Endothelial TFEB signaling-mediated autophagic disturbance initiates microglial activation and cognitive dysfunction

Microglia-Derived Interleukin 23: A Crucial Cytokine in Alzheimer's Disease?

(2021) Louisa Nitsch et al.   Frontiers in Neurology

The induction strategies administered in the treatment of multiple myeloma exhibit a deleterious effect on the endothelium

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Cellular mechanisms and treatments for chemobrain: insight from aging and neurodegenerative diseases

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APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline

(2020) Axel Montagne et al.   NATURE

Microglial Remodeling of the Extracellular Matrix Promotes Synapse Plasticity

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Chemotherapy-induced cognitive impairment (CICI): An overview of etiology and pathogenesis

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Clearing the Fog surrounding Chemobrain

(2019) David H. Gutmann   CELL

Blood–brain barrier breakdown is an early biomarker of human cognitive dysfunction

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TFEB-mediated enhancement of the autophagy-lysosomal pathway dually modulates the process of amyloid β-protein generation in neurons

(2019) Fumiko Yamamoto et al.   NEUROSCIENCE

Endothelium-Derived Semaphorin 3G Regulates Hippocampal Synaptic Structure and Plasticity via Neuropilin-2/PlexinA4

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Impaired TFEB-Mediated Lysosomal Biogenesis Promotes the Development of Pancreatitis in Mice and Is Associated with Human Pancreatitis

(2019) Shaogui Wang et al.   Autophagy

Fate-Mapping of GM-CSF Expression Identifies a Discrete Subset of Inflammation-Driving T Helper Cells Regulated by Cytokines IL-23 and IL-1β

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Efficient brain targeting and therapeutic intracranial activity of bortezomib through intranasal co-delivery with NEO100 in rodent glioblastoma models

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Propagation of Protein Aggregation in Neurodegenerative Diseases

(2019) Jaime Vaquer-Alicea et al.   Annual Review of Biochemistry

MIR145-3p promotes autophagy and enhances bortezomib sensitivity in multiple myeloma by targeting HDAC4

(2019) Hongkun Wu et al.   Autophagy

Microglia in Brain Development, Homeostasis, and Neurodegeneration

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Lysosomotropic beta blockers induce oxidative stress and IL23A production in Langerhans cells

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Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer’s disease model

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Bilateral activation of STAT3 by phosphorylation at the tyrosine-705 (Y705) and serine-727 (S727) positions and its nuclear translocation in primary sensory neurons following unilateral sciatic nerve injury

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Repopulated microglia are solely derived from the proliferation of residual microglia after acute depletion

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Lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging

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Epigenetic control of IL-23 expression in keratinocytes is important for chronic skin inflammation

(2018) Hui Li et al.   Nature Communications

STAT3 associates with vacuolar H+-ATPase and regulates cytosolic and lysosomal pH

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Neuronal-targeted TFEB rescues dysfunction of the autophagy-lysosomal pathway and alleviates ischemic injury in permanent cerebral ischemia

(2018) Yueyang Liu et al.   Autophagy

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Melatonin ameliorates hypoglycemic stress-induced brain endothelial tight junction injury by inhibiting protein nitration of TP53-induced glycolysis and apoptosis regulator

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Gpr124 is essential for blood–brain barrier integrity in central nervous system disease

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Digoxin reduces atherosclerosis in apolipoprotein E-deficient mice

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Digoxin in Heart Failure with a Reduced Ejection Fraction: A Risk Factor or a Risk Marker?

(2016) Dimitrios M. Konstantinou et al.   CARDIOLOGY

Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation

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A brain microvasculature endothelial cell‐specific viral vector with the potential to treat neurovascular and neurological diseases

(2016) Jakob Körbelin et al.   EMBO Molecular Medicine

Deficient autophagy in microglia impairs synaptic pruning and causes social behavioral defects

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A complement–microglial axis drives synapse loss during virus-induced memory impairment

(2016) Michael J. Vasek et al.   NATURE

Lysosomal calcium regulates autophagy

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P2RX7 sensitizes Mac-1/ICAM-1-dependent leukocyte-endothelial adhesion and promotes neurovascular injury during septic encephalopathy

(2015) Huan Wang et al.   CELL RESEARCH

TFEB Participates in the Aβ-Induced Pathogenesis of Alzheimer's Disease by Regulating the Autophagy-Lysosome Pathway

(2015) Yi-dan Zhang et al.   DNA AND CELL BIOLOGY

Host microbiota constantly control maturation and function of microglia in the CNS

(2015) Daniel Erny et al.   NATURE NEUROSCIENCE

Autophagy and ethanol neurotoxicity

(2014) Jia Luo   Autophagy

Bortezomib-induced Posterior Reversible Encephalopathy Syndrome: Clinical and Imaging Features

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Structural and Molecular Remodeling of Dendritic Spine Substructures during Long-Term Potentiation

(2014) Miquel Bosch et al.   NEURON

The role of autophagy in neurodegenerative disease

(2013) Ralph A Nixon   NATURE MEDICINE

PPARGC1A/PGC-1α, TFEB and enhanced proteostasis in Huntington disease

(2012) Albert R. La Spada   Autophagy

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