The evolution and polymorphism of mono-amino acid repeats in androgen receptor and their regulatory role in health and disease

Antisense oligonucleotides as a potential treatment for brain deficits observed in myotonic dystrophy type 1

(2022) Siham Ait Benichou et al.   GENE THERAPY

PROTAC targeted protein degraders: the past is prologue

(2022) Miklós Békés et al.   NATURE REVIEWS DRUG DISCOVERY

Poly-glutamine-dependent self-association as a potential mechanism for regulation of androgen receptor activity

(2022) Carlos M. Roggero et al.   PLoS One

Modifier pathways in polyglutamine (PolyQ) diseases: from genetic screens to drug targets

(2022) Marta Daniela Costa et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A dual conditional CRISPR-Cas9 system to activate gene editing and reduce off-target effects in human stem cells

(2022) Seung Bum Park et al.   Molecular Therapy-Nucleic Acids

Targeting Oncoproteins for Degradation by Small Molecule-Based Proteolysis-Targeting Chimeras (PROTACs) in Sex Hormone-Dependent Cancers

(2022) Li Liu et al.   Frontiers in Endocrinology

Anti-Androgen Receptor Therapies in Prostate Cancer: A Brief Update and Perspective

(2022) Jian Huang et al.   Frontiers in Oncology

Phase Separation Properties in Transcriptional Organization

(2022) Chenghao Guo et al.   BIOCHEMISTRY

Genetics of amyotrophic lateral sclerosis: seeking therapeutic targets in the era of gene therapy

(2022) Naoki Suzuki et al.   JOURNAL OF HUMAN GENETICS

Possible Co-Evolution of Polyglutamine and Polyproline in Huntingtin Protein: Proline-Rich Domain as Transient Folding Chaperone

(2022) Leili Zhang et al.   Journal of Physical Chemistry Letters

A detailed characterization of stepwise activation of the androgen receptor variant 7 in prostate cancer cells

(2021) Carlos M. Roggero et al.   ONCOGENE

Phasing the intranuclear organization of steroid hormone receptors

(2021) Martin Stortz et al.   BIOCHEMICAL JOURNAL

Shorter androgen receptor polyQ alleles protect against life-threatening COVID-19 disease in European males

(2021) Margherita Baldassarri et al.   EBioMedicine

Reimagining Druggability Using Chemoproteomic Platforms

(2021) Jessica N. Spradlin et al.   ACCOUNTS OF CHEMICAL RESEARCH

Combating deleterious phase transitions in neurodegenerative disease

(2021) April L. Darling et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

DNA ‐binding domain as the minimal region driving RNA ‐dependent liquid–liquid phase separation of androgen receptor

(2021) Junaid Ahmed et al.   PROTEIN SCIENCE

Simple biochemical features underlie transcriptional activation domain diversity and dynamic, fuzzy binding to Mediator

(2021) Adrian L Sanborn et al.   eLife

LncRNAs: Architectural Scaffolds or More Potential Roles in Phase Separation

(2021) Jie Luo et al.   Frontiers in Genetics

Androgen Receptor-Related Non-coding RNAs in Prostate Cancer

(2021) Yongyong Yang et al.   Frontiers in Cell and Developmental Biology

Intrinsically disordered proteins and biomolecular condensates as drug targets

(2021) Mateusz Biesaga et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

The long journey to bring a Myc inhibitor to the clinic

(2021) Jonathan R. Whitfield et al.   JOURNAL OF CELL BIOLOGY

A condensate-hardening drug blocks RSV replication in vivo

(2021) Jennifer Risso-Ballester et al.   NATURE

Highly accurate protein structure prediction with AlphaFold

(2021) John Jumper et al.   NATURE

Gene therapy with AR isoform 2 rescues spinal and bulbar muscular atrophy phenotype by modulating AR transcriptional activity

(2021) Wooi F. Lim et al.   Science Advances

Transcription Regulators and Membraneless Organelles Challenges to Investigate Them

(2021) Katarzyna Sołtys et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models

