Article
Pharmacology & Pharmacy
Shang Xian Bo, Wang Yan Jie, Cai De Chao, Ma Sai, Wang Zhe, Zhu Ya Kun, Guo Hui Hui, Wang Chen, Ma Xiao, Hu Zhong Yao, Yu Hao Ran, Zhang Ji Sen, Cheng Wen Dan
Summary: The study demonstrated that compound 22o effectively inhibited the inflammatory response and catabolism of chondrocytes, reducing articular cartilage injury in a rat OA model induced by ACLT. The compound showed potential as a disease-modifying OA drug.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shaimaa Maher, Lauren A. Smith, Celine A. El-Khoury, Haitham Kalil, Khalid Sossey-Alaoui, Mekki Bayachou
Summary: Nitric oxide (NO) is a small molecule that has a significant impact on various biological activities. It has been linked to cancer-related processes and has the potential to be used as an anti-cancer agent. In this study, NO-releasing materials were developed using modified sodium alginate hydrogel, which showed compatibility with cell growth. The release of NO from the hydrogel exhibited distinct kinetic features.
Review
Biochemistry & Molecular Biology
Amir Asgari, Paul Jurasz
Summary: Megakaryocytes are important members of the hematopoietic system, responsible for regulating vascular homeostasis through platelets. The process of megakaryopoiesis generates mature megakaryocytes which release proplatelets into blood vessels. Nitric oxide (NO) plays a modulatory role in hematopoiesis and hemostasis. This review summarizes the effect of NO and its signaling on megakaryopoiesis and thrombopoiesis under physiological and pathophysiological conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Francesca Fagiani, Marieva Vlachou, Daniele Di Marino, Ilaria Canobbio, Alice Romagnoli, Marco Racchi, Stefano Govoni, Cristina Lanni
Summary: Pin1 functions as a key regulator of vascular homeostasis by modulating nitric oxide bioavailability and influencing various pathways involved in vascular diseases. Understanding the role of Pin1 in vascular endothelium could provide new insights for potential therapeutic strategies in vascular pathologies and neurodegenerative diseases.
Article
Biology
Maximilian Lenz, Pia Kruse, Amelie Eichler, Jakob Straehle, Juergen Beck, Thomas Deller, Andreas Vlachos
Summary: A defining feature of the brain is its ability for synaptic contacts to adapt structurally and functionally, with atRA being identified as a potent mediator of synaptic plasticity in the adult human cortex. The coordinated structural and functional changes in excitatory synapses observed in cortical slices were accompanied by ultrastructural remodeling of the spine apparatus organelle and required mRNA translation for these synaptic adaptations. The absence of these changes in synaptopodin-deficient mice suggests the importance of this organelle in the process.
Article
Biochemistry & Molecular Biology
Jhana O. Hendrickx, Sofie De Moudt, Elke Calus, Peter Paul De Deyn, Debby Van Dam, Guido R. Y. De Meyer
Summary: This study investigates the association between arterial stiffness and cognitive decline by introducing arterial stiffness in genetic and pharmacological NO dysfunction models. The findings demonstrate that non-selective inhibition of NOS activity leads to cardiac dysfunction, arterial stiffness, and decline in hippocampal-dependent learning and memory, highlighting the importance of neuronal NOS in both cardiovascular and neurological pathophysiology.
Article
Biochemistry & Molecular Biology
Deepali Singh, Archana Yadav, Chetna Singh
Summary: The study revealed that iNOS and CYP2E1 in rat PMNs contribute to oxidative stress induced by MB+PQ through differential regulatory mechanisms, with iNOS being regulated by inflammatory mediators and CYP2E1 expression triggered via the MEK-ERK1/2-PKC pathway.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2021)
Review
Genetics & Heredity
Antero Salminen
Summary: 1. Low-grade inflammation is associated with aging and age-related diseases.
