Article
Clinical Neurology
Shijing Wang, Francesco Leri, Sakina J. Rizvi
Summary: Anhedonia, a core symptom of major depressive disorder, extends beyond impaired consummatory pleasure to deficits in various functions, with dopamine and other neurotransmitters playing key roles. While extensive research has explored reward anticipation and outcome, there are translational gaps in understanding reward motivation, effort, valuation, and learning.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Neurosciences
Yinghui Li, Yingying Yue, Suzhen Chen, Wenhao Jiang, Zhi Xu, Gang Chen, Zixin Zhu, Liangliang Tan, Yonggui Yuan
Summary: This study found that anhedonic major depressive disorder (MDD) patients have higher serum levels of cytokines and cortisol, and a combination of IL-6, CRP, and cortisol can serve as an early marker for distinguishing anhedonic MDD.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Psychiatry
Arti Gandhi, Jasmine Mote, Daniel Fulford
Summary: The research found that individuals with Major Depressive Disorder (MDD) and Schizophrenia Spectrum Disorder (SSDs) experience higher levels of physical and social anhedonia compared to controls. Depressive symptom severity influences the differences in physical anhedonia, while age moderates the differences between social and physical anhedonia in the SSD group.
PSYCHIATRY RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Montse Flores-Garcia, Arianna Rizzo, Maria Zelai Garcon-Poca, Victor Fernandez-Duenas, Jordi Bonaventura
Summary: Chronic pain and depression lead to a significant socioeconomic burden. This review focuses on the role of the ventral tegmental area (VTA) as a hub where pain and emotional processing converge, and discusses the feasibility of using VTA as a therapeutic target. The dopaminergic system and VTA have been extensively studied in mood disorders, but less attention has been given to their involvement in pain and mood-related consequences.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Neurosciences
Karl Goodkin, Teresa H. H. Evering, Albert M. M. Anderson, Ann Ragin, Cynthia L. L. Monaco, Christina Gavegnano, Ryan J. J. Avery, Sean B. B. Rourke, Lucette A. A. Cysique, Bruce J. J. Brew
Summary: Depression and neurocognitive disorder are prevalent in persons with HIV, with higher rates compared to the general population. However, the co-occurrence of these two disorders in HIV-infected individuals has not been formally studied. These disorders share overlapping symptoms and neurobehavioral aspects, as well as an increased risk for non-adherence to antiretroviral therapy. Understanding the shared pathophysiological mechanisms may lead to targeted treatments for the comorbidity.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Behavioral Sciences
Judith Gruber, Ruth Hanssen, Mishal Qubad, Aicha Bouzouina, Vivi Schack, Hannah Sochor, Carmen Schiweck, Mareike Aichholzer, Silke Matura, David A. Slattery, Yurdaguel Zopf, Stephanie L. Borgland, Andreas Reif, Sharmili Edwin Thanarajah
Summary: Type 2 diabetes and major depressive disorder (MDD) are highly comorbid and leading causes of disability. This review discusses the potential molecular mechanisms underlying their association by examining the effects of insulin on dopaminergic signaling and behavior in the brain. It also explores the impact of insulin resistance on depressive symptoms and anhedonia, and its relevance for treatment strategies.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Clinical Neurology
Wei Zheng, Li-Mei Gu, Chen-Hui Sun, Yan-Ling Zhou, Cheng-Yu Wang, Xiao-Feng Lan, Bin Zhang, Yu-Ping Ning
Summary: This study found that repeated ketamine infusions appeared to be effective at rapidly ameliorating anhedonia in Chinese individuals suffering from MDD and BD, with similar efficacy between the two groups.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Biochemistry & Molecular Biology
Simona Scheggi, Graziano Pinna, Giulia Braccagni, Maria Graziella De Montis, Carla Gambarana
Summary: Peroxisome proliferator-activator receptors (PPARs) play a role in regulating lipid and glucose metabolism, controlling inflammatory processes, and modulating various brain functions. Among them, PPAR gamma is particularly important in neuropsychiatric and neurodegenerative disorders, with its localization in neuronal circuits involved in emotion modulation and stress response, as well as its role in neurodevelopment and neuroinflammation. Future clinical trials should evaluate the efficacy of PPAR gamma agonists in the treatment of mood and neurodevelopmental disorders such as depression, schizophrenia, and ASD, based on robust preclinical evidence and initial results of clinical studies.
