The protective effect of luteolin on the depression-related dry eye disorder through Sirt1/NF-κB/NLRP3 pathway

Inflammation-related molecules in tears of patients with chronic ocular pain and dry eye disease

(2022) Marta Blanco-Vázquez et al.   EXPERIMENTAL EYE RESEARCH

The Protective Effect of Pilose Antler Peptide on CUMS-Induced Depression Through AMPK/Sirt1/NF-κB/NLRP3-Mediated Pyroptosis

(2022) Yue Hu et al.   Frontiers in Pharmacology

Protective effects of luteolin on the venous endothelium

(2021) Henrique Charlanti Reis Assunção et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Luteolin alleviates inflammation and modulates gut microbiota in ulcerative colitis rats

(2021) Bolin Li et al.   LIFE SCIENCES

Depression

(2021) Robert M. McCarron et al.   ANNALS OF INTERNAL MEDICINE

Luteolin inhibits H2O2-induced cellular senescence via modulation of SIRT1 and p53

(2021) Ri Zhe Zhu et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Luteolin Modulates Neural Stem Cells Fate Determination: In vitro Study on Human Neural Stem Cells, and in vivo Study on LPS-Induced Depression Mice Model

(2021) Mariem Achour et al.   Frontiers in Cell and Developmental Biology

Caspases in Cell Death, Inflammation, and Gasdermin-Induced Pyroptosis

(2020) Sannula Kesavardhana et al.   Annual Review of Immunology

Advanced oxidation protein products induce microglia-mediated neuroinflammation via MAPKs-NF-κB signaling pathway and pyroptosis after secondary spinal cord injury

(2020) Zhongyuan Liu et al.   Journal of Neuroinflammation

Map clusters of diseases to tackle multimorbidity

(2020) Christopher J. M. Whitty et al.   NATURE

The artemisinin analog SM934 alleviates dry eye disease in rodent models by regulating TLR4/NF-κB/NLRP3 signaling

(2020) Fang-ming Yang et al.   ACTA PHARMACOLOGICA SINICA

Ginsenoside Rg1 ameliorates chronic social defeat stress-induced depressive-like behaviors and hippocampal neuroinflammation

(2020) Ning Jiang et al.   LIFE SCIENCES

Luteolin Suppresses Sepsis-Induced Cold-Inducible Rna-Binding Protein Production and Lung Injury in Neonatal MICE

(2020) Yuanyuan Zhang et al.   SHOCK

Synergy between SIRT1 and SIRT6 helps recognize DNA breaks and potentiates the DNA damage response and repair in humans and mice

(2020) Fanbiao Meng et al.   eLife

Neuroprotective effects of flavone luteolin in neuroinflammation and neurotrauma

(2020) Duraisamy Kempuraj et al.   BIOFACTORS

Baicalin reverse depressive-like behaviors through regulation SIRT1-NF-kB signaling pathway in olfactory bulbectomized rats

(2019) Haiyang Yu et al.   PHYTOTHERAPY RESEARCH

SIRT1 in forebrain excitatory neurons produces sexually dimorphic effects on depression-related behaviors and modulates neuronal excitability and synaptic transmission in the medial prefrontal cortex

(2019) Yun Lei et al.   MOLECULAR PSYCHIATRY

Quercetin attenuates oxidative stress-induced apoptosis via SIRT1/AMPK-mediated inhibition of ER stress in rat chondrocytes and prevents the progression of osteoarthritis in a rat model

(2019) Kai Feng et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The protective effect of oleanolic acid on NMDA-induced MLE-12 cells apoptosis and lung injury in mice by activating SIRT1 and reducing NF-κB acetylation

(2019) Xiang-Ping Peng et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The molecular and cellular mechanisms of depression: a focus on reward circuitry

(2019) Megan E. Fox et al.   MOLECULAR PSYCHIATRY

Melatonin Attenuates LPS-Induced Acute Depressive-Like Behaviors and Microglial NLRP3 Inflammasome Activation Through the SIRT1/Nrf2 Pathway

(2019) Burak I. Arioz et al.   Frontiers in Immunology

Seahorse treatment improves depression-like behavior in mice exposed to CUMS through reducing inflammation/oxidants and restoring neurotransmitter and neurotrophin function

