Reducing the aneuploid cell burden – cell competition and the ribosome connection

The transcription factor Xrp1 orchestrates both reduced translation and cell competition upon defective ribosome assembly or function

(2022) Marianthi Kiparaki et al.   eLife

Extensive protein dosage compensation in aneuploid human cancers

(2022) Klaske M. Schukken et al.   GENOME RESEARCH

Proteotoxic stress is a driver of the loser status and cell competition

(2021) Michael E. Baumgartner et al.   NATURE CELL BIOLOGY

Ribosomopathy-associated mutations cause proteotoxic stress that is alleviated by TOR inhibition

(2021) Carles Recasens-Alvarez et al.   NATURE CELL BIOLOGY

Aneuploidy renders cancer cells vulnerable to mitotic checkpoint inhibition

(2021) Yael Cohen-Sharir et al.   NATURE

Cell competition removes segmental aneuploid cells from Drosophila imaginal disc-derived tissues based on ribosomal protein gene dose

(2021) Zhejun Ji et al.   eLife

Chromosome Instability, Aging and Brain Diseases

(2021) Ivan Y. Iourov et al.   Cells

Cell competition: A historical perspective

(2021) Ginés Morata   DEVELOPMENTAL BIOLOGY

Gene copy-number changes and chromosomal instability induced by aneuploidy confer resistance to chemotherapy

(2021) Marica Rosaria Ippolito et al.   DEVELOPMENTAL CELL

A p53-dependent translational program directs tissue-selective phenotypes in a model of ribosomopathies

(2021) Gerald C. Tiu et al.   DEVELOPMENTAL CELL

Proteostasis failure and mitochondrial dysfunction leads to aneuploidy-induced senescence

(2021) Jery Joy et al.   DEVELOPMENTAL CELL

Aneuploid senescent cells activate NF‐κB to promote their immune clearance by NK cells

(2021) Ruoxi W Wang et al.   EMBO REPORTS

Systems approaches identify the consequences of monosomy in somatic human cells

(2021) Narendra Kumar Chunduri et al.   Nature Communications

Genomic Mosaicism Formed by Somatic Variation in the Aging and Diseased Brain

(2021) Isabel Costantino et al.   Genes

Cell competition is driven by Xrp1-mediated phosphorylation of eukaryotic initiation factor 2α

(2021) Naotaka Ochi et al.   PLoS Genetics

Rpl24Bst mutation suppresses colorectal cancer by promoting eEF2 phosphorylation via eEF2K

(2021) John RP Knight et al.   eLife

Emerging mechanisms of cell competition

(2020) Nicholas E. Baker   NATURE REVIEWS GENETICS

The environmental stress response causes ribosome loss in aneuploid yeast cells

(2020) Allegra Terhorst et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy-mediated apoptosis eliminates aneuploid cells in a mouse model of chromosome mosaicism

(2020) Shruti Singla et al.   Nature Communications

Genetically predicted telomere length is associated with clonal somatic copy number alterations in peripheral leukocytes

(2020) Derek W. Brown et al.   PLoS Genetics

Cancer Biogenesis in Ribosomopathies

(2019) Sergey Sulima et al.   Cells

Insights into the loss of the Y chromosome with age in control individuals and in patients with age-related macular degeneration using genotyping microarray data

(2019) Felix Grassmann et al.   HUMAN GENETICS

Single-cell whole-genome sequencing reveals the functional landscape of somatic mutations in B lymphocytes across the human lifespan

(2019) Lei Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteotoxicity from aberrant ribosome biogenesis compromises cell fitness

(2019) Blake W Tye et al.   eLife

A ribosome assembly stress response regulates transcription to maintain proteome homeostasis

(2019) Benjamin Albert et al.   eLife

A direct comparison of interphase FISH versus low-coverage single cell sequencing to detect aneuploidy reveals respective strengths and weaknesses

(2019) Grasiella A. Andriani et al.   Scientific Reports

Cell Competition Is Driven by Autophagy

(2019) Rina Nagata et al.   DEVELOPMENTAL CELL

Genetic predisposition to mosaic Y chromosome loss in blood

(2019) Deborah J. Thompson et al.   NATURE

Drosophila RpS12 controls translation, growth, and cell competition through Xrp1

(2019) Zhejun Ji et al.   PLoS Genetics

Roles of C/EBP class bZip proteins in the growth and cell competition of Rp (‘Minute’) mutants in Drosophila

(2019) Jorge Blanco et al.   eLife

Genomic alterations of ribosomal protein genes in diffuse large B cell lymphoma

(2018) Enrico Derenzini et al.   BRITISH JOURNAL OF HAEMATOLOGY

Ribosomal Protein S12e Has a Distinct Function in Cell Competition

(2018) Abhijit Kale et al.   DEVELOPMENTAL CELL

The role of adult hippocampal neurogenesis in brain health and disease

(2018) Tomohisa Toda et al.   MOLECULAR PSYCHIATRY

FoxM1 repression during human aging leads to mitotic decline and aneuploidy-driven full senescence

