
- (2020) Tristan S. Maurer et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of N-Ethyl-4-[2-(4-fluoro-2,6-dimethyl-phenoxy)-5-(1-hydroxy-1-methyl-ethyl)phenyl]-6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridine-2-carboxamide (ABBV-744), a BET Bromodomain Inhibitor with Selectivity for the Second Bromodomain
- (2020) George S. Sheppard et al. JOURNAL OF MEDICINAL CHEMISTRY
- The Optimisation of a Novel, Weak Bromo and Extra Terminal Domain (BET) Bromodomain Fragment Ligand to a Potent and Selective Second Bromodomain (BD2) Inhibitor
- (2020) Jonathan Thomas Seal et al. JOURNAL OF MEDICINAL CHEMISTRY
- Intramolecular hydrogen bonding: An opportunity for improved design in medicinal chemistry
- (2019) Giulia Caron et al. MEDICINAL RESEARCH REVIEWS
- Concepts and Core Principles of Fragment-Based Drug Design
- (2019) Philine Kirsch et al. MOLECULES
- Bromodomain biology and drug discovery
- (2019) Nilesh Zaware et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Mapping the Efficiency and Physicochemical Trajectories of Successful Optimizations
- (2018) Robert J. Young et al. JOURNAL OF MEDICINAL CHEMISTRY
- Lipophilic Efficiency as an Important Metric in Drug Design
- (2018) Ted W. Johnson et al. JOURNAL OF MEDICINAL CHEMISTRY
- Fragment-Based, Structure-Enabled Discovery of Novel Pyridones and Pyridone Macrocycles as Potent Bromodomain and Extra-Terminal Domain (BET) Family Bromodomain Inhibitors
- (2017) Le Wang et al. JOURNAL OF MEDICINAL CHEMISTRY
- Bromodomain Histone Readers and Cancer
- (2017) Abhinav K Jain et al. JOURNAL OF MOLECULAR BIOLOGY
- Quality guidelines for oral drug candidates: dose, solubility and lipophilicity
- (2016) Martin K. Bayliss et al. DRUG DISCOVERY TODAY
- Bromodomain and extra-terminal (BET) family proteins: New therapeutic targets in major diseases
- (2016) Balasundaram Padmanabhan et al. JOURNAL OF BIOSCIENCES
- Optimization of a Series of Bivalent Triazolopyridazine Based Bromodomain and Extraterminal Inhibitors: The Discovery of (3R)-4-[2-[4-[1-(3-Methoxy-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-piperidyl]phenoxy]ethyl]-1,3-dimethyl-piperazin-2-one (AZD5153)
- (2016) Robert H. Bradbury et al. JOURNAL OF MEDICINAL CHEMISTRY
- Identification of a Benzoisoxazoloazepine Inhibitor (CPI-0610) of the Bromodomain and Extra-Terminal (BET) Family as a Candidate for Human Clinical Trials
- (2016) Brian K. Albrecht et al. JOURNAL OF MEDICINAL CHEMISTRY
- Potent and selective bivalent inhibitors of BET bromodomains
- (2016) Michael J Waring et al. Nature Chemical Biology
- Bromodomain and Extra Terminal (BET) Inhibitor Suppresses Macrophage-Driven Steroid-Resistant Exacerbations of Airway Hyper-Responsiveness and Inflammation
- (2016) Thi Hiep Nguyen et al. PLoS One
- The bromodomain protein inhibitor I-BET151 suppresses expression of inflammatory genes and matrix degrading enzymes in rheumatoid arthritis synovial fibroblasts
- (2014) Kerstin Klein et al. ANNALS OF THE RHEUMATIC DISEASES
- The Discovery of I-BET726 (GSK1324726A), a Potent Tetrahydroquinoline ApoA1 Up-Regulator and Selective BET Bromodomain Inhibitor
- (2014) Romain Gosmini et al. JOURNAL OF MEDICINAL CHEMISTRY
- The Mechanisms behind the Therapeutic Activity of BET Bromodomain Inhibition
- (2014) Junwei Shi et al. MOLECULAR CELL
- Targeting bromodomains: epigenetic readers of lysine acetylation
- (2014) Panagis Filippakopoulos et al. NATURE REVIEWS DRUG DISCOVERY
- Setting expectations in molecular optimizations: Strengths and limitations of commonly used composite parameters
- (2013) Michael D. Shultz BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- BET bromodomain inhibitors: a patent review
- (2013) Jean-Marc Garnier et al. EXPERT OPINION ON THERAPEUTIC PATENTS
- Lipophilic efficiency: the most important efficiency metric in medicinal chemistry
- (2013) Kevin D Freeman-Cook et al. Future Medicinal Chemistry
- Discovery of Epigenetic Regulator I-BET762: Lead Optimization to Afford a Clinical Candidate Inhibitor of the BET Bromodomains
- (2013) Olivier Mirguet et al. JOURNAL OF MEDICINAL CHEMISTRY
- From ApoA1 upregulation to BET family bromodomain inhibition: Discovery of I-BET151
- (2012) Olivier Mirguet et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Histone Recognition and Large-Scale Structural Analysis of the Human Bromodomain Family
- (2012) Panagis Filippakopoulos et al. CELL
- Multi-Parameter Optimization: Identifying High Quality Compounds with a Balance of Properties
- (2012) Matthew D. Segall CURRENT PHARMACEUTICAL DESIGN
- Methyl Effects on Protein–Ligand Binding
- (2012) Cheryl S. Leung et al. JOURNAL OF MEDICINAL CHEMISTRY
- Getting physical in drug discovery II: the impact of chromatographic hydrophobicity measurements and aromaticity
- (2011) Robert J. Young et al. DRUG DISCOVERY TODAY
- Bromodomains as therapeutic targets
- (2011) Susanne Muller et al. EXPERT REVIEWS IN MOLECULAR MEDICINE
- Fragment-Based Discovery of Bromodomain Inhibitors Part 1: Inhibitor Binding Modes and Implications for Lead Discovery
- (2011) Chun-wa Chung et al. JOURNAL OF MEDICINAL CHEMISTRY
- Optimization of Pharmacokinetics through Manipulation of Physicochemical Properties in a Series of HCV Inhibitors
- (2011) Scott E. Lazerwith et al. ACS Medicinal Chemistry Letters
- Strategic Use of Plasma and Microsome Binding To Exploit in Vitro Clearance in Early Drug Discovery
- (2010) George Chang et al. ACS Medicinal Chemistry Letters
- Prediction of Human Pharmacokinetics From Preclinical Information: Comparative Accuracy of Quantitative Prediction Approaches
- (2009) Natilie A. Hosea et al. JOURNAL OF CLINICAL PHARMACOLOGY
- Physiochemical drug properties associated with in vivo toxicological outcomes
- (2008) Jason D. Hughes et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Metabolic Soft Spot Identification and Compound Optimization in Early Discovery Phases Using MetaSite and LC-MS/MS Validation
- (2008) Markus Trunzer et al. JOURNAL OF MEDICINAL CHEMISTRY
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started