Review
Clinical Neurology
Henrik Heitmann, Till F. M. Andlauer, Thomas Korn, Mark Muhlau, Peter Henningsen, Bernhard Hemmer, Markus Ploner
Summary: Fatigue, depression, and pain are common symptoms in multiple sclerosis (MS) patients, with recent neuroimaging and neuroimmunological findings suggesting that dysfunctional reward processing may represent a shared mechanism for these symptoms. Therapeutic focus on monoaminergic neurotransmission is key, but current treatments have limitations in addressing these symptoms effectively.
MULTIPLE SCLEROSIS JOURNAL
(2022)
Article
Multidisciplinary Sciences
Daniel C. Lowes, Linda A. Chamberlin, Lisa N. Kretsge, Emma S. Holt, Atheir Abbas, Alan J. Park, Lyubov Yusufova, Zachary H. Bretton, Ayesha Firdous, Armen G. Enikolopov, Joshua A. Gordon, Alexander Z. Harris
Summary: In this study, researchers found that stress triggers GABAergic activity in the ventral tegmental area which blunts reward-seeking behavior in mice.
NATURE COMMUNICATIONS
(2021)
Article
Clinical Neurology
Juanjuan Ren, Zhiguo Wu, Daihui Peng, Jia Huang, Weiping Xia, Jingjing Xu, Chenglei Wang, Lvchun Cui, Yiru Fang, Chen Zhang
Summary: This study investigated the differences in anhedonia and its cognitive correlates between first episode of depression (FED) and recurrent depression (RD). The results showed that RD patients had more severe symptoms of anhedonia and cognitive impairment compared to FED patients. There was a significant correlation between cognitive symptoms and anhedonia, and different medications had different effects on cognitive symptoms.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Chemistry, Analytical
Marsilea A. Booth, Sally A. N. Gowers, Melinda Hersey, Isabelle C. Samper, Seongjun Park, Polina Anikeeva, Parastoo Hashemi, Molly M. Stevens, Martyn G. Boutelle
Summary: The study explored the potential of polymer fibers as a platform for sensing pH and neurometabolic lactate, successfully detecting transient lactate changes in an in vivo mouse model. The changes in lactate concentration were associated with spreading depolarizations.
ANALYTICAL CHEMISTRY
(2021)
Article
Clinical Neurology
Audrey Maillet, Elise Metereau, Leon Tremblay, Emilie Favre, Helene Klinger, Eugenie Lhommee, Didier Le Bars, Anna Castrioto, Stephane Prange, Veronique Sgambato, Emmanuel Broussolle, Paul Krack, Stephane Thobois
Summary: The severity of dopaminergic and serotonergic dysfunction in Parkinson's disease worsens with disease duration, spreading from midbrain/subcortical to cortical regions. Early onset apathy is associated with more severe dopaminergic and serotonergic disruption, similar to intermediate disease duration patients. The severity of neuropsychiatric symptoms appears primarily related to serotonergic alteration within corticostriatal limbic areas.
MOVEMENT DISORDERS
(2021)
Article
Clinical Neurology
Xiaoqin Wang, Yi Xia, Rui Yan, Hao Sun, Yinghong Huang, Haowen Zou, Yishan Du, Lingling Hua, Hao Tang, Hongliang Zhou, Zhijian Yao, Qing Lu
Summary: This study aimed to explore the sex differences in the regional brain neuroimaging features of anhedonia in the context of major depressive disorder (MDD). The results showed significant differences in brain activity between males and females in relation to anhedonia, which may have clinical implications for treating anhedonia symptoms in MDD.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Pharmacology & Pharmacy
Jenessa N. Johnston, Maximillian S. Greenwald, Ioline D. Henter, Christoph Kraus, Anahit Mkrtchian, Neil G. Clark, Lawrence T. Park, Philip Gold, Carlos A. Zarate Zarate, Bashkim Kadriu
Summary: Well-established animal models have demonstrated a strong connection between stress, inflammation in the central nervous system (CNS), and peripheral inflammatory biomarkers in individuals with depression. Stress-induced inflammatory states may contribute to treatment-resistant depression, while ketamine, a rapid-acting antidepressant, exerts its therapeutic effects partly through anti-inflammatory actions on the HPA axis, the kynurenine pathway, or cytokine suppression. Further research on the relationship between ketamine, inflammation, and stress could lead to the development of rapid-acting antidepressants based on anti-inflammatory mechanisms.
