Mutations and insights into the molecular mechanisms of resistance of Mycobacterium tuberculosis to first-line

Whole-genome sequencing of Mycobacterium tuberculosis for prediction of drug resistance

(2022) Luqi Wang et al.   EPIDEMIOLOGY AND INFECTION

Bedaquiline: current status and future perspectives

(2021) Saeed Khoshnood et al.   Journal of Global Antimicrobial Resistance

Recent Insights into the Structure and Function of Mycobacterial Membrane Proteins Facilitated by Cryo-EM

(2021) Ameya D. Bendre et al.   JOURNAL OF MEMBRANE BIOLOGY

Profiling Pretomanid as a Therapeutic Option for TB Infection: Evidence to Date

(2021) Stephani L Stancil et al.   Drug Design Development and Therapy

Genetic variants and their association with phenotypic resistance to bedaquiline in Mycobacterium tuberculosis: a systematic review and individual isolate data analysis

(2021) Nabila Ismail et al.   Lancet Microbe

Novel C-3-(N-alkyl-aryl)-aminomethyl rifamycin SV derivatives exhibit activity against rifampicin-resistant Mycobacterium tuberculosis RpoBS522L strain and display a different binding mode at the RNAP β-subunit site compared to rifampicin

(2021) Mire Zloh et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Rifamycins: do not throw the baby out with the bathwater. Is rifampicin still an effective anti-tuberculosis drug?

(2021) Federico Brucoli et al.   Future Medicinal Chemistry

Detection of Novel Gene Mutations Associated with Pyrazinamide Resistance in Multidrug-Resistant Mycobacterium tuberculosis Clinical Isolates in Southern China

(2020) HM Adnan Hameed et al.   Infection and Drug Resistance

Systematic review of mutations associated with resistance to the new and repurposed Mycobacterium tuberculosis drugs bedaquiline, clofazimine, linezolid, delamanid and pretomanid

(2020) Suha Kadura et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Structures of cell wall arabinosyltransferases with the anti-tuberculosis drug ethambutol

(2020) Lu Zhang et al.   SCIENCE

Detection of a Novel Mutation in the rpoB gene in a Multidrug Resistant Mycobacterium tuberculosis Isolate using Whole Genome Next Generation Sequencing

(2020) Nilma Hirani et al.   Journal of Global Antimicrobial Resistance

Bedaquiline and delamanid for drug-resistant tuberculosis: a clinician’s perspective

(2020) Lorenzo Guglielmetti et al.   Future Microbiology

Detection of mutations in the rpoB gene of rifampicin-resistant Mycobacterium tuberculosis strains inhibiting wild type probe hybridization in the MTBDR plus assay by DNA sequencing directly from clinical specimens

(2020) Pallavi Sinha et al.   BMC MICROBIOLOGY

Low-level rifampin resistance and rpoB mutations in Mycobacterium tuberculosis: An analysis of whole-genome sequencing and drug susceptibility test data in New York

(2020) Joseph Shea et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Characterization of Genomic Variants Associated with Resistance to Bedaquiline and Delamanid in Naive Mycobacterium tuberculosis Clinical Strains

(2020) S. Battaglia et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Structure of mycobacterial ATP synthase bound to the tuberculosis drug bedaquiline

(2020) Hui Guo et al.   NATURE

A structural insight of bedaquiline for the cardiotoxicity and hepatotoxicity

(2019) Harun Patel et al.   TUBERCULOSIS

Pretomanid: First Approval

(2019) Susan J. Keam   DRUGS

Evolution of rifampicin treatment for tuberculosis

(2019) Melanie Grobbelaar et al.   INFECTION GENETICS AND EVOLUTION

Linezolid Kills Acid Phase and Non-replicative Persister Phase Mycobacterium tuberculosis in a Hollow Fiber Infection Model

(2018) G.L. Drusano et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Clofazimine: A useful antibiotic for drug-resistant tuberculosis

(2018) Reza Mirnejad et al.   BIOMEDICINE & PHARMACOTHERAPY

Multi- and Extensively Drug Resistant Mycobacterium tuberculosis in South Africa: a Molecular Analysis of Historical Isolates

(2018) Nontuthuko E. Maningi et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Role of Disputed Mutations in the rpoB Gene in Interpretation of Automated Liquid MGIT Culture Results for Rifampin Susceptibility Testing of Mycobacterium tuberculosis

(2018) Paolo Miotto et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Molecular drug resistance profiles of Mycobacterium tuberculosis from sputum specimens using ion semiconductor sequencing

(2018) Joonhong Park et al.   JOURNAL OF MICROBIOLOGICAL METHODS

Linezolid: a review of its properties, function, and use in critical care

(2018) Seyed MohammadReza Hashemian et al.   Drug Design Development and Therapy

Determining Genotypic Drug Resistance by Ion Semiconductor Sequencing With the Ion AmpliSeq™ TB Panel in Multidrug-Resistant Mycobacterium tuberculosis Isolates

(2018) Joonhong Park et al.   Annals of Laboratory Medicine

Delamanid, Bedaquiline, and Linezolid Minimum Inhibitory Concentration Distributions and Resistance-related Gene Mutations in Multidrug-resistant and Extensively Drug-resistant Tuberculosis in Korea

(2018) Jeong Seong Yang et al.   Annals of Laboratory Medicine

Validation of Novel Mycobacterium tuberculosis Isoniazid Resistance Mutations Not Detectable by Common Molecular Tests

(2018) Justin L. Kandler et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Molecular mechanism of the synergistic activity of ethambutol and isoniazid against Mycobacterium tuberculosis

(2018) Chen Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

InhA, the enoyl-thioester reductase from Mycobacterium tuberculosis forms a covalent adduct during catalysis.

