Review
Chemistry, Multidisciplinary
Ridhdhi S. Dave, Taylor C. Goostrey, Maya Ziolkowska, Sofia Czerny-Holownia, Todd Hoare, Heather Sheardown
Summary: There is a growing demand for effective treatments for ocular conditions, with topical administration being the preferred method despite its drawbacks. Nanoparticles with tunable mucoadhesion and/or mucopenetration show potential to overcome these drawbacks and improve ocular bioavailability, reduce toxicity, and increase ocular retention. Recent advances in developing nanocarriers with tunable mucoadhesion and mucopenetration for drug delivery to the eye are highlighted in the current review.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Pharmacology & Pharmacy
Andrea Gabai, Marco Zeppieri, Lucia Finocchio, Carlo Salati
Summary: Innovative drug delivery systems have been developed for ocular posterior segment and retina treatments, including nanotechnology, novel matrices, and non-traditional strategies. This mini-review highlights promising strategies reported in the literature to overcome anatomical and physiological barriers and discusses challenges related to safety, efficacy, patient compliance, and sustained drug delivery. The clinical application of these approaches can contribute to standardized use of drug delivery systems and personalized therapeutic options for ocular pathologies.
Review
Polymer Science
Kevin Y. Wu, Said Ashkar, Shrieda Jain, Michael Marchand, Simon D. Tran
Summary: The eye has anatomical structures that act as barriers to topically administered medications. Polymeric nano-based drug-delivery systems (DDS) offer solutions to overcome these barriers and improve drug delivery to the eye. By using biodegradable and nano-sized polymers, the bioavailability of drugs can be increased while minimizing undesirable effects. This review comprehensively explores the use of polymeric nano-based DDS in treating ocular diseases and highlights the potential of different biopolymers to enhance therapeutic options.
Review
Pharmacology & Pharmacy
Beatriz Silva, Berta Sao Braz, Esmeralda Delgado, Lidia Goncalves
Summary: In recent years, there has been a growing scientific interest in topical ocular delivery targeting the posterior segment of the eye, as it is a non-invasive and well-tolerated administration route with fewer side effects. Improving corneal permeability or prolonging precorneal retention time can enhance intraocular bioavailability of drugs. Nanosystems utilizing mucoadhesive polymers or colloidal particles have emerged as promising strategies for more efficient treatment of ocular diseases.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Patrizia Nadia Hanieh, Angela Bonaccorso, Elide Zingale, Silvia Cimarelli, Eliana B. Souto, Federica Rinaldi, Carlotta Marianecci, Rosario Pignatello, Maria Carafa
Summary: The study aimed to develop oil-in-water nanoemulsions to extend the residence time of ophthalmic drugs in the eye, improving patient compliance.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Shiding Li, Liangbo Chen, Yao Fu
Summary: Ocular drug delivery is a challenging task for ophthalmologists and drug delivery scientists due to anatomical and physiological barriers. This review discusses the anatomy of the eye, common ocular diseases, and advancements in nanotechnology-based ocular drug delivery systems. It summarizes the characteristics of nanocarriers and provides insights into the challenges and directions for future research in novel ocular drug delivery systems. The review aims to inspire and motivate the design and development of innovative ophthalmic formulations.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Hala N. ElShagea, Rana R. Makar, Alaa H. Salama, Nermeen A. Elkasabgy, Emad B. Basalious
Summary: This study focuses on delivering the hydrophilic drug, rasagiline mesylate (RSM), directly to the brain through intranasal administration. Transferosomes were formed to encapsulate RSM and incorporated into an in situ gel. The optimized transferosomal in situ gel showed safety and biocompatibility, with enhanced brain bioavailability and direct nose-to-brain drug delivery.
Review
Engineering, Biomedical
Sony Priyanka Bandi, Shubhmita Bhatnagar, Venkata Vamsi Krishna Venuganti
Summary: Mucus is a viscoelastic gel that traps pathogens and foreign particles, while also being essential for drug carriers to access underlying epithelial tissues. Various strategies have been developed to achieve mucoadhesion and mucus penetration in drug delivery systems. Advances in materials chemistry have led to the expansion of materials available for mucosal drug delivery applications.
ACTA BIOMATERIALIA
(2021)
Article
Engineering, Biomedical
Mitchell Ross, Lindsay Sheardown, Benjamin Muirhead, Jonathan Mofford, Jennifer (JingYuan) Tian, Heather Sheardown
Summary: A platform of mucoadhesive and thermogelling eyedrops was developed for the treatment of various ocular conditions. The materials used were highly tunable, allowing for the delivery of different therapeutic agents. The safety and tolerability of the eyedrops was demonstrated in both in vitro and in vivo studies.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2023)
Article
Instruments & Instrumentation
Valentina Andretto, Annalisa Rosso, Stephanie Briancon, Giovanna Lollo
Summary: Oral delivery is a favored method for delivering active molecules, but challenges like the complexity of colloidal systems and their interaction with biological barriers need to be overcome for precision medicine.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2021)
Review
Polymer Science
Siphokazi B. K. Dludla, Leshasha T. Mashabela, Brian Ng'andwe, Pedzisai A. Makoni, Bwalya A. Witika
Summary: The application of nanotechnology in ophthalmic drug delivery systems shows great potential to overcome barriers faced by traditional ophthalmic formulations. Stimuli-responsive nano drug carriers have attracted significant attention due to their unique functionalities and therapeutic efficacy, playing a crucial role in the treatment and alleviation of ocular diseases.
Review
Pharmacology & Pharmacy
Bastien Leclercq, Dan Mejlachowicz, Francine Behar-Cohen
Summary: The eye is composed of tissues and cavities that are regulated to maintain their optical properties and functions. Specialized junctions between cells control the passage of drugs, while specific transporters regulate the movement of water, ions, and macromolecules. Ocular barriers limit the bioavailability of gene therapy products, but also allow for local treatment with minimal systemic side-effects. Understanding these barriers is essential for the development of efficient gene delivery systems.
Review
Pharmacology & Pharmacy
Xiaojun Wang, Fuxiao Luan, Hua Yue, Cui Song, Shuang Wang, Jing Feng, Xiao Zhang, Wei Yang, Yuxin Li, Wei Wei, Yong Tao
Summary: Due to the complexity of ocular diseases and the natural ocular barriers, drug therapy for these diseases has limitations. With the development of biotechnology, smart materials have been widely tested to treat ocular diseases. This review analyzes recent developments in smart materials and discusses future directions for clinical translation.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Article
Pharmacology & Pharmacy
Roman Moiseev, Fraser Steele, Vitaliy V. Khutoryanskiy
Summary: As drug delivery to the eye has advanced, researchers have focused on finding better treatments for ocular diseases. This study evaluated different polyaphron formulations and found that the 3% polyquaternium 10-based formulation had the best corneal retention, while the 10% poloxamer 188 and 1% polyquaternium 10-based formulations were the most stable. Toxicological evaluations showed that all four formulations had good biocompatibility with ocular tissues. These drug delivery systems have great potential for ocular drug delivery.
Review
Cell Biology
Nguyen Thi Thanh Nhan, Daniel E. Maidana, Kaori H. Yamada
Summary: Cell-penetrating peptides (CPPs) can facilitate the cellular uptake of drugs in the eye, particularly for retinal diseases. They have the potential to reduce the frequency of injections by delivering long-acting drugs to the posterior pole of the eye. Recent studies have shown that CPPs can effectively deliver FDA-approved drugs to the targeted area in animal models. This review summarizes the advances in CPPs, peptide-based drugs, and their use in ocular drug delivery.
