Article
Energy & Fuels
Yves Iradukunda, Guoying Wang, Xin Li, Gaofeng Shi, Yawen Hu, Fenfang Luo, Kaiqiang Yi, Abdalazeez Ismail Mohamed Albashir, Xiuli Niu, Zhijun Wu
Summary: The study presented a new method for producing mangosteen peels activated carbons with excellent electrochemical performance, attributed to their well-structured micro/mesoporous features. The optimized MPAC-1 exhibited a high specific capacitance and retention rate, indicating potential applications for green energy production in the future.
JOURNAL OF ENERGY STORAGE
(2021)
Article
Plant Sciences
Ching-Ching Wee, Nor Azlan Nor Muhammad, Vijay Kumar Subbiah, Masanori Arita, Yasukazu Nakamura, Hoe-Han Goh
Summary: This study reports the complete plastome of the Mesta variety of mangosteen cultivated in Malaysia, which is known for its flavor, texture, and seedlessness. Comparative analysis with other Garcinia plastomes found that the gene content, order, and orientation were highly conserved among the Garcinia species. These findings provide future references for species identification and phylogenomic analysis of the Garcinia genus.
Article
Multidisciplinary Sciences
Ching-Ching Wee, Nor Azlan Nor Muhammad, Vijay Kumar Subbiah, Masanori Arita, Yasukazu Nakamura, Hoe-Han Goh
Summary: This study reports the complete mitogenome of the Mesta variety of Garcinia mangostana L., which has great pharmaceutical potential. The mitogenome contains a total of 371,235 bp, with 1.7% possibly originating from plastid. The analysis of the mitogenome revealed various characteristics and evolutionary information about the Mesta variety.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Malgorzata Tokarska-Schlattner, Laurence Kay, Pascale Perret, Raffaella Isola, Stephane Attia, Frederic Lamarche, Cindy Tellier, Cecile Cottet-Rousselle, Amjad Uneisi, Isabelle Hininger-Favier, Marc Foretz, Herve Dubouchaud, Catherine Ghezzi, Christian Zuppinger, Benoit Viollet, Uwe Schlattner
Summary: AMPK, a key regulator of energy homeostasis, plays important roles in maintaining cardiac function under increased workload conditions. Deletion of AMPK genes in cardiomyocytes did not affect heart function under physiological conditions, but led to alterations in response to increased workload. AMPK deletion also resulted in decreased basal metabolic rate and locomotor activity, along with changes in cardiac mitochondrial function and bioenergetics.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Fiona M. Russell, David Grahame Hardie
Summary: AMP-activated protein kinase (AMPK) plays a crucial role in regulating cellular energy balance by promoting ATP production and inhibiting cell growth. It may restrain aberrant growth before tumorigenesis, but support the survival of cancer cells once cancer has arisen.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Veterinary Sciences
Xu-Yang Gao, Bu-Hao Deng, Xin-Rui Li, Yu Wang, Jian-Xin Zhang, Xiao-Yan Hao, Jun-Xing Zhao
Summary: The study found that melatonin enhances the formation of sheep brown adipocytes by activating AMPKα1, reducing lamb mortality and economic losses.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Pharmacology & Pharmacy
Mirielle C. Nauman, Jeremy J. Johnson
Summary: The purple mangosteen is a popular fruit in Southeast Asia that contains xanthones, which have significant anti-cancer and anti-tumor activities. Alpha-mangostin, the most abundant xanthone, has been extensively studied for its anticancer effects, while other xanthones and mangosteen extracts also show promise but their mechanisms of action are not well understood. Clinical anticancer activity of mangosteen products has not been evaluated.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Biology
Nabil Abdulhafiz Alhakamy, Gamal Abdallah Mohamed, Usama Ahmed Fahmy, Basma Ghazi Eid, Osama Abdelhakim Aly Ahmed, Mohammed Wanees Al-Rabia, Amgad Ibrahim Mansour Khedr, Mohammed Zahid Nasrullah, Sabrin Ragab Mohamed Ibrahim
Summary: Two new benzophenones were purified from the pericarps fraction of Garcinia mangostana and showed significant alpha-amylase inhibitory activity. Docking studies and molecular dynamics simulations further confirmed their potential as alpha-amylase inhibitors.
