Article
Clinical Neurology
Mani Puthuran, Gilbert Gravino, Feyi Babatola, Richard Pullicino, Souhyb Masri, Shubhabrata Biswas, Rene Chapot, Arun Chandran
Summary: This study analyzed the effectiveness of endovascular embolization as a primary treatment for intracranial arteriovenous malformations (AVMs). The results showed that endovascular embolization may be a favorable option for primary AVM treatment.
Article
Neurosciences
Yingkun He, Yanyan He, Weixing Bai, Dehua Guo, Taoyuan Lu, Lin Duan, Zhen Li, Lingfei Kong, Juha A. Hernesniemi, Tianxiao Li
Summary: This study analyzed the vascular stability of brain arteriovenous malformation (bAVM) in patients after partial embolization. The results showed that the biomarkers for bAVM vascular stability were most abnormal between 1 and 28 days after partial embolization.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Clinical Neurology
Jan Rodemerk, Marvin Darkwah Oppong, Andreas Junker, Cornelius Deuschl, Michael Forsting, Yuan Zhu, Philipp Dammann, Anne Uerschels, Ramazan Jabbarli, Ulrich Sure, Karsten H. Wrede
Summary: This study found that in AVMs, NLRP3 expression level is generally about 10 times higher than COX-2, suggesting that inflammation is mainly associated with ischemic-driven pathways. Additionally, no significant differences were found in the expression levels of NLRP3 or COX-2 between ruptured and unruptured AVMs.
NEUROSURGICAL FOCUS
(2022)
Article
Neuroimaging
Ian A. Ramsay, Vaidya Govindarajan, Turki Elarjani, Ahmed Abdelsalam, Michael Silva, Robert M. Starke, Evan Luther
Summary: During the COVID-19 pandemic in 2020, there was a decrease in the rate of intervention for unruptured cerebral AVMs compared to previous years, along with an increase in the rate of rupture. Patients with ruptured AVMs also had a higher risk of mortality.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2023)
Article
Neuroimaging
Songmi Lee, Youngran Kim, Babak B. Navi, Rania Abdelkhaleq, Sergio Salazar-Marioni, Spiros L. Blackburn, Arvind B. Bambhroliya, Victor Lopez-Rivera, Farhaan Vahidy, Sean Savitz, Annika Medhus, Hooman Kamel, James C. Grotta, Louise McCullough, Peng Roc Chen, Sunil A. Sheth
Summary: Among women with AVM, pregnancy and puerperium were associated with a greater than 3-fold risk of ICH.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2021)
Review
Cell Biology
S. Krithika, S. Sumi
Summary: Brain arteriovenous malformations (bAVM) are congenital or sporadic focal lesions with a significant risk of intracerebral hemorrhage, and individual differences exist in their onset, progression, and severity. Research supports the involvement of localized inflammation in bAVM disease progression, which is orchestrated by genetic moderators and inflammatory mediators. Targeting the inflammatory processes and mediators may offer potential therapies for the treatment of brain AVM, opening up new avenues for causal therapy.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Clinical Neurology
Hangeul Park, Eun Jung Lee, Jung-Eun Cheon, Jeong Eun Kim, Hyun-Seung Kang, Seung-Ki Kim
Summary: In this study, the combination of AVM and MMD was found to be rare, with AVM tending to occur in areas with higher angiographic stages of MMD. MMD bypass surgery was recommended for MMD patients based on symptoms and cerebral perfusion status, while less invasive but effective treatments, such as GKS, were suggested for concurrent AVM. Overall, favorable clinical outcomes were achieved in most patients, with the exception of one patient who experienced AVM rupture leading to a poor outcome.