(2021) Mihaly Varadi et al.   NUCLEIC ACIDS RESEARCH

The Eukaryotic Linear Motif resource: 2022 release

(2021) Manjeet Kumar et al.   NUCLEIC ACIDS RESEARCH

Androgen receptor and MYC equilibration centralizes on developmental super-enhancer

(2021) Haiyang Guo et al.   Nature Communications

Influence of polygenic risk scores for schizophrenia and resilience on the cognition of individuals at-risk for psychosis

(2021) Qin He et al.   Translational Psychiatry

Time-controlled and muscle-specific CRISPR/Cas9-mediated deletion of CTG-repeat expansion in the DMPK gene

(2021) Beatrice Cardinali et al.   Molecular Therapy-Nucleic Acids

Discovery of drugs that directly target the intrinsically disordered region of the androgen receptor

(2020) Marianne D. Sadar   Expert Opinion on Drug Discovery

Androgen receptor with short polyglutamine tract preferably enhances Wnt/β-catenin-mediated prostatic tumorigenesis

(2020) Yongfeng He et al.   ONCOGENE

Targeting the Oncogenic Long Non-coding RNA SLNCR1 by Blocking Its Sequence-Specific Binding to the Androgen Receptor

(2020) Karyn Schmidt et al.   Cell Reports

Unblending of Transcriptional Condensates in Human Repeat Expansion Disease

(2020) Shaon Basu et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Darolutamide antagonizes androgen signaling by blocking enhancer and super‐enhancer activation

(2020) Simon J. Baumgart et al.   Molecular Oncology

Unraveling the molecular interactions involved in phase separation of glucocorticoid receptor

(2020) Martin Stortz et al.   BMC BIOLOGY

Correction of amyotrophic lateral sclerosis related phenotypes in induced pluripotent stem cell-derived motor neurons carrying a hexanucleotide expansion mutation in C9orf72 by CRISPR/Cas9 genome editing using homology-directed repair

(2020) Nidaa A Ababneh et al.   HUMAN MOLECULAR GENETICS

Therapeutic antisense oligonucleotides for movement disorders

(2020) Epaminondas Doxakis   MEDICINAL RESEARCH REVIEWS

Structural Insights of Transcriptionally Active, Full-Length Androgen Receptor Coactivator Complexes

(2020) Xinzhe Yu et al.   MOLECULAR CELL

Advances in oligonucleotide drug delivery

(2020) Thomas C. Roberts et al.   NATURE REVIEWS DRUG DISCOVERY

RNA contributions to the form and function of biomolecular condensates

(2020) Christine Roden et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Uncoupling DNA damage from chromatin damage to detoxify doxorubicin

(2020) Xiaohang Qiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sex hormones signal why virus hits men harder

(2020) Meredith Wadman   SCIENCE

Biomolecular Condensates in the Nucleus

(2020) Benjamin R. Sabari et al.   TRENDS IN BIOCHEMICAL SCIENCES

CRISPR-Cas9 Gene Editing of Hematopoietic Stem Cells from Patients with Friedreich’s Ataxia

(2020) Celine J. Rocca et al.   Molecular Therapy-Methods & Clinical Development

Androgen receptor genetic variant predicts COVID‐19 disease severity: a prospective longitudinal study of hospitalized COVID‐19 male patients

(2020) J. McCoy et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Aberrant activation of super enhancer and choline metabolism drive antiandrogen therapy resistance in prostate cancer

(2020) Simeng Wen et al.   ONCOGENE

Role and therapeutic potential of liquid‒liquid phase separation in amyotrophic lateral sclerosis

(2020) Donya Pakravan et al.   Journal of Molecular Cell Biology

SEX DISPARITIES IN COVID-19 SEVERITY AND OUTCOME: ARE MEN WEAKER OR WOMEN STRONGER?