Article
Environmental Sciences
Zhenjie Sun, Wenhui Gu, Zezhong Feng, Yaqin Fan, Jianfeng Niu, Guangce Wang
Summary: This study elucidated the expression regulation mechanism of the heat shock protein 70 gene in Neopyropia yezoensis under high temperature stress. The findings showed the involvement of cAMP-dependent protein kinase and activating transcription factors element in the transcription regulation of the gene. In addition, AMPK was also found to play a role in the induction of the gene. Furthermore, posttranscriptional mechanisms were proposed to be involved in the synthesis regulation of the heat shock protein 70-2 protein.
FRONTIERS IN MARINE SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Yiguang Lin, Huijun Ji, Xiaocong Cao, Yongjie Cen, Yumei Chen, Shuangshun Ji, Sichun Zheng
Summary: Insecticides are commonly used to control the serious pest Nilaparvata lugens in rice fields, but their repeated application can have negative effects. A study found that AMP-activated protein kinase (AMPK) plays a crucial role in maintaining energy metabolism and responding to insecticide treatment in N. lugens. Knockdown of NlAMPK alpha significantly enhanced the insecticidal efficiency of pymetrozine against N. lugens.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2021)
Article
Plant Sciences
Alexander Th Wu, Yuan-Chieh Yeh, Yan-Jiun Huang, Ntlotlang Mokgautsi, Bashir Lawal, Tse-Hung Huang
Summary: This study evaluated the therapeutic potential of gamma-mangostin (gMG) isolated from Garcinia mangostana in colorectal cancer (CRC). The results showed that gMG suppressed CRC carcinogenesis and stemness by downregulating GSK3 beta-catenin/CDK6 signaling and upregulating the miR-26b-5p tumor suppressor. In an animal model, gMG reduced tumor growth and overcame chemotherapy resistance induced by cancer-associated fibroblasts (CAFs).
Article
Pharmacology & Pharmacy
Hui Quan, Mei Yin, Joungmin Kim, Eun-A Jang, Si-Ho Yang, Hong-Beom Bae, Seongtae Jeong
Summary: Resveratrol has beneficial effects on sepsis by regulating the inflammatory response, but its role in the development of endotoxin tolerance remains unclear. It has been found that resveratrol inhibits the expression of IRAK-M and SHIP1 through AMPK activation, suppressing the development of endotoxin tolerance.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Nathamon Suksamran, Visaka Anantawat, Phanphen Wattanaarsakit, Chen Wei, Md. Atiar Rahman, Hideyuki J. Majima, Jitbanjong Tangpong
Summary: Mangosteen vinegar produced through steam distillation has higher antioxidant activity and contains abundant phenolic compounds. Compared to apple cider vinegar, mangosteen vinegar exhibited higher total phenolic content, total flavonoid content, and free radical scavenging activity. HPLC analysis revealed the presence of various phenolic compounds in mangosteen vinegar, which were found to be higher than those in apple cider vinegar. Mangosteen vinegar received higher acceptance in sensory evaluation.
Article
Energy & Fuels
Peng Guang Lim, Choon Yoong Cheok, Jing Yao Sum, Min Kaung Htet Ko Ko
Summary: This study investigates the feasibility of non-thermal sequential ultrafiltration-nanofiltration for concentrating mangosteen rind extract. The results show that both ultrafiltration and nanofiltration have high rejection towards total monomeric anthocyanin (TMA) and total phenolic content (TPC), with rates above 75% and 86%, respectively. Acidified solvents enhance the release of anthocyanin and phenolic contents but also result in membrane fouling and lower permeability.
