Article
Geriatrics & Gerontology
Francesca Mantile, Angelo Capasso, Nadia Villacampa, Maria Donnini, Giovanna L. Liguori, Gabriela Constantin, Piergiuseppe De Berardinis, Michael T. Heneka, Antonella Prisco
Summary: Immunization against Aβ is being explored for AD prevention, but current vaccines face challenges in safety and immunogenicity. While immunization with (1-11)E2 can induce antibody response, it does not protect against Aβ accumulation and neuroinflammation, highlighting the need for further research into the immune response against Aβ that could prevent accumulation.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2021)
Article
Immunology
James S. Foster, Manasi Balachandran, Trevor J. Hancock, Emily B. Martin, Sallie Macy, Craig Wooliver, Tina Richey, Alan Stuckey, Angela D. Williams, Joseph W. Jackson, Stephen J. Kennel, Jonathan S. Wall
Summary: Systemic amyloidosis is a progressive disorder characterized by the deposition of amyloid fibrils and accessory proteins in organs and tissues. Current treatment focuses on reducing amyloid production, but this study introduces a peptide-antibody fusion molecule (mIgp5) that enhances macrophage uptake of amyloid, potentially offering a new approach for treating the disease.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Maria Elisabetta Clementi, Beatrice Sampaolese, Gabriele Di Sante, Francesco Ria, Rosa Di Liddo, Vincenzo Romano Spica, Fabrizio Michetti
Summary: The study demonstrated that the expression of S100B in astrocytoma cells plays a crucial role in the activation of reactive astrocytic processes, including cytotoxicity, ROS and NOS activation. Silencing S100B in astrocytoma cells effectively protected the cells from amyloid beta-peptide-induced damage, reducing cell death, oxygen radical generation and nitric oxide synthase activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Andrew M. Stern, Lei Liu, Shanxue Jin, Wen Liu, Angela L. Meunier, Maria Ericsson, Michael B. Miller, Megan Batson, Tingwan Sun, Sagar Kathuria, David Reczek, Laurent Pradier, Dennis J. Selkoe
Summary: Researchers have developed a new monoclonal antibody that specifically targets neurotoxic oligomers of amyloid-beta peptide. This antibody has a unique property that allows it to isolate soluble amyloid-beta aggregates from Alzheimer's disease brain without denaturation. These aggregates may be the principal neurotoxic forms of amyloid-beta in Alzheimer's disease, and they can lead to various pathological events.
Article
Chemistry, Multidisciplinary
Arghadwip Paul, Suman Samantray, Marco Anteghini, Mohammed Khaled, Birgit Strodel
Summary: This study analyzed molecular dynamics simulations of Aβ peptide using different force fields to study its structure and dynamics, providing answers to important questions related to Aβ, such as suitable force fields for modeling, the actual appearance of Aβ peptide, and the time required for MD simulations to reach equilibrium. The analyses presented in this study will serve as a useful reference guide for understanding the behavior of Aβ peptide and other similar disordered proteins.
Article
Biochemistry & Molecular Biology
Yang Gao, Stefan Wennmalm, Bengt Winblad, Sophia Schedin-Weiss, Lars O. Tjernberg
Summary: Through FRET imaging, Aβ42 oligomerization was successfully detected in primary neurons, showing that Aβ42 oligomerized in lysosomes/late endosomes in a concentration-dependent manner. These findings contribute to a better understanding of Aβ42 oligomerization in neurons.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Clinical Neurology
Boris Decourt, Fadel Boumelhem, Evans D. Pope, Jiong Shi, Zoltan Mari, Marwan Noel Sabbagh
Summary: According to the amyloid cascade hypothesis, removing amyloid beta (A beta) is believed to cure Alzheimer's disease (AD), but current clinical trials lack definitive efficacy. Therefore, research has shifted focus towards immunotherapy, particularly monoclonal antibody therapies targeting A beta plaques. This approach offers potential for treating different stages of AD and may provide valuable insights into the trajectory of drug development for neurodegenerative diseases.