(2018) Joana Catarina Macedo et al.   Nature Communications

Increased risk of colon cancer and osteogenic sarcoma in Diamond Blackfan anemia

(2018) Adrianna Vlachos et al.   BLOOD

Chromosomal Instability Induces Cellular Invasion in Epithelial Tissues

(2018) Najate Benhra et al.   DEVELOPMENTAL CELL

A Regulatory Response to Ribosomal Protein Mutations Controls Translation, Growth, and Cell Competition

(2018) Chang-Hyun Lee et al.   DEVELOPMENTAL CELL

Somatic reversion events point towards RPL4 as a novel disease gene in a condition resembling Diamond-Blackfan Anemia

(2018) Marjolijn C.J. Jongmans et al.   HAEMATOLOGICA

Xrp1 genetically interacts with the ALS-associated FUS orthologue caz and mediates its toxicity

(2018) Moushami Mallik et al.   JOURNAL OF CELL BIOLOGY

Chromosomal instability-induced senescence potentiates cell non-autonomous tumourigenic effects

(2018) Qianqian He et al.   Oncogenesis

The Genetic Landscape of Diamond-Blackfan Anemia

(2018) Jacob C. Ulirsch et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Spontaneous remission in a Diamond-Blackfan anaemia patient due to a revertant uniparental disomy ablating a de novo RPS19 mutation

(2018) Emanuela Garelli et al.   BRITISH JOURNAL OF HAEMATOLOGY

A potential link between p53, cell competition and ribosomopathy in mammals and in Drosophila

(2018) Nicholas E. Baker et al.   DEVELOPMENTAL BIOLOGY

Xrp1 is a transcription factor required for cell competition-driven elimination of loser cells

(2018) Ludovic Baillon et al.   Scientific Reports

Self-reverting mutations partially correct the blood phenotype in a Diamond Blackfan anemia patient

(2017) Parvathy Venugopal et al.   HAEMATOLOGICA

Mechanisms and consequences of aneuploidy and chromosome instability in the aging brain

(2017) Grasiella A. Andriani et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Biallelic TRIP13 mutations predispose to Wilms tumor and chromosome missegregation

(2017) Shawn Yost et al.   NATURE GENETICS

Aging and neurodegeneration are associated with increased mutations in single human neurons

(2017) Michael A. Lodato et al.   SCIENCE

Chronic activation of JNK JAK/STAT and oxidative stress signalling causes the loser cell status

(2017) Iwo Kucinski et al.   Nature Communications

How Ribosomes Translate Cancer

(2017) Sergey O. Sulima et al.   Cancer Discovery

Self-reverting mutations partially correct the blood phenotype in a Diamond Blackfan anemia patient

(2017) Parvathy Venugopal et al.   HAEMATOLOGICA

Aneuploidy in Cancer and Aging

(2016) Ryan M. Naylor et al.   Annual Review of Genetics

Rpl22 Loss Selectively Impairs αβ T Cell Development by Dysregulating Endoplasmic Reticulum Stress Signaling

(2016) Nehal R. Solanki et al.   JOURNAL OF IMMUNOLOGY

Binuclear Cells in the Lactating Mammary Gland: New Insights on an Old Concept?

(2016) Gilbert H. Smith   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

DrosophilaIRBP bZIP heterodimer binds P-element DNA and affects hybrid dysgenesis

(2016) Malik Joseph Francis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chromosome instability drives phenotypic switching to metastasis

(2016) ChongFeng Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The presence of extra chromosomes leads to genomic instability

(2016) Verena Passerini et al.   Nature Communications

Essential role for a novel population of binucleated mammary epithelial cells in lactation

(2016) Anne C. Rios et al.   Nature Communications

Mouse model of chromosome mosaicism reveals lineage-specific depletion of aneuploid cells and normal developmental potential

(2016) Helen Bolton et al.   Nature Communications

Loss of p53-mediated cell-cycle arrest, senescence and apoptosis promotes genomic instability and premature aging

(2016) Tongyuan Li et al.   Oncotarget

Whole-Genome Sequencing and iPLEX MassARRAY Genotyping Map an EMS-induced Mutation Affecting Cell Competition in Drosophila melanogaster

