Article
Engineering, Biomedical
Chuanmeizhi Wang, Bijan Pesaran, Maryam M. Shanechi
Summary: This paper presents a multiscale model-based Granger-like causality method for studying neural processes. The method, which combines spike trains and field potential signals, is able to recover multiscale neural causality and improve the prediction of neural signals compared to single-scale causality. The study shows the importance of understanding causal interactions across different scales of brain activity.
JOURNAL OF NEURAL ENGINEERING
(2022)
Article
Neurosciences
John C. Myers, Elliot H. Smith, Marcin Leszczynski, James O'Sullivan, Mark J. Yates, Guy McKhann, Nima Mesgarani, Charles Schroeder, Catherine Schevon, Sameer A. Sheth
Summary: Neuronal coherence is a fundamental mechanism in the brain that coordinates synaptic and spiking events. This study used electrocorticography and microelectrode arrays to estimate the spatial reach of neuronal coherence and found that its magnitude and spectral frequency have effects on its spatial range and coherence strength.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Materials Science, Multidisciplinary
Chunhua Li, Mengfan Wu, Jianyong Liu, Ruoyun Wang, Chaoyi Wei, Rui Wang, Yunlong Zhou, Haihong Jiang, Jingye Pan, Chuanfei Guo
Summary: In this study, a noninvasive wireless measurement system for urinary bladder pressure (UBP) was proposed, using a biomimetic structured piezoresistive sensor and low-power Bluetooth. The system exhibited high sensitivity, robustness, and real-time data transmission, providing an efficient strategy for clinicians or patients to diagnose abdominal impairment in real-time.
APPLIED MATERIALS TODAY
(2022)
Article
Computer Science, Artificial Intelligence
D. I. Antonov, K. V. Sviatov, S. Sukhov
Summary: This paper studies the susceptibility of spiking neural networks (SNNs) to catastrophic forgetting (CF) and tests several biologically inspired methods for mitigating CF. The experiments show that SNNs have the potential to provide better resilience against CF.
Article
Clinical Neurology
Christoph Wiest, Francesca Morgante, Flavie Torrecillos, Alek Pogosyan, Shenghong He, Fahd Baig, Ilaria Bertaina, Michael G. Hart, Mark J. Edwards, Erlick A. Pereira, Huiling Tan
Summary: This study explores the effects of subthalamic nucleus (STN) stimulation on Parkinson's disease and dystonia, and finds that stimulation-induced spectral changes are present in both conditions. These findings suggest that STN stimulation can be used for other disorders with excessive oscillatory peaks.
MOVEMENT DISORDERS
(2023)
Review
Chemistry, Physical
Yong Won Kwon, Yoon Sun Jun, Young-Geun Park, Jiuk Jang, Jang-Ung Park
Summary: Understanding the mechanisms of brain systems and developing electronic devices for brain interfaces are major challenges. Progress has been made in monitoring brain activity and assessing pharmacological systems within cerebral tissues.
Article
Engineering, Electrical & Electronic
Guihua Xiao, Yilin Song, Yu Zhang, Yiding Wang, Yu Xing, Shengwei Xu, Jingyu Xie, Yuchuan Dai, Mixia Wang, Jian Chen, Deyong Chen, Junbo Wang, Xinxia Cai
Summary: The study utilized a novel microelectrode array technology to record neural activities in awake and isoflurane-anesthetized epileptic mice, showing higher neural spike firing and LFP power under isoflurane anesthesia compared to wakefulness. Significant differences were observed in neural activities during seizures, with peak spike firing rate, amplitude, and LFP power values being the largest in epileptic mice.
SENSORS AND ACTUATORS A-PHYSICAL
(2021)
Article
Cell Biology
Hao Zhang, Jinlu Xie, Yaqiong Li, Huimin Liu, Chuanguo Liu, Dongfang Kan, Xiwen Geng, Sheng Wei
Summary: The study explores the impact of 6-OHDA lesion and L-DOPA therapy on the relationships between spike activities and local field potential within the PPN in Parkinson's disease. The findings suggest that the spike-LFP relationship in the PPN is significantly increased by the 6-OHDA lesion, with L-DOPA showing limited therapeutic effect on this increase. Understanding this relationship is crucial for the clinical treatment of refractory PD symptoms.
