A retrospective analysis of the Alzheimer's disease vaccine progress - The critical need for new development strategies

Aβ43 is neurotoxic and primes aggregation of Aβ40 in vivo

(2015) Sylvie Burnouf et al.   ACTA NEUROPATHOLOGICA

A fresh perspective from immunologists and vaccine researchers: Active vaccination strategies to prevent and reverse Alzheimer's disease

(2015) Michael G. Agadjanyan et al.   Alzheimers & Dementia

Vanutide Cridificar and the QS-21 Adjuvant in Japanese Subjects with Mild to Moderate Alzheimer’ s Disease: Results from Two Phase 2 Studies

(2015) Heii Arai et al.   Current Alzheimer Research

Mouse models rarely mimic the transcriptome of human neurodegenerative diseases: A systematic bioinformatics-based critique of preclinical models

(2015) Terry C. Burns et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Is fucose the answer to the immunomodulatory paradox of Quillaja saponins?

(2015) Dante J. Marciani   INTERNATIONAL IMMUNOPHARMACOLOGY

Alzheimer's disease vaccine development: A new strategy focusing on immune modulation

(2015) Dante J. Marciani   JOURNAL OF NEUROIMMUNOLOGY

An N-terminal antibody promotes the transformation of amyloid fibrils into oligomers and enhances the neurotoxicity of amyloid-beta: the dust-raising effect

(2015) Yu-Hui Liu et al.   Journal of Neuroinflammation

Vaccine-induced Aβ-specific CD8+ T cells do not trigger autoimmune neuroinflammation in a murine model of Alzheimer’s disease

(2015) Martine Bruley Rosset et al.   Journal of Neuroinflammation

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Decreased amyloid-β and increased neuronal hyperactivity by immunotherapy in Alzheimer's models

(2015) Marc Aurel Busche et al.   NATURE NEUROSCIENCE

A noninflammatory immune response in aged DNA Aβ42-immunized mice supports its safety for possible use as immunotherapy in AD patients

(2015) Doris Lambracht-Washington et al.   NEUROBIOLOGY OF AGING

Tailoring the Antibody Response to Aggregated Aß Using Novel Alzheimer-Vaccines

(2015) Markus Mandler et al.   PLoS One

Tau immunotherapy for Alzheimer's disease

(2015) Jan Torleif Pedersen et al.   TRENDS IN MOLECULAR MEDICINE

Co-immunization with DNA and protein mixture: A safe and efficacious immunotherapeutic strategy for Alzheimer's disease in PDAPP mice

(2015) Si Liu et al.   Scientific Reports

Long-term treatment with active Aβ immunotherapy with CAD106 in mild Alzheimer’s disease

(2015) Martin R Farlow et al.   Alzheimers Research & Therapy

A Comparative Evaluation of a Novel Vaccine in APP/PS1 Mouse Models of Alzheimer’s Disease

(2015) Iván Carrera et al.   Biomed Research International

Biopersistence and Brain Translocation of Aluminum Adjuvants of Vaccines

(2015) Romain Kroum Gherardi et al.   Frontiers in Neurology

Impact of amyloid β aggregate maturation on antibody treatment in APP23 mice

(2015) Karthikeyan Balakrishnan et al.   Acta Neuropathologica Communications

The Effects of Soluble A.β Oligomers on Neurodegeneration in Alzheimer's Disease

(2015) Jonathan Brouillette   CURRENT PHARMACEUTICAL DESIGN

IgG Conformer's Binding to Amyloidogenic Aggregates

(2015) Monichan Phay et al.   PLoS One

A critique of the drug discovery and phase 3 clinical programs targeting the amyloid hypothesis for Alzheimer disease

(2014) Eric Karran et al.   ANNALS OF NEUROLOGY

Immunotherapy for Alzheimer's disease

(2014) Thomas Wisniewski et al.   BIOCHEMICAL PHARMACOLOGY

Antibodies and protein misfolding: From structural research tools to therapeutic strategies

(2014) Erwin De Genst et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

New Th2 adjuvants for preventive and active immunotherapy of neurodegenerative proteinopathies

(2014) Dante J. Marciani   DRUG DISCOVERY TODAY

A dual vaccine against influenza & Alzheimer's disease failed to enhance anti-β-amyloid antibody responses in mice with pre-existing virus specific memory

