Review
Clinical Neurology
Xing Ren, Di Ai, Tong Li, Lei Xia, Lingzhi Sun
Summary: This study demonstrates that the combination therapy of lomustine and bevacizumab can effectively improve overall survival, progression-free survival, and 6-month progression-free survival in patients with glioblastoma. Further clinical trials are needed to confirm these encouraging results.
FRONTIERS IN NEUROLOGY
(2021)
Review
Oncology
Domenico Ribatti, Antonio Giovanni Solimando, Francesco Pezzella
Summary: Several anti-angiogenic drugs are approved for cancer treatment, but resistance and adverse effects may occur. Combining multiple anti-angiogenic molecules or using them in combination with other treatment regimens is indicated as alternative therapeutic strategies to overcome resistance. Comprehensive omics profiling is crucial for increasing clinical benefits and overcoming resistance to anti-angiogenic therapies.
Article
Anatomy & Morphology
Lin Zhu, Gaochao Guo, Yuwei Jin, Aixia Hu, Yang Liu
Summary: This study finds that IKBKE, a noncanonical inflammatory kinase, is frequently overexpressed and activated in glioblastoma. It functions as an oncogenic protein by inducing angiogenesis through the promotion of VEGF expression in glioblastoma through the AKT/FOXO3a pathway. Depletion of IKBKE significantly inhibits tumor growth and angiogenesis, suggesting the potential of targeting IKBKE for glioblastoma therapy.
Article
Biochemistry & Molecular Biology
Alexander Yuile, Adrian Lee, Elizabeth A. A. Moon, Amanda Hudson, Marina Kastelan, Samuel Miller, David Chan, Joe Wei, Michael F. F. Back, Helen R. R. Wheeler
Summary: This study found a potential association between PSMA and VEGF expression in glioblastoma. Additionally, it suggests a potential correlation between PSMA expression and overall survival in patients.
Article
Immunology
Peng Lin, Hao Jiang, Yu-jia Zhao, Jin-shu Pang, Wei Liao, Yun He, Zhang-Ya Lin, Hong Yang
Summary: The study revealed that rGBM patients have enrichment of activated CD8 T cells, and high CD8 T-cell infiltration is associated with better overall survival. CD8 T cells serve as an independent prognostic factor and could potentially assist in treatment selection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Oncology
Zhengmin Wang, Yifan Yuan, Xiong Ji, Xing Xiao, Zhujun Li, Xiao Yi, Yi Zhu, Tiannan Guo, Yin Wang, Liang Chen, Ying Liu
Summary: A specific isoform of VEGF-C was found in GBM-derived exosomes, which stimulated TAZ expression in endothelial cells and correlated with TAZ expression in tumor cells. Inhibiting exosomal release in combination with bevacizumab showed a cooperative inhibitory effect on GBM xenograft tumor growth and angiogenesis.
Article
Oncology
Henry S. Friedman, Michael D. Prados, Patrick Y. Wen, Tom Mikkelsen, David Schiff, Lauren E. Abrey, W. K. Alfred Yung, Nina Paleologos, Martin K. Nicholas, Randy Jensen, James Vredenburgh, Jane Huang, Maoxia Zheng, Timothy Cloughesy
Summary: This study evaluated the efficacy of bevacizumab, alone or in combination with irinotecan, in recurrent glioblastoma patients. The results showed that bevacizumab, either alone or in combination, was well tolerated and active in treating recurrent glioblastoma.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Shuhua Zheng, Wensi Tao
Summary: The study identified a simple three-gene transcriptome signature that can connect GBM's overall prognosis with gene expression, while also correlating perfusion imaging features with SOCS3 expression levels. SOCS3 expression levels are considered a potential selection marker for patients who may benefit from early initiation of angiogenesis inhibitors.
Article
Biochemistry & Molecular Biology
Grazia Maugeri, Agata Grazia D'Amico, Salvatore Saccone, Concetta Federico, Daniela Maria Rasa, Rosario Caltabiano, Giuseppe Broggi, Salvatore Giunta, Giuseppe Musumeci, Velia D'Agata
Summary: The study shows that PACAP plays a role in regulating the hypoxic micro-environment, angiogenesis and EMT in GBM cells. By inhibiting specific pathways and molecules, PACAP can reduce invasiveness of GBM cells and interfere with VEGF release and vessel formation. This study provides new insights into the complex role of PACAP in GBM malignancy.
