Review
Oncology
Chia Ching Lee, Yu Yang Soon, Timothy Cheo, Balamurugan Vellayappan, Jeremy Tey
Summary: The purpose of this study was to compare the efficacy and safety of SBRT and cEBRT in patients with previously unirradiated painful BM. The meta-analysis showed that SBRT significantly improved pain response and reduced local progression compared to cEBRT, but there were no differences in other outcomes.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2022)
Article
Oncology
Xuguang Chen, Michael C. LeCompte, Chengcheng Gui, Ellen Huang, Majid A. Khan, Chen Hu, Daniel M. Sciubba, Lawrence R. Kleinberg, Sheng-fu Larry Lo, Kristin J. Redmond
Summary: This study analyzed the impact of target delineation on local control after SBRT for spine metastasis. The results showed that deviations from consensus contouring guidelines led to inferior local control, and adherence to the guidelines was associated with superior local control and fewer marginal misses.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Clinical Neurology
Roman O. Kowalchuk, Michael R. Waters, K. Martin Richardson, Kelly Spencer, James M. Larner, William H. McAllister, Jason P. Sheehan, Charles R. Kersh
Summary: This study evaluated the impact of different spinal regions on local control, LPFS, and pain response among patients treated with stereotactic body radiation therapy for spinal metastases. Results showed that cervical spine cases had better local control and LPFS compared to sacral spine cases.
JOURNAL OF NEUROSURGERY-SPINE
(2021)
Article
Biology
Eric J. Lehrer, Henry Ruiz-Garcia, Anthony D. Nehlsen, Kunal K. Sindhu, Rachel Sarabia Estrada, Gerben R. Borst, Jason P. Sheehan, Alfredo Quinones-Hinojosa, Daniel M. Trifiletti
Summary: In summary, stereotactic radiosurgery (SRS) is a highly effective treatment option for tumors with minimal radiation exposure to healthy tissues. However, the role of preoperative SRS in glioblastoma (GBM) is not well understood due to limited evidence. This review provides an overview of GBM and discusses the potential role of preoperative SRS in its management.
Article
Oncology
Eunji Kim, Mi-Sook Kim, Eun Kyung Paik, Ung-Kyu Chang, Chang-Bae Kong
Summary: This study evaluated the treatment outcomes of spine stereotactic body radiation therapy (SBRT) in sarcoma patients. The results showed that treating a single vertebral body had better outcomes, and the extent of disease and disease progression before treatment significantly affected the prognosis of patients.
RADIATION ONCOLOGY
(2023)
Article
Oncology
Palak Kundu, Eric Y. Lin, Stephanie M. Yoon, Neil R. Parikh, Dan Ruan, Amar U. Kishan, Alan Lee, Michael L. Steinberg, Albert J. Chang
Summary: This study showed that hydrogel can reduce rectal radiation dose in patients receiving prostate SBRT, leading to a decreased rate of acute GI toxicity.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Laura Uder, Marcel Nachbar, Sarah Butzer, Jessica Boldt, Sabrina Baumeister, Michael Bitzer, Alfred Koenigsrainer, Thomas Seufferlein, Ruediger Hoffmann, Sergios Gatidis, Konstantin Nikolaou, Daniel Zips, Daniela Thorwarth, Cihan Gani, Simon Boeke
Summary: This study reported on the use of online magnetic resonance guided radiotherapy for liver metastases. The results showed high local control rates and improvements in patient reported outcome measures and quality of life. Further prospective trials are ongoing to define the patient population that will benefit most from this online adaptive workflow.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Savino Cilla, Francesco Cellini, Carmela Romano, Gabriella Macchia, Donato Pezzulla, Pietro Viola, Milly Buwenge, Luca Indovina, Vincenzo Valentini, Alessio G. Morganti, Francesco Deodato
Summary: This study evaluated the dosimetric effects of a new personalized planning engine for SBRT treatment of vertebral metastases. The results showed that automated plans using the personalized engine demonstrated significant improvements in plan quality and treatment efficiency.
FRONTIERS IN ONCOLOGY
(2022)
Article
Urology & Nephrology
Shankar Siva, Mathias Bressel, Simon T. Wood, Mark G. Shaw, Sherene Loi, Shahneen K. Sandhu, Ben Tran, Arun A. Azad, Jeremy H. Lewin, Katharine E. Cuff, Howard Y. Liu, Daniel Moon, Jeremy Goad, Lih-Ming Wong, Michael LimJoon, Jennifer Mooi, Sarat Chander, Declan G. Murphy, Nathan Lawrentschuk, David Pryor
Summary: The RAPPORT trial investigated the combination of high-dose precision radiotherapy and a short course of immunotherapy in patients with low-volume metastatic kidney cancer. The results showed that this treatment regimen was well tolerated, with excellent cancer control in known disease sites, and a proportion of patients were free from cancer relapse in the longer term. These findings are encouraging and warrant further investigation.
