Elevated sphingosine-1-phosphate lyase leads to increased metabolism and reduced survival in adrenocortical carcinoma

Targeting Sphingolipid Metabolism as a Therapeutic Strategy in Cancer Treatment

(2022) Alhaji H. Janneh et al.   Cancers

The diversity and breadth of cancer cell fatty acid metabolism

(2021) Shilpa R. Nagarajan et al.   Cancer & Metabolism

Targeting the Sphingosine Kinase/Sphingosine-1-Phosphate Signaling Axis in Drug Discovery for Cancer Therapy

(2021) Preeti Gupta et al.   Cancers

Sphingolipid metabolism in the development and progression of cancer: one cancer’s help is another’s hindrance

(2021) Antonia Piazzesi et al.   Molecular Oncology

Identification of novel lipid metabolic biomarkers associated with poor adrenocortical carcinoma prognosis using integrated bioinformatics

(2021) Chitra Subramanian et al.   SURGERY

Sgpl1 deletion elevates S1P levels, contributing to NPR2 inactivity and p21 expression that block germ cell development

(2021) Feifei Yuan et al.   Cell Death & Disease

S1P signaling, its interactions and cross-talks with other partners and therapeutic importance in colorectal cancer

(2021) Real Sumayya Abdul Sattar et al.   CELLULAR SIGNALLING

Targeting Sphingolipids for Cancer Therapy

(2021) Osmel Companioni et al.   Frontiers in Oncology

Reign in the membrane: How common lipids govern mitochondrial function

(2020) Katsuhiko Funai et al.   CURRENT OPINION IN CELL BIOLOGY

Recent advances in the role of sphingosine 1‐phosphate in cancer

(2020) Nigel J. Pyne et al.   FEBS LETTERS

Sphingosine-1-phosphate lyase (SGPL1) deficiency is associated with mitochondrial dysfunction

(2020) A. Maharaj et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Targeted assessment of G0S2 methylation identifies a rapidly recurrent, routinely fatal molecular subtype of adrenocortical carcinoma

(2019) Dipika R. Mohan et al.   CLINICAL CANCER RESEARCH

Roles of sphingosine-1-phosphate signaling in cancer

(2019) Peng Wang et al.   Cancer Cell International

Oxidative Phosphorylation as an Emerging Target in Cancer Therapy

(2018) Thomas M. Ashton et al.   CLINICAL CANCER RESEARCH

An Accurate and Cost-Effective Alternative Method for Measuring Cell Migration with the Circular Wound Closure Assay

(2018) Michael L De Ieso et al.   BIOSCIENCE REPORTS

Longitudinal patterns of recurrence in patients with adrenocortical carcinoma

(2018) Jason A. Glenn et al.   SURGERY

Sphingosine-1-phosphate lyase mutations cause primary adrenal insufficiency and steroid-resistant nephrotic syndrome

(2017) Rathi Prasad et al.   JOURNAL OF CLINICAL INVESTIGATION

Mutations in sphingosine-1-phosphate lyase cause nephrosis with ichthyosis and adrenal insufficiency

(2017) Svjetlana Lovric et al.   JOURNAL OF CLINICAL INVESTIGATION

Comprehensive Pan-Genomic Characterization of Adrenocortical Carcinoma

(2016) Siyuan Zheng et al.   CANCER CELL

The Warburg Effect: How Does it Benefit Cancer Cells?

(2016) Maria V. Liberti et al.   TRENDS IN BIOCHEMICAL SCIENCES

Sphingosine-1-Phosphate Lyase Deficient Cells as a Tool to Study Protein Lipid Interactions

(2016) Mathias J. Gerl et al.   PLoS One

Aberrant expression of the S1P regulating enzymes, SPHK1 and SGPL1, contributes to a migratory phenotype in OSCC mediated through S1PR2

(2016) Sathya Narayanan Patmanathan et al.   Scientific Reports

Major Prognostic Role of Ki67 in Localized Adrenocortical Carcinoma After Complete Resection

(2015) Felix Beuschlein et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Sphingosine kinase 1 is overexpressed and promotes adrenocortical carcinoma progression

(2015) Yunze Xu et al.   Oncotarget

CerS2 Haploinsufficiency Inhibits β-Oxidation and Confers Susceptibility to Diet-Induced Steatohepatitis and Insulin Resistance

(2014) Suryaprakash Raichur et al.   Cell Metabolism

Adrenocortical Carcinoma

(2014) Tobias Else et al.   ENDOCRINE REVIEWS

Integrated genomic characterization of adrenocortical carcinoma

(2014) Guillaume Assié et al.   NATURE GENETICS

Adrenocortical carcinoma: A population-based study on incidence and survival in the Netherlands since 1993

(2013) Thomas M.A. Kerkhofs et al.   EUROPEAN JOURNAL OF CANCER

Ablation of Ceramide Synthase 2 Causes Chronic Oxidative Stress Due to Disruption of the Mitochondrial Respiratory Chain

(2013) Hila Zigdon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Diagnostic and prognostic role of steroidogenic factor 1 in adrenocortical carcinoma: a validation study focusing on clinical and pathologic correlates

(2012) Eleonora Duregon et al.   HUMAN PATHOLOGY

First Evidence of Sphingosine 1-Phosphate Lyase Protein Expression and Activity Downregulation in Human Neoplasm: Implication for Resistance to Therapeutics in Prostate Cancer

(2012) L. Brizuela et al.   MOLECULAR CANCER THERAPEUTICS

A Phase I Clinical Trial of Safingol in Combination with Cisplatin in Advanced Solid Tumors

(2011) M. A. Dickson et al.   CLINICAL CANCER RESEARCH

High Diagnostic and Prognostic Value of Steroidogenic Factor-1 Expression in Adrenal Tumors

(2010) Silviu Sbiera et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Inhibition of Sphingosine 1-Phosphate Lyase for the Treatment of Rheumatoid Arthritis: Discovery of (E)-1-(4-((1R,2S,3R)-1,2,3,4-Tetrahydroxybutyl)-1H-imidazol-2-yl)ethanone Oxime (LX2931) and (1R,2S,3R)-1-(2-(Isoxazol-3-yl)-1H-imidazol-4-yl)butane-1,2,3,4-tetraol (LX2932)

(2010) Jeffrey T. Bagdanoff et al.   JOURNAL OF MEDICINAL CHEMISTRY

Disruption of Sphingosine 1-Phosphate Lyase Confers Resistance to Chemotherapy and Promotes Oncogenesis through Bcl-2/Bcl-xL Upregulation

(2009) S. Colie et al.   CANCER RESEARCH

Gene Expression Profiling Reveals a New Classification of Adrenocortical Tumors and Identifies Molecular Predictors of Malignancy and Survival

(2009) Aurélien de Reyniès et al.   JOURNAL OF CLINICAL ONCOLOGY

Limited prognostic value of the 2004 International Union Against Cancer staging classification for adrenocortical carcinoma

(2008) Martin Fassnacht et al.   CANCER