Article
Multidisciplinary Sciences
April N. Herrity, Sevda C. Aslan, Samineh Mesbah, Ricardo Siu, Karthik Kalvakuri, Beatrice Ugiliweneza, Ahmad Mohamed, Charles H. Hubscher, Susan J. Harkema
Summary: Despite profound dysfunction and loss of functional continuity, individuals with spinal cord injury can achieve coordinated voluntary activity and multi-systemic autonomic control. Spinal cord epidural stimulation (scES), including specific parameters for modulating lower urinary tract (LUT) activity, improves bladder function and reduces urinary incontinence. Functional bladder mapping studies and neuroimaging techniques have identified neuroanatomical structures responsible for bladder function regulation.
SCIENTIFIC REPORTS
(2022)
Article
Engineering, Marine
Kaidong Tao, Xueqian Zhou, Huilong Ren
Summary: The local semi-fixed ghost particles method proposed for WCSPH is more effective and has a simpler and more robust fictitious particle generation mechanism compared to previous methods. Results show that the new boundary method helps reduce the oscillations in numerical solutions and improves the numerical accuracy of the pressure field.
JOURNAL OF MARINE SCIENCE AND ENGINEERING
(2021)
Article
Engineering, Biomedical
Lekshmy Sudha Kumari, Abbas Z. Kouzani
Summary: Efficient acquisition and analysis of neural signals are crucial for understanding brain function and abnormalities. A miniaturized sensor called TinyLFP is presented, which is designed to capture and monitor low-frequency neural signals (LFPs) with low power, compactness, and low noise.
IEEE TRANSACTIONS ON MEDICAL ROBOTICS AND BIONICS
(2022)
Article
Engineering, Electrical & Electronic
Shashank Dwivedi, Anup K. Gogoi
Summary: This paper presents the design methodology of a local field potential amplifier for an implantable neural recording system. The amplifier is implemented using a low power, low noise front-end instrumentation amplifier, and a modified pseudo resistor is employed to suppress electrode-induced DC offset voltages. The measurement results show that the proposed amplifier has low-pass and high-pass corner frequencies suitable for capturing neural signals in the sub-Hertz frequency range.
MICROELECTRONICS JOURNAL
(2022)
Review
Computer Science, Information Systems
Federica Semproni, Veronica Iacovacci, Arianna Menciassi
Summary: This review paper summarizes the efforts made in efficient bladder monitoring at the clinical and research level, and proposes potential future directions in LUT dysfunction management through engineering solutions. After introducing technologies to support urination, three groups of monitoring devices are highlighted: instruments for a clinical setting, wearable devices for continuous and domestic monitoring, and implantable sensors for chronic monitoring. The main challenges and treatment opportunities in this field are identified and discussed.
Article
Neurosciences
Daniel D. Cummins, Ryan B. Kochanski, Roee Gilron, Nicole C. Swann, Simon Little, Lauren H. Hammer, Philip A. Starr
Summary: This study compared the sensing capabilities of the first-generation Medtronic PC + S and second-generation Percept PC neurostimulators in a single patient with Parkinson's disease. The results showed that the Percept PC had improved ability to sense local field potential signals during active stimulation compared to the PC + S, which was limited by artifact interference. The advancement in implantable neurostimulator technology between the first and second generation devices demonstrates the potential for further exploration into the neurophysiology of movement disorders and the clinical implementation of adaptive algorithms.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Xin Sally Zheng, Qianru Yang, Alberto Vazquez, Xinyan Tracy Cui
Summary: This study is important for understanding the challenges of chronic microstimulation in terms of stability and safety. Silicon arrays coated with PEDOT/CNT or PC and IrOx were implanted into the cortex of GCaMP6s mice and electrical stimulation was applied for up to 12 weeks. The neuronal responses to stimulation were quantified using two-photon imaging and mesoscale fluorescence microscopy, and the performance of the electrodes over time was characterized. The results showed dynamic changes in stimulation stability over time and revealed the advantage of PC coated electrodes in terms of energy efficiency compared to IrOx coated electrodes. Abnormal cortical responses were also observed in some mice, suggesting the need for further investigation of potential neuronal damage and redefining the safety limit of stimulation.