2. Persistent inflammation activates compensatory immunosuppression with aging.
3. The numbers of immunosuppressive cells increase with aging and age-related diseases.
4. Immunosuppressive mechanisms evoke harmful bystander effects in host tissues.
5. Immunosuppression promotes tissue degeneration with aging and age-related diseases.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Article
Biotechnology & Applied Microbiology
Agnieszka Zablocka, Dominika Jakubczyk, Katarzyna Leszczynska, Katarzyna Pacyga-Prus, Jozefa Macala, Sabina Gorska
Summary: This study investigated the ability of Bifidobacterium species to induce iNOS-dependent NO synthesis in macrophages. The results showed that Bifidobacterium can regulate the expression of iNOS and produce NO by activating MAPK kinases. TLR2 and TLR4 receptors are involved in Bifidobacterium-induced macrophage activation and NO production. The study suggests that Bifidobacterium has a protective mechanism in the intestine, and its efficacy is strain-dependent.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Article
Medicine, Research & Experimental
George J. Dugbartey
Summary: Kidney transplantation is the preferred treatment for patients with kidney failure. However, ischemia-reperfusion injury (IRI) poses a significant challenge to the long-term success of this intervention. Nitric oxide (NO) has emerged as a potential candidate for mitigating IRI and preventing graft rejection in kidney transplantation. This review provides an overview of the sources and protective effects of endogenous and exogenous NO in kidney transplantation.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Robert J. Webber, Richard M. Sweet, Douglas S. Webber
Summary: The study found that anti-MV-A iNOS monoclonal antibodies can mitigate the harmful effects of MV-A iNOS and increase the survival rate of mice challenged with sepsis. The efficacy of the treatment is both time- and dose-dependent. Humanized anti-MV-A iNOS mAbs could potentially save tens of thousands of lives annually and improve antibiotic stewardship.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Amelia Cataldi, Rosa Amoroso, Viviana di Giacomo, Susi Zara, Cristina Maccallini, Marialucia Gallorini
Summary: Nitric oxide plays a key role in physiological and pathological processes in mammals, and excessive production is associated with inflammation. Dental pulp inflammation caused by pathogenic bacteria may affect the functions of dental pulp stem cells. Inhibiting nitric oxide production could be a new strategy for treating inflammation and promoting the regeneration of the dentin-pulp complex. This study evaluated two acetamidines related to a selective inhibitor of nitric oxide, and the results showed that they have potential as anti-inflammatory compounds while retaining the mineralization and angiogenic potential of cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Health Care Sciences & Services
Corina Daniela Ene, Ilinca Nicolae
Summary: This study explores the relationship between NOS2-associated inflammation profiles and SLE phenotypes. The variations in biomarkers are strongly associated with the decrease in eGFR and increase in albuminuria.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Fabio Arias, Francisco Franco-Montalban, Miguel Romero, Juan Duarte, M. Dora Carrion, M. Encarnacion Camacho
Summary: This paper describes the design, synthesis, and biological evaluation of selective inhibitors of inducible nitric oxide synthase (iNOS). The most potent and selective compound showed inhibitory activity against iNOS without undesirable cardiovascular effects. In silico analysis predicted good drug-likeness properties for promising compounds, which also exhibited adequate cell viability. Docking studies revealed a unique binding mode for one compound and explained its selectivity towards iNOS.
BIOORGANIC CHEMISTRY
(2022)
Editorial Material
Plant Sciences
Francisco J. Corpas, Salvador Gonzalez-Gordo, Jose M. Palma
Summary: Nitric oxide is a crucial signaling molecule in plant physiological processes, but the enzymatic generation of nitric oxide in higher plants is still controversial.