(2014) Hayk Davtyan et al.   JOURNAL OF NEUROIMMUNOLOGY

Passive Immunization with Tau Oligomer Monoclonal Antibody Reverses Tauopathy Phenotypes without Affecting Hyperphosphorylated Neurofibrillary Tangles

(2014) D. L. Castillo-Carranza et al.   JOURNAL OF NEUROSCIENCE

Animal models of Alzheimer disease: historical pitfalls and a path forward

(2014) Sarah E. Cavanaugh   ALTEX-Alternatives to Animal Experimentation

A coimmunization vaccine of Aβ42 ameliorates cognitive deficits without brain inflammation in an Alzheimer’s disease model

(2014) Shuang Wang et al.   Alzheimers Research & Therapy

First-in-man tau vaccine targeting structural determinants essential for pathological tau–tau interaction reduces tau oligomerisation and neurofibrillary degeneration in an Alzheimer’s disease model

(2014) Eva Kontsekova et al.   Alzheimers Research & Therapy

Active immunotherapy options for Alzheimer’s disease

(2014) Bengt Winblad et al.   Alzheimers Research & Therapy

Peptide-based vaccines for cancer therapy

(2014) Giorgio Parmiani et al.   Human Vaccines & Immunotherapeutics

Global Epidemiology of Dementia: Alzheimer’s and Vascular Types

(2014) Liara Rizzi et al.   Biomed Research International

Affinity Enhancement of Antibodies: How Low-Affinity Antibodies Produced Early in Immune Responses Are Followed by High-Affinity Antibodies Later and in Memory B-Cell Responses

(2014) H. N. Eisen   Cancer Immunology Research

A canine model of human aging and Alzheimer's disease

(2013) Elizabeth Head   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Inflammatory components in human Alzheimer’s disease and after active amyloid-β42 immunization

(2013) Elina Zotova et al.   BRAIN

Pyroglutamate-Modified Amyloid Beta Peptides: Emerging Targets for Alzheimer´s Disease Immunotherapy

(2013) Roxanna Perez-Garmendia et al.   Current Neuropharmacology

Repeated immunization of mice with phosphorylated-tau peptides causes neuroinflammation

(2013) Lea Rozenstein-Tsalkovich et al.   EXPERIMENTAL NEUROLOGY

Mechanisms of action of naturally occurring antibodies against β-amyloid on microglia

(2013) Maike Gold et al.   Journal of Neuroinflammation

Understanding immunosenescence to improve responses to vaccines

(2013) Jörg J Goronzy et al.   NATURE IMMUNOLOGY

Development of a New DNA Vaccine for Alzheimer Disease Targeting a Wide Range of Aβ Species and Amyloidogenic Peptides

(2013) Yoh Matsumoto et al.   PLoS One

Neurotoxicity of Amyloid  -Protein: Synaptic and Network Dysfunction

(2013) L. Mucke et al.   Cold Spring Harbor Perspectives in Medicine

DNA vaccines

(2013) Cevayir Coban et al.   Human Vaccines & Immunotherapeutics

Naturally occurring autoantibodies interfere with β-amyloid metabolism and improve cognition in a transgenic mouse model of Alzheimer’s disease 24 h after single treatment

(2013) D Mengel et al.   Translational Psychiatry

Polarization of host immune responses by helminth-expressed glycans

(2012) Smanla Tundup et al.   Annals of the New York Academy of Sciences

Amyloid-β Immunotherapy for Alzheimers Disease

(2012) H.J. Fu et al.   CNS & Neurological Disorders-Drug Targets

Technologies for enhanced efficacy of DNA vaccines

(2012) Fadi Saade et al.   Expert Review of Vaccines

Identification of oligomers at early stages of tau aggregation in Alzheimer's disease

(2012) Cristian A. Lasagna-Reeves et al.   FASEB JOURNAL

Vaccination with a non-human random sequence amyloid oligomer mimic results in improved cognitive function and reduced plaque deposition and micro hemorrhage in Tg2576 mice

(2012) Suhail Rasool et al.   Molecular Neurodegeneration

Human Anti-Aβ IgGs Target Conformational Epitopes on Synthetic Dimer Assemblies and the AD Brain-Derived Peptide

