Article
Oncology
Julian P. Layer, Katharina Layer, Gustavo R. Sarria, Fred Roehner, Cas S. Dejonckheere, Lea L. Friker, Thomas Zeyen, David Koch, Davide Scafa, Christina Leitzen, Muemtaz Koeksal, Frederic Carsten Schmeel, Niklas Schaefer, Jennifer Landsberg, Michael Hoelzel, Ulrich Herrlinger, Matthias Schneider, Frank A. Giordano, Leonard Christopher Schmeel
Summary: This study evaluates the safety and outcome profile of five-fraction stereotactic radiotherapy (FSRT) for brain metastases (BM). It shows that FSRT is a feasible and efficient approach for both adjuvant and definitive treatment, with acceptable local control rates and comparable radiation necrosis rates.
Article
Clinical Neurology
Christine Park, Elizabeth P. Howell, Vikram A. Mehta, Luis Ramirez, Meghan J. Price, Scott R. Floyd, John P. Kirkpatrick, Jordan Torok, Muhammad M. Abd-El-Barr, Isaac O. Karikari, C. Rory Goodwin
Summary: Patients with spinal metastases who received hypofractionated SBRT more frequently achieved significant pain relief and an increased frequency of improvement in Karnofsky Performance Scale (KPS) compared with those treated with single-fraction SBRT. Local tumor control was similar in both groups, indicating the need for further research to understand the relationship between fractionation schedule and clinical outcomes.
JOURNAL OF NEUROSURGERY-SPINE
(2021)
Article
Oncology
Megumi Uto, Kengo Ogura, Tomohiro Katagiri, Keiichi Takehana, Takashi Mizowaki
Summary: This study retrospectively analyzed treatment target changes in patients with brain metastases treated with 13-fraction SRT. The mid-treatment target volume changed by more than 20% compared to the initial target volume in nearly one-third of the lesions. The study highlights the importance of adaptive radiotherapy in monitoring target changes during fractionated stereotactic radiotherapy.
RADIATION ONCOLOGY
(2021)
Article
Medicine, General & Internal
Morgan Michalet, Ons Bettaieb, Samia Khalfi, Asma Ghorbel, Simon Valdenaire, Pierre Debuire, Norbert Ailleres, Roxana Draghici, Mailys De Meric De Bellefon, Marie Charissoux, Pierre Boisselier, Sylvain Demontoy, Alexis Marguerit, Morgane Cabaille, Marie Cantaloube, Aicha Keskes, Touria Bouhafa, Marie-Pierre Farcy-Jacquet, Pascal Fenoglietto, David Azria, Olivier Riou
Summary: Stereotactic MR-guided Radiotherapy (MRgRT) is an interesting treatment option for adrenal gland metastases (AGM). This study reviewed data from 12 consecutive patients treated with MRgRT for AGM and assessed the treatment's impact on target volume coverage, organ protection, local control, and overall survival. The results showed improved dosimetric quality and good tolerance of the treatment, with high rates of local control and overall survival. Longer follow-up is needed to evaluate late toxicities and clinical outcomes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Laura Uder, Marcel Nachbar, Sarah Butzer, Jessica Boldt, Sabrina Baumeister, Michael Bitzer, Alfred Koenigsrainer, Thomas Seufferlein, Ruediger Hoffmann, Sergios Gatidis, Konstantin Nikolaou, Daniel Zips, Daniela Thorwarth, Cihan Gani, Simon Boeke
Summary: This study reported on the use of online magnetic resonance guided radiotherapy for liver metastases. The results showed high local control rates and improvements in patient reported outcome measures and quality of life. Further prospective trials are ongoing to define the patient population that will benefit most from this online adaptive workflow.
