Review
Integrative & Complementary Medicine
Lynda Doyle, Prabakaran Desomayanandam, Arun Bhuvanendran, Shefali Thanawala, Rajat Shah, Venkateswarlu Somepalli, Surendra Bachu
Summary: This article performs a systematic review and meta-analysis to evaluate the effective dose, safety, and efficacy of commercial turmeric extract and curcumin supplements in musculoskeletal health. The results show that turmeric extract and curcumin supplements can be effective adjuvants for the management of musculoskeletal health, with a low incidence of adverse events.
ALTERNATIVE THERAPIES IN HEALTH AND MEDICINE
(2023)
Review
Immunology
Liuting Zeng, Tiejun Yang, Kailin Yang, Ganpeng Yu, Jun Li, Wang Xiang, Hua Chen
Summary: Curcumin and Curcuma longa Extract may improve symptoms and inflammation levels in people with arthritis. However, the conclusions need to be interpreted carefully due to the low quality and small quantity of RCTs.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, General & Internal
Christina Abdel Shaheed, Wasim Awal, Geoffrey Zhang, Stephen E. Gilbert, Daniel Gallacher, Andrew McLachlan, Richard O. Day, Giovanni E. Ferreira, Caitlin Mp Jones, Harbeer Ahedi, Mamata Tamrakar, Fiona M. Blyth, Fiona Stanaway, Christopher G. Maher
Summary: This study evaluated the efficacy and safety of opioids for analgesic therapy in patients with osteoarthritis. The results show that opioids may provide very small pain and disability benefits, but also increase the risk of adverse events.
MEDICAL JOURNAL OF AUSTRALIA
(2022)
Review
Biochemistry & Molecular Biology
Liuting Zeng, Ganpeng Yu, Wensa Hao, Kailin Yang, Hua Chen
Summary: The study indicates that Curcuma longa extract and curcumin are effective and safe supplements for osteoarthritis patients, showing similar effects compared to placebo and NSAIDs. It is recommended for osteoarthritis patients to use Curcuma longa extract and curcumin supplements for an extended period.
BIOSCIENCE REPORTS
(2021)
Review
Chemistry, Medicinal
Bibi Marjan Razavi, Mahboobeh Ghasemzadeh Rahbardar, Hossein Hosseinzadeh
Summary: Turmeric and its active constituent, curcumin, possess anti-inflammatory, antinociceptive, and antioxidant effects, making them potentially effective in preventing and treating inflammatory disorders and pain. While literature and patents support their clinical application, further high-quality studies are needed to establish their clinical efficacy.
PHYTOTHERAPY RESEARCH
(2021)
Review
Plant Sciences
Ji Hee Jun, Tae-Young Choi, Nicola Robinson, Ji-Yeun Park, Eun-Young Jun, Kyeong Han Kim, Hye Won Lee, Myeong Soo Lee, Sunju Park
Summary: This study systematically evaluated the clinical efficacy and safety of warm needle acupuncture (WA) in the treatment of osteoarthritis (OA) through a systematic review and meta-analysis. The results showed that WA may have advantages in improving the symptoms of OA and can achieve better treatment outcomes compared to oral drugs or intra-articular injections. However, studies on this therapy still have issues of bias risk and low certainty of evidence, and further well-designed randomized controlled trials are needed for validation.
Review
Anesthesiology
Cameron Dickson, Rutger M. J. de Zoete, Carolyn Berryman, Philip Weinstein, Kexun Kenneth Chen, Paul Rothmore
Summary: The objective of this study was to identify and synthesize patient-related barriers to and enablers of high-value physiotherapy for chronic pain. The study also aimed to review patient-related interventions for facilitating the implementation of high-value physiotherapy for chronic pain and assess their efficacy.