(2018) Bastian Vögeli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clofazimine for the treatment of multidrug-resistant tuberculosis

(2018) C. Lange et al.   CLINICAL MICROBIOLOGY AND INFECTION

Detection of novel mutations associated with independent and cross-resistance to isoniazid and prothionamide in Mycobacterium tuberculosis clinical isolates

(2018) Md Mahmudul Islam et al.   CLINICAL MICROBIOLOGY AND INFECTION

Characterization of novel Mycobacterium tuberculosis pncA gene mutations in clinical isolates from the Ukraine

(2018) LT Daum et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

Bedaquiline and delamanid in the treatment of multidrug‐resistant tuberculosis: Promising but challenging

(2018) Yang Li et al.   DRUG DEVELOPMENT RESEARCH

Pyrazinamide resistance and mutations L19R, R140H, and E144K in Pyrazinamidase of Mycobacterium tuberculosis

(2018) Muhammad Tahir Khan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Interplay between Mutations and Efflux in Drug Resistant Clinical Isolates of Mycobacterium tuberculosis

(2017) Diana Machado et al.   Frontiers in Microbiology

Screening mutations in drug-resistant Mycobacterium tuberculosis strains in Yunnan, China

(2017) Daoqun Li et al.   Journal of Infection and Public Health

Overview on mechanisms of isoniazid action and resistance in Mycobacterium tuberculosis

(2016) Ameeruddin Nusrath Unissa et al.   INFECTION GENETICS AND EVOLUTION

Mechanisms of drug resistance in Mycobacterium tuberculosis: update 2015

(2015) Y. Zhang et al.   INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE

Crystal structure of the enoyl-ACP reductase of Mycobacterium tuberculosis (InhA) in the apo-form and in complex with the active metabolite of isoniazid pre-formed by a biomimetic approach

(2015) Aurélien Chollet et al.   JOURNAL OF STRUCTURAL BIOLOGY

Tuberculosis Treatment and Drug Regimens

(2015) G. Sotgiu et al.   Cold Spring Harbor Perspectives in Medicine

Genetic Mutations Associated with Isoniazid Resistance in Mycobacterium tuberculosis: A Systematic Review

(2015) Marva Seifert et al.   PLoS One

Mutations in theembC-embAIntergenic Region Contribute to Mycobacterium tuberculosis Resistance to Ethambutol

(2014) Zhenling Cui et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Reactive dirty fragments: implications for tuberculosis drug discovery

(2014) Pooja Gopal et al.   CURRENT OPINION IN MICROBIOLOGY

Resistance to rifampicin: a review

(2014) Beth P Goldstein   JOURNAL OF ANTIBIOTICS

Mycobacterium canettii is intrinsically resistant to both pyrazinamide and pyrazinoic acid

(2013) S. Feuerriegel et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Mutations in panD encoding aspartate decarboxylase are associated with pyrazinamide resistance in Mycobacterium tuberculosis

(2013) Shuo Zhang et al.   Emerging Microbes & Infections

Current status and future trends in the diagnosis and treatment of drug-susceptible and multidrug-resistant tuberculosis

(2013) Suhail Ahmad et al.   Journal of Infection and Public Health

Study of the Rifampin Monoresistance Mechanism in Mycobacterium tuberculosis

(2012) Y. Pang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Strategies for potentiation of ethionamide and folate antagonists againstMycobacterium tuberculosis

(2012) Kerstin A Wolff et al.   Expert Review of Anti-Infective Therapy

Crystal Structure of the Pyrazinamidase of Mycobacterium tuberculosis: Insights into Natural and Acquired Resistance to Pyrazinamide

(2011) Stéphanie Petrella et al.   PLoS One

Pyrazinamide Inhibits Trans-Translation in Mycobacterium tuberculosis

(2011) W. Shi et al.   SCIENCE

embCAB sequence variation among ethambutol-resistant Mycobacterium tuberculosis isolates without embB306 mutation

(2010) C. Plinke et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

The Arabinosyltransferase EmbC Is Inhibited by Ethambutol in Mycobacterium tuberculosis

(2009) R. Goude et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Diversity in enoyl-acyl carrier protein reductases

(2009) R. P. Massengo-Tiassé et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Tuberculosis ethambutol resistance: Concordance between phenotypic and genotypic test results

(2009) Claudia Plinke et al.   TUBERCULOSIS

Transfer of embB Codon 306 Mutations into Clinical Mycobacterium tuberculosis Strains Alters Susceptibility to Ethambutol, Isoniazid, and Rifampin

(2008) H. Safi et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY