PDGFRα signalling promotes fibrogenic responses in collagen-producing cells in Duchenne muscular dystrophy

Nilotinib reduces muscle fibrosis in chronic muscle injury by promoting TNF-mediated apoptosis of fibro/adipogenic progenitors

(2015) Dario R Lemos et al.   NATURE MEDICINE

Fibrogenic Cell Plasticity Blunts Tissue Regeneration and Aggravates Muscular Dystrophy

(2015) Patrizia Pessina et al.   Stem Cell Reports

Resident fibroblast lineages mediate pressure overload–induced cardiac fibrosis

(2014) Thomas Moore-Morris et al.   JOURNAL OF CLINICAL INVESTIGATION

Activation of Platelet-Derived Growth Factor Receptor Alpha Contributes to Liver Fibrosis

(2014) Brian J. Hayes et al.   PLoS One

Identification and characterization of PDGFRα+ mesenchymal progenitors in human skeletal muscle

(2014) A Uezumi et al.   Cell Death & Disease

Src-dependent impairment of autophagy by oxidative stress in a mouse model of Duchenne muscular dystrophy

(2014) Rituraj Pal et al.   Nature Communications

Understanding the Process of Fibrosis in Duchenne Muscular Dystrophy

(2014) Yacine Kharraz et al.   Biomed Research International

Crenolanib is active against models of drug-resistant FLT3-ITD-positive acute myeloid leukemia

(2013) E. I. Zimmerman et al.   BLOOD

Large-scale Analysis of PDGFRA Mutations in Melanomas and Evaluation of Their Sensitivity to Tyrosine Kinase Inhibitors Imatinib and Crenolanib

(2013) J. Dai et al.   CLINICAL CANCER RESEARCH

Coronary adventitial cells are linked to perivascular cardiac fibrosis via TGFβ1 signaling in the mdx mouse model of Duchenne muscular dystrophy

(2013) Nicholas Ieronimakis et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Imatinib attenuates severe mouse dystrophy and inhibits proliferation and fibrosis-marker expression in muscle mesenchymal progenitors

(2013) Takahito Ito et al.   NEUROMUSCULAR DISORDERS

Increased sphingosine-1-phosphate improves muscle regeneration in acutely injured mdx mice

(2013) Nicholas Ieronimakis et al.   Skeletal Muscle

Crenolanib Inhibits the Drug-Resistant PDGFRA D842V Mutation Associated with Imatinib-Resistant Gastrointestinal Stromal Tumors

(2012) M. C. Heinrich et al.   CLINICAL CANCER RESEARCH

The bHLH transcription factor Tcf21 is required for lineage-specific EMT of cardiac fibroblast progenitors

(2012) A. Acharya et al.   DEVELOPMENT

Clinical cardiac safety profile of nilotinib

(2012) T. D. Kim et al.   HAEMATOLOGICA

PDGFRβ Signaling Regulates Mural Cell Plasticity and Inhibits Fat Development

(2011) Lorin E. Olson et al.   DEVELOPMENTAL CELL

Efficient inducible Cre-mediated recombination in Tcf21cell lineages in the heart and kidney

(2011) Asha Acharya et al.   GENESIS

Losartan Decreases Cardiac Muscle Fibrosis and Improves Cardiac Function in Dystrophin-Deficient Mdx Mice

(2011) Christopher F. Spurney et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS

Fibrosis and adipogenesis originate from a common mesenchymal progenitor in skeletal muscle

(2011) A. Uezumi et al.   JOURNAL OF CELL SCIENCE

Expression of collagen VI α5 and α6 chains in human muscle and in Duchenne muscular dystrophy-related muscle fibrosis

(2011) Patrizia Sabatelli et al.   MATRIX BIOLOGY

Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition

(2011) J. R. Rock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapid quantification of myocardial fibrosis: a new macro-based automated analysis

(2011) Awal M. Hadi et al.   CELLULAR ONCOLOGY

Aberrant repair and fibrosis development in skeletal muscle

(2011) Christopher J Mann et al.   Skeletal Muscle

Origins of Cardiac Fibroblasts

(2010) Elisabeth M. Zeisberg et al.   CIRCULATION RESEARCH

Increased connective tissue growth factor associated with cardiac fibrosis in the mdx mouse model of dystrophic cardiomyopathy

(2010) Carol G. Au et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Mesenchymal progenitors distinct from satellite cells contribute to ectopic fat cell formation in skeletal muscle

(2010) Akiyoshi Uezumi et al.   NATURE CELL BIOLOGY

Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis

(2010) Aaron W. B. Joe et al.   NATURE CELL BIOLOGY

NG2+ CNS Glial Progenitors Remain Committed to the Oligodendrocyte Lineage in Postnatal Life and following Neurodegeneration

(2010) Shin H. Kang et al.   NEURON

Absence of CD34 on Murine Skeletal Muscle Satellite Cells Marks a Reversible State of Activation during Acute Injury

(2010) Nicholas Ieronimakis et al.   PLoS One

Syndecan-1

(2009) Nozomi Fukai et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Increased PDGFRα Activation Disrupts Connective Tissue Development and Drives Systemic Fibrosis

(2009) Lorin E. Olson et al.   DEVELOPMENTAL CELL

Imatinib attenuates skeletal muscle dystrophy in mdx mice

(2009) Ping Huang et al.   FASEB JOURNAL

Phase I Study of the Safety, Tolerability, and Pharmacokinetics of Oral CP-868,596, a Highly Specific Platelet-Derived Growth Factor Receptor Tyrosine Kinase Inhibitor in Patients With Advanced Cancers

(2009) Nancy L. Lewis et al.   JOURNAL OF CLINICAL ONCOLOGY

Endomysial Fibrosis in Duchenne Muscular Dystrophy: A Marker of Poor Outcome Associated With Macrophage Alternative Activation

(2009) Isabelle Desguerre et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Pericytes and Perivascular Fibroblasts Are the Primary Source of Collagen-Producing Cells in Obstructive Fibrosis of the Kidney

(2008) Shuei-Liong Lin et al.   AMERICAN JOURNAL OF PATHOLOGY

DIAPHRAGM MUSCLE STRIP PREPARATION FOR EVALUATION OF GENE THERAPIES IN mdx MICE

(2008) John A Faulkner et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

The transcriptome of retinal Müller glial cells

(2008) Karin Roesch et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Direct Isolation, Culture and Transplant of Mouse Skeletal Muscle Derived Endothelial Cells with Angiogenic Potential

(2008) Nicholas Ieronimakis et al.   PLoS One