WORLD NEUROSURGERY
(2021)
Article
Clinical Neurology
Ching-Jen Chen, Dale Ding, Jeyan S. Kumar, Kathryn N. Kearns, Natasha Ironside, Huai-Che Yang, Akiyoshi Ogino, Hideyuki Kano, Roman Liscak, Jaromir May, Brian J. Williams, Michael J. Gigliotti, Kevin Cockroft, James McInerney, Scott Simon, Cheng-Chia Lee, Jason P. Sheehan
Summary: The study found that intracranial hemorrhage and recurrent arteriovenous shunting after complete nidal obliteration are rare in AVM patients treated with SRS, with each phenomenon harboring an annual risk of <1%. Routine postobliteration DSA may not be recommended, but long-term neuroimaging could be advisable for these patients.
Article
Clinical Neurology
Pengfei Tong, Tikun Shan, Jiyang An, Shuang Liu, Gehan Jing, Jiajia Bi, Zhengfeng Wang
Summary: This study retrospectively analyzed patients with MMD and IVH and found that lower GCS score and higher Graeb score are independent risk factors for poor prognosis, while surgery treatment is a protective factor for MMD with IVH.
WORLD NEUROSURGERY
(2023)
Article
Clinical Neurology
Georgios Mantziaris, Stylianos Pikis, Chloe Dumot, Samantha Dayawansa, Roman Liscak, Jaromir May, Cheng-chia Lee, Huai-che Yang, Nuria Martinez Moreno, Roberto Martinez Alvarez, L. Dade Lunsford, Ajay Niranjan, Zhishuo Wei, Priyanka Srinivasan, Lilly W. W. Tang, Ahmed M. Nabeel, Wael A. Reda, Sameh R. Tawadros, Khaled Abdelkarim, Amr M. N. El-Shehaby, Reem M. Emad, Ahmed Hesham Elazzazi, Selcuk Peker, Yavuz Samanci, Varun Padmanaban, Francis J. Jareczek, James McInerney, Kevin M. Cockroft, David Mathieu, Salman Aldakhil, Juan Diego Alzate, Douglas Kondziolka, Manjul Tripathi, Joshua D. Palmer, Rituraj Upadhyay, Michelle Lin, Gabriel Zada, Cheng Yu, Christopher P. Cifarelli, Daniel T. Cifarelli, Zhiyuan Xu, Jason P. Sheehan
Summary: This study aimed to provide the combined experience of multiple centers to fully define the role of repeat stereotactic radiosurgery (SRS) for patients with cerebral arteriovenous malformation (AVM). The results showed that repeat SRS achieves reasonable obliteration rates with low complication risk. Extending the latency period to 5 years generally increases the rate of favorable patient outcomes and reduces the necessity of a third intervention.
Review
Clinical Neurology
Luis A. Robles, Victor Volovici
Summary: Primary intraventricular hemorrhage (PIVH) is a subtype of intraventricular hemorrhage (IVH) without hemorrhagic parenchymal component. A study analyzed characteristics of hypertensive PIVH, finding hypertension as the most common cause, followed by hemorrhage caused by vascular anomalies. Prognosis is poorer in patients with low Glasgow Coma Score, old age, hydrocephalus, or more extensive intraventricular bleeding.
NEUROSURGICAL REVIEW
(2022)
Review
Biotechnology & Applied Microbiology
Hamid Tanzadehpanah, Mohammad Hadi Saeed Modaghegh, Hanie Mahaki
Summary: The formation of vascular networks is crucial for embryogenesis and adulthood. Cerebral arteriovenous malformations (CAVMs) are associated with a high risk of intracerebral hemorrhage due to shunting of arterial blood into veins. Inflammation plays a critical role in CAVM pathogenesis, with proinflammatory cytokines causing endothelial cell activation and leukocyte recruitment. Matrix metalloproteinase-9 secretion by leukocytes leads to CAVM wall disruption and rupture. Inflammation also impacts the angioarchitecture of CAVMs by upregulating angiogenic factors, affecting endothelial cell functions. Understanding the molecular signature of CAVM may help in predicting complications and guiding gene therapy.