BIOMASS CONVERSION AND BIOREFINERY
(2023)
Article
Multidisciplinary Sciences
Tae-Jun Song, Choon-Ho Park, Kyu-Ree In, Jong-Bae Kim, Joo Hee Kim, Miran Kim, Hye Jin Chang
Summary: Betulinic acid (BA) is a naturally occurring compound with various biological effects including anti-malarial, anti-inflammatory, anti-cancer, and recently discovered anti-obesity and anti-diabetic activities. BA activates AMPK, leading to reduced blood glucose levels, increased glucose uptake, and enhanced endurance in mice, indicating its therapeutic potential for diabetes.
Article
Plant Sciences
Piseth Nhoek, Hee-Sung Chae, Young-Mi Kim, Pisey Pel, Jungmoo Huh, Hyun Woo Kim, Young Hee Choi, Kyeong Lee, Young-Won Chin
Summary: A phytochemical investigation of the methanol extract of Salvia plebeia led to the identification of 19 compounds, including new norsesquiterpene and eudesmane sesquiterpenoids. While most compounds did not inhibit the PCSK9-LDLR interactions, compounds 1, 9, and 10 were found to downregulate PCSK9 mRNA expression.
JOURNAL OF NATURAL PRODUCTS
(2021)
Article
Pharmacology & Pharmacy
Young Hee Choi, Chao Zhang, Zhenzhen Liu, Mei-Juan Tu, Ai-Xi Yu, Ai-Ming Yu
Summary: This study developed a novel pharmacokinetic (PK)-pharmacodynamic (PD) model for assessing combination treatment by considering contributions from individual drugs, and incorporated the combination index method to define in vivo synergism accurately. The research found that sorafenib contributed more to tumor growth inhibition compared to coadministered doxorubicin, explaining previously inexplicable clinical observations. This model and strategy will have broad applications in translational research for identifying optimal dosage combinations with stronger synergy to improve therapeutic outcomes.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2021)
Correction
Pharmacology & Pharmacy
Young Hee Choi, Young-Won Chin
Article
Biochemistry & Molecular Biology
Jongmin Ahn, Hee-Sung Chae, Pisey Pel, Young-Mi Kim, Young Hee Choi, Jinwoong Kim, Young-Won Chin
Summary: Natural products have been important in drug discovery, but traditional strategies for evaluating them are costly and time-consuming. The use of MS/MS-based molecular networking strategy with in silico annotation tool can accelerate the dereplication of secondary metabolites. In this study, two new dilignans were discovered from Magnolia obovata Thunb., showing potent lipid controlling activities and detailed insight into lipid metabolism caused by one of the compounds was obtained through bioinformatic analysis.
Article
Biochemistry & Molecular Biology
Mingoo Bae, Seung Yon Han, Eun-Sun Kim, Byung Hoon You, Young-Mi Kim, Jungsook Cho, Young-Won Chin, Young Hee Choi
Summary: The combination of water extract of mangosteen pericarp (WMP) and donepezil (DNP) for Alzheimer's disease (AD) treatment showed a stronger inhibitory effect on neurotoxicity induced by A beta((25-35)) compared to donepezil alone. WMP increased the concentration of donepezil in the brain without affecting systemic exposure, suggesting a potential therapeutic benefit for AD.
Article
Chemistry, Multidisciplinary
Pisey Pel, Hee-Sung Chae, Piseth Nhoek, Young-Mi Kim, Chae-Yeong An, Hunseung Yoo, Minseok Kang, Hyun Woo Kim, Young Hee Choi, Young-Won Chin
Summary: This study investigated bioactive molecules from Sophora tonkinensis that inhibit PCSK9 expression. A new compound was identified and its absolute configuration was determined. The compound inhibited PCSK9 expression by down-regulating HNF1 alpha and SREBPs.
