Article
Gastroenterology & Hepatology
Peter A. C. Wing, Peter Jianrui Liu, James M. Harris, Andrea Magri, Thomas Michler, Xiaodong Zhuang, Helene Borrmann, Rosalba Minisini, Nicholas R. Frampton, Jochen M. Wettengel, Laurent Mailly, Valentina D'Arienzo, Tobias Riedl, Luis Nobre, Michael P. Weekes, Mario Pirisi, Mathias Heikenwalder, Thomas F. Baumert, Ester M. Hammond, David R. Mole, Ulrike Protzer, Peter Balfe, Jane A. McKeating
Summary: HIFs play a crucial role in regulating HBV replication, revealing an evolutionary mechanism by which HBV exploits the HIF signaling pathway to persist in the low oxygen environment of the liver.
JOURNAL OF HEPATOLOGY
(2021)
Review
Oncology
Zilan Zhu, Ziyi Zheng, Jian Liu
Summary: COVID-19 and lung cancer have dysregulated signaling pathways, with ROS playing a crucial role. The activation of inflammation pathways affects the development of both diseases, while the NRF2 pathway shows opposite trends between them. The modulation of ROS signaling pathways may alleviate the potentially mutual impacts between COVID-19 and lung cancer patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Petr Fojtik, Deborah Beckerova, Katerina Holomkova, Martin Senfluk, Vladimir Rotrekl
Summary: Mild hypoxia attenuates the pluripotency-promoting PI3K/AKT signaling pathway in human pluripotent stem cells compared to normoxic conditions, due to the downregulation of ROS. In addition, the MAPK pathway also downregulates ROS and attenuates the PI3K/AKT signaling via a novel interaction between these pathways. This ROS-mediated regulatory circuit may have implications for enhancing cultivation and differentiation protocols for hPSCs, as well as providing insights into cancer stem cell signaling regulation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Deborah Fratantonio, Fabio Virgili, Alessandro Zucchi, Kate Lambrechts, Tiziana Latronico, Pierre Lafere, Peter Germonpre, Costantino Balestra
Summary: The study found that exposure to different concentrations of hyperoxia leads to activation of different oxygen-sensitive transcription factor patterns in human peripheral blood mononuclear cells. Mild hyperoxia is perceived as hypoxic stress, leading to activation of HIF-1α and NRF2, while high and very high concentrations of hyperoxia induce an oxidative stress response, characterized by activation of NRF2 and NF-κB.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
Kelsie R. S. Doering, Xuanjin Cheng, Luke Milburn, Ramesh Ratnappan, Arjumand Ghazi, Dana L. Miller, Stefan Taubert
Summary: NHR-49, a nuclear hormone receptor in Caenorhabditis elegans, regulates a hypoxia response pathway that acts in parallel with HIF-1. In hypoxia, NHR-49 regulates a set of genes independent of HIF-1, including autophagy genes that promote hypoxia survival. NHR-67 acts as a negative regulator and HPK-1 acts as a positive regulator of the NHR-49 pathway.
Review
Pharmacology & Pharmacy
Shubham Rastogi, Sara Aldosary, Abdulaziz S. S. Saeedan, Mohd Nazam Ansari, Manjari Singh, Gaurav Kaithwas
Summary: Hypoxia in cancer cells is caused by persistent inflammation and involves the activation of NF-kappa B and HIF-1 alpha. NF-kappa B promotes tumor development and maintenance, while HIF-1 alpha aids cellular proliferation and adaptability to angiogenic signals. The key oxygen-dependent regulator of HIF-1 alpha and NF-kappa B activity is hypothesized to be Prolyl hydroxylase-2 (PHD-2). In non-hypoxic tumor cells, PHD-2 is inactive due to pyruvate-mediated competitive inhibition of 2-oxo-glutarate, leading to the canonical activation of NF-kappa B.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Kiichi Hirota
Summary: Oxygen is essential for the body, with the hypoxia-inducible factor playing a key role in hypoxic environments. HIF-prolyl hydroxylases serve as oxygen sensors, detecting decreases in oxygen partial pressure. Inhibiting HIF-PH can activate HIF artificially for medical intervention purposes.