(2019) Kangwei Li et al.   JOURNAL OF ETHNOPHARMACOLOGY

Chronic dry eye induced corneal hypersensitivity, neuroinflammatory responses, and synaptic plasticity in the mouse trigeminal brainstem

(2019) Darine Fakih et al.   Journal of Neuroinflammation

SIRT1 Controls Acetaminophen Hepatotoxicity by Modulating Inflammation and Oxidative Stress

(2018) Patricia Rada et al.   ANTIOXIDANTS & REDOX SIGNALING

Targeting the NLRP3 inflammasome in inflammatory diseases

(2018) Matthew S. J. Mangan et al.   NATURE REVIEWS DRUG DISCOVERY

Dry Eye

(2018) Janine A. Clayton   NEW ENGLAND JOURNAL OF MEDICINE

NF-κB-Gasdermin D (GSDMD) Axis Couples Oxidative Stress and NACHT, LRR and PYD Domains-Containing Protein 3 (NLRP3) Inflammasome-Mediated Cardiomyocyte Pyroptosis Following Myocardial Infarction

(2018) Qian Lei et al.   MEDICAL SCIENCE MONITOR

The Relationship of Dry Eye Disease with Depression and Anxiety: A Naturalistic Observational Study

(2018) Momoko Kitazawa et al.   Translational Vision Science & Technology

Negative regulation of NLRP3 inflammasome by SIRT1 in vascular endothelial cells

(2017) Yanxiang Li et al.   IMMUNOBIOLOGY

TFOS DEWS II Report Executive Summary

(2017) Jennifer P. Craig et al.   Ocular Surface

TFOS DEWS II Epidemiology Report

(2017) Fiona Stapleton et al.   Ocular Surface

Luteolin: A Flavonoid that Has Multiple Cardio-Protective Effects and Its Molecular Mechanisms

(2017) Yuanyuan Luo et al.   Frontiers in Pharmacology

Hippocampal Sirtuin 1 Signaling Mediates Depression-like Behavior

(2016) Naoko Abe-Higuchi et al.   BIOLOGICAL PSYCHIATRY

SIRT1 protects the heart from ER stress-induced cell death through eIF2α deacetylation

(2016) Alexandre Prola et al.   CELL DEATH AND DIFFERENTIATION

Comparison of Topical Application of TSG-6, Cyclosporine, and Prednisolone for Treating Dry Eye

(2016) Yu Jeong Kim et al.   CORNEA

Ameliorating effect of luteolin on memory impairment in an Alzheimer's disease model

(2016) HUIMIN WANG et al.   Molecular Medicine Reports

Regulation of Sirt1/Nrf2/TNF-α signaling pathway by luteolin is critical to attenuate acute mercuric chloride exposure induced hepatotoxicity

(2016) Daqian Yang et al.   Scientific Reports

The Association Between Dry Eye Disease and Depression and Anxiety in a Large Population-Based Study

(2015) Robert van der Vaart et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Inflammation: Depression Fans the Flames and Feasts on the Heat

(2015) Janice K. Kiecolt-Glaser et al.   AMERICAN JOURNAL OF PSYCHIATRY

Dry Eye-Related Visual Blurring and Irritative Symptoms and Their Association with Depression and Anxiety in Eye Clinic Patients

(2015) Hong Liyue et al.   CURRENT EYE RESEARCH

Sparse whole-genome sequencing identifies two loci for major depressive disorder

(2015) Na Cai et al.   NATURE

Luteolin Reduces Alzheimer’s Disease Pathologies Induced by Traumatic Brain Injury

(2014) Darrell Sawmiller et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Association of polypharmacy with fall-related fractures in older Taiwanese people: age- and gender-specific analyses

(2014) Hsueh-Hsing Pan et al.   BMJ Open

Dry eye disease, dry eye symptoms and depression: the Beijing Eye Study

(2013) Antoine Labbé et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Depression, Post-traumatic Stress Disorder, and Dry Eye Syndrome: A Study Utilizing the National United States Veterans Affairs Administrative Database

(2012) Anat Galor et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

The Inflammasomes

(2010) Kate Schroder et al.   CELL