Nanoagonist‐Mediated GSDME‐Dependent Pyroptosis Remodels the Inflammatory Microenvironment for Tumor Photoimmunotherapy

Pyroptosis Remodeling Tumor Microenvironment to Enhance Pancreatic Cancer Immunotherapy Driven by Membrane Anchoring Photosensitizer

(2022) Meng Wang et al.   Advanced Science

Inspired Epigenetic Modulation Synergy with Adenosine Inhibition Elicits Pyroptosis and Potentiates Cancer Immunotherapy

(2021) Honggang Xiong et al.   ADVANCED FUNCTIONAL MATERIALS

Activation of Pyroptosis by Membrane‐Anchoring AIE Photosensitizer Design: New Prospect for Photodynamic Cancer Cell Ablation

(2021) Min Wu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Protonated 2D carbon nitride sensitized with Ce6 as a smart metal-free nanoplatform for boosted acute multimodal photo-sono tumor inactivation and long-term cancer immunotherapy

(2021) Mengya Chen et al.   CHEMICAL ENGINEERING JOURNAL

Regulation of zeolite-derived upconversion photocatalytic system for near infrared light/ultrasound dual-triggered multimodal melanoma therapy under a boosted hypoxia relief tumor microenvironment via autophagy

(2021) Yule Zhang et al.   CHEMICAL ENGINEERING JOURNAL

A Multiaction and Multitarget Ru(II)-Pt(IV) Conjugate Combining Cancer Activated Chemotherapy and Photodynamic Therapy to Overcome Drug Resistant Cancers

(2020) Johannes Karges et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mechanism and regulation of pyroptosis-mediated in cancer cell death

(2020) Jianwei Ruan et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Gasdermin E suppresses tumour growth by activating anti-tumour immunity

(2020) Zhibin Zhang et al.   NATURE

A bioorthogonal system reveals antitumour immune function of pyroptosis

(2020) Qinyang Wang et al.   NATURE

PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis

(2020) Junwei Hou et al.   NATURE CELL BIOLOGY

Enhancing anti-tumour efficacy with immunotherapy combinations

(2020) Funda Meric-Bernstam et al.   LANCET

A versatile strategy for improving phototherapeutic efficacy on deep-sited tumor by tissue optical clearing technique

(2020) Hao Zhao et al.   Nano Today

Approaches to treat immune hot, altered and cold tumours with combination immunotherapies

(2019) Jérôme Galon et al.   NATURE REVIEWS DRUG DISCOVERY

Methylation analysis of Gasdermin E shows great promise as a biomarker for colorectal cancer

(2019) Joe Ibrahim et al.   Cancer Medicine

Colour compound lenses for a portable fluorescence microscope

(2019) Bo Dai et al.   Light-Science & Applications

Epigenetics-Based Tumor Cells Pyroptosis for Enhancing the Immunological Effect of Chemotherapeutic Nanocarriers

(2019) Jin-Xuan Fan et al.   NANO LETTERS

Electrostatic self-assembled Iridium(III) nano-photosensitizer for selectively disintegrated and mitochondria targeted photodynamic therapy

(2019) Yong Deng et al.   DYES AND PIGMENTS

A Simply Modified Lymphocyte for Systematic Cancer Therapy

(2018) Di-Wei Zheng et al.   ADVANCED MATERIALS

Cancer immunotherapy using checkpoint blockade

(2018) Antoni Ribas et al.   SCIENCE

High response rate to PD-1 blockade in desmoplastic melanomas

(2018) Zeynep Eroglu et al.   NATURE

Light-Triggered Biomimetic Nanoerythrocyte for Tumor-Targeted Lung Metastatic Combination Therapy of Malignant Melanoma

(2018) Wen Liu et al.   Small

Rationale for Combining Bispecific T Cell Activating Antibodies With Checkpoint Blockade for Cancer Therapy

(2018) Sebastian Kobold et al.   Frontiers in Oncology

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

(2017) Yupeng Wang et al.   NATURE

Antigen-capturing nanoparticles improve the abscopal effect and cancer immunotherapy

(2017) Yuanzeng Min et al.   Nature Nanotechnology

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

(2017) Jianjin Shi et al.   TRENDS IN BIOCHEMICAL SCIENCES

Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death

(2017) Corey Rogers et al.   Nature Communications

Innate immune signaling and regulation in cancer immunotherapy

(2016) Leticia Corrales et al.   CELL RESEARCH

Association of Pembrolizumab With Tumor Response and Survival Among Patients With Advanced Melanoma

(2016) Antoni Ribas et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

(2015) Wan-ting He et al.   CELL RESEARCH

The fluorescence properties and binding mechanism of SYTOX green, a bright, low photo-damage DNA intercalating agent

(2015) Shreyasi Thakur et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Pyroptotic cell death defends against intracellular pathogens

(2015) Ine Jorgensen et al.   IMMUNOLOGICAL REVIEWS

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma

(2015) James Larkin et al.   NEW ENGLAND JOURNAL OF MEDICINE

The future of immune checkpoint therapy

(2015) P. Sharma et al.   SCIENCE

Inflammatory caspases are innate immune receptors for intracellular LPS

(2014) Jianjin Shi et al.   NATURE

Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome

(2014) Hao Xu et al.   NATURE

Immunogenic Cell Death in Cancer Therapy

(2012) Guido Kroemer et al.   Annual Review of Immunology

The DFNA5 gene, responsible for hearing loss and involved in cancer, encodes a novel apoptosis-inducing protein

(2011) Ken Op de Beeck et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Efficient Non-Viral Reprogramming of Myoblasts to Stemness with a Single Small Molecule to Generate Cardiac Progenitor Cells

(2011) Zeeshan Pasha et al.   PLoS One

Detection of reactive oxygen species (ROS) by the oxidant-sensing probe 2′,7′-dichlorodihydrofluorescein diacetate in the cyanobacterium Anabaena variabilis PCC 7937

(2010) Rajesh P. Rastogi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria

(2010) Edward A Miao et al.   NATURE IMMUNOLOGY

Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis

(2010) J. W. Jones et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aberrant promoter methylation and tumor suppressive activity of the DFNA5 gene in colorectal carcinoma

(2008) M S Kim et al.   ONCOGENE