Article
Immunology
Ming Jing, Junjie Yang, Lirong Zhang, Jing Liu, Sen Xu, Meiling Wang, Leiming Zhang, Yue Sun, Weibin Yan, Guige Hou, Chunhua Wang, Wenyu Xin
Summary: The study demonstrates that Celastrol effectively alleviates rheumatoid arthritis (RA) symptoms by inhibiting the activation of the NF-κB signaling pathway and NLRP3 inflammasome, ultimately suppressing inflammation. Celastrol also inhibits ROS production induced by LPS and ATP, suggesting a potential therapeutic mechanism for treating RA.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ju Won Eom, Joo Weon Lim, Hyeyoung Kim
Summary: Anticancer agents induce apoptosis in gastric cancer cells by increasing reactive oxygen species (ROS) production, activating NADPH oxidase, and promoting DNA fragmentation.
Article
Pharmacology & Pharmacy
Jie Su, Wei Yin, Mengmeng Huo, Qing Yao, Liqiong Ding
Summary: In this study, the researchers discovered that lycorine, when used in combination with glioma cells, could inhibit cell growth, induce apoptosis, and generate reactive oxygen species. Additionally, lycorine disrupted the NF-kappa B signaling pathway and reduced drug resistance. These findings suggest that lycorine may be a potential treatment for glioma.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Naoko Kida, Yoshiyuki Matsuo, Yoshiko Hashimoto, Kenichiro Nishi, Tomoko Tsuzuki-Nakao, Hidemasa Bono, Tetsuo Maruyama, Kiichi Hirota, Hidetaka Okada
Summary: Cigarette smoking is a major risk factor for various fatal diseases, including cancers. The study found that smoking induced HIF-1 alpha activation in human endometrial cells, leading to cellular stress, inflammation, and endometrial remodeling. These findings suggest a potential mechanism underlying the detrimental effects of smoking on endometrial health.
Review
Biochemistry & Molecular Biology
Jan Korbecki, Donata Siminska, Magdalena Gassowska-Dobrowolska, Joanna Listos, Izabela Gutowska, Dariusz Chlubek, Irena Baranowska-Bosiacka
Summary: This paper discusses the mechanisms and effects of chronic low-grade inflammation caused by chronic hypoxia and cycling hypoxia in malignant tumors, as well as their impact on the tumor microenvironment and cell recruitment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Anna Keppner, Darko Maric, Ilaria Maria Christina Orlando, Laurent Falquet, Edith Hummler, David Hoogewijs
Summary: The kidney is highly dependent on a continuous oxygen supply and is sensitive to hypoxia. In this study, the authors investigated the response of cortical collecting duct cells to hypoxia using a mouse cell line. They found that hypoxia led to significant changes in gene expression, with decreased oxygen-linked processes and increased pathways associated with hypoxic responses. Knockdown experiments revealed the involvement of certain genes in the hypoxic induction of other genes. Overall, the study suggests that the mCCD(cl1) cell line is a suitable model for studying the cellular response to hypoxia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Yuling Chen, Timo Gaber
Summary: Oxygen availability varies in the human body, impacting immune cell function through transcriptional regulation by HIFs. Severe hypoxia under pathophysiological conditions can lead to dysfunctional immune response and tissue damage.
Review
Urology & Nephrology
Armando Luis Negri
Summary: The morbidity and mortality of chronic kidney disease (CKD) patients are closely related to vascular calcification. Recent studies have shown that under low oxygen conditions, hypoxia can activate the HIF-1 pathway, causing vascular smooth muscle cells (VSMCs) to transform into bone-forming cells, leading to vascular calcification. Inhibition of the HIF-1 pathway can prevent this differentiation. The combination of phosphate and hypoxia further enhances VSMC calcification. The use of prolyl hydroxylase inhibitors to treat anemia in CKD patients and its effect on vascular calcification needs further exploration.
CLINICAL KIDNEY JOURNAL
(2023)