DRUG DISCOVERY TODAY
(2023)
Letter
Public, Environmental & Occupational Health
Karin A. Kasza, Kathryn C. Edwards, Shannon Gravely, Blair Coleman, Heather Kimmel, Colm Everard, Maciej L. Goniewicz, Geoffrey T. Fong, Andrew Hyland
AMERICAN JOURNAL OF PREVENTIVE MEDICINE
(2021)
Article
Oncology
Kathryn C. Edwards, Tasmia Naz, Cassandra A. Stanton, Maciej L. Goniewicz, Dorothy K. Hatsukami, Danielle M. Smith, Lanqing Wang, Andrea Villanti, Jennifer Pearson, Benjamin C. Blount, Maansi Bansal-Travers, June Feng, Raymond Niaura, Michelle T. Bover Manderski, Connie S. Sosnoff, Cristine D. Delnevo, Kara Duffy, Arseima Y. Del Valle-Pinero, Brian L. Rostron, Colm Everard, Heather L. Kimmel, Dana M. van Bemmel, Andrew Hyland
Summary: This study aimed to determine the cut-points for distinguishing tobacco users from nonusers based on urinary cotinine and total nicotine equivalents in a population from the U.S. PATH Study. Results showed significant variations by sex and race/ethnicity in defining these cut-points, suggesting the importance of considering these factors when evaluating tobacco use status. These cut-points may be valuable for verifying self-reported tobacco use in epidemiologic studies and clinical trials.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2021)
Article
Pediatrics
Saida Coreas, Erik J. Rodriquez, Sana G. Rahman, Sherine El-Toukhy, Wilson M. Compton, Carlos Blanco, Heather L. Kimmel, Eliseo J. Perez-Stable
Summary: Research showed that exposure to tobacco industry-related marketing and smoking susceptibility were predictive factors for cigarette smoking initiation among youth, with those who had higher susceptibility levels more likely to become experimental, current, or established smokers.
Article
Oncology
Carol H. Christensen, Joanne T. Chang, Brian L. Rostron, Hoda T. Hammad, Dana M. van Bemmel, Arseima Y. Del Valle-Pinero, Baoguang Wang, Elena Mishina, Lisa M. Faulcon, Ana DePina, La'nissa Brown-Baker, Heather L. Kimmel, Elizabeth Lambert, Benjamin C. Blount, Huber W. Vesper, Lanqing Wang, Maciej L. Goniewicz, Andrew Hyland, Mark J. Travers, Dorothy K. Hatsukami, Raymond Niaura, K. Michael Cummings, Kristie A. Taylor, Kathryn C. Edwards, Nicolette Borek, Bridget K. Ambrose, Cindy M. Chang
Summary: The study found that dual users of cigarettes and e-cigarettes have higher concentrations of oxidative stress markers compared to exclusive cigarette smokers. Former smokers who currently use e-cigarettes have biomarker concentrations similar to those of former smokers who do not currently use tobacco and never tobacco users, but lower than those of exclusive cigarette smokers. The concentration of F2-isoprostane decreases over time since smoking cessation among exclusive e-cigarette users and former smokers who do not currently use any tobacco.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2021)
Article
Public, Environmental & Occupational Health
Sherry T. Liu, Jocelyn Newsome, Victoria Castleman, Karl Poonai, MeLisa R. Creamer, Heather L. Kimmel, Izabella Zandberg
Summary: This qualitative study aims to understand how adult e-cigarette users describe quantity of e-cigarettes used, analyzing data from a sample of U.S. adult dual e-cigarette and cigarette users and former cigarette smokers. The study found that users describe quantity in multiple ways, with the most common approach being the number of times and/or puffs taken in a day. It suggests that the variety of approaches, along with device type and other contextual factors, should be considered when developing survey questions.