TRENDS IN PLANT SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Assia Galleze, Abdurrahim Kocyigit, Nacira Cherif, Nabila Attal, Chafia Touil-Boukoffa, Rachida Raache
DRUG AND CHEMICAL TOXICOLOGY
(2020)
Article
Parasitology
Sarah Tilioua, Dalila Mezioug, Zine-Charaf Amir-Tidadini, Yacine-Miloud Medjdoub, Chafia Touil-Boukoffa
Article
Immunology
Arezki Chekaoui, Houda Belguendouz, Karima Lahmar, Fettoum Mazari, Malika Terahi, Djanette Hakem, Pierre Youinou, Chafia Touil-Boukoffa
INTERNATIONAL IMMUNOPHARMACOLOGY
(2020)
Article
Oncology
Nora Kariche, Nabila Moulai, Leila Sarah Sellam, Samir Benyahia, Wahiba Ouahioune, Djamel Djennaoui, Chafia Touil-Boukoffa, Mehdi Bourouba
JOURNAL OF ONCOLOGY
(2019)
Article
Immunology
Sana Douaoui, Reda Djidjik, Mokhtar Boubakeur, Merzak Ghernaout, Chafia Touil-Boukoffa, Mustapha Oumouna, Fawzi Derrar, Yassine Amrani
Article
Endocrinology & Metabolism
Meroua Bouchemal, Djennat Hakem, Malha Azzouz, Chafia Touil-Boukoffa, Dalila Mezioug
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
(2020)
Article
Immunology
Fatmazohra Djaballah-Ider, Chafia Touil-Boukoffa
INFLAMMOPHARMACOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Leila Sarah Sellam, Roberta Zappasodi, Faycal Chettibi, Djamel Djennaoui, Nadia Yahi-Ait Mesbah, Zine-Charaf Amir-Tidadini, Chafia Touil-Boukoffa, Wahiba Ouahioune, Taha Merghoub, Mehdi Bourouba
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2020)
Article
Endocrinology & Metabolism
Faiza Bouldjennet, Anette P. Gjesing, Malha Azzouz, Samir Ait Abderrahman, Amina El Guecier, Said Ali, Brahim Oudjit, Farida Mennadi-Lacete, Lyece Yargui, Aissa Boudiba, Ahcene Chibane, Chafia Touil-Boukoffa, Torben Hansen, Rachida Raache
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2020)
Article
Endocrinology & Metabolism
Sarah Benchabane, Assia Slimani-Kaddouri, Dahbia Acheli, Thouraya Bendimerad-Iratene, Redouane Mesbah, Chafia Touil-Boukoffa
Summary: This study investigates the role of apoptosis-related factors in primary Sjogren Syndrome (pSS). The levels of Bcl-2, Fas, and FasL were found to be associated with the severity of inflammation and were significantly elevated in pSS patients compared to healthy controls. The levels of these factors decreased after combined corticosteroid-hydroxychloroquine therapy. Immunohistochemistry analysis revealed strong expression of Bcl-2 in infiltrating mononuclear cells, while the expression of Fas and FasL was less significant and localized in infiltrating mononuclear cells.
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
(2022)
Article
Immunology
Hadj Rabia Samia, Debib Aicha, Mezaguer Meriem, Yefsah Rabah, Soufli Imene, Hamrioui Bousaad, Chafia Touil-Boukoffa, Baz Ahsene, Giaimis Jean, Mameri Saadia
Summary: Cystic echinococcosis is an important zoonotic disease with a global distribution. Immunization with radio-attenuated protoscoleces may induce protective immunity against this disease.
PARASITE IMMUNOLOGY
(2022)
Meeting Abstract
Immunology
N. Kariche, N. Moulai, S. Benyahia, W. Ouahioune, D. Djennaoui, C. Touil-Boukoffa, M. Bourouba
EUROPEAN JOURNAL OF IMMUNOLOGY
(2019)
Meeting Abstract
Immunology
S. Benazzouz, M. Amri, J. Wang, B. Gottstein, A. Ketfi, M. Gharnaout, C. Touil-Boukoffa
EUROPEAN JOURNAL OF IMMUNOLOGY
(2019)
Meeting Abstract
Immunology
H. Rafa, S. Benkhelifa, N. Delhem, C. Touil-Boukoffa
EUROPEAN JOURNAL OF IMMUNOLOGY
(2019)
Article
Public, Environmental & Occupational Health
Nahla Deghbar, Dalila Mezioug, Touri Kahina, Yacine-Miloud Medjdoub, Chafia Touil-Boukoffa
ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE
(2019)