FRONTIERS IN ONCOLOGY
(2023)
Review
Oncology
Zilan Wang, Longyuan Li, Xingyu Yang, Haiying Teng, Xiaoxiao Wu, Zhouqing Chen, Zhong Wang, Gang Chen
Summary: This study compared SBRT and cRT in patients with painful bone metastases, with the results showing that patients treated with SBRT experienced better pain relief 3 months after radiation compared to cRT patients, and there was no increase in adverse events with SBRT.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Fabian Weykamp, Philipp Hoegen, Sebastian Regnery, Efthimios Katsigiannopulos, C. Katharina Renkamp, Kristin Lang, Laila Koenig, Elisabetta Sandrini, Eva Meixner, Carolin Rippke, Carolin Buchele, Jakob Liermann, Juergen Debus, Sebastian Klueter, Juliane Hoerner-Rieber
Summary: MR-guided SBRT is an effective and non-invasive treatment for liver metastases, with promising long-term local control. However, achieving distant tumor control still poses challenges.
Article
Multidisciplinary Sciences
Caroline John, Riccardo Dal Bello, Nicolaus Andratschke, Matthias Guckenberger, Judit Boda-Heggemann, Eleni Gkika, Frederick Mantel, Hanno M. Specht, Carmen Stromberger, Franz Zehentmayr, Oliver Blanck, Panagiotis Balermpas
Summary: The study investigated the feasibility and safety of a second course of thoracic SBRT with PTV overlap, and found it to be safe and achieve reasonable local control. Factors correlating with tumor control were identified as peripheral location and dose.
SCIENTIFIC REPORTS
(2021)
Review
Clinical Neurology
Julius July, Raymond Pranata
Summary: This study found that hypofractionated stereotactic radiosurgery (HF-SRS) resulted in better local control for patients with brain metastases compared to single-fraction stereotactic radiosurgery (SF-SRS), while the rate of radionecrosis was similar between the two treatment groups.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2021)
Article
Oncology
Samuel Ryu, Snehal Deshmukh, Robert D. Timmerman, Benjamin Movsas, Peter Gerszten, Fang-Fang Yin, Adam Dicker, Christopher D. Abraham, Jim Zhong, Stephen L. Shiao, Richard Tuli, Anand Desai, Loren K. Mell, Puneeth Iyengar, Ying J. Hitchcock, Aaron Max Allen, Steven Burton, Doris Brown, Hadley J. Sharp, Neal E. Dunlap, M. Salim Siddiqui, Timothy H. Chen, Stephanie L. Pugh, Lisa A. Kachnic
Summary: This study compared the pain relief effects of stereotactic radiosurgery (SRS) and conventional external beam radiotherapy (cEBRT) for patients with 1 to 3 vertebral metastases and found that SRS did not significantly improve pain relief. However, there were no spinal cord complications reported at 2 years after SRS, which is important for further investigation of using spine radiosurgery for oligometastases.
Article
Oncology
Gregory M. M. Videtic, Chandana A. Reddy, Neil M. Woody, Kevin L. Stephans
Summary: The review of ten years of using single-fraction lung stereotactic body radiation therapy for medically inoperable early-stage lung cancer found high survival rates and low toxicity reactions, with no significant differences in outcomes between different dosage levels.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Oncology
Fabian Weykamp, Efthimios Katsigiannopulos, Lars Piskorski, Sebastian Regnery, Philipp Hoegen, Jonas Ristau, C. Katharina Renkamp, Jakob Liermann, Tobias Forster, Kristin Lang, Laila Koenig, Carolin Rippke, Carolin Buchele, Juergen Debus, Sebastian Klueter, Juliane Hoerner-Rieber
Summary: This study assessed the dosimetry benefits of stereotactic magnetic resonance (MR)-guided online adaptive radiotherapy (SMART) for liver metastases. The adapted plan showed significantly superior tumor coverage and improved sparing of organs-at-risk (OAR) compared to the predicted plan.
