期刊
NANO RESEARCH
卷 14, 期 9, 页码 3070-3095出版社
TSINGHUA UNIV PRESS
DOI: 10.1007/s12274-021-3476-y
关键词
neural interfaces; neural recording; neuromodulation; intracranial pressure monitoring; microfluidic drug delivery
类别
资金
- Ministry of Science ICT (MSIT)
- Ministry of Trade, Industry and Energy (MOTIE) of Korea through the National Research Foundation [2019R1A2B5B03069358, 2016R1A5A1009926]
- Bio & Medical Technology Development Program [2018M3A9F1021649]
- Nano Material Technology Development Program [2016M3A7B4910635]
- Sejong Science Fellowship [2021R1C1C2008657]
- Technology Innovation Program [20010366, 20013621]
- Institute for Basic Science [IBS-R026-D1]
- Yonsei University [2019-22-0228]
- Ministry of Science & ICT (MSIT), Republic of Korea [IBS-R026-D1-2021-A00] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [4199990514159] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Understanding the mechanisms of brain systems and developing electronic devices for brain interfaces are major challenges. Progress has been made in monitoring brain activity and assessing pharmacological systems within cerebral tissues.
The brain is actuated by billions of neurons with trillions of interconnections that regulate human behaviors. Understanding the mechanisms of these systems that induce sensory reactions and respond to disease remains one of the greatest challenges in science, engineering, and medicine. Recent advances in nanomaterials and nanotechnologies have led to the extensive research of electronic devices for brain interfaces to better understand the neural activities of the brain's complex nervous system. The development of sensor devices for monitoring the physiological signals of the brain related to traumatic injury status has accompanied by the progress of electronic neural probes in parallel. In addition, these neurological and stereotactic surgical revolutions hold immense potential for clinical analysis of pharmacological systems within cerebral tissues. Here, we review the progress of electronic devices interfacing with brain in terms of the materials, fabrication technologies, and device designs. Neurophysiological activity can be measured and modulated by brain probes based on newly developed nanofabrication methodologies. Furthermore, in vivo pathological monitoring of the brain and pharmacological assessment has been developed in miniaturized and wireless form. We also consider the key challenges and prospects for further development, and explore the future directions emerging in the latest research.
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