Article
Cell Biology
Camilla Bjornbak Holst, Henriette Pedersen, Elisabeth Anne Adanma Obara, Kristoffer Vitting-Seerup, Kamilla Ellermann Jensen, Jane Skjoth-Rasmussen, Eva Lobner Lund, Hans Skovgaard Poulsen, Julia Sidenius Johansen, Petra Hamerlik
Summary: In the study, the challenges in treating GBM patients were explored, including the frustrations brought by anti-angiogenic agents and immunotherapy, the historical trajectory of bevacizumab as a treatment modality, and the role of dual targeting strategies in therapy. The study emphasizes that pursuing pleiotropic targets and leaning toward multitarget strategies may be key to more effective therapeutic intervention in GBM.
Article
Parasitology
Dina Abou Rayia, Ahmad Othman, Samar Harras, Duaa Helal, Lamees Dawood, Shaimaa Soliman
Summary: This study evaluated the effect of the anti-angiogenic agent bevacizumab on the muscle larvae of Trichinella spiralis. The results showed that bevacizumab reduced the number of encapsulated larvae in the muscles, improved muscle inflammation, reduced oxidative stress, and suppressed angiogenesis. Therefore, bevacizumab could be considered as a useful adjuvant treatment in the late stages of trichinellosis.
Article
Veterinary Sciences
Ulrike Lessiak, Barbara Pratscher, Alexander Tichy, Barbara Nell
Summary: Angiogenesis plays a crucial role in physiological processes, but pathological vascularization can lead to tissue and organ dysfunctions. Vascular endothelial growth factor A (VEGF-A) and its receptors are important in angiogenesis. This study investigated the effect of bevacizumab on an equine cell line and found that it efficiently inhibited cellular processes associated with angiogenesis, suggesting it could be a promising therapeutic approach in vascular-driven diseases in horses.
VETERINARY SCIENCES
(2023)
Article
Chemistry, Medicinal
Donghwa Kim, Sang Won Choi, Jihee Cho, Jae-Hui Been, Kyoungsun Choi, Wenzhe Jiang, Jaeho Han, Jedo Oh, Changmin Park, Soongyu Choi, Songyi Seo, Koung Li Kim, Wonhee Suh, Sang Kook Lee, Sanghee Kim
Summary: Diabetic retinopathy is a leading cause of blindness associated with excessive angiogenesis. Researchers have developed a novel antiangiogenesis agent by modifying the structure of wondonin marine natural products, resulting in improved bioactivity and selectivity. This compound, 31, shows potential as a lead for developing small-molecule drugs to treat diabetic retinopathy and to uncover new mechanisms of angiogenesis.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Oncology
Menglu Zhang, Jiaqi Liu, Gang Liu, Zeyu Xing, Ziqi Jia, Jiaxin Li, Wenyan Wang, Jie Wang, Ling Qin, Xin Wang, Xiang Wang
Summary: Breast cancer, the highest incidence of female malignancy, is heavily reliant on neo-vascularization for growth and metastasis, with Vascular Endothelial Growth Factor (VEGF) playing a crucial role. This review focuses on the prognostic value of VEGF in breast cancer, clinical experiences with anti-VEGF therapeutics, and biomarkers for predicting the effectiveness of anti-angiogenic treatment.
Editorial Material
Oncology
Shanmugarajan Krishnan, Zohreh Amoozgar, Dai Fukumura, Rakesh K. Jain
Summary: The failure of anti-VEGF/R and immune checkpoint therapies in improving overall survival in glioblastoma (GBM) patients may be attributed to prevalent immunosuppression in the tumor microenvironment. A granulocyte-rich GBM tumor microenvironment could lead to immune suppression and resistance to anti-VEGF/R therapies, suggesting potential new targets for therapy beyond VEGF. Consideration of various parameters could help reprogram the immunosuppressive GBM tumor microenvironment to an immunostimulatory one for better treatment outcomes.
