Article
Clinical Neurology
Joji B. Kuramatsu, Stefan T. Gerner, Wendy Ziai, Juergen Bardutzky, Jochen A. Sembill, Maximilian Spruegel, Anne Mrochen, Kathrin Koelbl, Malathi Ram, Radhika Avadhani, Guido J. Falcone, Magdy H. Selim, Vasileios-Arsenios Lioutas, Matthias Endres, Sarah Zweynert, Peter Vajkoczy, Peter A. Ringleb, Jan C. Purrucker, Jens Volkmann, Hermann Neugebauer, Frank Erbguth, Peter D. Schellinger, Ulrich J. Knappe, Gereon R. Fink, Christian Dohmen, Jens Minnerup, Heinz Reichmann, Hauke Schneider, Joachim Roether, Gernot Reimann, Michael Schwarz, Hansjoerg Baezner, Joseph Classen, Dominik Michalski, Otto W. Witte, Albrecht Guenther, Gerhard F. Hamann, Hannes Luecking, Arnd Doerfler, Muhammad Fawad Ishfaq, Jason J. Chang, Fernando D. Testai, Daniel Woo, Andrei Alexandrov, Dimitre Staykov, Nitin Goyal, Georgios Tsivgoulis, Kevin N. Sheth, Issam A. Awad, Stefan Schwab, Daniel F. Hanley, Hagen B. Huttner
Summary: In patients with intracerebral hemorrhage (ICH), intraventricular fibrinolysis (IVF) treatment was associated with significantly improved functional outcomes at 6 months compared to standard of care. Early treatment within 48 hours had a better effect.
Review
Clinical Neurology
Zelong Zheng, Qi Wang, Shujie Sun, Jinbiao Luo
Summary: Spontaneous intracerebral hemorrhage is one of the most devastating types of stroke, with high mortality and morbidity. The optimal management of this condition remains controversial, and conventional surgical interventions and medical management have shown limited benefit. However, minimally invasive surgery for intracerebral hemorrhage has shown promising results in early phase clinical trials.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Edward R. Bader, Tiberiu A. Pana, Raphae S. Barlas, Anthony K. Metcalf, John F. Potter, Phyo K. Myint
Summary: This study investigates the association between admission inflammatory biomarkers and adverse outcomes in spontaneous intracerebral hemorrhage (ICH) using a stroke register in the United Kingdom. The results show that elevated inflammatory biomarkers are associated with poor outcomes in ICH, highlighting the importance of inflammation in this condition.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Maximilian Spruegel, Joji B. Kuramatsu, Stefan T. Gerner, Jochen A. Sembill, Dominik Madzar, Caroline Reindl, Tobias Bobinger, Tamara Mueller, Philip Hoelter, Hannes Luecking, Tobias Engelhorn, Hagen B. Huttner
Summary: This study examined the impact of age on bleeding characteristics and clinical outcomes in different types of intracerebral hemorrhage. Results showed that elderly patients had worse functional outcomes at three months, with oral anticoagulant patients having larger baseline hemorrhage volumes and hematoma enlargement compared to non-OAC patients.
INTERNATIONAL JOURNAL OF STROKE
(2021)
Article
Clinical Neurology
Raywat Noiphithak, Warot Ratanavinitkul, Vich Yindeedej, Pree Nimmannitya, Pornchai Yodwisithsak
Summary: This study investigated and compared the outcomes of intraventricular fibrinolysis (IVF) and endoscopic surgery (ES) for the treatment of intraventricular hemorrhage (IVH). The results showed that a combination of ES and IVF was safe and effective, leading to improved clinical outcomes in patients with IVH.
WORLD NEUROSURGERY
(2023)
Article
Clinical Neurology
Kay-Cheong Teo, Sze-Man Fong, William C. Y. Leung, Ian Y. H. Leung, Yuen-Kwun Wong, Olivia M. Y. Choi, Ka-Keung Yam, Rachel C. N. Lo, Raymond T. F. Cheung, Shu-Leong Ho, Anderson C. O. Tsang, Gilberto K. K. Leung, Koon-Ho Chan, Kui-Kai Lau
Summary: This study aimed to determine the ideal hematoma volume cutoff for different intracerebral hemorrhage (ICH) locations in predicting ICH outcomes. The results showed that location-specific volume cutoff should be considered in patient selection for ICH trials, as the outcomes differed based on the size of the hematoma in different locations.
Article
Clinical Neurology
Jens Witsch, David Roh, Stephanie Oh, Costantino Iadecola, Ramon Diaz-Arrastia, Scott E. Kasner, Stephan A. Mayer, Santosh B. Murthy
Summary: Neutrophil-mediated inflammation exacerbates intracerebral hemorrhage (ICH) outcomes. This study aimed to investigate the association between serum levels of sICAM-1 and poor outcomes after ICH. After adjustment, sICAM-1 was found to be associated with mortality, poor outcome, and hematoma expansion.