(2012) Alfred T. Welzel et al.   PLoS One

Active DNA Aβ42 vaccination as immunotherapy for Alzheimer disease

(2012) Doris Lambracht-Washington et al.   Translational Neuroscience

Aging, cancer, and cancer vaccines

(2012) Paolo Mazzola et al.   Immunity & Ageing

Amyloid Structure: Conformational Diversity and Consequences

(2011) Brandon H. Toyama et al.   Annual Review of Biochemistry

CpG DNA as a vaccine adjuvant

(2011) Christian Bode et al.   Expert Review of Vaccines

Low-n oligomers as therapeutic targets of Alzheimer’s disease

(2011) Kenjiro Ono et al.   JOURNAL OF NEUROCHEMISTRY

Soluble Aβ oligomer production and toxicity

(2011) Megan E. Larson et al.   JOURNAL OF NEUROCHEMISTRY

Autoreactive-Aβ antibodies promote APP β-secretase processing

(2011) Juan Deng et al.   JOURNAL OF NEUROCHEMISTRY

Naturally Occurring Autoantibodies against  -Amyloid: Investigating Their Role in Transgenic Animal and In Vitro Models of Alzheimer's Disease

(2011) R. Dodel et al.   JOURNAL OF NEUROSCIENCE

Innate immunity and adjuvants

(2011) S. Akira   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

A Cyclic Undecamer Peptide Mimics a Turn in Folded Alzheimer Amyloid β and Elicits Antibodies against Oligomeric and Fibrillar Amyloid and Plaques

(2011) Peter Hoogerhout et al.   PLoS One

Anti-amyloidogenic Activity of IgGs Contained in Normal Plasma

(2010) Brian O’Nuallain et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Active Immunization with Amyloid-  1-42 Impairs Memory Performance through TLR2/4-Dependent Activation of the Innate Immune System

(2010) P. Vollmar et al.   JOURNAL OF IMMUNOLOGY

An improved method for generating consistent soluble amyloid-beta oligomer preparations for in vitro neurotoxicity studies

(2010) Deborah A. Ryan et al.   JOURNAL OF NEUROSCIENCE METHODS

Linear and conformation specific antibodies in aged beagles after prolonged vaccination with aggregated Abeta

(2010) Vitaly Vasilevko et al.   NEUROBIOLOGY OF DISEASE

Stabilization of neurotoxic Alzheimer amyloid-  oligomers by protein engineering

(2010) A. Sandberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antibody Responses, Amyloid-β Peptide Remnants and Clinical Effects of AN-1792 Immunization in Patients with AD in an Interrupted Trial

(2009) Tyler Kokjohn et al.   CNS & Neurological Disorders-Drug Targets

DNA prime–protein boost increased the titer, avidity and persistence of anti-Aβ antibodies in wild-type mice

(2009) H Davtyan et al.   GENE THERAPY

The Structure of Aβ42 C-Terminal Fragments Probed by a Combined Experimental and Theoretical Study

(2009) Chun Wu et al.   JOURNAL OF MOLECULAR BIOLOGY

Development of AFFITOPE vaccines for Alzheimer’s disease (AD) — From concept to clinical testing

(2009) A. Schneeberger et al.   Journal of Nutrition Health & Aging

IV immunoglobulin is associated with a reduced risk of Alzheimer disease and related disorders

(2009) H. Fillit et al.   NEUROLOGY

Neuroprotective natural antibodies to assemblies of amyloidogenic peptides decrease with normal aging and advancing Alzheimer's disease

(2009) M. Britschgi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ISCOMs and ISCOMATRIX™

(2009) Hong-Xiang Sun et al.   VACCINE

The coming of age of virus-like particle vaccines

(2008) Gary T. Jennings et al.   BIOLOGICAL CHEMISTRY

Biology of Immune Responses to Vaccines in Elderly Persons

(2008) Birgit Weinberger et al.   CLINICAL INFECTIOUS DISEASES

Amyloid β-Protein Assembly and Alzheimer Disease

(2008) Robin Roychaudhuri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid-β immunisation for Alzheimer's disease

(2008) Thomas Wisniewski et al.   LANCET NEUROLOGY

Maleimide conjugation markedly enhances the immunogenicity of both human and murine idiotype-KLH vaccines

(2008) Kamran Kafi et al.   MOLECULAR IMMUNOLOGY