Emerging evidence for beneficial macrophage functions in atherosclerosis and obesity-induced insulin resistance

Breaking the Barrier—Chaperone-Mediated Autophagy of Perilipins Regulates the Lipolytic Degradation of Fat

(2015) Martina Schweiger et al.   Cell Metabolism

Weekly Treatment of 2-Hydroxypropyl-β-cyclodextrin Improves Intracellular Cholesterol Levels in LDL Receptor Knockout Mice

(2015) Sofie Walenbergh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

mTOR: a pharmacologic target for autophagy regulation

(2015) Young Chul Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Cellular and Molecular Connections between Autophagy and Inflammation

(2015) Pierre Lapaquette et al.   MEDIATORS OF INFLAMMATION

Lipid-Overloaded Enlarged Adipocytes Provoke Insulin Resistance Independent of Inflammation

(2015) Jong In Kim et al.   MOLECULAR AND CELLULAR BIOLOGY

Degradation of lipid droplet-associated proteins by chaperone-mediated autophagy facilitates lipolysis

(2015) Susmita Kaushik et al.   NATURE CELL BIOLOGY

Perivascular Adipose Tissue-Derived Adiponectin Inhibits Collar-Induced Carotid Atherosclerosis by Promoting Macrophage Autophagy

(2015) Changlong Li et al.   PLoS One

Lipid storage by adipose tissue macrophages regulates systemic glucose tolerance

(2014) Myriam Aouadi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Brown and white adipose tissues: intrinsic differences in gene expression and response to cold exposure in mice

(2014) Meritxell Rosell et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Eosinophils and Type 2 Cytokine Signaling in Macrophages Orchestrate Development of Functional Beige Fat

(2014) Yifu Qiu et al.   CELL

Meteorin-like Is a Hormone that Regulates Immune-Adipose Interactions to Increase Beige Fat Thermogenesis

(2014) Rajesh R. Rao et al.   CELL

Eosinophils in Fat: Pink Is the New Brown

(2014) Stephen D. Lee et al.   CELL

Metabolic Dysfunction Drives a Mechanistically Distinct Proinflammatory Phenotype in Adipose Tissue Macrophages

(2014) Mario Kratz et al.   Cell Metabolism

A Smooth Muscle-Like Origin for Beige Adipocytes

(2014) Jonathan Z. Long et al.   Cell Metabolism

Local Proliferation of Macrophages Contributes to Obesity-Associated Adipose Tissue Inflammation

(2014) Shinya U. Amano et al.   Cell Metabolism

Adipocyte Inflammation Is Essential for Healthy Adipose Tissue Expansion and Remodeling

(2014) Ingrid Wernstedt Asterholm et al.   Cell Metabolism

Systemic administration of 2-hydroxypropyl-β-cyclodextrin to symptomatic Npc1-deficient mice slows cholesterol sequestration in the major organs and improves liver function

(2014) Adam M Lopez et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Cholesterol Crystals Induce Complement-Dependent Inflammasome Activation and Cytokine Release

(2014) E. O. Samstad et al.   JOURNAL OF IMMUNOLOGY

Lysosomal cholesterol accumulation: driver on the road to inflammation during atherosclerosis and non-alcoholic steatohepatitis

(2014) T. Hendrikx et al.   Obesity Reviews

Selective Inhibition of PI3K/Akt/mTOR Signaling Pathway Regulates Autophagy of Macrophage and Vulnerability of Atherosclerotic Plaque

(2014) Chungang Zhai et al.   PLoS One

Obesity Activates a Program of Lysosomal-Dependent Lipid Metabolism in Adipose Tissue Macrophages Independently of Classic Activation

(2013) Xiaoyuan Xu et al.   Cell Metabolism

The machinery of macroautophagy

(2013) Yuchen Feng et al.   CELL RESEARCH

The Mechanism and Physiological Function of Macroautophagy

(2013) Daniel J. Klionsky et al.   Journal of Innate Immunity

Macrophage biology in development, homeostasis and disease

(2013) Thomas A. Wynn et al.   NATURE

Local proliferation dominates lesional macrophage accumulation in atherosclerosis