Article
Polymer Science
D. S. Kazybayeva, G. S. Irmukhametova, V. V. Khutoryanskiy
Summary: This review focuses on the synthesis of novel organic compounds and polymer materials using click chemistry concept, specifically highlighting thiol-ene reactions and their diverse applications in biocompatible materials, cell culture, block copolymer synthesis, degradable materials, and various functionalized systems.
POLYMER SCIENCE SERIES B
(2022)
Review
Chemistry, Multidisciplinary
Nathalie Hock, Giuseppe Francesco Racaniello, Sam Aspinall, Nunzio Denora, Vitaliy V. Khutoryanskiy, Andreas Bernkop-Schnuerch
Summary: This review discusses the interface between thiol chemistry and nanoparticles, highlighting the various functionalities gained by thiolation. These include enhanced bio- and mucoadhesive properties, improved cellular uptake, and permeation enhancement. Various applications such as drug delivery, targeted therapy, and diagnostics can benefit from thiolated nanoparticles.
Article
Chemistry, Applied
Stephanie P. Bull, Vitaliy V. Khutoryanskiy, Jane K. Parker, Marianthi Faka, Lisa Methven
Summary: This study found that heated whey protein concentrate has a longer retention time in the oral cavity compared to unheated WPC, causing structural changes, increased free thiol concentration, and exposure of hydrophobic regions. These factors contribute to increased mucoadhesive strength and mouthdrying perception.
Article
Pharmacology & Pharmacy
Roman Moiseev, Fraser Steele, Vitaliy V. Khutoryanskiy
Summary: As drug delivery to the eye has advanced, researchers have focused on finding better treatments for ocular diseases. This study evaluated different polyaphron formulations and found that the 3% polyquaternium 10-based formulation had the best corneal retention, while the 10% poloxamer 188 and 1% polyquaternium 10-based formulations were the most stable. Toxicological evaluations showed that all four formulations had good biocompatibility with ocular tissues. These drug delivery systems have great potential for ocular drug delivery.
Article
Pharmacology & Pharmacy
Adaeze L. Onugwu, Anthony A. Attama, Petra O. Nnamani, Sabastine O. Onugwu, Ebele B. Onuigbo, Vitaliy V. Khutoryanskiy
Summary: This study developed and evaluated solid lipid nanoparticles coated with poly(2-ethyl-2-oxazoline) and chitosan for ocular delivery of ciprofloxacin. The optimized formulation showed good particle size and encapsulation efficiency, and chitosan-coated solid lipid nanoparticles exhibited higher mucoadhesion and retention on corneal tissues compared to poly(2-ethyl-2-oxazoline) formulation.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Physical
Twana Mohammed M. Ways, Sergey K. Filippov, Samarendra Maji, Mathias Glassner, Michal Ceglowski, Richard Hoogenboom, Stephen King, Wing Man Lau, Vitaliy V. Khutoryanskiy
Summary: Transmucosal administration has many advantages for drug delivery, such as avoiding first pass metabolism, providing rapid onset of action, and being a non-invasive route. However, the mucus gel layer on mucosal surfaces acts as a protective barrier and inhibits the diffusion of drugs, reducing their efficacy. The design of mucus-penetrating nanoparticles can overcome this barrier and improve therapeutic outcomes.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Sam R. Aspinall, Vitaliy V. Khutoryanskiy
Summary: This study synthesized and tested a range of functionalized silica particles and found that the particles with modified surfaces can significantly improve the retention of oral care formulations on oral mucosal surfaces.
Article
Polymer Science
Fhataheya Buang, Afroditi Chatzifragkou, Mohd Cairul Iqbal Mohd Amin, Vitaliy V. V. Khutoryanskiy
Summary: Non-ionic hydroxyethylcellulose (HEC) was chemically modified with glycidyl methacrylate to enhance its mucoadhesive properties. The modification was confirmed by H-1 NMR and FTIR spectroscopy, and quantification of methacryloyl groups was done using HPLC. Toxicity studies showed no toxicological effects of the modified HEC. Mucoadhesive wafers developed from the modified HEC exhibited significantly better mucoadhesive properties compared to unmodified HEC.