PREVENTIVE MEDICINE REPORTS
(2021)
Article
Psychology, Clinical
Maansi Bansal-Travers, Cheryl Rivard, Marushka L. Silveira, Heather Kimmel, Karl Poonai, Jennifer K. Bernat, Kia Jackson, Susan Rudy, Amanda Johnson, Karen A. Cullen, Maciej Goniewicz, Mark Travers, Andrew Hyland, Andrea Villanti, Mary Hrywna, David Abrams, Geoffrey Fong, Tara Elton-Marshall, Cassandra Stanton, Eva Sharma
Summary: This study found that flavored non-cigarette tobacco products are widely used in the US, with fruit-flavored options being the most popular among youth and young adults. Candy/sweets-flavored electronic nicotine delivery systems (ENDS) were more commonly used by youth and young adults compared to adults. Among adult ENDS users, younger users were more likely to change flavors compared to older users. Age seemed to play a role in the stability of flavor preferences.
ADDICTIVE BEHAVIORS
(2022)
Article
Environmental Sciences
Gabriella M. Anic, Brian L. Rostron, Hoda T. Hammad, Dana M. van Bemmel, Arseima Y. Del Valle-Pinero, Carol H. Christensen, Gladys Erives, Lisa M. Faulcon, Benjamin C. Blount, Yuesong Wang, Lanqing Wang, Deepak Bhandari, Antonia M. Calafat, Heather L. Kimmel, Colm D. Everard, Wilson M. Compton, Kathryn C. Edwards, Maciej L. Goniewicz, Binnian Wei, Andrew Hyland, Dorothy K. Hatsukami, Stephen S. Hecht, Raymond S. Niaura, Nicolette Borek, Bridget K. Ambrose, Cindy M. Chang
Summary: Limited data are available on how biomarkers of tobacco exposure change when smokers switch to using electronic nicotine delivery systems (ENDS). This study found that transitioning to exclusive ENDS use or quitting tobacco led to significant reductions in most biomarker concentrations, while dual users experienced smaller changes.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Medicine, General & Internal
Karin A. Kasza, Kathryn C. Edwards, Heather L. Kimmel, Andrew Anesetti-Rothermel, K. Michael Cummings, Raymond S. Niaura, Akshika Sharma, Erin M. Ellis, Rebecca Jackson, Carlos Blanco, Marushka L. Silveira, Dorothy K. Hatsukami, Andrew Hyland
Summary: This study found that daily e-cigarette use was associated with higher chances of smokers discontinuing cigarette smoking, even if they initially had no plans to quit. This suggests that e-cigarettes could be beneficial for smoking cessation among smokers not planning to quit.
Article
Pediatrics
Susanne Tanski, Michael J. Halenar, Kathryn C. Edwards, Jennifer Emond, Steven Woloshin, Mary Brunette, Lisa Schwartz, Kristie A. Taylor, Maciej L. Goniewicz, Ray Niaura, Gabriella Anic, Yanling Chen, Priscilla Callahan-Lyon, Lisa D. Gardner, Theresa Thekkudan, Nicolette Borek, Heather L. Kimmel, K. Michael Cummings, Andrew Hyland, James Sargent
Summary: During the period of 2016-17, smoking, marijuana use, and exposure to secondhand smoke were found to be associated with functionally important respiratory symptoms in adolescents/young adults in the United States. The risk increased with higher frequency of cigarette smoking, but there was no association between e-cigarette use and respiratory symptoms.
ACADEMIC PEDIATRICS
(2022)
Article
Environmental Sciences
Martin C. Mahoney, Cheryl Rivard, Heather L. Kimmel, Hoda T. Hammad, Eva Sharma, Michael J. Halenar, Jim Sargent, K. Michael Cummings, Ray Niaura, Maciej L. Goniewicz, Maansi Bansal-Travers, Dorothy Hatsukami, Diann Gaalema, Geoffrey Fong, Shannon Gravely, Carol H. Christensen, Ryan Haskins, Marushka L. Silveira, Carlos Blanco, Wilson Compton, Cassandra A. Stanton, Andrew Hyland
Summary: This study compared the incidence of cardiovascular disease (CVD) among smokers who switched to electronic nicotine delivery systems (ENDS), tobacco quitters, and never tobacco users. The findings showed no significant difference in CVD incidence among these groups over three 3-year intervals.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Substance Abuse
Connie S. Sosnoff, Kevin Caron, J. Ricky Akins, Kristin Dortch, Ronald E. Hunter, Brittany N. Pine, June Feng, Benjamin C. Blount, Yao Li, Dana M. van Bemmel, Heather L. Kimmel, Kathryn C. Edwards, Maciej L. Goniewicz, Dorothy K. Hatsukami, B. Rey deCastro, John T. Bernert, Stephen Arnstein, Nicolette Borek, Ying Deng-Bryant, Elena Mishina, Charles Lawrence, Andrew Hyland, Stephen S. Hecht, Kevin P. Conway, James L. Pirkle, Lanqing Wang
Summary: This study provides nationally representative estimates of nicotine biomarker concentrations in tobacco users and nonusers, which can serve as reference ranges for characterizing nicotine exposure in the US population.
