Glycocholic acid aggravates liver fibrosis by promoting the up-regulation of connective tissue growth factor in hepatocytes

A new perspective of triptolide-associated hepatotoxicity: the relevance of NF-κB and NF-κB-mediated cellular FLICE-inhibitory protein

(2020) Ziqiao Yuan et al.   Acta Pharmaceutica Sinica B

Glycochenodeoxycholate Promotes Liver Fibrosis in Mice with Hepatocellular Cholestasis

(2020) Simon Hohenester et al.   Cells

A CTGF-YAP Regulatory Pathway Is Essential for Angiogenesis and Barriergenesis in the Retina

(2020) Sohyun Moon et al.   iScience

Long non‐coding RNA H19 contributes to cholangiocyte proliferation and cholestatic liver fibrosis in biliary atresia

(2019) Yongtao Xiao et al.   HEPATOLOGY

Cholangiocyte‐Derived Exosomal Long Noncoding RNA H19 Promotes Hepatic Stellate Cell Activation and Cholestatic Liver Fibrosis

(2019) Runping Liu et al.   HEPATOLOGY

Bile salts regulate CYP7A1 expression and elicit a fibrotic response and abnormal lipid production in 3D liver microtissues

(2019) Catherine Jane Messner et al.   TOXICOLOGY IN VITRO

CTGF mediates tumor-stroma interactions between hepatoma cells and hepatic stellate cells to accelerate HCC progression.

(2018) Yuki Makino et al.   CANCER RESEARCH

Connective tissue growth factor (CTGF) from basics to clinics

(2018) Yasaman Ramazani et al.   MATRIX BIOLOGY

Analysis of cholyglycine acid as a biomarker for the early diagnosis of liver disease by fluorescence polarization immunoassay

(2018) Ding Shen et al.   SENSORS AND ACTUATORS B-CHEMICAL

Liver fibrosis: Pathophysiology, pathogenetic targets and clinical issues

(2018) Maurizio Parola et al.   MOLECULAR ASPECTS OF MEDICINE

Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase

(2018) Helmut Pein et al.   Nature Communications

Yinchenhao Decoction Alleviates Liver Fibrosis by Regulating Bile Acid Metabolism and TGF-β/Smad/ERK Signalling Pathway

(2018) Fei-Fei Cai et al.   Scientific Reports

Secondary Unconjugated Bile Acids Induce Hepatic Stellate Cell Activation

(2018) Kunihiro Saga et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dysregulated bile acid signaling contributes to the neurological impairment in murine models of acute and chronic liver failure

(2018) Guoxiang Xie et al.   EBioMedicine

The role of sphingosine 1-phosphate receptor 2 in bile-acid-induced cholangiocyte proliferation and cholestasis-induced liver injury in mice

(2017) Yongqing Wang et al.   HEPATOLOGY

Biliary bile acids in hepatobiliary injury – What is the link?

(2017) Peter Fickert et al.   JOURNAL OF HEPATOLOGY

EASL Clinical Practice Guidelines: The diagnosis and management of patients with primary biliary cholangitis

(2017) Gideon M. Hirschfield et al.   JOURNAL OF HEPATOLOGY

Quantitative profiling of 19 bile acids in rat plasma, liver, bile and different intestinal section contents to investigate bile acid homeostasis and the application of temporal variation of endogenous bile acids

(2017) Tingting Yang et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Dihydroartemisinin counteracts fibrotic portal hypertensionviafarnesoid X receptor-dependent inhibition of hepatic stellate cell contraction

(2016) Wenxuan Xu et al.   FEBS Journal

Alpha-naphthylisothiocyanate impairs bile acid homeostasis through AMPK-FXR pathways in rat primary hepatocytes

(2016) Xiaojiaoyang Li et al.   TOXICOLOGY

UDCA and CDCA alleviate 17α-ethinylestradiol-induced cholestasis through PKA-AMPK pathways in rats

(2016) Xiaojiaoyang Li et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Bile Acids in Physiology, Pathology and Pharmacology

(2015) Jose J.G. Marin et al.   CURRENT DRUG METABOLISM

Fibrates and cholestasis

(2015) Nisanne S. Ghonem et al.   HEPATOLOGY

CTGF directs fibroblast differentiation from human mesenchymal stem/stromal cells and defines connective tissue healing in a rodent injury model

(2015) Chang H. Lee et al.   JOURNAL OF CLINICAL INVESTIGATION

High-yield and high-purity isolation of hepatic stellate cells from normal and fibrotic mouse livers

(2015) Ingmar Mederacke et al.   Nature Protocols

Bile acids induce hepatic differentiation of mesenchymal stem cells

(2015) Iris Sawitza et al.   Scientific Reports

Bile Acids Activate YAP to Promote Liver Carcinogenesis

(2013) Sayeepriyadarshini Anakk et al.   Cell Reports

Hepatocarcinogenesis in FXR−/−Mice Mimics Human HCC Progression That Operates through HNF1α Regulation of FXR Expression

(2012) Nian Liu et al.   MOLECULAR ENDOCRINOLOGY

Bile Acids Induce Inflammatory Genes in Hepatocytes

(2011) Katryn Allen et al.   AMERICAN JOURNAL OF PATHOLOGY

Pathogenesis of Liver Fibrosis

(2011) Virginia Hernandez-Gea et al.   Annual Review of Pathology-Mechanisms of Disease

Metabolomic profiling of 17 bile acids in serum from patients with primary biliary cirrhosis and primary sclerosing cholangitis: A pilot study

(2011) Jocelyn Trottier et al.   DIGESTIVE AND LIVER DISEASE

Profiling Circulating and Urinary Bile Acids in Patients with Biliary Obstruction before and after Biliary Stenting

(2011) Jocelyn Trottier et al.   PLoS One

A Comparison of Whole Genome Gene Expression Profiles of HepaRG Cells and HepG2 Cells to Primary Human Hepatocytes and Human Liver Tissues

(2010) S. N. Hart et al.   DRUG METABOLISM AND DISPOSITION

Connective tissue growth factor: a fibrogenic master switch in fibrotic liver diseases

(2010) Olav A. Gressner et al.   LIVER INTERNATIONAL

Evolving challenges in hepatic fibrosis

(2010) Scott L. Friedman   Nature Reviews Gastroenterology & Hepatology

Inhibition of Endothelin-1-Mediated Contraction of Hepatic Stellate Cells by FXR Ligand

(2010) Jiang Li et al.   PLoS One

Bile Acid-induced Epidermal Growth Factor Receptor Activation in Quiescent Rat Hepatic Stellate Cells Can Trigger Both Proliferation and Apoptosis

(2009) Annika Sommerfeld et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

EASL Clinical Practice Guidelines: Management of cholestatic liver diseases

(2009)   JOURNAL OF HEPATOLOGY

Mechanisms of Hepatic Fibrogenesis

(2008) Scott L. Friedman   GASTROENTEROLOGY

TEAD mediates YAP-dependent gene induction and growth control

(2008) B. Zhao et al.   GENES & DEVELOPMENT

The CCN family of proteins: structure–function relationships

(2008) Kenneth P. Holbourn et al.   TRENDS IN BIOCHEMICAL SCIENCES