(2013) Clinton S Robbins et al.   NATURE MEDICINE

Gene silencing in adipose tissue macrophages regulates whole-body metabolism in obese mice

(2013) M. Aouadi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammation during obesity is not all bad: evidence from animal and human studies

(2012) Jianping Ye et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Inflammation in Atherosclerosis

(2012) Peter Libby   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Toll-like receptor 7 stimulation by imiquimod induces macrophage autophagy and inflammation in atherosclerotic plaques

(2012) Inge Meyer et al.   BASIC RESEARCH IN CARDIOLOGY

Regulation of lipid stores and metabolism by lipophagy

(2012) K Liu et al.   CELL DEATH AND DIFFERENTIATION

Autophagy Links Inflammasomes to Atherosclerotic Progression

(2012) Babak Razani et al.   Cell Metabolism

Inflammation and Lipid Signaling in the Etiology of Insulin Resistance

(2012) Christopher K. Glass et al.   Cell Metabolism

Macrophage Autophagy Plays a Protective Role in Advanced Atherosclerosis

(2012) Xianghai Liao et al.   Cell Metabolism

The cellular and signaling networks linking the immune system and metabolism in disease

(2012) Olivia Osborn et al.   NATURE MEDICINE

Monocyte and Macrophage Dynamics During Atherogenesis

(2011) Klaus Ley et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Regulation of Lipid Droplet Cholesterol Efflux From Macrophage Foam Cells

(2011) Mireille Ouimet et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Autophagy Regulates Cholesterol Efflux from Macrophage Foam Cells via Lysosomal Acid Lipase

(2011) Mireille Ouimet et al.   Cell Metabolism

Inflammation Is Necessary for Long-Term but Not Short-Term High-Fat Diet-Induced Insulin Resistance

(2011) Y. S. Lee et al.   DIABETES

Increased Macrophage Migration Into Adipose Tissue in Obese Mice

(2011) D. Y. Oh et al.   DIABETES

Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis

(2011) Khoa D. Nguyen et al.   NATURE

Dynamic, M2-Like Remodeling Phenotypes of CD11c+ Adipose Tissue Macrophages During High-Fat Diet-Induced Obesity in Mice

(2010) M. E. Shaul et al.   DIABETES

Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue

(2010) Aliki Kosteli et al.   JOURNAL OF CLINICAL INVESTIGATION

Endocytosis of beta-cyclodextrins is responsible for cholesterol reduction in Niemann-Pick type C mutant cells

(2010) A. I. Rosenbaum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myeloid Cell-Restricted Insulin Receptor Deficiency Protects Against Obesity-Induced Inflammation and Systemic Insulin Resistance

(2010) Jan Mauer et al.   PLoS Genetics

Autophagy in Atherosclerosis

(2009) Wim Martinet et al.   CIRCULATION RESEARCH

Differential roles of NHERF1, NHERF2, and PDZK1 in regulating CFTR-mediated intestinal anion secretion in mice

(2009) Anurag Kumar Singh et al.   JOURNAL OF CLINICAL INVESTIGATION

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

Molecular mechanisms of mTOR-mediated translational control

(2009) Xiaoju Max Ma et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Adipose-specific deletion of autophagy-related gene 7 (atg7) in mice reveals a role in adipogenesis

(2009) Y. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endolysosomal phospholipidosis and cytosolic lipid droplet storage and release in macrophages

(2008) Gerd Schmitz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Interactions between cell death induced by statins and 7-ketocholesterol in rabbit aorta smooth muscle cells

(2008) W Martinet et al.   BRITISH JOURNAL OF PHARMACOLOGY

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Hepatic Insulin Resistance Is Sufficient to Produce Dyslipidemia and Susceptibility to Atherosclerosis

(2008) Sudha B. Biddinger et al.   Cell Metabolism

Ablation of CD11c-Positive Cells Normalizes Insulin Sensitivity in Obese Insulin Resistant Animals

(2008) David Patsouris et al.   Cell Metabolism

Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes

(2008) Adilson Guilherme et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Fat Metabolism Links Germline Stem Cells and Longevity in C. elegans

(2008) M. C. Wang et al.   SCIENCE