Article
Neurosciences
Jeong Woo Choi, Kwang Su Cha, Jong Doo Choi, Ki-Young Jung, Kyung Hwan Kim
Article
Clinical Neurology
Yong Seo Koo, Sung Min Kim, Chany Lee, Byeong Uk Lee, Ye Ji Moon, Yong Won Cho, Chang-Hwan Im, Jeong Woo Choi, Kyung Hwan Kim, Ki-Young Jung
Article
Clinical Neurology
Ki-Young Jung, Sung Min Kim, Jin-Young Song, Byeong Uk Lee, Chany Lee, Sang Kun Lee, Yong Seo Koo, Yong Won Cho, Jeong Woo Choi, Kyung Hwan Kim
Article
Multidisciplinary Sciences
Jeong Woo Choi, Kyoung-Mi Jang, Ki-Young Jung, Myung-Sun Kim, Kyung Hwan Kim
Article
Medicine, General & Internal
Sang Baek Ryu, Jeong Woo Choi, Kun No Ahn, Yong Sook Goo, Kyung Hwan Kim
JOURNAL OF KOREAN MEDICAL SCIENCE
(2017)
Article
Clinical Neurology
Jun-Sang Sunwoo, Sanghun Lee, Jung-Hoon Kim, Jung-Ah Lim, Tae-Joon Kim, Jung-Ick Byun, Min Hee Jeong, Kwang Su Cha, Jeong Woo Choi, Kyung Hwan Kim, Soon-Tae Lee, Keun-Hwa Jung, Kyung-Il Park, Kon Chu, Manho Kim, Sang Kun Lee, Ki-Young Jung
Article
Clinical Neurology
Jun-Sang Sunwoo, Sanghun Lee, Jung-Hoon Kim, Jung-Ah Lim, Tae-Joon Kim, Jung-Ick Byun, Min Hee Jeong, Kwang Su Cha, Jeong Woo Choi, Kyung Hwan Kim, Soon-Tae Lee, Keun-Hwa Jung, Kyung-Il Park, Kon Chu, Manho Kim, Sang Kun Lee, Ki-Young Jung
Article
Neurosciences
Gwan-Taek Lee, Chany Lee, Kyung Hwan Kim, Ki-Young Jung
BRAIN AND COGNITION
(2014)
Article
Mathematical & Computational Biology
Kyung Hwan Kim, Sung Jin Choi, Jin Ho Kim
COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE
(2013)
Article
Biochemistry & Molecular Biology
Yeong-Min Yoo, Ji Hyun Kwag, Kyung Hwan Kim, Chi Hyun Kim
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2014)
Article
Psychiatry
Miseon Shim, Do-Won Kim, Seung-Hwan Lee, Chang-Hwan Im
SCHIZOPHRENIA RESEARCH
(2014)
Article
Clinical Neurology
Sung Min Kim, Jeong Woo Choi, Chany Lee, Byeong Uk Lee, Yong Seo Koo, Kyung Hwan Kim, Ki-Young Jung
Article
Clinical Neurology
Jun-Sang Sunwoo, Kwang Su Cha, Jung-Ick Byun, Tae-Joon Kim, Jin-Sun Jun, Jung-Ah Lim, Soon-Tae Lee, Keun-Hwa Jung, Kyung-Il Park, Kon Chu, Han-Joon Kim, Manho Kim, Sang Kun Lee, Kyung Hwan Kim, Carlos H. Schenck, Ki-Young Jung
Article
Neurosciences
Jeong Woo Choi, Kwang Su Cha, Ki-Young Jung, Kyung Hwan Kim