The development of fluconazole resistance in Candida albicans – an example of microevolution of a fungal pathogen

Mutations in transcription factor Mrr2p contribute to fluconazole resistance in clinical isolates of Candida albicans

(2015) Ying Wang et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Contribution of Clinically Derived Mutations inERG11to Azole Resistance in Candida albicans

(2014) Stephanie A. Flowers et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A Tetraploid Intermediate Precedes Aneuploid Formation in Yeasts Exposed to Fluconazole

(2014) Benjamin D. Harrison et al.   PLOS BIOLOGY

Distinct Roles of Candida albicans Drug Resistance Transcription Factors TAC1 , MRR1 , and UPC2 in Virulence

(2013) Andrea Lohberger et al.   EUKARYOTIC CELL

Analysis of a fungus-specific transcription factor family, theCandida albicanszinc cluster proteins, by artificial activation

(2013) Rebecca Schillig et al.   MOLECULAR MICROBIOLOGY

Azole Resistance by Loss of Function of the Sterol Δ5,6-Desaturase Gene (ERG3) in Candida albicans Does Not Necessarily Decrease Virulence

(2012) L. A. Vale-Silva et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Gain-of-Function Mutations in UPC2 Are a Frequent Cause of ERG11 Upregulation in Azole-Resistant Clinical Isolates of Candida albicans

(2012) Stephanie A. Flowers et al.   EUKARYOTIC CELL

Amino acid substitutions in the Candida albicans sterol  5,6-desaturase (Erg3p) confer azole resistance: characterization of two novel mutants with impaired virulence

(2012) F. Morio et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

The stepwise acquisition of fluconazole resistance mutations causes a gradual loss of fitness inCandida albicans

(2012) Christoph Sasse et al.   MOLECULAR MICROBIOLOGY

Does stress induce (para)sex? Implications for Candida albicans evolution

(2012) Judith Berman et al.   TRENDS IN GENETICS

Regulation of Efflux Pump Expression and Drug Resistance by the Transcription Factors Mrr1, Upc2, and Cap1 in Candida albicans

(2011) Sabrina Schubert et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Evolutionary Dynamics of Candida albicans during In Vitro Evolution

(2011) Mian Huang et al.   EUKARYOTIC CELL

A d-octapeptide drug efflux pump inhibitor acts synergistically with azoles in a murine oral candidiasis infection model

(2011) Kazumi Hayama et al.   FEMS MICROBIOLOGY LETTERS

Difference in virulence between fluconazole-susceptible and fluconazole-resistant Candida albicans in a mouse model

(2011) Bettina Schulz et al.   MYCOSES

Stress Alters Rates and Types of Loss of Heterozygosity in Candida albicans

(2011) A. Forche et al.   mBio

An A643V Amino Acid Substitution in Upc2p Contributes to Azole Resistance in Well-Characterized Clinical Isolates ofCandida albicans

(2010) Samantha J. Hoot et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Identification and Characterization of Four Azole-Resistant erg3 Mutants of Candida albicans

(2010) C. M. Martel et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Azole Drugs Are Imported By Facilitated Diffusion in Candida albicans and Other Pathogenic Fungi

(2010) Bryce E. Mansfield et al.   PLoS Pathogens

N-Acetylglucosamine Induces White to Opaque Switching, a Mating Prerequisite in Candida albicans

(2010) Guanghua Huang et al.   PLoS Pathogens

An A643T Mutation in the Transcription Factor Upc2p Causes Constitutive ERG11 Upregulation and Increased Fluconazole Resistance in Candida albicans

(2009) C. J. Heilmann et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Relative Contributions of the Candida albicans ABC Transporters Cdr1p and Cdr2p to Clinical Azole Resistance

(2009) S. Tsao et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

CO2 Regulates White-to-Opaque Switching in Candida albicans

(2009) Guanghua Huang et al.   CURRENT BIOLOGY

Functional Analysis ofcis- andtrans-Acting Elements of theCandida albicans CDR2Promoter with a Novel Promoter Reporter System

(2009) Alix T. Coste et al.   EUKARYOTIC CELL

Stress-Induced Phenotypic Switching in Candida albicans

(2009) Kevin Alby et al.   MOLECULAR BIOLOGY OF THE CELL

Acquisition of Aneuploidy Provides Increased Fitness during the Evolution of Antifungal Drug Resistance

(2009) Anna M. Selmecki et al.   PLoS Genetics

Increase of Virulence and Its Phenotypic Traits in Drug-Resistant Strains of Candida albicans

(2008) L. Angiolella et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Gain-of-Function Mutations in the Transcription Factor MRR1 Are Responsible for Overexpression of the MDR1 Efflux Pump in Fluconazole-Resistant Candida dubliniensis Strains

(2008) S. Schubert et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Genomewide Location Analysis ofCandida albicansUpc2p, a Regulator of Sterol Metabolism and Azole Drug Resistance

(2008) Sadri Znaidi et al.   EUKARYOTIC CELL

A Gain-of-Function Mutation in the Transcription Factor Upc2p Causes Upregulation of Ergosterol Biosynthesis Genes and Increased Fluconazole Resistance in a ClinicalCandida albicansIsolate

(2008) Nico Dunkel et al.   EUKARYOTIC CELL

Mutations in the multi-drug resistance regulatorMRR1, followed by loss of heterozygosity, are the main cause ofMDR1overexpression in fluconazole-resistantCandida albicansstrains

(2008) Nico Dunkel et al.   MOLECULAR MICROBIOLOGY

An isochromosome confers drug resistance in vivo by amplification of two genes, ERG11 and TAC1

(2008) Anna Selmecki et al.   MOLECULAR MICROBIOLOGY

The Parasexual Cycle in Candida albicans Provides an Alternative Pathway to Meiosis for the Formation of Recombinant Strains

(2008) Anja Forche et al.   PLOS BIOLOGY

Environmental Induction of White–Opaque Switching in Candida albicans

(2008) Bernardo Ramírez-Zavala et al.   PLoS Pathogens