Reductions in the mitochondrial enzyme α-ketoglutarate dehydrogenase complex in neurodegenerative disease - beneficial or detrimental?

Mild mitochondrial metabolic deficits by α-ketoglutarate dehydrogenase inhibition cause prominent changes in intracellular autophagic signaling: Potential role in the pathobiology of Alzheimer's disease

(2016) Kalpita Banerjee et al.   NEUROCHEMISTRY INTERNATIONAL

Reactive oxygen species mediate insulin signal transduction in mouse hypothalamus

(2016) Takeshi Onoue et al.   NEUROSCIENCE LETTERS

Induction of mitochondrial reactive oxygen species production by GSH mediated S-glutathionylation of 2-oxoglutarate dehydrogenase

(2016) Ryan J. Mailloux et al.   Redox Biology

The 2-Oxoacid Dehydrogenase Complexes in Mitochondria Can Produce Superoxide/Hydrogen Peroxide at Much Higher Rates Than Complex I

(2014) Casey L. Quinlan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neural correlates of cognitive dysfunction in Lewy body diseases and tauopathies: Combined assessment with FDG-PET and the CERAD test battery

(2013) Sabine Hellwig et al.   BRAIN AND LANGUAGE

Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers

(2013) Clifford R Jack et al.   LANCET NEUROLOGY

Cognitive impairment in patients with Parkinson's disease: diagnosis, biomarkers, and treatment

(2012) Per Svenningsson et al.   LANCET NEUROLOGY

Abnormal thiamine-dependent processes in Alzheimer's Disease. Lessons from diabetes

(2012) Gary E. Gibson et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Brain metabolite alterations and cognitive dysfunction in early Huntington's disease

(2012) Paul G. Unschuld et al.   MOVEMENT DISORDERS

Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease

(2012) Randall J. Bateman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Thioredoxin Reductase Deficiency Potentiates Oxidative Stress, Mitochondrial Dysfunction and Cell Death in Dopaminergic Cells

(2012) Pamela Lopert et al.   PLoS One

Inactivation and Reactivation of the Mitochondrial α-Ketoglutarate Dehydrogenase Complex

(2011) Qingli Shi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crosstalk between mitochondrial (dys)function and mitochondrial abundance

(2011) Sébastien Michel et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Important Role of Oxidative Stress Biomarkers in Huntington’s Disease

(2011) Isaac Túnez et al.   JOURNAL OF MEDICINAL CHEMISTRY

Brain [U-13C]glucose metabolism in mice with decreased α-ketoglutarate dehydrogenase complex activity

(2011) Linn Hege Nilsen et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Deficits in the mitochondrial enzyme α-ketoglutarate dehydrogenase lead to Alzheimer's disease-like calcium dysregulation

(2011) Gary E. Gibson et al.   NEUROBIOLOGY OF AGING

α-Ketoglutarate dehydrogenase: A mitochondrial redox sensor

(2010) Aaron L. McLain et al.   FREE RADICAL RESEARCH

Respiration-dependent H2O2Removal in Brain Mitochondria via the Thioredoxin/Peroxiredoxin System

(2010) Derek A. Drechsel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cognition, glucose metabolism and amyloid burden in Alzheimer's disease

(2010) Ansgar J. Furst et al.   NEUROBIOLOGY OF AGING

Synthetic regulators of the 2-oxoglutarate oxidative decarboxylation alleviate the glutamate excitotoxicity in cerebellar granule neurons

(2009) Maria S. Kabysheva et al.   BIOCHEMICAL PHARMACOLOGY

Mitochondrial dihydrolipoyl succinyltransferase deficiency accelerates amyloid pathology and memory deficit in a transgenic mouse model of amyloid deposition

(2009) Magali Dumont et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mild reduction in the activity of the α-ketoglutarate dehydrogenase complex elevates GABA shunt and glycolysis

(2009) Qingli Shi et al.   JOURNAL OF NEUROCHEMISTRY

Mice deficient in dihydrolipoyl succinyl transferase show increased vulnerability to mitochondrial toxins

(2009) Lichuan Yang et al.   NEUROBIOLOGY OF DISEASE

Novel functions of the α-ketoglutarate dehydrogenase complex may mediate diverse oxidant-induced changes in mitochondrial enzymes associated with Alzheimer's disease

(2008) Qingli Shi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Novel isoenzyme of 2-oxoglutarate dehydrogenase is identified in brain, but not in heart

(2008) Victoria Bunik et al.   FEBS Journal

Influence of mitochondrial enzyme deficiency on adult neurogenesis in mouse models of neurodegenerative diseases

(2008) N.Y. Calingasan et al.   NEUROSCIENCE

Reversible Inhibition of α-Ketoglutarate Dehydrogenase by Hydrogen Peroxide:  Glutathionylation and Protection of Lipoic Acid†

(2007) Milana A. B. Applegate et al.   BIOCHEMISTRY