期刊
DEVELOPMENTAL CELL
卷 18, 期 6, 页码 985-998出版社
CELL PRESS
DOI: 10.1016/j.devcel.2010.05.010
关键词
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资金
- European Research Council
- Fundacion Mutua Madrilena
- Fundacion Caja Madrid
- Comunidad of Madrid
Cell competition promotes the elimination of weaker cells from a growing population. Here we investigate how cells of Drosophila wing imaginal discs distinguish winners from losers during cell competition. Using genomic and functional assays, we have identified several factors implicated in the process, including Flower (Fwe), a cell membrane protein conserved in multicellular animals. Our results suggest that Fwe is a component of the cell competition response that is required and sufficient to label cells as winners or losers. In Drosophila, the fwe locus produces three isoforms, fwe(ubi), fwe(Lose-A), and fwe(Lose-B). Basal levels of fwe(ubi) are constantly produced. During competition, the fwe(Lose) isoforms are upregulated in prospective loser cells. Cell-cell comparison of relative fwe(Lose) and fwe(ubi) levels ultimately determines which cell undergoes apoptosis. This extracellular code may constitute an ancient mechanism to terminate competitive conflicts among cells.
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