Targeted inhibition of FcRn reduces NET formation to ameliorate experimental ulcerative colitis by accelerating ANCA clearance

Expression levels of cellular inhibitor of apoptosis proteins and colitogenic cytokines are inversely correlated with the activation of interferon regulatory factor 4

(2022) Sho Masaki et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Annickia polycarpa extract attenuates inflammation, neutrophil recruitment, and colon damage during colitis

(2022) Nathaniel L. Lartey et al.   IMMUNOLOGY LETTERS

Neutrophil Extracellular Traps and Their Implications in Cardiovascular and Inflammatory Disease

(2021) Johannes Klopf et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Emerging Therapies in Immune Thrombocytopenia

(2021) Sylvain Audia et al.   Journal of Clinical Medicine

Ulcerative colitis: an update

(2021) Jonathan P Segal et al.   CLINICAL MEDICINE

IgG regulation through FcRn blocking: A novel mechanism for the treatment of myasthenia gravis

(2021) Gil I. Wolfe et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

First- and Second-line Pharmacotherapies for Patients with Moderate to Severely Active Ulcerative Colitis: An Updated Network Meta-Analysis

(2020) Siddharth Singh et al.   Clinical Gastroenterology and Hepatology

Ulcerative colitis: understanding its cellular pathology could provide insights into novel therapies

(2020) Amandip Kaur et al.   Journal of Inflammation-London

The neonatal Fc receptor in cancer FcRn in cancer

(2020) Diana Cadena Castaneda et al.   Cancer Medicine

Assessment of clinical activity and severity using serum ANCA and ASCA antibodies in patients with ulcerative colitis

(2020) Yanhua Pang et al.   Allergy Asthma and Clinical Immunology

The biodistribution of therapeutic proteins: Mechanism, implications for pharmacokinetics, and methods of evaluation

(2020) Kip P. Conner et al.   PHARMACOLOGY & THERAPEUTICS

Biologic Therapy for Ulcerative Colitis

(2020) Abhik Bhattacharya et al.   GASTROENTEROLOGY CLINICS OF NORTH AMERICA

Ulcerative Colitis

(2020) Tanyaporn Kaenkumchorn et al.   GASTROENTEROLOGY CLINICS OF NORTH AMERICA

Epidemiology and Pathogenesis of Ulcerative Colitis

(2020) Lillian Du et al.   GASTROENTEROLOGY CLINICS OF NORTH AMERICA

Targeting FcRn for immunomodulation: Benefits, risks, and practical considerations

(2020) Hans-Hartmut Peter et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Ulcerative colitis: Gut microbiota, immunopathogenesis and application of natural products in animal models

(2020) Roberto de Paula do Nascimento et al.   LIFE SCIENCES

Neutrophil Extracellular Traps Sustain Inflammatory Signals in Ulcerative Colitis

(2019) Vincenzo Dinallo et al.   Journal of Crohns & Colitis

Induction and maintenance treatment of inflammatory bowel disease: A comprehensive review

(2019) Dong Yeon Jeong et al.   AUTOIMMUNITY REVIEWS

Human cytomegalovirus evades antibody-mediated immunity through endoplasmic reticulum-associated degradation of the FcRn receptor

(2019) Xiaoyang Liu et al.   Nature Communications

Next-generation Fc receptor–targeting biologics for autoimmune diseases

(2019) Adrian W. Zuercher et al.   AUTOIMMUNITY REVIEWS

Phase 2 study of efgartigimod, a novel FcRn antagonist, in adult patients with primary immune thrombocytopenia

(2019) Adrian C. Newland et al.   AMERICAN JOURNAL OF HEMATOLOGY

Blocking FcRn in humans reduces circulating IgG levels and inhibits IgG immune complex–mediated immune responses

(2019) L. J. Blumberg et al.   Science Advances

Neutrophil Extracellular Traps: The Biology of Chromatin Externalization

(2018) Gabriel Sollberger et al.   DEVELOPMENTAL CELL

M281, an Anti-FcRn Antibody: Pharmacodynamics, Pharmacokinetics, and Safety Across the Full Range of IgG Reduction in a First-in-Human Study

(2018) Leona E. Ling et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Pathogenesis and therapeutic interventions for ANCA-associated vasculitis

(2018) Daigo Nakazawa et al.   Nature Reviews Rheumatology

Neutrophil Extracellular Traps and Its Implications in Inflammation: An Overview

(2017) Vidal Delgado-Rizo et al.   Frontiers in Immunology

The clinical presentation and therapy of diseases related to anti-neutrophil cytoplasmic antibodies (ANCA)

(2016) Maria Weiner et al.   AUTOIMMUNITY REVIEWS

The role of neutrophils and NETosis in autoimmune and renal diseases

(2016) Sarthak Gupta et al.   Nature Reviews Nephrology

New Insights into Neutrophil Extracellular Traps: Mechanisms of Formation and Role in Inflammation

(2016) Hang Yang et al.   Frontiers in Immunology

FcRn: The Architect Behind the Immune and Nonimmune Functions of IgG and Albumin

(2015) Michal Pyzik et al.   JOURNAL OF IMMUNOLOGY

Immunopathogenesis of IBD: current state of the art

(2015) Heitor S. P. de Souza et al.   Nature Reviews Gastroenterology & Hepatology

Presence of Anti-proteinase 3 Antineutrophil Cytoplasmic Antibodies (Anti-PR3 ANCA) as Serologic Markers in Inflammatory Bowel Disease

(2013) Maria Teresa Arias-Loste et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Neutrophil Extracellular Traps: Double-Edged Swords of Innate Immunity

(2012) M. J. Kaplan et al.   JOURNAL OF IMMUNOLOGY