Neuropathic Pain: Mechanisms, Sex Differences, and Potential Therapies for a Global Problem

Sex‐specific transcriptome of spinal microglia in neuropathic pain due to peripheral nerve injury

(2022) Nathan T. Fiore et al.   GLIA

Single-cell RNA sequencing reveals time- and sex-specific responses of mouse spinal cord microglia to peripheral nerve injury and links ApoE to chronic pain

(2022) Shannon Tansley et al.   Nature Communications

Microglia-independent peripheral neuropathic pain in male and female mice

(2022) YuShan Tu et al.   PAIN

A spinal microglia population involved in remitting and relapsing neuropathic pain

(2022) Keita Kohno et al.   SCIENCE

STING controls nociception via type I interferon signalling in sensory neurons

(2021) Christopher R. Donnelly et al.   NATURE

Reactive astrocyte nomenclature, definitions, and future directions

(2021) Carole Escartin et al.   NATURE NEUROSCIENCE

Spinal macrophages resolve nociceptive hypersensitivity after peripheral injury

(2021) Jesse K. Niehaus et al.   NEURON

Chemogenetic Activation of CX3CR1-Expressing Spinal Microglia Using Gq-DREADD Elicits Mechanical Allodynia in Male Mice

(2021) Fumihiro Saika et al.   Cells

Chemogenetic activation of central gastrin‐releasing peptide‐expressing neurons elicits itch‐related scratching behavior in male and female mice

(2021) Norikazu Kiguchi et al.   Pharmacology Research & Perspectives

Spared Nerve Injury Causes Sexually Dimorphic Mechanical Allodynia and Differential Gene Expression in Spinal Cords and Dorsal Root Ganglia in Rats

(2021) F.H.G. Ahlström et al.   MOLECULAR NEUROBIOLOGY

IL-23/IL-17A/TRPV1 axis produces mechanical pain via macrophage-sensory neuron crosstalk in female mice

(2021) Xin Luo et al.   NEURON

Social factors and chronic pain: the modifying effect of sex in the Stockholm Public Health Cohort Study

(2021) Jesús Prego-Domínguez et al.   RHEUMATOLOGY

Single-Dose P2 X4R Single-Chain Fragment Variable Antibody Permanently Reverses Chronic Pain in Male Mice

(2021) Karin N. Westlund et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

iPSCs and DRGs: stepping stones to new pain therapies

(2021) Matthew Alsaloum et al.   TRENDS IN MOLECULAR MEDICINE

Regulatory T-cells inhibit microglia-induced pain hypersensitivity in female mice

(2021) Julia A Kuhn et al.   eLife

STING regulates peripheral nerve regeneration and colony stimulating factor 1 receptor (CSF1R) processing in microglia

(2021) Giulio Morozzi et al.   iScience

The PPARγ agonist pioglitazone produces a female-predominant inhibition of hyperalgesia associated with surgical incision, peripheral nerve injury, and painful diabetic neuropathy

(2021) D.F.S. Santos et al.   NEUROPHARMACOLOGY

Dorsal root ganglion macrophages contribute to both the initiation and persistence of neuropathic pain

(2020) Xiaobing Yu et al.   Nature Communications

Regulatory T cells counteract neuropathic pain through inhibition of the Th1 response at the site of peripheral nerve injury

(2020) Marcela Davoli-Ferreira et al.   PAIN

Computer-aided Discovery of a New Nav1.7 Inhibitor for Treatment of Pain and Itch

(2020) Sharat Chandra et al.   ANESTHESIOLOGY

Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition

(2020) Emanuela Pasciuto et al.   CELL

A myelin basic protein fragment induces sexually dimorphic transcriptome signatures of neuropathic pain in mice

(2020) Andrei V. Chernov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The revised International Association for the Study of Pain definition of pain

(2020) Srinivasa N. Raja et al.   PAIN

Chemogenetic Regulation of CX3CR1-Expressing Microglia Using Gi-DREADD Exerts Sex-Dependent Anti-Allodynic Effects in Mouse Models of Neuropathic Pain