JOURNAL OF GENE MEDICINE
(2023)
Article
Multidisciplinary Sciences
Franziska Loebel, Antonio Pontoriero, Anne Kluge, Giuseppe Iati, Gueliz Acker, Markus Kufeld, Alberto Cacciola, Stefano Pergolizzi, Sergio Vinci, Sara Lillo, Ran Xu, Carmen Stromberger, Volker Budach, Peter Vajkoczy, Carolin Senger, Alfredo Conti
Summary: Robotic radiosurgery is an effective approach for treating cerebral arteriovenous malformations (AVMs) of all Spetzler-Martin grades, with satisfactory obliteration rates, low toxicity, and a relatively rare incidence of rebleeding. Embolization before treatment can downstage the lesions and improve treatment outcomes.
Article
Clinical Neurology
Yanyan He, Weixing Bai, Bin Xu, Xiaoyu Kang, Jiangyu Xue, Yingkun He, Tianxiao Li
Summary: This study investigated the perioperative complications of transvenous embolization of ruptured intracranial arteriovenous malformations. The most common complication was cerebral hemorrhage, and there were no significant differences in complication rates based on factors such as nidus size, location, and venous drainage.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neuroimaging
Hengwei Jin, Zhipeng Li, Dezhi Gao, Yu Chen, Heze Han, Li Ma, Debin Yan, Ruinan Li, Anqi Li, Haibin Zhang, Kexin Yuan, Yukun Zhang, Yang Zhao, Xiangyu Meng, Youxiang Li, Xiaolin Chen, Hao Wang, Shibin Sun, Yuanli Zhao
Summary: This study compared the long-term outcomes of stereotactic radiosurgery (SRS) with or without prior embolization in brain arteriovenous malformations (AVMs) (volume ≤10 mL). The findings suggest that the combined strategy of embolization and SRS does not provide substantial advantages over SRS alone in the treatment of AVMs.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2023)
Article
Neurosciences
Sarah T. Menacho, Ramesh Grandhi, Alen Delic, Mohammad Anadani, Wendy C. Ziai, Issam A. Awad, Daniel F. Hanley, Adam de Havenon
Summary: The study assessed the impact of ICP monitor placement on neurologic outcome in patients with spontaneous intracranial hemorrhage and found that ICP monitor placement was associated with higher rates of poor outcome and death. Further research is needed to identify patients who might benefit from invasive ICP monitoring.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2021)
Article
Clinical Neurology
Santosh B. Murthy, Cenai Zhang, Ajay Gupta, Sung-Min Cho, Lucia Rivera-Lara, Radhika Avadhani, Joshua Gruber, Costantino Iadecola, Guido J. Falcone, Kevin N. Sheth, Adnan Qureshi, Joshua N. Goldstein, Daniel F. Hanley, Hooman Kamel, Wendy C. Ziai
Summary: Presence of DWI lesions in patients with ICH is associated with a heightened risk of stroke, particularly ischemic stroke. The increased risk persists for ischemic stroke but not for recurrent ICH.