Article
Pharmacology & Pharmacy
Nadezda E. Kashapova, Ruslan R. Kashapov, Albina Y. Ziganshina, Dmitry O. Nikitin, Irina I. Semina, Vadim V. Salnikov, Vitaliy V. Khutoryanskiy, Rouslan I. Moustafine, Lucia Y. Zakharova
Summary: A water-soluble form of haloperidol was obtained by coaggregation with calix[4]resorcinol to form vesicular nanoparticles. The nanoparticles showed mucoadhesive and thermosensitive properties, making them potentially effective drug delivery systems. In pharmacological studies, haloperidol formulated with calix[4]resorcinol exhibited a cataleptogenic effect in rats both when administered intranasally and intraperitoneally.
Article
Polymer Science
Regina R. Vildanova, Svetlana F. Petrova, Sergey V. Kolesov, Vitaliy V. Khutoryanskiy
Summary: Preparation of stable hydrogels using charge-complementary polyelectrolyte chains offers practical advantages over the use of organic crosslinking agents. This study utilizes natural polyelectrolytes-chitosan and pectin-with their biocompatibility and biodegradability. Different molecular weights of pectin are used to prepare hydrogels with varying rheological characteristics and swelling kinetics. These polyelectrolyte hydrogels can release the cytostatic drug cisplatin over an extended period, potentially improving the effectiveness of cancer treatment.
Article
Pharmacology & Pharmacy
Fhataheya Buang, Manfei Fu, Afroditi Chatzifragkou, Mohd Cairul Iqbal Mohd Amin, Vitaliy V. Khutoryanskiy
Summary: Hydroxyethylcellulose (HEC) is a water-soluble polymer with poor mucoadhesive properties. This study explores the modification of HEC by conjugation with maleimide groups to improve its mucoadhesive properties. The modified HEC exhibits superior mucoadhesive properties compared to unmodified HEC, forming a strong bond with mucin. The safety and efficacy of the newly synthesized polymer derivatives were also evaluated.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Physical
Saul J. Hunter, Mahmoud H. Abu Elella, Edwin C. Johnson, Laura Taramova, Emma E. Brotherton, Steven P. Armes, Vitaliy V. Khutoryanskiy, Mark J. Smallridge
Summary: Spherical aldehyde-functionalized nanoparticles were prepared through aqueous emulsion polymerization, and when combined with oil droplets, formed nanoemulsions. The aldehyde-functionalized nanoparticles showed stronger adhesion to sheep nasal mucosal tissue due to the formation of imine bonds.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Chemistry, Physical
Zhiwei Huang, Roman V. Moiseev, Solomon S. Melides, Wooli Bae, Izabela Jurewicz, Vitaliy V. Khutoryanskiy, Joseph L. Keddie
Summary: This study evaluated the use of nanoparticles-stabilised Pickering emulsions for the confinement of organic components in ocular drug delivery. The results showed that these emulsions had good stability and mucoadhesive properties, and were non-toxic to tissues. These emulsions have distinct advantages for ocular drug delivery and could serve as a reference for future formulation design for drug delivery.
Article
Chemistry, Multidisciplinary
Sergey K. Filippov, Ramil Khusnutdinov, Anastasiia Murmiliuk, Wali Inam, Lucia Ya. Zakharova, Hongbo Zhang, Vitaliy V. Khutoryanskiy
Summary: This focus article provides a detailed analysis of transmission electron microscopy (TEM) and dynamic light scattering (DLS) as two common methods for studying nanoparticle sizes in pharmaceutics and drug delivery. The article highlights the importance of controlling nanoparticle size and shape in biomedical systems and discusses the discrepancies in size measurements obtained from TEM and DLS. The authors convincingly demonstrate that properly conducted experimental procedures and careful analysis of results can eliminate or reduce the mismatch between DLS and TEM data.
MATERIALS HORIZONS
(2023)
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)
