Egr-1 deficiency protects from renal inflammation and fibrosis

Egr-1 Mediates Chronic Hypoxia-Induced Renal Interstitial Fibrosis via the PKC/ERK Pathway

(2017) Shiren Sun et al.   AMERICAN JOURNAL OF NEPHROLOGY

Loss of Egr-1 sensitizes pancreatic β-cells to palmitate-induced ER stress and apoptosis

(2015) Mun-Wai Cheong et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

TGF-β stimulation in human and murine cells reveals commonly affected biological processes and pathways at transcription level

(2014) Khalid Abnaof et al.   BMC Systems Biology

The NLRP3/ASC inflammasome promotes T-cell-dependent immune complex glomerulonephritis by canonical and noncanonical mechanisms

(2014) Kirstin Andersen et al.   KIDNEY INTERNATIONAL

Overview of the cellular and molecular basis of kidney fibrosis

(2014) Allison A. Eddy   Kidney International Supplements

Transcriptional regulation of the growth-regulated oncogene α gene by early growth response protein-1 in response to tumor necrosis factor α stimulation

(2013) Soon Young Shin et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Reference genes in real-time PCR

(2013) Bartłomiej Kozera et al.   JOURNAL OF APPLIED GENETICS

Proteasome Inhibition Increases Recruitment of IκB Kinase β (IKKβ), S536P-p65, and Transcription Factor EGR1 to Interleukin-8 (IL-8) Promoter, Resulting in Increased IL-8 Production in Ovarian Cancer Cells

(2013) Bipradeb Singha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Canonical and non-canonical effects of the NLRP3 inflammasome in kidney inflammation and fibrosis

(2013) Georg Lorenz et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Ambivalent roles of early growth response 1 in inflammatory signaling following ribosomal insult in human enterocytes

(2012) Kee Hun Do et al.   BIOCHEMICAL PHARMACOLOGY

HuR posttranscriptionally regulates early growth response-1 (Egr-1) expression at the early stage of T cell activation

(2012) Zongchun Mou et al.   FEBS LETTERS

TNF-α induces early growth response gene-1 expression via ERK1/2 activation in endothelial cells

(2011) Yanli Cao et al.   ACTA DIABETOLOGICA

Bile Acids Induce Inflammatory Genes in Hepatocytes

(2011) Katryn Allen et al.   AMERICAN JOURNAL OF PATHOLOGY

The role of EMT in renal fibrosis

(2011) Rosemarie M. Carew et al.   CELL AND TISSUE RESEARCH

Pivotal Role of Toll-Like Receptors 2 and 4, Its Adaptor Molecule MyD88, and Inflammasome Complex in Experimental Tubule-Interstitial Nephritis

(2011) Matheus Correa-Costa et al.   PLoS One

Hepatic Fibrosis Is Enhanced and Accompanied by Robust Oval Cell Activation after Chronic Carbon Tetrachloride Administration to Egr-1-Deficient Mice

(2010) Michele T. Pritchard et al.   AMERICAN JOURNAL OF PATHOLOGY

An Inflammasome-Independent Role for Epithelial-Expressed Nlrp3 in Renal Ischemia-Reperfusion Injury

(2010) A. A. Shigeoka et al.   JOURNAL OF IMMUNOLOGY

NF- B in Renal Inflammation

(2010) A. B. Sanz et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

An integrative view on the role of TGF-β in the progressive tubular deletion associated with chronic kidney disease

(2010) Omar García-Sánchez et al.   KIDNEY INTERNATIONAL

Essential Roles for Early Growth Response Transcription Factor Egr-1 in Tissue Fibrosis and Wound Healing

(2009) Minghua Wu et al.   AMERICAN JOURNAL OF PATHOLOGY

Fate Tracing Reveals the Pericyte and Not Epithelial Origin of Myofibroblasts in Kidney Fibrosis

(2009) Benjamin D. Humphreys et al.   AMERICAN JOURNAL OF PATHOLOGY

Early Growth Response Protein-1 (Egr-1) Is Preferentially Expressed in T Helper Type 2 (Th2) Cells and Is Involved in Acute Transcription of the Th2 Cytokine Interleukin-4

(2009) Michael Lohoff et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of alveolar epithelial early growth response-1 (Egr-1) in CD8+ T cell-mediated lung injury

(2009) Chilakamarti V. Ramana et al.   MOLECULAR IMMUNOLOGY

Smad-Independent Transforming Growth Factor-β Regulation of Early Growth Response-1 and Sustained Expression in Fibrosis

(2008) Swati Bhattacharyya et al.   AMERICAN JOURNAL OF PATHOLOGY

IL-13 Signaling via IL-13Rα2 Induces Major Downstream Fibrogenic Factors Mediating Fibrosis in Chronic TNBS Colitis

(2008) Stefan Fichtner–Feigl et al.   GASTROENTEROLOGY