Kynurenine metabolic balance is disrupted in the hippocampus following peripheral lipopolysaccharide challenge

Mouse chronic social stress increases blood and brain kynurenine pathway activity and fear behaviour: Both effects are reversed by inhibition of indoleamine 2,3-dioxygenase

(2016) René Fuertig et al.   BRAIN BEHAVIOR AND IMMUNITY

Indoleamine 2,3-dioxygenase-dependent neurotoxic kynurenine metabolism mediates inflammation-induced deficit in recognition memory

(2015) Jillian M. Heisler et al.   BRAIN BEHAVIOR AND IMMUNITY

CD40-TNF activation in mice induces extended sickness behavior syndrome co-incident with but not dependent on activation of the kynurenine pathway

(2015) Flurin Cathomas et al.   BRAIN BEHAVIOR AND IMMUNITY

Greater amygdala activity and dorsomedial prefrontal–amygdala coupling are associated with enhanced inflammatory responses to stress

(2015) Keely A. Muscatell et al.   BRAIN BEHAVIOR AND IMMUNITY

Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq

(2015) A. Zeisel et al.   SCIENCE

The NIMH Research Domain Criteria (RDoC) Project: Precision Medicine for Psychiatry

(2014) Thomas R. Insel   AMERICAN JOURNAL OF PSYCHIATRY

Indoleamine 2,3-dioxygenase 2 (IDO2) and the kynurenine pathway: characteristics and potential roles in health and disease

(2013) Amos A. Fatokun et al.   AMINO ACIDS

Intracerebroventricular administration of lipopolysaccharide induces indoleamine-2,3-dioxygenase-dependent depression-like behaviors

(2013) Marcus A Lawson et al.   Journal of Neuroinflammation

Chronic Interferon-α Decreases Dopamine 2 Receptor Binding and Striatal Dopamine Release in Association with Anhedonia-Like Behavior in Nonhuman Primates

(2013) Jennifer C Felger et al.   NEUROPSYCHOPHARMACOLOGY

NMDA Receptor Blockade by Ketamine Abrogates Lipopolysaccharide-Induced Depressive-Like Behavior in C57BL/6J Mice

(2013) Adam K Walker et al.   NEUROPSYCHOPHARMACOLOGY

Lipopolysaccharide-induced brain activation of the indoleamine 2,3-dioxygenase and depressive-like behavior are impaired in a mouse model of metabolic syndrome

(2013) Anne-Laure Dinel et al.   PSYCHONEUROENDOCRINOLOGY

Indoleamine 2,3-dioxygenase inhibition attenuates lipopolysaccharide induced persistent microglial activation and depressive-like complications in fractalkine receptor (CX3CR1)-deficient mice

(2012) Angela W. Corona et al.   BRAIN BEHAVIOR AND IMMUNITY

Central administration of murine interferon-α induces depressive-like behavioral, brain cytokine and neurochemical alterations in mice: A mini-review and original experiments

(2012) Shawn Hayley et al.   BRAIN BEHAVIOR AND IMMUNITY

Indoleamine 2,3-dioxygenase mediates anhedonia and anxiety-like behaviors caused by peripheral lipopolysaccharide immune challenge

(2012) Alexander Salazar et al.   HORMONES AND BEHAVIOR

Kynurenines in the mammalian brain: when physiology meets pathology

(2012) Robert Schwarcz et al.   NATURE REVIEWS NEUROSCIENCE

Opposing Biological Functions of Tryptophan Catabolizing Enzymes During Intracellular Infection

(2011) Senad Divanovic et al.   JOURNAL OF INFECTIOUS DISEASES

Inflammation selectively enhances amygdala activity to socially threatening images

(2011) Tristen K. Inagaki et al.   NEUROIMAGE

Dose-Dependent Effects of Endotoxin on Neurobehavioral Functions in Humans

(2011) Jan-Sebastian Grigoleit et al.   PLoS One

Research Domain Criteria (RDoC): Toward a New Classification Framework for Research on Mental Disorders

(2010) Thomas Insel et al.   AMERICAN JOURNAL OF PSYCHIATRY

Inflammation-Induced Anhedonia: Endotoxin Reduces Ventral Striatum Responses to Reward

(2010) Naomi I. Eisenberger et al.   BIOLOGICAL PSYCHIATRY

Inflammation-associated depression: From serotonin to kynurenine

(2010) Robert Dantzer et al.   PSYCHONEUROENDOCRINOLOGY

Inflammation Causes Mood Changes Through Alterations in Subgenual Cingulate Activity and Mesolimbic Connectivity

(2009) Neil A. Harrison et al.   BIOLOGICAL PSYCHIATRY

Induction of IDO by Bacille Calmette-Guerin Is Responsible for Development of Murine Depressive-Like Behavior

(2009) J. C. O'Connor et al.   JOURNAL OF IMMUNOLOGY

Interferon-  and Tumor Necrosis Factor-  Mediate the Upregulation of Indoleamine 2,3-Dioxygenase and the Induction of Depressive-Like Behavior in Mice in Response to Bacillus Calmette-Guerin

(2009) J. C. O'Connor et al.   JOURNAL OF NEUROSCIENCE

CSF concentrations of brain tryptophan and kynurenines during immune stimulation with IFN-α: relationship to CNS immune responses and depression

(2009) C L Raison et al.   MOLECULAR PSYCHIATRY

Agouti C57BL/6N embryonic stem cells for mouse genetic resources

(2009) Stephen J Pettitt et al.   NATURE METHODS

Administration of Interferon-Alpha in Mice Provokes Peripheral and Central Modulation of Immune Cells, Accompanied by Behavioral Effects

(2009) Arif S. Orsal et al.   NEUROPSYCHOBIOLOGY

Peripheral Inflammation is Associated with Altered Substantia Nigra Activity and Psychomotor Slowing in Humans

(2008) Lena Brydon et al.   BIOLOGICAL PSYCHIATRY

Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression

(2008) Wayne C. Drevets et al.   Brain Structure & Function

Central nervous action of interleukin-1 mediates activation of limbic structures and behavioural depression in response to peripheral administration of bacterial lipopolysaccharide

(2008) J. P. Konsman et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Spatio-temporal differences in the profile of murine brain expression of proinflammatory cytokines and indoleamine 2,3-dioxygenase in response to peripheral lipopolysaccharide administration

(2008) Caroline André et al.   JOURNAL OF NEUROIMMUNOLOGY

Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice

(2008) J C O'Connor et al.   MOLECULAR PSYCHIATRY

Induction of indolamine 2,3-dioxygenase and kynurenine 3-monooxygenase in rat brain following a systemic inflammatory challenge: A role for IFN-γ?

(2008) Thomas J. Connor et al.   NEUROSCIENCE LETTERS

From inflammation to sickness and depression: when the immune system subjugates the brain

(2007) Robert Dantzer et al.   NATURE REVIEWS NEUROSCIENCE