(2020) Fumihiro Saika et al.   Frontiers in Pharmacology

Sex differences in nociceptor translatomes contribute to divergent prostaglandin signaling in male and female mice

(2020) Diana Tavares-Ferreira et al.   BIOLOGICAL PSYCHIATRY

Transcriptional Reprogramming of Distinct Peripheral Sensory Neuron Subtypes after Axonal Injury

(2020) William Renthal et al.   NEURON

Central Nervous System Targets: Glial Cell Mechanisms in Chronic Pain

(2020) Christopher R. Donnelly et al.   Neurotherapeutics

Sexual dimorphism of pain control: analgesic effects of pioglitazone and azithromycin in chronic spinal cord injury.

(2019) John Gensel et al.   JOURNAL OF NEUROTRAUMA

Genetic pathway analysis reveals a major role for extracellular matrix organization in inflammatory and neuropathic pain

(2019) Marc Parisien et al.   PAIN

Sex differences in depression: Insights from clinical and preclinical studies

(2019) Rand S. Eid et al.   PROGRESS IN NEUROBIOLOGY

Activation of Sphingosine-1-Phosphate Receptor 1 in the Spinal Cord Produces Mechanohypersensitivity Through the Activation of Inflammasome and IL-1β Pathway

(2019) Timothy M. Doyle et al.   JOURNAL OF PAIN

Sphingosine-1-phosphate receptor 1 activation in astrocytes contributes to neuropathic pain

(2019) Zhoumou Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An update on reactive astrocytes in chronic pain

(2019) Ting Li et al.   Journal of Neuroinflammation

Macrophage toll-like receptor 9 contributes to chemotherapy-induced neuropathic pain in male mice

(2019) Xin Luo et al.   JOURNAL OF NEUROSCIENCE

Chloride Dysregulation through Downregulation of KCC2 Mediates Neuropathic Pain in Both Sexes

(2019) Josiane C.S. Mapplebeck et al.   Cell Reports

Sexually dimorphic therapeutic response in bortezomib-induced neuropathic pain reveals altered pain physiology in female rodents

(2019) Katherine Stockstill et al.   PAIN

TNFR2 promotes Treg-mediated recovery from neuropathic pain across sexes

(2019) Roman Fischer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T Cells as an Emerging Target for Chronic Pain Therapy

(2019) Geoffroy Laumet et al.   Frontiers in Molecular Neuroscience

Sting is a critical regulator of spinal cord injury by regulating microglial inflammation via interacting with TBK1 in mice

(2019) Yue-yi Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Intrathecal administration of antisense oligonucleotide against p38α but not p38β MAP kinase isoform reduces neuropathic and postoperative pain and TLR4-induced pain in male mice

(2018) Xin Luo et al.   BRAIN BEHAVIOR AND IMMUNITY

DREADDed microglia in pain: Implications for spinal inflammatory signaling in male rats

(2018) Peter M. Grace et al.   EXPERIMENTAL NEUROLOGY

Sex differences in the metabolic effects of diet-induced obesity vary by age of onset

(2018) Abigail E. Salinero et al.   INTERNATIONAL JOURNAL OF OBESITY

CD4+ αβ T cell infiltration into the leptomeninges of lumbar dorsal roots contributes to the transition from acute to chronic mechanical allodynia after adult rat tibial nerve injuries

(2018) Bin Du et al.   Journal of Neuroinflammation

Microglia in neuropathic pain: cellular and molecular mechanisms and therapeutic potential

(2018) Kazuhide Inoue et al.   NATURE REVIEWS NEUROSCIENCE

Microglial P2X4R-evoked pain hypersensitivity is sexually dimorphic in rats

(2018) Josiane C.S. Mapplebeck et al.   PAIN

Mechanistic Differences in Neuropathic Pain Modalities Revealed by Correlating Behavior with Global Expression Profiling