Article
Clinical Neurology
Kristin Tveitan Larsen, Maiken Nordahl Selseth, Silje Holt Jahr, Vigdis Hillestad, Nojoud Koubaa, Else Charlotte Sandset, Ole Morten Ronning, Espen Saxhaug Kristoffersen
Summary: This study investigated the relationship between prehospital blood pressure (BP) and clinical and radiological outcomes in acute intracerebral hemorrhage patients. The results showed that elevated prehospital BP parameters were associated with in-hospital death and hematoma expansion. Changes in prehospital BP were not consistently associated with outcome. A possible U-shaped association between prehospital BP and in-hospital death needs further investigation.
Article
Clinical Neurology
Anne Mrochen, Maximilian Spruegel, Stefan T. Gerner, Jochen A. Sembill, Stefan Lang, Hannes Luecking, Joji B. Kuramatsu, Hagen B. Huttner
Summary: The study found that thrombocytopenia does not significantly affect hematoma enlargement and functional outcomes in ICH patients, but may increase mortality risk in patients receiving antiplatelet therapy.
Article
Cardiac & Cardiovascular Systems
Wen-Song Yang, Shu-Qiang Zhang, Yi-Qing Shen, Xiao Wei, Li-Bo Zhao, Xiong-Fei Xie, Lan Deng, Xin-Hui Li, Xin-Ni Lv, Fa-Jin Lv, Dar Dowlatshahi, Qi Li, Peng Xie
Summary: The study revealed that NCCT markers are independently associated with IVH growth and RHE, with the expansion-prone hematoma showing higher predictive accuracy. These findings can aid in risk stratification based on NCCT markers for predicting active bleeding.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Critical Care Medicine
Mengying Yu, Dongqin Zhu, Zhixian Luo, Zhifang Pan, Yunjun Yang, Haoli Xu
Summary: This study aimed to investigate the correlation between white matter lesion (WML) severity and delayed intraventricular hemorrhage (IVH) in patients with intracerebral hemorrhage (ICH), as well as the association between WML and baseline IVH. The results showed that moderate-severe WML was an independent risk factor for both delayed IVH and baseline IVH.
NEUROCRITICAL CARE
(2022)
Article
Medicine, General & Internal
Julia Masomi-Bornwasser, Axel Heimann, Christian Schneider, Tristan Klodt, Hammoud Elmehdawi, Andrea Kronfeld, Harald Krenzlin, Yasemin Tanyildizi, Karl-Friedrich Kreitner, Oliver Kempski, Clemens Sommer, Florian Ringel, Naureen Keric
Summary: The combined therapy of drainage, rtPA, and ultrasound is a safe and effective technique for hematoma reduction and protection of the perihematomal tissue in regard to ultra-early effects, leading to a significantly higher hematoma reduction compared to other treatment groups.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Ping Zhang, Shuo Pang, Lijuan Du, Junlei Li, Xin Su
Summary: This study investigates the incidence, clinical characteristics, prevention, treatment, and prognosis of intracranial hemorrhage (ICH) in patients with acute myocardial infarction (AMI). In-hospital mortality rate is extremely high, with sudden loss of consciousness associated with all deaths. The CRUSADE and ARC-HBR scores can complement each other in risk assessment. The volume of ICH is significantly higher in patients who die in the hospital compared to those who survive.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Xin-Ni Lv, Jing Cheng, Xue-Yun Liu, Jin-Cheng Liu, Lan Deng, Zuo-Qiao Li, Ming-Jun Pu, Chu Chen, Qi Li
Summary: This study found that ultraearly intraventricular hemorrhage growth is associated with early neurologic deterioration and poor functional outcomes in patients with intracerebral hemorrhage.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Medicine, General & Internal
Ying Xian, Shuaiqi Zhang, Taku Inohara, Maria Grau-Sepulveda, Roland A. Matsouaka, Eric D. Peterson, Jonathan P. Piccini, Eric E. Smith, Kevin N. Sheth, Deepak L. Bhatt, Gregg C. Fonarow, Lee H. Schwamm
Summary: Patients with FXa inhibitor-associated ICH had a higher risk of mortality compared to those with warfarin-associated ICH but had better outcomes overall. Concomitant use of warfarin and antiplatelet therapy was associated with worse outcomes, while incremental risk was not significant in patients taking FXa inhibitors.