Article
Clinical Neurology
Zach Pennington, Sutipat Pairojboriboon, Xuguang Chen, Amanda Sacino, Aladine A. Elsamadicy, Rafael de la Garza Ramos, Jaimin Patel, Benjamin D. Elder, Lawrence R. Kleinberg, Daniel M. Sciubba, Kristin J. Redmond, Sheng-fu Larry Lo
Summary: This study aimed to examine the effect of anterior column debulking versus epidural disease resection alone on the local control of metastases to the bony spine. The study found that anterior column debulking decreased the odds of local recurrence and improved long-term local control compared to epidural debulking-alone.
Article
Clinical Neurology
Dukagjin M. Blakaj, Joshua D. Palmer, Khaled Dibs, Alexander Olausson, Eric C. Bourekas, Daniel Boulter, Ahmet S. Ayan, Eric Cochran, William S. Marras, Prasath Mageswaran, Miki Katzir, Vedat O. Yildiz, John Grecula, Andrea Arnett, Raju Raval, Thomas Scharschmidt, James B. Elder, Russell Lonser, Arnab Chakravarti, Ehud Mendel
Summary: Factors associated with local control and progression-free survival for patients receiving postoperative stereotactic spine radiosurgery included time from surgery to radiosurgery, radiotherapy dose, and preoperative embolization.
Article
Oncology
Khaled Dibs, Dukagjin M. Blakaj, Rahul N. Prasad, Alexander Olausson, Eric C. Bourekas, Daniel Boulter, Ahmet S. Ayan, Eric Cochran, William S. Marras, Prasath Mageswaran, Evan Thomas, Hyeri Lee, John Grecula, Raju R. Raval, Ehud Mendel, Thomas Scharschmidt, Russell Lonser, Arnab Chakravarti, James B. Elder, Joshua D. Palmer
Summary: Spine SBRT treatment for patients with >= 3 contiguous involved levels is feasible and may offer excellent local control without significant toxicity. Prospective evaluation is warranted.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Hsiang-Chieh Hsieh, Hung-Kuan Yen, Ting-En Tseng, Yu-Ting Pan, Min-Tsun Liao, Shau-Huai Fu, Mao-Hsu Yen, Fu-Shan Jaw, Wei-Hsin Lin, Ming-Hsiao Hu, Shu-Hua Yang, Olivier Q. Groot, Andrew J. Schoenfeld
Summary: This study aimed to determine the cost-effectiveness of operative and nonoperative treatments for spinal metastasis based on patients' predicted survival probability. The study found that operative intervention with postoperative radiotherapy could be more cost-effective than radiotherapy alone for patients with a better survival outlook. The study emphasizes the importance of carefully selecting patients and accurately predicting survival, and suggests that future research using accurate survival prediction tools and larger sample sizes could provide more detailed insights for clinical decisions.
Review
Oncology
Andrew B. Barbour, Simon Kirste, Anca-Liga Grosu, Shankar Siva, Alexander V. Louie, Hiroshi Onishi, Anand Swaminath, Bin S. Teh, Sarah P. Psutka, Emily S. Weg, Jonathan J. J. Chen, Jing Zeng, John L. Gore, Evan Hall, Jay J. J. Liao, Rohann J. M. Correa, Simon S. Lo
Summary: Patients with localized renal cell carcinoma often have medical comorbidities limiting their surgical candidacy, thus necessitating less invasive treatment options. Stereotactic ablative radiotherapy has emerged as a safe and effective management option with a growing body of evidence supporting its use. This article discusses recent advances in the use of stereotactic ablation radiotherapy for localized renal cell carcinoma, while guiding providers on practical points for patient selection and clinical application.
Article
Oncology
N. Ari Wijetunga, Carlos H. dos Anjos, W. Iris Zhi, Mark Robson, C. Jillian Tsai, Yoshiya Yamada, Laura Dover, Erin F. Gillespie, Amy J. Xu, Jonathan T. Yang
Summary: The study found that long-term systemic disease control and survival can be achieved with SABR for oligometastatic breast cancer. Hormone receptor-positive patients with a long disease interval from initial diagnosis and limited systemic progression history may be ideal candidates for SABR to all sites of disease.
Article
Critical Care Medicine
Margot Kelly-Hedrik, Muhammad M. Abd-El-Barr, Bizhan Aarabi, Armin Curt, Susan P. Howley, James S. Harrop, Steven Kirshblum, Christopher J. Neal, Vanessa Noonan, Christine Park, Beatrice Ugiliweneza, Charles Tator, Elizabeth G. Toups, Michael G. Fehlings, Theresa Williamson, James D. Guest
Summary: Only 100 years ago, traumatic spinal cord injury (SCI) was commonly lethal. Today, most people who sustain SCI survive with continual efforts to improve their quality of life and neurological outcomes. SCI epidemiology is changing as preventative interventions reduce injuries in younger individuals, and there is an increased incidence of incomplete injuries in aging populations.
