High-Resolution Transcriptomic Profiling of the Heart During Chronic Stress Reveals Cellular Drivers of Cardiac Fibrosis and Hypertrophy

Dynamic Interstitial Cell Response during Myocardial Infarction Predicts Resilience to Rupture in Genetically Diverse Mice

(2020) Elvira Forte et al.   Cell Reports

Loss of estrogen-related receptor alpha facilitates angiogenesis in endothelial cells

(2019) Neah Likhite et al.   MOLECULAR AND CELLULAR BIOLOGY

Fast interpolation-based t-SNE for improved visualization of single-cell RNA-seq data

(2019) George C. Linderman et al.   NATURE METHODS

The single-cell transcriptional landscape of mammalian organogenesis

(2019) Junyue Cao et al.   NATURE

Single-cell expression profiling reveals dynamic flux of cardiac stromal, vascular and immune cells in health and injury

(2019) Nona Farbehi et al.   eLife

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

Characterization of a mouse model of obesity-related fibrotic cardiomyopathy that recapitulates features of human Heart Failure with Preserved Ejection Fraction

(2018) Linda Alex et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Slingshot: cell lineage and pseudotime inference for single-cell transcriptomics

(2018) Kelly Street et al.   BMC GENOMICS

Single-Cell Sequencing of the Healthy and Diseased Heart Reveals Cytoskeleton-Associated Protein 4 as a New Modulator of Fibroblasts Activation

(2018) Monika M. Gladka et al.   CIRCULATION

Endoplasmic reticulum stress in the pathogenesis of fibrotic disease

(2018) Jonathan A. Kropski et al.   JOURNAL OF CLINICAL INVESTIGATION

Specialized fibroblast differentiated states underlie scar formation in the infarcted mouse heart

(2018) Xing Fu et al.   JOURNAL OF CLINICAL INVESTIGATION

Bias, robustness and scalability in single-cell differential expression analysis

(2018) Charlotte Soneson et al.   NATURE METHODS

Single-Cell Transcriptional Profiling Reveals Cellular Diversity and Intercommunication in the Mouse Heart

(2018) Daniel A. Skelly et al.   Cell Reports

RNA velocity of single cells

(2018) Gioele La Manno et al.   NATURE

Estrogen receptor α promotes protein synthesis by fine-tuning the expression of the eukaryotic translation initiation factor 3 subunit f (eIF3f)

(2018) Rafael Cuesta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Profiling proliferative cells and their progeny in damaged murine hearts

(2018) Kai Kretzschmar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-cell sequencing reveals dissociation-induced gene expression in tissue subpopulations

(2017) Susanne C van den Brink et al.   NATURE METHODS

Cartilage intermediate layer protein 1 (CILP1): A novel mediator of cardiac extracellular matrix remodelling

(2017) Frans A. van Nieuwenhoven et al.   Scientific Reports

Deregulation of XBP1 expression contributes to myocardial vascular endothelial growth factor-A expression and angiogenesis during cardiac hypertrophyin vivo

(2016) Quanlu Duan et al.   AGING CELL

The Importance of Biological Sex and Estrogen in Rodent Models of Cardiovascular Health and Disease

(2016) Christa L. Blenck et al.   CIRCULATION RESEARCH

A Simplified, Langendorff-Free Method for Concomitant Isolation of Viable Cardiac Myocytes and Nonmyocytes From the Adult Mouse HeartNovelty and Significance

(2016) Matthew Ackers-Johnson et al.   CIRCULATION RESEARCH

Epicardium is required for cardiac seeding by yolk sac macrophages, precursors of resident macrophages of the adult heart

(2016) Sean M. Stevens et al.   DEVELOPMENTAL BIOLOGY

Single-Cell Resolution of Temporal Gene Expression during Heart Development

(2016) Daniel M. DeLaughter et al.   DEVELOPMENTAL CELL

Report of the National Heart, Lung, and Blood Institute Working Group on Sex Differences Research in Cardiovascular Disease

(2016) Christine Maric-Bilkan et al.   HYPERTENSION

Novel therapeutic strategies targeting fibroblasts and fibrosis in heart disease

(2016) Robert G. Gourdie et al.   NATURE REVIEWS DRUG DISCOVERY

Age-related changes in tissue macrophages precede cardiac functional impairment

(2016) Alexander R. Pinto et al.   Aging-US

Inhibition of the Unfolded Protein Response Mechanism Prevents Cardiac Fibrosis

(2016) Jody Groenendyk et al.   PLoS One

The XBP1 Arm of the Unfolded Protein Response Induces Fibrogenic Activity in Hepatic Stellate Cells Through Autophagy

(2016) Rosa S. Kim et al.   Scientific Reports

ER Stress and Angiogenesis

(2015) François Binet et al.   Cell Metabolism

Revisiting Cardiac Cellular CompositionNovelty and Significance

(2015) Alexander R. Pinto et al.   CIRCULATION RESEARCH

Estrogen receptor α inhibitor activates the unfolded protein response, blocks protein synthesis, and induces tumor regression

(2015) Neal D. Andruska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A draft network of ligand–receptor-mediated multicellular signalling in human

(2015) Jordan A. Ramilowski et al.   Nature Communications

circlize implements and enhances circular visualization in R

(2014) Zuguang Gu et al.   BIOINFORMATICS

Estrogen Regulates Protein Synthesis and Actin Polymerization in Hippocampal Neurons through Different Molecular Mechanisms

(2014) Victor Briz et al.   Frontiers in Endocrinology

Regulation of expression of atrial and brain natriuretic peptide, biomarkers for heart development and disease

(2013) Irina A. Sergeeva et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Periostin expression is upregulated and associated with myocardial fibrosis in human failing hearts

(2013) Sheng Zhao et al.   Journal of Cardiology

Endoplasmic Reticulum Stress Is Involved in Cardiac Damage and Vascular Endothelial Dysfunction in Hypertensive Mice

(2012) Modar Kassan et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

(2012) Guangchuang Yu et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

An Abundant Tissue Macrophage Population in the Adult Murine Heart with a Distinct Alternatively-Activated Macrophage Profile

(2012) Alexander R. Pinto et al.   PLoS One

Attenuation of endoplasmic reticulum stress using the chemical chaperone 4-phenylbutyric acid prevents cardiac fibrosis induced by isoproterenol

(2011) Pedro Ayala et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

A sex-specific role for androgens in angiogenesis

(2010) Daniel P. Sieveking et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Relation of Disease Pathogenesis and Risk Factors to Heart Failure With Preserved or Reduced Ejection Fraction

(2009) Douglas S. Lee et al.   CIRCULATION

Sex and Age Dimorphism of Myocardial Gene Expression in Nonischemic Human Heart Failure

(2008) David R. Fermin et al.   Circulation-Cardiovascular Genetics