Article
Neurosciences
Sarah T. Menacho, Ramesh Grandhi, Alen Delic, Mohammad Anadani, Wendy C. Ziai, Issam A. Awad, Daniel F. Hanley, Adam de Havenon
Summary: The study assessed the impact of ICP monitor placement on neurologic outcome in patients with spontaneous intracranial hemorrhage and found that ICP monitor placement was associated with higher rates of poor outcome and death. Further research is needed to identify patients who might benefit from invasive ICP monitoring.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2021)
Article
Clinical Neurology
Santosh B. Murthy, Cenai Zhang, Ajay Gupta, Sung-Min Cho, Lucia Rivera-Lara, Radhika Avadhani, Joshua Gruber, Costantino Iadecola, Guido J. Falcone, Kevin N. Sheth, Adnan Qureshi, Joshua N. Goldstein, Daniel F. Hanley, Hooman Kamel, Wendy C. Ziai
Summary: Presence of DWI lesions in patients with ICH is associated with a heightened risk of stroke, particularly ischemic stroke. The increased risk persists for ischemic stroke but not for recurrent ICH.
Article
Geriatrics & Gerontology
Johannes Boltze, Jaroslaw A. Aronowski, Jerome Badaut, Marion S. Buckwalter, Mateo Caleo, Michael Chopp, Kunjan R. Dave, Nadine Didwischus, Rick M. Dijkhuizen, Thorsten R. Doeppner, Jens P. Dreier, Karim Fouad, Mathias Gelderblom, Karen Gertz, Dominika Golubczyk, Barbara A. Gregson, Edith Hamel, Daniel F. Hanley, Wolfgang Haertig, Friedhelm C. Hummel, Maulana Ikhsan, Miroslaw Janowski, Jukka Jolkkonen, Saravanan S. Karuppagounder, Richard F. Keep, Inga K. Koerte, Zaal Kokaia, Peiying Li, Fudong Liu, Ignacio Lizasoain, Peter Ludewig, Gerlinde A. S. Metz, Axel Montagne, Andre Obenaus, Alex Palumbo, Monica Pearl, Miguel Perez-Pinzon, Anna M. Planas, Nikolaus Plesnila, Ami P. Raval, Maria A. Rueger, Lauren H. Sansing, Farida Sohrabji, Charlotte J. Stagg, R. Anne Stetler, Ann M. Stowe, Dandan Sun, Akihiko Taguchi, Mickael Tanter, Sabine U. Vay, Raghu Vemuganti, Denis Vivien, Piotr Walczak, Jian Wang, Ye Xiong, Marietta Zille
Summary: The past decade has witnessed significant advancements in both diagnosis and treatment of cerebrovascular diseases, with the introduction of thrombectomy in ischemic stroke and the identification of new therapeutic targets based on deeper understanding of pathomechanisms. Additionally, translational aspects are increasingly recognized in basic science studies, enhancing their predictive value for clinical application.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Immunology
Michael H. Askenase, Brittany A. Goods, Hannah E. Beatty, Arthur F. Steinschneider, Sofia E. Velazquez, Artem Osherov, Margaret J. Landreneau, Shaina L. Carroll, Tho B. Tran, Victor S. Avram, Riley S. Drake, G. James Gatter, Jordan A. Massey, Saravanan S. Karuppagounder, Rajiv R. Ratan, Charles C. Matouk, Kevin N. Sheth, Wendy C. Ziai, Adrian R. Parry-Jones, Issam A. Awad, Mario Zuccarello, Richard E. Thompson, Jesse Dawson, Daniel F. Hanley, J. Christopher Love, Alex K. Shalek, Lauren H. Sansing
Summary: By analyzing longitudinal transcriptional profiles in the hematomas of patients with ICH, it was found that the myeloid response to ICH displays a conserved progression from proinflammatory to proresolution states over time. These findings provide insights into the time course of immune responses in the human brain after injury and identify transcriptional programs associated with neurological recovery.
SCIENCE IMMUNOLOGY
(2021)
Correction
Immunology
Wei Zhu, Yufeng Gao, Jieru Wan, Xi Lan, Xiaoning Han, Shanshan Zhu, Weidong Zang, Xuemei Chen, Wendy Ziai, Daniel F. Hanley, Scott J. Russo, Ricardo E. Jorge, Jian Wang
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Clinical Neurology
David J. Roh, Ifeyinwa S. Asonye, Fernanda Carvalho Poyraz, Jessica R. Magid-Bernstein, Evan F. Joiner, Radhika Avadhani, Issam Awad, Daniel F. Hanley, Wendy C. Ziai, Santosh B. Murthy
Summary: This study aimed to evaluate factors associated with intraventricular hemorrhage expansion and its impact on long-term outcomes. The authors found that acute hematoma characteristics, such as larger parenchymal volume, hematoma expansion, and thalamic intracerebral hemorrhage location, were associated with intraventricular hemorrhage expansion. Additionally, intraventricular hemorrhage expansion was associated with poor clinical outcomes. This study highlights the importance of optimizing hemostasis and preventing intraventricular hemorrhage expansion.