(2018) Enrique J. Cobos et al.   Cell Reports

Exploring the transcriptome of resident spinal microglia after collagen antibody-induced arthritis

(2018) Teresa Fernandez-Zafra et al.   PAIN

Targeting The NaV1.8 ion Channel Engenders Sex-Specific Responses in Lysophosphatidic Acid-Induced Joint Neuropathy

(2018) Melissa S. O’Brien et al.   PAIN

Pan-Canadian Estimates of Chronic Pain Prevalence From 2000 to 2014: A Repeated Cross-Sectional Survey Analysis

(2018) Matthew S. Shupler et al.   JOURNAL OF PAIN

TNFR1 inhibition is therapeutic for neuropathic pain in males but not females

(2018) Tania del Rivero et al.   PAIN

Chronic pain as a symptom or a disease

(2018) Rolf-Detlef Treede et al.   PAIN

Critical role of Cav3.2 T-type calcium channels in the peripheral neuropathy induced by bortezomib, a proteasome-inhibiting chemotherapeutic agent, in mice

(2018) Shiori Tomita et al.   TOXICOLOGY

Microglia emerge as central players in brain disease

(2017) Michael W Salter et al.   NATURE MEDICINE

Exosomal cargo including microRNA regulates sensory neuron to macrophage communication after nerve trauma

(2017) Raffaele Simeoli et al.   Nature Communications

Sex-Dependent Glial Signaling in Pathological Pain: Distinct Roles of Spinal Microglia and Astrocytes

(2017) Gang Chen et al.   Neuroscience Bulletin

Molecules in pain and sex: a developing story

(2017) Josiane C. S. Mapplebeck et al.   Molecular Brain

Sex differences in peripheral not central immune responses to pain-inducing injury

(2017) Douglas M. Lopes et al.   Scientific Reports

Spinal inhibition of p38 MAP kinase reduces inflammatory and neuropathic pain in male but not female mice: Sex-dependent microglial signaling in the spinal cord

(2016) Sarah Taves et al.   BRAIN BEHAVIOR AND IMMUNITY

CD8+ T Cells and Endogenous IL-10 Are Required for Resolution of Chemotherapy-Induced Neuropathic Pain

(2016) K. Krukowski et al.   JOURNAL OF NEUROSCIENCE

Sex differences in neuroimmunity and pain

(2016) Sarah Rosen et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Chloride Regulation: A Dynamic Equilibrium Crucial for Synaptic Inhibition

(2016) Nicolas Doyon et al.   NEURON

Sex as a Biological Variable: Who, What, When, Why and How

(2016) Tracy L Bale et al.   NEUROPSYCHOPHARMACOLOGY

Dorsal horn neurons release extracellular ATP in a VNUT-dependent manner that underlies neuropathic pain

(2016) Takahiro Masuda et al.   Nature Communications

Potentiation of Synaptic GluN2B NMDAR Currents by Fyn Kinase Is Gated through BDNF-Mediated Disinhibition in Spinal Pain Processing

(2016) Michael E. Hildebrand et al.   Cell Reports

The Prevalence of Chronic Pain in Canada

(2016) Donald Schopflocher et al.   Pain Research & Management

Macrophage-T Cell Interactions Mediate Neuropathic Pain through the Glucocorticoid-induced Tumor Necrosis Factor Ligand System

(2015) Yuka Kobayashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Different immune cells mediate mechanical pain hypersensitivity in male and female mice

(2015) Robert E Sorge et al.   NATURE NEUROSCIENCE

Injured sensory neuron–derived CSF1 induces microglial proliferation and DAP12-dependent pain

(2015) Zhonghui Guan et al.   NATURE NEUROSCIENCE

Reduction of Neuropathic and Inflammatory Pain through Inhibition of the Tetrahydrobiopterin Pathway

(2015) Alban Latremoliere et al.   NEURON

The association between chronic pain and obesity

(2015) Akiko Okifuji et al.   Journal of Pain Research

Monocytes expressing CX3CR1 orchestrate the development of vincristine-induced pain