Article
Oncology
Robert Olson, Will Jiang, Mitchell Liu, Alanah Bergman, Devin Schellenberg, Benjamin Mou, Abraham Alexander, Hannah Carolan, Fred Hsu, Stacy Miller, Siavash Atrchian, Elisa Chan, Clement Ho, Islam Mohamed, Angela Lin, Tanya Berrang, Andrew Bang, Nick Chng, Quinn Matthews, Sarah Baker, Vicky Huang, Ante Mestrovic, Derek Hyde, Chad Lund, Howard Pai, Boris Valev, Shilo Lefresene, Scott Tyldesley
Summary: This study confirms that the incidence of high-grade toxic effects in the large cohort of patients receiving SABR for oligometastases is less than 5%. The lower rates of toxic effects compared to previous studies may support further enrollment in randomized phase 3 clinical trials.
Article
Oncology
Michael Yan, Osbert Zalay, Thomas Kennedy, Timothy E. Owen, James Purzner, Shervin Taslimi, Teresa Purzner, Ryan Alkins, Nikitha Moideen, Andrea S. Fung, Fabio Y. Moraes
Summary: This study retrospectively analyzed data from patients with brain metastases treated with fractionated stereotactic radiotherapy (FSRT) without size restriction. The results showed that FSRT is safe and effective in the treatment of brain metastases of any size, with excellent local control and toxicity outcomes.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Rohann J. M. Correa, Gerard Morton, Hans T. Chung, Chia-Lin Tseng, Patrick Cheung, William Chu, Stanley K. Liu, Merrylee McGuffin, Anam Shahid, Melanie Davidson, Ananth Ravi, Joelle Helou, Yasir Alayed, Liying Zhang, Alexandre Mamedov, Andrew Loblaw
Summary: This study compared the outcomes of two-fraction prostate SABR and two-fraction HDR monotherapy. The results showed similar rates of biochemical failure, toxicity, and quality of life between the two treatment approaches. These findings support the need for a randomized controlled trial to further evaluate these treatments.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Oncology
Andrew J. Bishop, Gunar K. Zagars, Elizabeth G. Demicco, Wei-Lien Wang, Barry W. Feig, B. Ashleigh Guadagnolo
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS
(2018)
Article
Oncology
Andrew J. Bishop, J. Andrew Livingston, Dejka M. Araujo, Bryan S. Moon, Shreyaskumar Patel, Wei-Lien Wang, Alexander J. Lazar, Christina L. Roland, B. Ashleigh Guadagnolo
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS
(2019)
Article
Oncology
Timothy A. Lin, Ethan B. Ludmir, Kai-Ping Liao, Mary Frances McAleer, David R. Grosshans, Susan L. McGovern, Andrew J. Bishop, Kristina D. Woodhouse, Arnold C. Paulino, Debra Nana Yeboa
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2019)
Article
Oncology
Andrew J. Bishop, Maria A. Zarzour, Ravin Ratan, Keila E. Torres, Barry W. Feig, Wei-Lien Wang, Alexander J. Lazar, Bryan S. Moon, Christina L. Roland, B. Ashleigh Guadagnolo
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2019)
Article
Clinical Neurology
Debra Nana Yeboa, Kia-ping Liao, Beverly Ashleigh Guadagnolo, Ganesh Rao, Andrew Bishop, Caroline Chung, Jing Li, Claudio Esteves Tatsui, Laurence D. Rhines, Sherise Ferguson, Arnold de la Cruz Paulino, Amol Jitendra Ghia
WORLD NEUROSURGERY
(2019)
Article
Clinical Neurology
Heather N. Hayenga, Andrew J. Bishop, Zabi Wardak, Chandra Sen, Bruce Mickey
WORLD NEUROSURGERY