(2016) C.-H. Lee et al.   G3-Genes Genomes Genetics

Age-Related and Heteroplasmy-Related Variation in Human mtDNA Copy Number

(2016) Manja Wachsmuth et al.   PLoS Genetics

Selective advantage of trisomic human cells cultured in non-standard conditions

(2016) Samuel D. Rutledge et al.   Scientific Reports

Whole Chromosome Instability induces senescence and promotes SASP

(2016) Grasiella Angelina Andriani et al.   Scientific Reports

Apoptotic mechanisms during competition of ribosomal protein mutant cells: roles of the initiator caspases Dronc and Dream/Strica

(2015) A Kale et al.   CELL DEATH AND DIFFERENTIATION

Aneuploidy-induced cellular stresses limit autophagic degradation

(2015) Stefano Santaguida et al.   GENES & DEVELOPMENT

Whole chromosome aneuploidy in the brain of Bub1bH/Hand Ercc1−/Δ7mice

(2015) Grasiella A. Andriani et al.   HUMAN MOLECULAR GENETICS

Short- and long-term effects of chromosome mis-segregation and aneuploidy

(2015) Stefano Santaguida et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Healthy Babies after Intrauterine Transfer of Mosaic Aneuploid Blastocysts

(2015) Ermanno Greco et al.   NEW ENGLAND JOURNAL OF MEDICINE

Somatic mutation in single human neurons tracks developmental and transcriptional history

(2015) M. A. Lodato et al.   SCIENCE

Single-Cell, Genome-wide Sequencing Identifies Clonal Somatic Copy-Number Variation in the Human Brain

(2015) Xuyu Cai et al.   Cell Reports

Thyrocyte-specific inactivation of p53 and Pten results in anaplastic thyroid carcinomas faithfully recapitulating human tumors

(2015) Valeria G. Antico Arciuch et al.   Oncotarget

Mosaic loss of chromosome Y in peripheral blood is associated with shorter survival and higher risk of cancer

(2014) Lars A Forsberg et al.   NATURE GENETICS

Single cell sequencing reveals low levels of aneuploidy across mammalian tissues

(2014) Kristin A. Knouse et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An ancient defense system eliminates unfit cells from developing tissues during cell competition

(2014) S. N. Meyer et al.   SCIENCE

Aneuploidy and tumorigenesis in Drosophila

(2014) Marco Milán et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Aneuploidy induces profound changes in gene expression, proliferation and tumorigenicity of human pluripotent stem cells

(2014) Uri Ben-David et al.   Nature Communications

Single-Cell, Genome-wide Sequencing Identifies Clonal Somatic Copy-Number Variation in the Human Brain

(2014) Xuyu Cai et al.   Cell Reports

X chromosome aneuploidy in the Alzheimer’s disease brain

(2014) Yuri B Yurov et al.   Molecular Cytogenetics

Aneuploidy, oncogene amplification and epithelial to mesenchymal transition define spontaneous transformation of murine epithelial cells

(2013) H. M. Padilla-Nash et al.   CARCINOGENESIS

Defect of Mitotic Vimentin Phosphorylation Causes Microophthalmia and Cataract via Aneuploidy and Senescence in Lens Epithelial Cells

(2013) Makoto Matsuyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Role of Transposable Elements in Health and Diseases of the Central Nervous System

(2013) M. T. Reilly et al.   JOURNAL OF NEUROSCIENCE

Mosaic Copy Number Variation in Human Neurons

(2013) M. J. McConnell et al.   SCIENCE

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

Self-Correction of Chromosomal Abnormalities in Human Preimplantation Embryos and Embryonic Stem Cells

(2013) Masood Bazrgar et al.   STEM CELLS AND DEVELOPMENT

Changes in neuronal DNA content variation in the human brain during aging

(2012) Hans-Georg Fischer et al.   AGING CELL

The consequences of chromosomal aneuploidy on the transcriptome of cancer cells

(2012) Thomas Ried et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Genetics of early miscarriage

(2012) Merel M.J. van den Berg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Incidence of neoplasia in Diamond Blackfan anemia: a report from the Diamond Blackfan Anemia Registry

(2012) A. Vlachos et al.   BLOOD

Single-Neuron Sequencing Analysis of L1 Retrotransposition and Somatic Mutation in the Human Brain

(2012) Gilad D. Evrony et al.   CELL

Losing balance: the origin and impact of aneuploidy in cancer

(2012) Andrew J Holland et al.   EMBO REPORTS

Chromosomal instability and aneuploidy in cancer: from yeast to man

(2012) Sarah J Pfau et al.   EMBO REPORTS

Chromosome-specific accumulation of aneuploidy in the aging mouse brain

(2012) Francesca Faggioli et al.   HUMAN MOLECULAR GENETICS

Aneuploidy as a mechanism for stress-induced liver adaptation

(2012) Andrew W. Duncan et al.   JOURNAL OF CLINICAL INVESTIGATION

Aneuploid Cells Are Differentially Susceptible to Caspase-Mediated Death during Embryonic Cerebral Cortical Development

