ATM Protein Kinase Signaling, Type 2 Diabetes and Cardiovascular Disease

Lack of ataxia telangiectasia mutated kinase induces structural and functional changes in the heart: role in β-adrenergic receptor-stimulated apoptosis

(2014) Cerrone R. Foster et al.   EXPERIMENTAL PHYSIOLOGY

Direct Activation of ATM by Resveratrol under Oxidizing Conditions

(2014) Ji-Hoon Lee et al.   PLoS One

Pathogenesis of ataxia-telangiectasia: the next generation of ATM functions

(2013) M. Ambrose et al.   BLOOD

Mammalian Target of Rapamycin (mTOR) Inhibition with Rapamycin Improves Cardiac Function in Type 2 Diabetic Mice

(2013) Anindita Das et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The ATM protein kinase: regulating the cellular response to genotoxic stress and more

(2013) Yosef Shiloh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ATM and GLUT1-S490 Phosphorylation Regulate GLUT1 Mediated Transport in Skeletal Muscle

(2013) Stanley Andrisse et al.   PLoS One

Deficiency of Ataxia Telangiectasia Mutated Kinase Modulates Cardiac Remodeling Following Myocardial Infarction: Involvement in Fibrosis and Apoptosis

(2013) Cerrone R. Foster et al.   PLoS One

Boosting the pentose phosphate pathway restores cardiac progenitor cell availability in diabetes

(2012) Rajesh Katare et al.   CARDIOVASCULAR RESEARCH

Wip1-Dependent Regulation of Autophagy, Obesity, and Atherosclerosis

(2012) Xavier Le Guezennec et al.   Cell Metabolism

Ataxia telangiectasia mutated impacts insulin-like growth factor 1 signalling in skeletal muscle

(2012) James Kain Ching et al.   EXPERIMENTAL PHYSIOLOGY

AMP-activated protein kinase modulates cardiac autophagy in diabetic cardiomyopathy

(2011) Zhonglin Xie et al.   Autophagy

Mitochondrial dysfunction in ataxia-telangiectasia

(2011) Y. A. Valentin-Vega et al.   BLOOD

ATM protects against oxidative stress induced by oxidized low-density lipoprotein

(2011) Michaela Semlitsch et al.   DNA REPAIR

Cytoplasmic ATM protein kinase: an emerging therapeutic target for diabetes, cancer and neuronal degeneration

(2011) Da-Qing Yang et al.   DRUG DISCOVERY TODAY

The mitochondria-targeted antioxidant MitoQ decreases features of the metabolic syndrome in ATM+/–/ApoE–/– mice

(2011) John R. Mercer et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ataxia telangiectasia mutated kinase plays a protective role in β-adrenergic receptor-stimulated cardiac myocyte apoptosis and myocardial remodeling

(2011) Cerrone R. Foster et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Drugs, diabetes and cancer

(2011) Morris J. Birnbaum et al.   NATURE

ATM Is a Redox Sensor Linking Genome Stability and Carbon Metabolism

(2011) A. Kruger et al.   Science Signaling

The ATM protein kinase and cellular redox signaling: beyond the DNA damage response

(2011) Scott Ditch et al.   TRENDS IN BIOCHEMICAL SCIENCES

New insights into insulin resistance in the diabetic heart

(2011) Susan Gray et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Loss of ATM positively regulates the expression of hypoxia inducible factor 1 (HIF-1) through oxidative stress: Role in the physiopathology of the disease

(2010) Marielle Ousset et al.   CELL CYCLE

DNA Damage Links Mitochondrial Dysfunction to Atherosclerosis and the Metabolic Syndrome

(2010) John R. Mercer et al.   CIRCULATION RESEARCH

ATM activates the pentose phosphate pathway promoting anti-oxidant defence and DNA repair

(2010) Claudia Cosentino et al.   EMBO JOURNAL

p53 is required for chloroquine-induced atheroprotection but not insulin sensitization

(2010) Babak Razani et al.   JOURNAL OF LIPID RESEARCH

Requirement of the ATM/p53 Tumor Suppressor Pathway for Glucose Homeostasis

(2010) H. L. Armata et al.   MOLECULAR AND CELLULAR BIOLOGY

mTORC1 Signaling under Hypoxic Conditions Is Controlled by ATM-Dependent Phosphorylation of HIF-1α

(2010) Hakan Cam et al.   MOLECULAR CELL

Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes

(2010) Kaixin Zhou et al.   NATURE GENETICS

ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS

(2010) A. Alexander et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ATM Activation by Oxidative Stress

(2010) Z. Guo et al.   SCIENCE

Role of ataxia telangiectasia mutated in insulin signalling of muscle-derived cell lines and mouse soleus

(2009) I. Jeong et al.   Acta Physiologica

Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion

(2009) S. E. Golding et al.   MOLECULAR CANCER THERAPEUTICS

Association Between Diabetes Mellitus and Left Ventricular Hypertrophy in a Multiethnic Population

(2008) Kazuo Eguchi et al.   AMERICAN JOURNAL OF CARDIOLOGY

ATM protein kinase mediates full activation of Akt and regulates glucose transporter 4 translocation by insulin in muscle cells

(2008) Marie-Jo Halaby et al.   CELLULAR SIGNALLING

Hypoxia regulates TSC1/2 mTOR signaling and tumor suppression through REDD1-mediated 14 3 3 shuttling

(2008) M. P. DeYoung et al.   GENES & DEVELOPMENT