Review
Biochemistry & Molecular Biology
Praneet Dara, Zeba Farooqui, Fackson Mwale, Chungyoul Choe, Andre J. van Wijnen, Hee-Jeong Im
Summary: Chronic pain conditions caused by arthritis have devastating effects on both individuals and society. The main objective of pharmacological treatments is to reduce pain, and several types of drugs have been considered. Naltrexone, an oral-activated opioid antagonist, has been shown to have beneficial effects on chronic pain conditions such as fibromyalgia and multiple sclerosis.
Review
Orthopedics
P. Solanki, S. M. Hussain, J. Abidi, J. Cheng, J. L. Fairley, M. J. Page, F. M. Cicuttini, A. E. Wluka
Summary: This study conducted a systematic review and data synthesis, showing that weight gain in adults is associated with increased clinical and structural KOA and TKR. Preventing weight gain should be considered to improve outcomes in KOA.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Review
Rheumatology
Diana Fonseca-Rodrigues, Andre Rodrigues, Teresa Martins, Joana Pinto, Diana Amorim, Armando Almeida, Filipa Pinto-Ribeiro
Summary: This study found a moderate positive correlation between pain severity and both anxious and depressive symptomatology in osteoarthritis (OA) patients through a systematic review and meta-analysis.
Review
Health Care Sciences & Services
Sameer Badri AL-Mhanna, Mahaneem Mohamed, Norhayati Mohd Noor, Monira Aldhahi, Hafeez Abiola Afolabi, Yahkub Babatunde Mutalub, Ahmad Adebayo Irekeola, Kizito Eneye Bello, Wan Syaheedah Wan Ghazali
Summary: The findings in this meta-analysis suggest that circuit training could effectively complement the conventional treatment of knee osteoarthritis, particularly in alleviating pain.
Article
Pharmacology & Pharmacy
Kailin Yang, Liuting Zeng, Zhiyong Long, Qi He, Wang Xiang, Anqi Ge, Huang Zhen, Wei Xiao, Jinwen Ge
Summary: This study evaluated the efficacy and safety of total glucosides of paeony (TGP) in the treatment of 5 types of inflammatory arthritis. The results showed that TGP can improve symptoms and inflammation levels in patients with inflammatory arthritis. However, larger and more high-quality clinical trials are still needed for further validation.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Rafael Tamborena Malheiros, Gabriela Escalante Brites, Elizandra Gomes Schmitt, Laura Smolski dos Santos, Genifer Erminda Schreiner, Silvia Muller de Moura Sarmento, Itamar Luis Goncalves, Morgana Duarte da Silva, Vanusa Manfredini
Summary: This study aimed to evaluate whether obesity associated with osteoarthritis (OA) may increase inflammation and pain. The results showed that obesity altered the nociceptive profile, increased systemic inflammatory cytokines, and reduced anti-inflammatory cytokines. When obesity occurred together with OA, the inflammatory progression was intensified, leading to increased pain scores.
Review
Integrative & Complementary Medicine
Zeinab Vafaeipour, Bibi Marjan Razavi, Hossein Hosseinzadeh
Summary: This paper provides an updated review on the effects of turmeric and its constituent, curcumin, on metabolic syndrome (MS). Studies have shown that turmeric and curcumin have beneficial effects on different components of MS, including anti-inflammatory, anti-oxidant, antidiabetic, antihyperlipidemic, anti-obesity, and antihypertensive effects. The findings suggest that turmeric or curcumin may serve as a complementary therapy for MS. However, more clinical trials are needed to confirm these effects.
JOURNAL OF INTEGRATIVE MEDICINE-JIM
(2022)
Review
Pharmacology & Pharmacy
Marta Bryk, Katarzyna Starowicz
Summary: The rising prevalence of arthritis is mainly attributed to an aging population and increased risk of civilization diseases like obesity. Current therapeutic strategies focus on pain relief and maintaining joint functionality, with stronger analgesics needed in advanced stages of the disease.
PHARMACOLOGICAL REPORTS
(2021)