Article
Critical Care Medicine
Aaron M. Gusdon, Chenlian Fu, Vasanta Putluri, Atzhiry S. Paz, Hua Chen, Xuefang Ren, Mohammed Khurshidul Hassan, Pramod Dash, Cristian Coarfa, Nagireddy Putluri, Huimahn A. Choi, Jude P. J. Savarraj
Summary: This study found that aneurysmal subarachnoid hemorrhage (aSAH) leads to a unique pattern of plasma metabolites, indicating a shift towards glycolysis. Higher levels of fumarate and lower levels of citrate were associated with better functional outcomes. These metabolites may represent targets to improve metabolism after aSAH.
NEUROCRITICAL CARE
(2022)
Article
Cell Biology
Aaron M. Gusdon, Nauder Faraday, John S. Aita, Sunil Kumar, Ishan Mehta, HuiMahn A. Choi, Jeffery L. Cleland, Keith Robinson, Louise D. McCullough, Derek K. Ng, Rangaramanujam M. Kannan, Sujatha Kannan
Summary: The findings suggest that OP-101 is well tolerated and may have the potential to reduce inflammation and neuronal injury, leading to decreased morbidity and mortality in severe COVID-19 patients.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Review
Clinical Neurology
Adnan Qureshi, Abdullah Lodhi, Iqra N. Akhtar, Xiaoyu Ma, Danish Kherani, Chun Shing Kwok, Daniel E. Ford, Daniel F. Hanley, Ameer E. Hassan, Thanh N. Nguyen, Alejandro M. Spiotta, Syed F. Zaidi
Summary: This systematic review found conflicting evidence on the benefit of intra-arterial thrombolysis (IAT) in patients with acute stroke undergoing mechanical thrombectomy (MT). Statistical analysis showed no significant difference in functional independence, mortality, or angiographic recanalization between IAT and MT alone. Furthermore, the study design and quality had a significant impact on the association between IAT and functional independence at 90 days.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Editorial Material
Critical Care Medicine
Lourdes R. Carhuapoma, Radhika Avadhani, Daniel F. Hanley
NEUROCRITICAL CARE
(2023)
Article
Clinical Neurology
Abdulaziz T. Bako, Thomas Potter, Alan P. Pan, Jonika Tannous, Gavin Britz, Wendy C. Ziai, Issam Awad, Daniel Hanley, Farhaan S. Vahidy
Summary: The study examined the relationship between corticostriatal A beta-amyloid deposition and cognitive dysfunction in patients with Parkinson disease at risk for dementia. PET imaging and neuropsychological assessments were conducted on 40 PD patients, revealing a significant correlation between cortical PiB binding and global cognitive function.
Letter
Clinical Neurology
Vishank A. Shah, Lourdes Carhuapoma, Daniel F. Hanley, Wendy C. Ziai
Article
Medicine, Research & Experimental
Daniel F. F. Hanley Jr, Gordon R. Bernard, Consuelo H. Wilkins, Harry P. Selker, Jamie P. Dwyer, J. Michael Dean, Daniel Kelly Benjamin Jr, Sarah E. Dunsmore, Salina P. Waddy, Kenneth L. L. Wiley Jr, Marisha E. Palm, W. Andrew Mould, Daniel F. Ford, Jeri S. Burr, Jacqueline Huvane, Karen Lane, Lori Poole, Terri L. Edwards, Nan Kennedy, Leslie R. Boone, Jasmine Bell, Emily Serdoz, Loretta M. Byrne, Paul A. Harris
Summary: New technologies and disruptions caused by COVID-19 have led to the expansion of decentralized clinical trials, which hold promise for increasing efficiency and reducing barriers. The Trial Innovation Network has provided recommendations for decentralized approaches and has consulted on numerous research proposals. While some elements of decentralized trials have worked well, others require further refinement and assessment. Efforts are needed to build trust and ensure access to remote technology for inclusive participation in decentralized clinical trials.
JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE
(2023)
Review
Medicine, Research & Experimental
Michael E. Singer, Dallas C. Hack, Daniel F. Hanley
Summary: This article explores the integration of the long development path of medical devices with the necessity for diagnostic capabilities for mild traumatic brain injury (mTBI/concussion), demonstrating the effective role of public-private partnerships (PPPs). Through PPP collaborations, multiple FDA clearances and product introductions have been achieved, meeting urgent military and public needs.
JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE
(2022)