JOURNAL OF NEUROTRAUMA
(2023)
Article
Critical Care Medicine
Daniyal Mansoor Ali, Ahilan Sivaganesan, Chris J. Neal, Sara Thalheimer, Beatrice Ugiliweneza, Elizabeth G. Toups, Muhammad Abd-El-Barr, George Jimsheleishvili, Shekar N. Kurpad, Bizhan Aarabi, Christopher I. Shaffrey, Michael G. Fehlings, Charles H. Tator, Robert G. Grossman, James D. Guest, James S. Harrop
Summary: The bulbocavernosus reflex (BCR) has been used as a metric to determine prognosis and spinal shock in spinal cord injury patients. However, a review found that BCR is not a reliable marker for predicting neurological outcomes post-injury.
JOURNAL OF NEUROTRAUMA
(2023)
Article
Critical Care Medicine
Margot Kelly-Hedrick, Beatrice Ugiliweneza, Elizabeth G. Toups, George Jimsheleishvili, Shekar N. Kurpad, Bizhan Aarabi, James S. Harrop, Norah Foster, Rory C. Goodwin, Christopher I. Shaffrey, Michael G. Fehlings, Charles H. Tator, James D. Guest, Chris J. Neal, Muhammad M. Abd-El-Barr, Theresa Williamson
Summary: The North America Clinical Trials Network for Spinal Cord Injury (NACTN) has maintained a prospective registry since 2004 and supports early surgical intervention for improved outcomes. This study examined the association between interhospital transfer (IHT), early surgery, and outcome using data from the NACTN SCI Registry. The findings suggest barriers in timely recognition and management of spinal cord injury, with IHT patients less likely to receive surgery within 24 hours of injury. Rating: 8/10.
JOURNAL OF NEUROTRAUMA
(2023)
Article
Critical Care Medicine
Chris J. Neal, Beatrice Ugiliweneza, Elizabeth G. Toups, Muhammad Abd-El-Barr, George Jimsheleishvili, Shekar N. Kurpad, Bizhan Aarabi, James S. Harrop, Christopher I. Shaffrey, Michael G. Fehlings, Charles H. Tator, Robert G. Grossman, James D. Guest
Summary: Data supports the benefits of early surgical intervention in acute spinal cord injury (SCI). This study analyzed the factors affecting the timing of surgery for acute cervical SCI within the North American Clinical Trials Network for SCI registry. The severity of neurological injury, the day of the week, and the treating center were found to be related to the variability in achieving early surgery.
JOURNAL OF NEUROTRAUMA
(2023)
Article
Critical Care Medicine
Brittany Grace Futch, Romaric Waguia Kouam, Beatrice Ugiliweneza, James Harrop, Shekar Kurpad, Norah Foster, Khoi Than, Clifford Crutcher, C. Rory Goodwin, Charles Tator, Christopher I. Shaffrey, Bizhan Aarabi, Michael Fehlings, Chris J. Neal, James Guest, Muhammad M. Abd-El-Barr
Summary: This study compared the demographics, mechanism of injury, and outcomes of upper versus lower cervical spinal cord injuries (cSCI). The findings showed that there were significant differences between C3 and C4, with upper cSCI (C1-C3) being associated with falls and diabetes, while lower cSCI (C4-C7) being associated with sports injuries, worse ASIA scores, and more complications.
JOURNAL OF NEUROTRAUMA
(2023)
Article
Clinical Neurology
David A. W. Sykes, Troy Q. Tabarestani, David S. Salven, Nauman S. Chaudhry, Timothy Y. Wang, Oren N. Gottfried, Christopher I. Shaffrey, Nicole R. Guinn, Jeffrey Gadsden, Chakib M. Ayoub, W. Michael Bullock, Miles Berger, Muhammad M. Abd-El-Barr
Summary: The study aims to summarize the outcomes of a series of highly comorbid patients who received spine surgery under spinal anesthesia (SA), and found that SA may facilitate safe surgical intervention with excellent outcomes for patients with relative contraindications to general anesthesia (GA).
Article
Clinical Neurology
Mohamed A. R. Soliman, Luis Diaz-Aguilar, Cathleen C. Kuo, Alexander O. Aguirre, Asham Khan, Jose E. San Miguel-Ruiz, Rodrigo Amaral, Muhammad M. Abd-El-Barr, Isaac L. Moss, Tyler Smith, Gurvinder S. Deol, Jeff Ehresman, Madison Battista, Bryan S. Lee, M. Craig Mcmains, Samuel A. Joseph, David Schwartz, Andrew D. Nguyen, William R. Taylor, Luiz Pimenta, John Pollina
Summary: In this multicenter case series, the PTP approach was well tolerated and associated with a satisfactory safety profile.