(2014) Elizabeth A. Old et al.   JOURNAL OF CLINICAL INVESTIGATION

Normal and abnormal coding of somatosensory stimuli causing pain

(2014) Steven A Prescott et al.   NATURE NEUROSCIENCE

The Deubiquitinating Enzyme USP5 Modulates Neuropathic and Inflammatory Pain by Enhancing Cav3.2 Channel Activity

(2014) Agustin García-Caballero et al.   NEURON

Spinal HMGB1 induces TLR4-mediated long-lasting hypersensitivity and glial activation and regulates pain-like behavior in experimental arthritis

(2014) Nilesh M. Agalave et al.   PAIN

Transcription factor IRF5 drives P2X4R+-reactive microglia gating neuropathic pain

(2014) Takahiro Masuda et al.   Nature Communications

Neuropathic pain in the general population: A systematic review of epidemiological studies

(2013) O. van Hecke et al.   PAIN

The Economic Costs of Pain in the United States

(2012) Darrell J. Gaskin et al.   JOURNAL OF PAIN

The role of the immune system in the generation of neuropathic pain

(2012) Margarita Calvo et al.   LANCET NEUROLOGY

P2X4R+ microglia drive neuropathic pain

(2012) Simon Beggs et al.   NATURE NEUROSCIENCE

Sex differences in pain and pain inhibition: multiple explanations of a controversial phenomenon

(2012) Jeffrey S. Mogil   NATURE REVIEWS NEUROSCIENCE

IRF8 Is a Critical Transcription Factor for Transforming Microglia into a Reactive Phenotype

(2012) Takahiro Masuda et al.   Cell Reports

TNF-α and neuropathic pain - a review

(2010) Lawrence Leung et al.   Journal of Neuroinflammation

Targeting astrocyte signaling for chronic pain

(2010) Yong-Jing Gao et al.   Neurotherapeutics

Role of voltage-gated calcium channels in ascending pain pathways

(2009) Gerald W. Zamponi et al.   BRAIN RESEARCH REVIEWS

Cellular and Molecular Mechanisms of Pain

(2009) Allan I. Basbaum et al.   CELL

T-Cell Infiltration and Signaling in the Adult Dorsal Spinal Cord Is a Major Contributor to Neuropathic Pain-Like Hypersensitivity

(2009) M. Costigan et al.   JOURNAL OF NEUROSCIENCE

P2X4-Receptor-Mediated Synthesis and Release of Brain-Derived Neurotrophic Factor in Microglia Is Dependent on Calcium and p38-Mitogen-Activated Protein Kinase Activation

(2009) T. Trang et al.   JOURNAL OF NEUROSCIENCE

Differential Regulation of Immune Responses and Macrophage/Neuron Interactions in the Dorsal Root Ganglion in Young and Adult Rats following Nerve Injury

(2009) David Vega-Avelaira et al.   Molecular Pain

In vivo silencing of the CaV3.2 T-type calcium channels in sensory neurons alleviates hyperalgesia in rats with streptozocin-induced diabetic neuropathy

(2009) Richard B. Messinger et al.   PAIN

CNS-infiltrating CD4+ T lymphocytes contribute to murine spinal nerve transection-induced neuropathic pain

(2008) Ling Cao et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Common Chronic Pain Conditions in Developed and Developing Countries: Gender and Age Differences and Comorbidity With Depression-Anxiety Disorders

(2008) Adley Tsang et al.   JOURNAL OF PAIN

Socioeconomic disadvantage and pain

(2008) Ellen L. Poleshuck et al.   PAIN

Comorbidity of pain and anxiety disorders

(2008) Oye Gureje   Current Psychiatry Reports

Characterization of cell proliferation in rat spinal cord following peripheral nerve injury and the relationship with neuropathic pain

(2007) Stefania Echeverry et al.   PAIN