JOURNAL OF PATHOLOGY
(2021)
Article
Oncology
J. J. Raizer, P. Giglio, J. Hu, M. Groves, R. Merrell, C. Conrad, S. Phuphanich, V. K. Puduvalli, M. Loghin, N. Paleologos, Y. Yuan, D. Liu, A. Rademaker, W. K. Yung, B. Vaillant, J. Rudnick, M. Chamberlain, N. Vick, S. Grimm, I. W. Tremont-Lukats, J. De Groot, K. Aldape, M. R. Gilbert
JOURNAL OF NEURO-ONCOLOGY
(2016)
Editorial Material
Oncology
Nibal Rizk, Carlos Kamiya-Matsuoka, Ivo W. Tremont-Lukats
Meeting Abstract
Oncology
Stefania Maraka, Morris D. Groves, Aaron Gerald Mammoser, Isaac Melguizo-Gavilanes, Charles A. Conrad, Ivo Tremont-Lukats, Monica Elena Loghin, Barbara Jane O'Brien, Vinay K. Puduvalli, Erik P. Sulman, Kenneth R. Hess, Kenneth D. Aldape, Mark R. Gilbert, John Frederick De Groot, W. K. Alfred Yung, Marta Penas-Prado
JOURNAL OF CLINICAL ONCOLOGY
(2018)
Article
Oncology
Stefania Maraka, Morris D. Groves, Aaron G. Mammoser, Isaac Melguizo-Gavilanes, Charles A. Conrad, Ivo W. Tremont-Lukats, Monica E. Loghin, Barbara J. Obrien, Vinay K. Puduvalli, Erik P. Sulman, Kenneth R. Hess, Kenneth D. Aldape, Mark R. Gilbert, John F. de Groot, W. K. Alfred Yung, Marta Penas-Prado
Article
Oncology
Robert A. Scranton, Saeed Sadrameli, Edward Brian Butler, Andrew Farach, Hui-Chuan Wang, Bin S. Teh, Ivo W. Tremont-Lukats, Steve H. Fung, Paolo Zanotti-Fregonara, Robert C. Rostomily
PRACTICAL RADIATION ONCOLOGY
(2020)
Editorial Material
Oncology
Ivo W. Tremont-Lukats, Bin S. Teh
TRANSLATIONAL CANCER RESEARCH
(2019)
Letter
Oncology
Akhil Shivaprasad, Prashant Rai, Bhanu Gogia, Ivo W. Tremont-Lukats
Letter
Clinical Neurology
Esther Arbona-Haddad, Ivo W. Tremont-Lukats, Bhanu Gogia, Prashant K. Rai
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2021)
Letter
Clinical Neurology
Prashant Rai, Bhanu Gogia, Ivo W. Tremont-Lukats
Article
Clinical Neurology
Brian Stocksdale, Seema Nagpal, John D. Hixson, Derek R. Johnson, Prashant Rai, Akhil Shivaprasad, Ivo W. Tremont-Lukats
NEURO-ONCOLOGY PRACTICE
(2020)
Meeting Abstract
Oncology
James Jurica, Eric Bernicker, Shraddha Dalwadi, Ivo Tremont-Lukats, Brian Butler, Bin Teh, Andrew Farach
Meeting Abstract
Clinical Neurology
Fernando Santos-Pinheiro, Na Tosha Gatson, Carlos Kamiya-Matsuoka, Gregory Fuller, Jeffrey Weinberg, Ivo Tremont, John De Groot, Monica Loghin
Meeting Abstract
Oncology
Na Tosha Gatson, Carlos Kamiya Matsuoka, Yvo Rodriguez-Linares, Clement Pillainayagam, David Cachia, T. Linda Chi, Jeffrey Weinberg, Ivo Tremont-Lukats, Gregory Fuller, John de Groot, Monica Loghin
Review
Medicine, General & Internal
Julia Day, Shlomit Yust-Katz, David Cachia, Jeffrey Wefel, Lior H. Katz, Ivo Tremont, Helen Bulbeck, Terri Armstrong, Alasdair G. Rooney
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2016)