Article
Clinical Neurology
Troy Q. Tabarestani, David A. W. Sykes, Romaric W. Kouam, David S. Salven, Timothy Y. Wang, Vikram A. Mehta, Christopher I. Shaffrey, Walter F. Wiggins, John H. Chi, Muhammad M. Abd-El-Barr
Summary: This study found that pathology can significantly decrease the area of Kambin's Triangle at certain levels, and that higher spondylolisthesis and smaller posterior disk heights are associated with decreased areas. Preoperatively segmenting lumbosacral nerves and measuring Kambin's Triangle can help guide surgical planning and determine the ideal approach for percutaneous lumbar interbody fusion.
WORLD NEUROSURGERY
(2023)
Article
Clinical Neurology
David A. W. Sykes, Troy Q. Tabarestani, Nauman S. Chaudhry, David S. Salven, Christopher I. Shaffrey, W. Michael Bullock, Nicole R. Guinn, Jeffrey Gadsden, Miles Berger, Muhammad M. Abd-El-Barr
Summary: A retrospective study suggests that spinal anesthesia (SA) may be preferable to general anesthesia (GA) for lumbar fusion surgeries, as it is associated with reduced hospital length of stay, opioid usage, and time to ambulation. However, further randomized prospective studies are needed to confirm these findings.
WORLD NEUROSURGERY
(2023)
Article
Clinical Neurology
Andrew A. Hardigan, Troy Q. Tabarestani, Christopher F. Dibble, Eli Johnson, Timothy Y. Wang, Jessica Albanese, Isaac O. Karikari, Malcolm R. Debaun, Muhammad M. Abd-El-Barr
Summary: This study evaluated 7 patients with traumatic sacral fractures treated with robotic-assisted minimally invasive spinopelvic fixation, showing a mean blood loss of 85.7 mL and mean operative time of 178.4 minutes. Six patients had no complications postoperatively, while one patient experienced complications but all patients were safely discharged. Robotic-assisted minimally invasive spinopelvic fixation appears to be a safe and feasible treatment option for traumatic sacral fractures.
WORLD NEUROSURGERY
(2023)
Article
Clinical Neurology
Stephen M. Bergin, Muhammad M. Abd-El-Barr, Oren N. Gottfried, C. Rory Goodwin, Christopher I. Shaffrey, Khoi D. Than
Summary: SRS-22 and ODI are predominantly used PRO measurements for deformity surgery. Improvements in sagittal alignment correlated with better PRO, with T1-SPI performing better than SVA. Functional outcomes and accelerometer measurements are newer methods that have not been widely adopted or validated. Adoption of a minimum set of core outcome domains, PROs such as SRS-22, and contributing risk factors will facilitate international comparisons and benchmarking, ultimately enhancing value-based healthcare.
NEUROSURGERY CLINICS OF NORTH AMERICA
(2023)
Article
Multidisciplinary Sciences
Valentina Cigliola, Adam Shoffner, Nutishia Lee, Jianhong Ou, Trevor J. J. Gonzalez, Jiaul Hoque, Clayton J. J. Becker, Yanchao Han, Grace Shen, Timothy D. D. Faw, Muhammad M. M. Abd-El-Barr, Shyni Varghese, Aravind Asokan, Kenneth D. D. Poss
Summary: Zebrafish can regenerate and regain locomotor ability after spine injuries, unlike mammals. The neurogenic factor Hb-egf promotes spinal cord regeneration in zebrafish and is regulated by an enhancer that can also direct expression in neonatal mice.
NATURE COMMUNICATIONS
(2023)
Meeting Abstract
Clinical Neurology
Mohamed A. R. Soliman, Luis Daniel Diaz-Aguilar, Asham Khan, Jose San Miguel, Rodrigo Augusto Amaral, Bryan S. Lee, Muhammad M. Abd-El-Barr, Gene Massey, Craig McMains, David Gary Schwartz, Gurvinder Deol, Andrew D. Nguyen, Tyler Smith, Luiz Pimenta, William R. Taylor, John Pollina
Meeting Abstract
Clinical Neurology
David Sykes, Troy Tabarestani, Nauman Shaukat Chaudhry, Miles Berger, Chakib Ayoub, Jeffrey Gadsden, Dhanesh Kumar Gupta, Christopher I. Shaffrey, Muhammad M. Abd-El-Barr
Meeting Abstract
Clinical Neurology
David Sykes, Troy Tabarestani, Nauman Shaukat Chaudhry, Miles Berger, Chakib Ayoub, Jeffrey Gadsden, Dhanesh Kumar Gupta, Christopher I. Shaffrey, Muhammad M. Abd-El-Barr