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Serena Silvestro, Andrea Valeri, Emanuela Mazzon
Summary: Alzheimer's disease is a neurodegenerative disorder with beta-amyloid plaques and neurofibrillary tangles of Tau proteins as its main pathological mechanisms. Aducanumab, a monoclonal antibody targeting A beta, has shown promising results in reducing Aβ accumulation and slowing cognitive impairment progression, potentially marking a milestone in the development of efficient drugs for AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Ayan Chatterjee, Chiranjit Mahato, Dibyendu Das
Summary: Bioinspired by nature's ingenuity, short peptide-based cross-beta amyloid nanotubular hybrids were shown to promote various cascade reactions, while compartmentalizing enzymes within the cellular milieu. The ability to integrate different logic networks and access complex designs was achieved through the utilization of amyloid nanotubes with ordered arrays of imidazoles.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Peter Faller, Christelle Hureau
Summary: Controlling protein and peptide aggregation in vitro and obtaining reproducible results poses a challenge, which is scarcely reported and discussed in the literature, potentially hindering progress in the field and misleading newcomers.
FRONTIERS IN CHEMISTRY
(2021)
Article
Neurosciences
Sara L. Paulo, Leonor Ribeiro-Rodrigues, Rui S. Rodrigues, Joana M. Mateus, Joao Fonseca-Gomes, Rita Soares, Maria J. Diogenes, Susana Sola, Ana M. Sebastiao, Filipa F. Ribeiro, Sara Xapelli
Summary: The study focused on a rat model of Alzheimer's disease obtained by intracerebroventricular injection of soluble amyloid-C-42 (A beta(42)), and found that immature neuronal dendritic morphology was abnormally enhanced one month after injection. Surprisingly, there were no changes in cognitive performance or locomotor and anxious-related activity in the animal behavior tests.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Multidisciplinary Sciences
Ryo Morita, Ritsuko Kubota-Koketsu, Xiuyuan Lu, Tadahiro Sasaki, Emi E. Nakayama, Yu-chen Liu, Daisuke Okuzaki, Daisuke Motooka, James Badger Wing, Yasunori Fujikawa, Yuji Ichida, Kiyoko Amo, Tetsushi Goto, Junichi Hara, Michinori Shirano, Sho Yamasaki, Tatsuo Shioda
Summary: A 25-year-old patient with primary immunodeficiency experienced a relapse of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection after a 239-day period. Genetic sequencing revealed that the virus had evolved during the infection, with mutations associated with evasion of immune recognition. The relapsed virus showed increased proliferative capacity. It is important to eliminate SARS-CoV-2 early in immunocompromised patients to prevent the emergence of mutants and improve patient outcomes.
Article
Chemistry, Analytical
Yuwei Bu, Mengjie Zhang, Junliang Fu, Xiaoyan Yang, Shufeng Liu
Summary: In this study, a quantitative cathodic photoelectrochemical aptasensor was developed using black phosphorous quantum dots as the photoactive material and heme as the electron acceptor for sensing amyloid beta peptide. The sensor exhibited a good linear response range and a low detection limit, showing promising performance in bioanalysis applications.
ANALYTICA CHIMICA ACTA
(2022)
Article
Biochemistry & Molecular Biology
Irina V. Zueva, Elmira A. Vasilieva, Gulnara A. Gaynanova, Andrey V. Moiseenko, Anna D. Burtseva, Konstantin M. Boyko, Lucia Ya. Zakharova, Konstantin A. Petrov
Summary: The accumulation of senile plaques composed of aggregated amyloid-beta (A beta) peptides is a central event in the pathogenesis of Alzheimer's disease (AD). Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors are the main class of drugs used for AD treatment. The study shows that A beta can enhance AChE activity and also increase BChE activity, although less efficiently compared to AChE. In addition, A beta can reduce the effect of AChE inhibitors on synaptic potential parameters.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Kumju Youn, Chi-Tang Ho, Mira Jun
Summary: Alzheimer's disease is characterized by cognitive decline and memory impairment, with amyloid peptide generation and aggregation playing a key role in its pathogenesis. (-)-Epigallocatechin-3-gallate (EGCG) has been shown to have multiple neuroprotective effects in AD, focusing on amyloid peptide-induced damage and regulation.
FOOD SCIENCE AND HUMAN WELLNESS
(2022)