(2019)
Letter
Oncology
Ethan B. Ludmir, Anita Mahajan, Verity Ahern, Thankamma Ajithkumar, Claire Alapetite, Valerie Bernier-Chastagner, Ranjit S. Bindra, Andrew J. Bishop, Stephanie Bolle, Paul D. Brown, Christian Carrie, Anthony J. Chalmers, Eric L. Chang, Caroline Chung, Karin Dieckmann, Natia Esiashvili, Lorenza Gandola, Amol J. Ghia, Vinai Gondi, David R. Grosshans, Semi B. Harrabi, Gail Horan, Danny J. Indelicato, Rakesh Jalali, Geert O. Janssens, Mechthild Krause, Nadia N. Laack, Normand Laperriere, Anne Laprie, Jing Li, Karen J. Marcus, Susan L. McGovern, Thomas E. Merchant, Kenneth W. Merrell, Laetitia Padovani, Jeannette Parkes, Arnold C. Paulino, Rudolf Schwarz, Helen A. Shih, Luis Souhami, Erik P. Sulman, Roger E. Taylor, Nicola Thorp, Beate Timmermann, Greg Wheeler, Suzanne L. Wolden, Kristina D. Woodhouse, Debra N. Yeboa, Torunn I. Yock, Rolf-Dieter Kortmann, Mary Frances McAleer
NATURE REVIEWS CLINICAL ONCOLOGY
(2019)
Article
Oncology
Matthew S. Ning, Brian J. Deegan, Jennifer C. Ho, Bhavana V. Chapman, Andrew J. Bishop, Pamela K. Allen, Nizar M. Tannir, Behrang Amini, Tina M. Briere, Xin A. Wang, Claudio E. Tatsui, Laurence D. Rhines, Paul D. Brown, Jing Li, Amol J. Ghia
RADIOTHERAPY AND ONCOLOGY
(2019)
Article
Oncology
Andrew J. Bishop, Justin E. Bird, Anthony P. Conley, Christina L. Roland, Bryan S. Moon, Robert L. Satcher, John A. Livingston, Shreyaskumar Patel, Wei-Lien Wang, Alexander J. Lazar, Valerae O. Lewis, Patrick P. Lin, B. Ashleigh Guadagnolo
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS
(2019)
Article
Oncology
Andrew J. Bishop, Jace P. Landry, Christina L. Roland, Ravin Ratan, Barry W. Feig, Bryan S. Moon, Maria A. Zarzour, Wei-Lien Wang, Alexander J. Lazar, Valerae O. Lewis, Keila E. Torres, B. Ashleigh Guadagnolo
Review
Oncology
Ahsan Farooqi, Devarati Mitra, B. Ashleigh Guadagnolo, Andrew J. Bishop
CURRENT ONCOLOGY REPORTS
(2020)
Editorial Material
Oncology
Andrew J. Bishop, Christina L. Roland
Summary: The role of radiation therapy in multimodality treatment of retroperitoneal sarcoma is evolving, emphasizing the importance of quality-assurance programs in radiotherapy.
Article
Oncology
Vinod Ravi, Aparna Subramaniam, Jing Zheng, Behrang Amini, Van A. Trinh, Jocelyn Joseph, Robert G. Mennel, Andrew J. Bishop, Erich M. Sturgis, Ryan P. Goepfert, Sudha Yalamanchili, Gilberto Botello, Bettzy Stephen, Sarina A. Piha-Paul, Anisha B. Patel, Alexander J. Lazar, Anthony P. Conley, Robert S. Benjamin, Shreyaskumar R. Patel, Phillip A. Futreal, Neeta Somaiah, Aung Naing
Summary: This retrospective study assessed the clinical activity of pembrolizumab monotherapy in patients with angiosarcoma. The results showed durable clinical activity of pembrolizumab in angiosarcoma, indicating a high probability of success for checkpoint inhibition as monotherapy or combination therapy.
Article
Oncology
Ahsan Farooqi, Andrew J. Bishop, Saphal Narang, Pamela K. Allen, Jing Li, Mary Frances McAleer, Claudio E. Tatsui, Laurence D. Rhines, Behrang Amini, Xin A. Wang, Amol J. Ghia
PRACTICAL RADIATION ONCOLOGY
(2019)
Article
Surgery
Annabelle L. Fonseca, Christina L. Roland, Janice N. Cormier, Keila E. Torres, Kelly H. Hunt, Andrew J. Bishop, Ashleigh Guadagnolo, Barry W. Feig