4.7 Article

Electrospun healthcare nanofibers from medicinal liquor of Phellinus igniarius

期刊

ADVANCED COMPOSITES AND HYBRID MATERIALS
卷 5, 期 4, 页码 3045-3056

出版社

SPRINGERNATURE
DOI: 10.1007/s42114-022-00551-x

关键词

Nano healthcare products; Phellinus igniarius; Coaxial electrospinning; Medicinal liquor; Core-shell nanofibers

资金

  1. National Natural Science Foundation of China [81874034]
  2. Natural Science Foundation of Shanghai [20ZR1439000, 21ZR1459500]
  3. Municipal Commission of Health and Family Planning Foundation of Shanghai [202140413]
  4. Medical Health Science and Technology Innovation Plan of Jinan [201805038, 201907085, 202019182]
  5. Science and Technology Innovation Project of Medical Staff in Shandong province
  6. Natural Science Foundation of Shandong Province [ZR2020QH264]
  7. Key Research and Development Project of Shandong Province [2019GSF108002]

向作者/读者索取更多资源

In this study, the traditional medicinal liquor was transformed into medicinal core-shell nanofibers using coaxial electrospinning technology. The nanofibers exhibited a clear core-shell structure, with the active ingredients in an amorphous state and good compatibility with the polymeric matrix. In vitro experiments demonstrated that the nanofibers could quickly dissolve and release the loaded active ingredients, ensuring rapid permeation. This study pioneers a new approach to transform traditional medicine into nano healthcare products.
Although the healthcare market has billions of dollars in trade every year in this nano era, the nano products for healthcare remain limited. In this study, polyvinylpyrrolidone was used as a filament-forming matrix and drug carrier, and Phellinus igniarius (PI) was explored as a raw medicinal material. Coaxial electrospinning was implemented to transfer a traditional healthcare product (medicinal liquor) from PI into a nano healthcare product, that is, medicinal core-shell nanofibers. A homemade Teflon-coated concentric spinneret was utilized for setting up the coaxial electrospinning apparatus. The microformation mechanism of core-shell nanostructures from the spinneret was disclosed. The prepared core-shell nanofibers were characterized using scanning electron microscopy, transmission electron microscopy, X-ray diffraction, and Fourier transform infrared spectroscopy, by which they were demonstrated to have a linear morphology with an evident core-shell structure. In addition, the active ingredients (primarily polysaccharides) from PI were presented in the nanofibers in an amorphous state, indicating good compatibility with the polymeric matrix. Homemade methods and ex vivo permeation tests were explored to evaluate the functional performance of medicinal core-shell nanofibers, which could be quickly dissolved to release the loaded active ingredients when they encountered water and ensured a rapid permeation effect. The present study pioneered a potential application to more people of electrospun core-shell healthcare nano products from traditional medicinal liquor.

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