(2012) S. E. Peterson et al.   JOURNAL OF NEUROSCIENCE

Global analysis of genome, transcriptome and proteome reveals the response to aneuploidy in human cells

(2012) Silvia Stingele et al.   Molecular Systems Biology

DNA breaks and chromosome pulverization from errors in mitosis

(2012) Karen Crasta et al.   NATURE

Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan

(2012) Darren J. Baker et al.   NATURE CELL BIOLOGY

Detectable clonal mosaicism and its relationship to aging and cancer

(2012) Kevin B Jacobs et al.   NATURE GENETICS

Human aneuploidy: mechanisms and new insights into an age-old problem

(2012) So I. Nagaoka et al.   NATURE REVIEWS GENETICS

Aneuploidy-induced delaminating cells drive tumorigenesis in Drosophila epithelia

(2012) A. Dekanty et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Distinct p53 Transcriptional Programs Dictate Acute DNA-Damage Responses and Tumor Suppression

(2011) Colleen A. Brady et al.   CELL

Cell competition

(2011) Nicholas E. Baker   CURRENT BIOLOGY

Frequent Aneuploidy Among Normal Human Hepatocytes

(2011) Andrew W. Duncan et al.   GASTROENTEROLOGY

Chromosomal mosaicism in human preimplantation embryos: a systematic review

(2011) Jannie van Echten-Arends et al.   HUMAN REPRODUCTION UPDATE

Chromosomal aneuploidy in the aging brain

(2011) Francesca Faggioli et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Mutations in CEP57 cause mosaic variegated aneuploidy syndrome

(2011) Katie Snape et al.   NATURE GENETICS

Single-Cell Analysis of Ploidy and Centrosomes Underscores the Peculiarity of Normal Hepatocytes

(2011) Francesca Faggioli et al.   PLoS One

Full p53 transcriptional activation potential is dispensable for tumor suppression in diverse lineages

(2011) D. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective Cell Death of Hyperploid Neurons in Alzheimer’s Disease

(2010) Thomas Arendt et al.   AMERICAN JOURNAL OF PATHOLOGY

Chromosome missegregation causes colon cancer byAPCloss of heterozygosity

(2010) Darren J. Baker et al.   CELL CYCLE

Cellular senescence: putting the paradoxes in perspective

(2010) Judith Campisi   CURRENT OPINION IN GENETICS & DEVELOPMENT

Flower Forms an Extracellular Code that Reveals the Fitness of a Cell to its Neighbors in Drosophila

(2010) Christa Rhiner et al.   DEVELOPMENTAL CELL

The ploidy conveyor of mature hepatocytes as a source of genetic variation

(2010) Andrew W. Duncan et al.   NATURE

The landscape of somatic copy-number alteration across human cancers

(2010) Rameen Beroukhim et al.   NATURE

Copy Number Variation in Human Health, Disease, and Evolution

(2009) Feng Zhang et al.   Annual Review of Genomics and Human Genetics

Whole Chromosome Instability Caused by Bub1 Insufficiency Drives Tumorigenesis through Tumor Suppressor Gene Loss of Heterozygosity

(2009) Darren J. Baker et al.   CANCER CELL

Cell competition, growth and size control in the Drosophila wing imaginal disc

(2009) F. A. Martin et al.   DEVELOPMENT

p53-Independent Apoptosis Limits DNA Damage-Induced Aneuploidy

(2009) L. M. McNamee et al.   GENETICS

Neurodegeneration mediated by chromosome instability suggests changes in strategy for therapy development in ataxia-telangiectasia

(2009) Yuri B. Yurov et al.   MEDICAL HYPOTHESES

Aneuploidy in the normal, Alzheimer's disease and ataxia-telangiectasia brain: Differential expression and pathological meaning

(2009) Ivan Y. Iourov et al.   NEUROBIOLOGY OF DISEASE

Timed Somatic Deletion of p53 in Mice Reveals Age-Associated Differences in Tumor Progression

(2009) George Hinkal et al.   PLoS One

Clinical and genetic heterogeneity in patients with mosaic variegated aneuploidy: Delineation of clinical subtypes

(2008) Herbert García‐Castillo et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Telomere Loss Provokes Multiple Pathways to Apoptosis and Produces Genomic Instability in Drosophila melanogaster

(2008) S. W. A. Titen et al.   GENETICS

Cell fusion is a physiological process in mouse liver

(2008) Francesca Faggioli et al.   HEPATOLOGY

Aneuploid mosaicism in the developing and adult cerebellar cortex

(2008) Jurjen W. Westra et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Identification of RPS14 as a 5q- syndrome gene by RNA interference screen

(2008) Benjamin L. Ebert et al.   NATURE