Article
Geriatrics & Gerontology
Johannes Boltze, Jaroslaw A. Aronowski, Jerome Badaut, Marion S. Buckwalter, Mateo Caleo, Michael Chopp, Kunjan R. Dave, Nadine Didwischus, Rick M. Dijkhuizen, Thorsten R. Doeppner, Jens P. Dreier, Karim Fouad, Mathias Gelderblom, Karen Gertz, Dominika Golubczyk, Barbara A. Gregson, Edith Hamel, Daniel F. Hanley, Wolfgang Haertig, Friedhelm C. Hummel, Maulana Ikhsan, Miroslaw Janowski, Jukka Jolkkonen, Saravanan S. Karuppagounder, Richard F. Keep, Inga K. Koerte, Zaal Kokaia, Peiying Li, Fudong Liu, Ignacio Lizasoain, Peter Ludewig, Gerlinde A. S. Metz, Axel Montagne, Andre Obenaus, Alex Palumbo, Monica Pearl, Miguel Perez-Pinzon, Anna M. Planas, Nikolaus Plesnila, Ami P. Raval, Maria A. Rueger, Lauren H. Sansing, Farida Sohrabji, Charlotte J. Stagg, R. Anne Stetler, Ann M. Stowe, Dandan Sun, Akihiko Taguchi, Mickael Tanter, Sabine U. Vay, Raghu Vemuganti, Denis Vivien, Piotr Walczak, Jian Wang, Ye Xiong, Marietta Zille
Summary: The past decade has witnessed significant advancements in both diagnosis and treatment of cerebrovascular diseases, with the introduction of thrombectomy in ischemic stroke and the identification of new therapeutic targets based on deeper understanding of pathomechanisms. Additionally, translational aspects are increasingly recognized in basic science studies, enhancing their predictive value for clinical application.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Immunology
Michael H. Askenase, Brittany A. Goods, Hannah E. Beatty, Arthur F. Steinschneider, Sofia E. Velazquez, Artem Osherov, Margaret J. Landreneau, Shaina L. Carroll, Tho B. Tran, Victor S. Avram, Riley S. Drake, G. James Gatter, Jordan A. Massey, Saravanan S. Karuppagounder, Rajiv R. Ratan, Charles C. Matouk, Kevin N. Sheth, Wendy C. Ziai, Adrian R. Parry-Jones, Issam A. Awad, Mario Zuccarello, Richard E. Thompson, Jesse Dawson, Daniel F. Hanley, J. Christopher Love, Alex K. Shalek, Lauren H. Sansing
Summary: By analyzing longitudinal transcriptional profiles in the hematomas of patients with ICH, it was found that the myeloid response to ICH displays a conserved progression from proinflammatory to proresolution states over time. These findings provide insights into the time course of immune responses in the human brain after injury and identify transcriptional programs associated with neurological recovery.
SCIENCE IMMUNOLOGY
(2021)
Article
Clinical Neurology
Carlos S. Kase, Daniel F. Hanley
NEUROLOGIC CLINICS
(2021)
Article
Medicine, Research & Experimental
Brittany A. Goods, Michael H. Askenase, Erica Markarian, Hannah E. Beatty, Riley S. Drake, Ira Fleming, Jonathan H. DeLong, Naomi H. Philip, Charles C. Matouk, Issam A. Awad, Mario Zuccarello, Daniel F. Hanley, J. Christopher Love, Alex K. Shalek, Lauren H. Sansing
Summary: This study focused on intracerebral hemorrhage (ICH) in a patient, revealing the importance of inflammation in brain tissue injury and demonstrating dynamic changes in leukocyte responses over time using single-cell RNA-Seq. The findings suggest that sensitive methods such as scRNA-Seq could provide greater understanding of complex intracerebral events.
Article
Immunology
Aaron M. Gusdon, Carol B. Thompson, Kendel Quirk, Yunis M. Mayasi, Radhika Avadhani, Issam A. Awad, Daniel F. Hanley, Wendy C. Ziai
Summary: The study found that in patients with ICH and IVH, treatment with alteplase compared to saline resulted in significantly enhanced inflammatory response in CSF leukocyte subtypes. Increased serum lymphocytes may be associated with better outcomes, while increased neutrophil-to-lymphocyte ratio (NLR) may be associated with worse outcomes.
