Differential transcriptional regulation of hypoxia-inducible factor-1α by arsenite under normoxia and hypoxia: involvement of Nrf2

Reactive oxygen species, nutrition, hypoxia and diseases: Problems solved?

(2015) Agnes Görlach et al.   Redox Biology

Reversal of Persistent Fibrosis in Aging by Targeting Nox4-Nrf2 Redox Imbalance

(2014) L. Hecker et al.   Science Translational Medicine

Oxygen Sensing, Hypoxia-Inducible Factors, and Disease Pathophysiology

(2013) Gregg L. Semenza   Annual Review of Pathology-Mechanisms of Disease

Hypoxia-Inducible Factor 1 and Cardiovascular Disease

(2013) Gregg L. Semenza   Annual Review of Physiology

Nutritional Countermeasures Targeting Reactive Oxygen Species in Cancer: From Mechanisms to Biomarkers and Clinical Evidence

(2013) Anatoly Samoylenko et al.   ANTIOXIDANTS & REDOX SIGNALING

Blockage of Nrf2 suppresses the migration and invasion of esophageal squamous cell carcinoma cells in hypoxic microenvironment

(2013) H. Shen et al.   DISEASES OF THE ESOPHAGUS

What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer

(2013) J.-A. Losman et al.   GENES & DEVELOPMENT

Knockdown of Nrf2 suppresses glioblastoma angiogenesis by inhibiting hypoxia-induced activation of HIF-1α

(2013) Xiangjun Ji et al.   INTERNATIONAL JOURNAL OF CANCER

KEAP1-NRF2 complex in ischemia-induced hepatocellular damage of mouse liver transplants

(2013) Bibo Ke et al.   JOURNAL OF HEPATOLOGY

Correlation of Nrf2 and HIF-1α in glioblastoma and their relationships to clinicopathologic features and survival

(2013) Xiangjun Ji et al.   NEUROLOGICAL RESEARCH

The effect of inorganic arsenic on endothelium-dependent relaxation: Role of NADPH oxidase and hydrogen peroxide

(2013) David H. Edwards et al.   TOXICOLOGY

Arsenic induces the expressions of angiogenesis-related factors through PI3K and MAPK pathways in SV-HUC-1 human uroepithelial cells

(2013) Fei Wang et al.   TOXICOLOGY LETTERS

NADPH oxidase-mitochondria axis-derived ROS mediate arsenite-induced HIF-1α stabilization by inhibiting prolyl hydroxylases activity

(2013) Ying-Na Li et al.   TOXICOLOGY LETTERS

Nrf2 activation supports cell survival during hypoxia and hypoxia/reoxygenation in cardiomyoblasts; the roles of reactive oxygen and nitrogen species

(2013) Rajitha T Kolamunne et al.   Redox Biology

NADPH oxidase-produced superoxide mediates EGFR transactivation by c-Src in arsenic trioxide-stimulated human keratinocytes

(2012) Hong-Yu Tseng et al.   ARCHIVES OF TOXICOLOGY

Nox4 Is a Protective Reactive Oxygen Species Generating Vascular NADPH Oxidase

(2012) Katrin Schröder et al.   CIRCULATION RESEARCH

Regulation of miRNA-21 by reactive oxygen species-activated ERK/NF-κB in arsenite-induced cell transformation

(2012) Min Ling et al.   FREE RADICAL BIOLOGY AND MEDICINE

The accumulations of HIF-1α and HIF-2α by JNK and ERK are involved in biphasic effects induced by different levels of arsenite in human bronchial epithelial cells

(2012) Yuan Xu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Arsenite induces cell transformation by reactive oxygen species, AKT, ERK1/2, and p70S6K1

(2011) Richard L. Carpenter et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

GSK-3  regulates cell growth, migration, and angiogenesis via Fbw7 and USP28-dependent degradation of HIF-1 

(2011) D. Flugel et al.   BLOOD

NRF2 Blockade Suppresses Colon Tumor Angiogenesis by Inhibiting Hypoxia-Induced Activation of HIF-1 

(2011) T.-H. Kim et al.   CANCER RESEARCH

Nox4 regulates Nrf2 and glutathione redox in cardiomyocytes in vivo

(2011) Alison C. Brewer et al.   FREE RADICAL BIOLOGY AND MEDICINE

Arsenic trioxide induces apoptosis of p53 null osteosarcoma MG63 cells through the inhibition of catalase

(2011) Yang Wang et al.   MEDICAL ONCOLOGY

Role and Mechanism of Arsenic in Regulating Angiogenesis

(2011) Ling-Zhi Liu et al.   PLoS One

HIF-1α signaling is augmented during intermittent hypoxia by induction of the Nrf2 pathway in NOX1-expressing adenocarcinoma A549 cells

(2010) Viktor Malec et al.   FREE RADICAL BIOLOGY AND MEDICINE

The NADPH Oxidase Subunit NOX4 Is a New Target Gene of the Hypoxia-inducible Factor-1

(2010) Isabel Diebold et al.   MOLECULAR BIOLOGY OF THE CELL

HIF-1 Induction Attenuates Nrf2-Dependent IL-8 Expression in Human Endothelial Cells

(2009) Agnieszka Loboda et al.   ANTIOXIDANTS & REDOX SIGNALING

The Hypoxia-Inducible Factor-2α Is Stabilized by Oxidative Stress Involving NOX4

(2009) Isabel Diebold et al.   ANTIOXIDANTS & REDOX SIGNALING

The Antioxidant Quercetin Inhibits Cellular Proliferation via HIF-1-Dependent Induction of p21WAF

(2009) Aline Bach et al.   ANTIOXIDANTS & REDOX SIGNALING

Receptor Activation of NADPH Oxidases

(2009) Andreas Petry et al.   ANTIOXIDANTS & REDOX SIGNALING

Reciprocal Regulation of Rac1 and PAK-1 by HIF-1α: A Positive-Feedback Loop Promoting Pulmonary Vascular Remodeling

(2009) Isabel Diebold et al.   ANTIOXIDANTS & REDOX SIGNALING

Arsenic induces mitochondria-dependent apoptosis by reactive oxygen species generation rather than glutathione depletion in Chang human hepatocytes

(2009) Yi Wang et al.   ARCHIVES OF TOXICOLOGY

Regulation of HIF-1α at the Transcriptional Level

(2009) Agnes Gorlach   CURRENT PHARMACEUTICAL DESIGN

Enhanced ROS production and redox signaling with combined arsenite and UVA exposure: Contribution of NADPH oxidase

(2009) Karen L. Cooper et al.   FREE RADICAL BIOLOGY AND MEDICINE

Arsenic-stimulated liver sinusoidal capillarization in mice requires NADPH oxidase–generated superoxide

(2008) Adam C. Straub et al.   JOURNAL OF CLINICAL INVESTIGATION