Clinical Pharmacology of RNA Interference–Based Therapeutics: A Summary Based on Food and Drug Administration–Approved Small Interfering RNAs

Strategies for improving the safety and RNAi efficacy of noncovalent peptide/siRNA nanocomplexes

(2022) Jun Wang et al.   ADVANCES IN COLLOID AND INTERFACE SCIENCE

Givosiran Likely Inhibits Cytochrome P450 More Substantially Than Reported

(2022) Sander Bins et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Proteolysis-targeting chimeras (PROTACs) in cancer therapy

(2022) Xinyi Li et al.   Molecular Cancer

Pharmacokinetic and Pharmacodynamic Modeling of siRNA Therapeutics – a Minireview

(2022) Jae Yoon Jeon et al.   PHARMACEUTICAL RESEARCH

siRNA Drugs: Here to Stay

(2021) John J. Rossi et al.   MOLECULAR THERAPY

Physiologically based pharmacokinetic (PBPK) modeling of RNAi therapeutics: Opportunities and challenges

(2021) Kiara Fairman et al.   BIOCHEMICAL PHARMACOLOGY

A Drug‐Drug Interaction Study Evaluating the Effect of Givosiran, a Small Interfering Ribonucleic Acid (siRNA), on Cytochrome P450 Activity in Liver

(2021) Daphne Vassiliou et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

The Nonclinical Disposition and PK/PD Properties of GalNAc-conjugated siRNA Are Highly Predictable and Build Confidence in Translation to Man

(2021) Robin McDougall et al.   DRUG METABOLISM AND DISPOSITION

The current landscape of nucleic acid therapeutics

(2021) Jayesh A. Kulkarni et al.   Nature Nanotechnology

Antibody–oligonucleotide conjugates enter the clinic

(2021) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

RNA-Based Therapeutics: From Antisense Oligonucleotides to miRNAs

(2020) Sarah Bajan et al.   Cells

Advances with RNAi-Based Therapy for Hepatitis B Virus Infection

(2020) Fiona van den Berg et al.   Viruses-Basel

Paving the Road for RNA Therapeutics

(2020) Niels Dammes et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Clinical Pharmacology Studies Supporting Oligonucleotide Therapy Development: An Assessment of Therapies Approved and in Development Between 2012‐2018

(2020) Hobart Rogers et al.   CTS-Clinical and Translational Science

In Vitro Drug-Drug Interaction Evaluation of GalNAc conjugated siRNAs Against CYP450 Enzymes and Transporters

(2019) Diane Ramsden et al.   DRUG METABOLISM AND DISPOSITION

Evaluation of GalNAc-siRNA Conjugate Activity in Pre-clinical Animal Models with Reduced Asialoglycoprotein Receptor Expression

(2018) Jennifer L.S. Willoughby et al.   MOLECULAR THERAPY

GalNAc-siRNA Conjugates: Leading the Way for Delivery of RNAi Therapeutics

(2018) Aaron D. Springer et al.   Nucleic Acid Therapeutics

CRISPR-Cas guides the future of genetic engineering

(2018) Gavin J. Knott et al.   SCIENCE

The delivery of therapeutic oligonucleotides

(2016) Rudolph L. Juliano   NUCLEIC ACIDS RESEARCH

Pharmacokinetic Behaviors of Intravenously Administered siRNA in Glandular Tissues

(2016) Yuanyu Huang et al.   Theranostics

Variable asialoglycoprotein receptor 1 expression in liver disease: Implications for therapeutic intervention

(2015) Dominik Witzigmann et al.   HEPATOLOGY RESEARCH

siRNA Versus miRNA as Therapeutics for Gene Silencing

(2015) Jenny K W Lam et al.   Molecular Therapy-Nucleic Acids

Molecular Mechanisms of RNA Interference

(2013) Ross C. Wilson et al.   Annual Review of Biophysics

History of gene therapy

(2013) Thomas Wirth et al.   GENE

Action and Reaction: The Biological Response to siRNA and Its Delivery Vehicles

(2012) Rosemary L Kanasty et al.   MOLECULAR THERAPY

siRNA Off-Target Effects Can Be Reduced at Concentrations That Match Their Individual Potency

(2011) Daniel R. Caffrey et al.   PLoS One

Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application

(2009) Aimee L. Jackson et al.   NATURE REVIEWS DRUG DISCOVERY