Article
Biochemistry & Molecular Biology
Phuong Linh Nguyen, Ahmed Elkamhawy, Young Hee Choi, Chang Hoon Lee, Kyeong Lee, Jungsook Cho
Summary: The study evaluated the antitumor effects of a series of CA inhibitors on various cancer cell lines, identifying two compounds with potent anticancer activity against breast cancer cells MCF-7 and SK-BR-3, especially in combination with DOX, demonstrating synergistic cytotoxic effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Seungchan An, Seok Young Hwang, Junpyo Gong, Sungjin Ahn, In Guk Park, Soyeon Oh, Young-Won Chin, Minsoo Noh
Summary: In this study, a machine-learning model was developed to predict the adiponectin-secretion-promoting activity of flavonoid-associated phytochemicals (FAPs). By establishing a structure-activity relationship model and a multiple linear regression model, the adiponectin activity of FAPs was successfully predicted and validated through experimental validation, providing a computational reconstruction method for phenotype-based screening systems.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2023)
Article
Plant Sciences
Young-Won Chin, Piseth Nhoek, Sungjin Ahn, Pisey Pel, Young-Mi Kim, Jungmoo Huh, Hyun Woo Kim, Minsoo Noh
Summary: Five new quinoline alkaloids (1, 2, 4, 8, and 9) and three new coumarins (15, 17, and 19), along with 20 known compounds, were identified from a methanol extract of Orixa japonica leaves. The structures were determined using NMR spectroscopic data analysis. Compound 19's absolute configuration was proposed using electronic circular dichroism calculation. Compound 4 and 12 were found to stimulate adiponectin secretion in human bone marrow mesenchymal stem cells, with EC50 values of 13.8 and 25.8 mu M, respectively. Compound 4 and 12 were also identified as selective PPARy agonists based on PPARy binding assay and molecular modeling.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Pharmacology & Pharmacy
Byoung Hoon You, Mingoo Bae, Seung Yon Han, Jieun Jung, Kiwon Jung, Young Hee Choi
Summary: The pharmacokinetic feasibility of the stability-enhanced SESS-TD crystal was evaluated and found to be comparable to TDF, with no changes observed even after 12 months of storage. This suggests that the SESS-TD crystal may have enough pharmacokinetic feasibility to replace TDF.
Article
Pharmacology & Pharmacy
Seo-Yeon Kim, Byung Hoon You, Mingoo Bae, Seung Yon Han, Kiwon Jung, Young Hee Choi
Summary: This study aimed to characterize the pharmacokinetic profiles of co-amorphous dispersions of Mirabegron (MBR) in rats and mice. The results showed that these co-amorphous dispersions can improve the relative bioavailability and area under the curve of MBR.
Article
Pharmacology & Pharmacy
Jina Kim, Young-Won Chin
Summary: The prevalence of antimicrobial-resistant bacteria poses a global challenge. Methicillin-resistant Staphylococcus aureus (MRSA), a leading cause of infections, forms biofilms on medical devices, making them more resistant to antibiotics. A study investigated the use of Raman spectroscopy to monitor MRSA biofilm formation and found that Eugenol, when applied within the first 5 hours of biofilm formation, showed promise in breaking down the biofilm. The study also demonstrated the efficacy of Raman spectroscopy coupled with principal component analysis (PCA) in identifying planktonic bacteria from biofilm conglomerates.
Article
Chemistry, Organic
Hongic Won, Min-Gyung Son, Pisey Pel, Piseth Nhoek, Chae-Yeong An, Young-Mi Kim, Hee-Sung Chae, Young-Won Chin
Summary: Six new flavanones and fourteen known compounds were isolated from the methanol extract of Morus alba root bark. Betulinic acid (13) showed potent regulatory activity on PCSK9 and LDLR at both mRNA and protein levels, and it also inhibited PCSK9 secretion, indicating its potential as a future PCSK9 synthesis inhibitor.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Seung Yon Han, Jeong-Eun Yu, Byoung Hoon You, Seo-Yeon Kim, Mingoo Bae, Hee-Sung Chae, Young-Won Chin, Soo-Hwa Hong, Ju-Hee Lee, Seung Hyun Jung, Young Hee Choi
Summary: In a mouse model, the combination of trastuzumab and H9 extract for breast cancer treatment showed no changes in trastuzumab pharmacokinetics, indicating that H9 does not affect the exposure of trastuzumab.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)