Endothelial hyperactivation of mutant MAP3K3 induces cerebral cavernous malformation enhanced by PIK3CA GOF mutation

Simplex cerebral cavernous malformations with MAP3K3 mutation have distinct clinical characteristics

(2022) Ran Huo et al.   Frontiers in Neurology

Selective endothelial hyperactivation of oncogenic KRAS induces brain arteriovenous malformations in mice

(2021) Eun S. Park et al.   ANNALS OF NEUROLOGY

Diversity and versatility of p38 kinase signalling in health and disease

(2021) Begoña Canovas et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Somatic MAP3K3 mutation defines a subclass of cerebral cavernous malformation

(2021) Jiancong Weng et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Somatic MAP3K3 and PIK3CA mutations in sporadic cerebral and spinal cord cavernous malformations

(2021) Tao Hong et al.   BRAIN

PIK3CA and CCM mutations fuel cavernomas through a cancer-like mechanism

(2021) Aileen A. Ren et al.   NATURE

Cerebral Cavernous Malformation: From Mechanism to Therapy

(2021) Daniel A. Snellings et al.   CIRCULATION RESEARCH

De Novo Germline and Somatic Variants Convergently Promote Endothelial-to-Mesenchymal Transition in Simplex Brain Arteriovenous Malformation

(2021) Hao Li et al.   CIRCULATION RESEARCH

Single-Cell Transcriptome Atlas of Murine Endothelial Cells

(2020) Joanna Kalucka et al.   CELL

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

Distinct cellular roles for PDCD10 define a gut-brain axis in cerebral cavernous malformation

(2019) Alan T. Tang et al.   Science Translational Medicine

Cranial Cavernous Malformations

(2018) Christopher J. Stapleton et al.   STROKE

Cerebral cavernous malformations form an anticoagulant vascular domain in humans and mice

(2018) Miguel Alejandro Lopez-Ramirez et al.   BLOOD

Thrombospondin1 (TSP1) replacement prevents cerebral cavernous malformations

(2017) Miguel Alejandro Lopez-Ramirez et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A brain microvasculature endothelial cell‐specific viral vector with the potential to treat neurovascular and neurological diseases

(2016) Jakob Körbelin et al.   EMBO Molecular Medicine

Cerebral cavernous malformations arise from endothelial gain of MEKK3–KLF2/4 signalling

(2016) Zinan Zhou et al.   NATURE

KLF4 is a key determinant in the development and progression of cerebral cavernous malformations

(2015) R. Cuttano et al.   EMBO Molecular Medicine

Lesions from patients with sporadic cerebral cavernous malformations harbor somatic mutations in the CCM genes: evidence for a common biochemical pathway for CCM pathogenesis

(2014) David A. McDonald et al.   HUMAN MOLECULAR GENETICS

EndMT contributes to the onset and progression of cerebral cavernous malformations

(2013) Luigi Maddaluno et al.   NATURE

In Vivo Imaging of Cerebral Microvascular Plasticity from Birth to Death

(2012) Roa Harb et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Natural history and imaging prevalence of cavernous malformations in children and young adults

(2012) Wajd N. Al-Holou et al.   Journal of Neurosurgery-Pediatrics

Developmental timing of CCM2 loss influences cerebral cavernous malformations in mice

(2011) Gwénola Boulday et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Retro-orbital injections in mice

(2011) Tal Yardeni et al.   LAB ANIMAL

A novel mouse model of cerebral cavernous malformations based on the two-hit mutation hypothesis recapitulates the human disease

(2010) D. A. McDonald et al.   HUMAN MOLECULAR GENETICS

Phosphatase and tensin homolog in cerebral cavernous malformation: a potential role in pathological angiogenesis

(2008) Yuan Zhu et al.   JOURNAL OF NEUROSURGERY

Hemorrhage From Cavernous Malformations of the Brain

(2008) Rustam Al-Shahi Salman et al.   STROKE