NICOTINE & TOBACCO RESEARCH
(2022)
Article
Substance Abuse
June Feng, Connie S. Sosnoff, John T. Bernert, Benjamin C. Blount, Yao Li, Arseima Y. Del Valle-Pinero, Heather L. Kimmel, Dana M. van Bemmel, Sharyn M. Rutt, Juan Crespo-Barreto, Nicolette Borek, Kathryn C. Edwards, Ricky Alexander, Stephen Arnstein, Charles Lawrence, Andrew Hyland, Maciej L. Goniewicz, Imran Rehmani, Brittany Pine, Vincent Pagnotti, Erin Wade, James Sandlin, Zuzheng Luo, Sujeewa Piyankarage, Dorothy K. Hatsukami, Stephen S. Hecht, Kevin P. Conway, Lanqing Wang
Summary: This article provides a summary of urinary nicotine metabolite measurements among adult tobacco users and non-users from the Population Assessment of Tobacco and Health (PATH) Study. The study found that nicotine exposure levels varied based on age, gender, race/ethnicity, and educational attainment.
NICOTINE & TOBACCO RESEARCH
(2022)
Article
Substance Abuse
David R. Strong, Eric Leas, Madison Noble, Martha White, Allison Glasser, Kristie Taylor, Kathryn C. Edwards, Kevin C. Frissell, Wilson M. Compton, Kevin P. Conway, Elizabeth Lambert, Heather L. Kimmel, Marushka L. Silveira, Lynn C. Hull, Dana van Bemmel, Megan J. Schroeder, Kenneth Michael Cummings, Andrew Hyland, June Feng, Benjamin Blount, Lanqing Wang, Ray Niaura
Summary: This study found that higher levels of tobacco dependence and nicotine exposure were associated with more frequent smoking and decreased likelihood of quitting after one year for cigarette smokers and multiple tobacco product users who smoked cigarettes. Nicotine exposure was a more consistent predictor of quitting for other product user groups.
NICOTINE & TOBACCO RESEARCH
(2022)
Article
Substance Abuse
Danielle M. Smith, Carol Christensen, Dana van Bemmel, Nicolette Borek, Bridget Ambrose, Gladys Erives, Raymond Niaura, Kathryn C. Edwards, Cassandra A. Stanton, Benjamin C. Blount, Lanqing Wang, Jun Feng, Jeffery M. Jarrett, Cynthia D. Ward, Dorothy Hatsukami, Stephen S. Hecht, Heather L. Kimmel, Mark Travers, Andrew Hyland, Maciej L. Goniewicz
Summary: The study found that most dual users primarily smoked cigarettes daily and used e-cigarettes occasionally. Smoking cigarettes appeared to be the main driver of toxicant exposure among dual users, with little effect of e-cigarette use on biomarker levels.
NICOTINE & TOBACCO RESEARCH
(2021)
Article
Substance Abuse
Baoyun Xia, Benjamin C. Blount, Tonya Guillot, Christina Brosius, Yao Li, Dana M. Van Bemmel, Heather L. Kimmel, Cindy M. Chang, Nicolette Borek, Kathryn C. Edwards, Charlie Lawrence, Andrew Hyland, Maciej L. Goniewicz, Brittany N. Pine, Yang Xia, John T. Bernert, B. Rey De Castro, John Lee, Justin L. Brown, Stephen Arnstein, Diane Choi, Erin L. Wade, Dorothy Hatsukami, Gladys Ervies, Angel Cobos, Keegan Nicodemus, Dana Freeman, Stephen S. Hecht, Kevin Conway, Lanqing Wang
Summary: This study described and characterized the levels of TSNAs in US adult tobacco users, finding associations between TSNA concentrations and choice of tobacco product and frequency of use. Different exposure levels were observed among various tobacco product users, and urinary TSNAs were highly correlated with nicotine metabolite biomarkers.
NICOTINE & TOBACCO RESEARCH
(2021)