JOURNAL OF NEUROINFLAMMATION
(2021)
Correction
Immunology
Wei Zhu, Yufeng Gao, Jieru Wan, Xi Lan, Xiaoning Han, Shanshan Zhu, Weidong Zang, Xuemei Chen, Wendy Ziai, Daniel F. Hanley, Scott J. Russo, Ricardo E. Jorge, Jian Wang
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Clinical Neurology
David J. Roh, Ifeyinwa S. Asonye, Fernanda Carvalho Poyraz, Jessica R. Magid-Bernstein, Evan F. Joiner, Radhika Avadhani, Issam Awad, Daniel F. Hanley, Wendy C. Ziai, Santosh B. Murthy
Summary: This study aimed to evaluate factors associated with intraventricular hemorrhage expansion and its impact on long-term outcomes. The authors found that acute hematoma characteristics, such as larger parenchymal volume, hematoma expansion, and thalamic intracerebral hemorrhage location, were associated with intraventricular hemorrhage expansion. Additionally, intraventricular hemorrhage expansion was associated with poor clinical outcomes. This study highlights the importance of optimizing hemostasis and preventing intraventricular hemorrhage expansion.
Review
Clinical Neurology
Adnan Qureshi, Abdullah Lodhi, Iqra N. Akhtar, Xiaoyu Ma, Danish Kherani, Chun Shing Kwok, Daniel E. Ford, Daniel F. Hanley, Ameer E. Hassan, Thanh N. Nguyen, Alejandro M. Spiotta, Syed F. Zaidi
Summary: This systematic review found conflicting evidence on the benefit of intra-arterial thrombolysis (IAT) in patients with acute stroke undergoing mechanical thrombectomy (MT). Statistical analysis showed no significant difference in functional independence, mortality, or angiographic recanalization between IAT and MT alone. Furthermore, the study design and quality had a significant impact on the association between IAT and functional independence at 90 days.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Editorial Material
Critical Care Medicine
Lourdes R. Carhuapoma, Radhika Avadhani, Daniel F. Hanley
NEUROCRITICAL CARE
(2023)
Article
Clinical Neurology
Abdulaziz T. Bako, Thomas Potter, Alan P. Pan, Jonika Tannous, Gavin Britz, Wendy C. Ziai, Issam Awad, Daniel Hanley, Farhaan S. Vahidy
Summary: The study examined the relationship between corticostriatal A beta-amyloid deposition and cognitive dysfunction in patients with Parkinson disease at risk for dementia. PET imaging and neuropsychological assessments were conducted on 40 PD patients, revealing a significant correlation between cortical PiB binding and global cognitive function.
Letter
Clinical Neurology
Vishank A. Shah, Lourdes Carhuapoma, Daniel F. Hanley, Wendy C. Ziai
Article
Medicine, Research & Experimental
Daniel F. F. Hanley Jr, Gordon R. Bernard, Consuelo H. Wilkins, Harry P. Selker, Jamie P. Dwyer, J. Michael Dean, Daniel Kelly Benjamin Jr, Sarah E. Dunsmore, Salina P. Waddy, Kenneth L. L. Wiley Jr, Marisha E. Palm, W. Andrew Mould, Daniel F. Ford, Jeri S. Burr, Jacqueline Huvane, Karen Lane, Lori Poole, Terri L. Edwards, Nan Kennedy, Leslie R. Boone, Jasmine Bell, Emily Serdoz, Loretta M. Byrne, Paul A. Harris
Summary: New technologies and disruptions caused by COVID-19 have led to the expansion of decentralized clinical trials, which hold promise for increasing efficiency and reducing barriers. The Trial Innovation Network has provided recommendations for decentralized approaches and has consulted on numerous research proposals. While some elements of decentralized trials have worked well, others require further refinement and assessment. Efforts are needed to build trust and ensure access to remote technology for inclusive participation in decentralized clinical trials.
JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE
(2023)
Review
Medicine, Research & Experimental
Michael E. Singer, Dallas C. Hack, Daniel F. Hanley
Summary: This article explores the integration of the long development path of medical devices with the necessity for diagnostic capabilities for mild traumatic brain injury (mTBI/concussion), demonstrating the effective role of public-private partnerships (PPPs). Through PPP collaborations, multiple FDA clearances and product introductions have been achieved, meeting urgent military and public needs.
JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE
(2022)