(2020) Rosario Pivonello et al.   NEUROENDOCRINOLOGY

UniProt: the universal protein knowledgebase in 2021

(2020) et al.   NUCLEIC ACIDS RESEARCH

The number of glutamines in the N‐terminal of the canine androgen receptor affects signalling intensities

(2020) Kazuhiko Ochiai et al.   Veterinary and Comparative Oncology

The Impact of African Ancestry on Prostate Cancer Disparities in the Era of Precision Medicine

(2020) Deyana D. Lewis et al.   Genes

Antisense oligonucleotide and adjuvant exercise therapy reverse fatigue in old mice with myotonic dystrophy

(2020) Ningyan Hu et al.   Molecular Therapy-Nucleic Acids

Side chain to main chain hydrogen bonds stabilize a polyglutamine helix in a transcription factor

(2019) Albert Escobedo et al.   Nature Communications

The lncRNA SLNCR Recruits the Androgen Receptor to EGR1-Bound Genes in Melanoma and Inhibits Expression of Tumor Suppressor p21

(2019) Karyn Schmidt et al.   Cell Reports

CRISPR/Cas Applications in Myotonic Dystrophy: Expanding Opportunities

(2019) Renée H.L. Raaijmakers et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

CRISPR-Cas9-mediated genome editing increases lifespan and improves motor deficits in a Huntington’s disease mouse model

(2019) Freja K. Ekman et al.   Molecular Therapy-Nucleic Acids

ATTEC: a potential new approach to target proteinopathies

(2019) Zhaoyang Li et al.   Autophagy

MicroRNA-Based Therapeutic Perspectives in Myotonic Dystrophy

(2019) Arturo López Castel et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

ipyrad: Interactive assembly and analysis of RADseq datasets

(2019) Deren A R Eaton et al.   BIOINFORMATICS

Evolution of the androgen receptor: Perspectives from human health to dancing birds

(2019) Eric R. Schuppe et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Emerging antisense oligonucleotide and viral therapies for amyotrophic lateral sclerosis

(2018) Cindy V. Ly et al.   CURRENT OPINION IN NEUROLOGY

Regulation of Androgen Receptor Activity by Transient Interactions of Its Transactivation Domain with General Transcription Regulators

(2018) Eva De Mol et al.   STRUCTURE

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Targeting intrinsically disordered proteins at the edge of chaos

(2018) Hao Ruan et al.   DRUG DISCOVERY TODAY

Cancer Mutations of the Tumor Suppressor SPOP Disrupt the Formation of Active, Phase-Separated Compartments

(2018) Jill J. Bouchard et al.   MOLECULAR CELL

Phase-separation mechanism for C-terminal hyperphosphorylation of RNA polymerase II

(2018) Huasong Lu et al.   NATURE

Transcription Factors Activate Genes through the Phase-Separation Capacity of Their Activation Domains

(2018) Ann Boija et al.   CELL

Structure and dynamics conspire in the evolution of affinity between intrinsically disordered proteins

(2018) Per Jemth et al.   Science Advances

CRISPR/Cas9 Editing of the Mutant Huntingtin Allele In Vitro and In Vivo

(2017) Alex Mas Monteys et al.   MOLECULAR THERAPY

Biomolecular condensates: organizers of cellular biochemistry

(2017) Salman F. Banani et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Protein complex scaffolding predicted as a prevalent function of long non-coding RNAs

(2017) Diogo M Ribeiro et al.   NUCLEIC ACIDS RESEARCH

Structure of the homodimeric androgen receptor ligand-binding domain

(2017) Marta Nadal et al.   Nature Communications

Androgen receptor gene polymorphisms and risk of prostate cancer: a meta-analysis

(2017) Hong Weng et al.   Scientific Reports

The number of CAG and GGN triplet repeats in the Androgen Receptor gene exert combinatorial effect on hormonal and sperm parameters in young men

(2017) M. Grigorova et al.   Andrology

EPI-001, A Compound Active against Castration-Resistant Prostate Cancer, Targets Transactivation Unit 5 of the Androgen Receptor

(2016) Eva De Mol et al.   ACS Chemical Biology

Sequence Context Influences the Structure and Aggregation Behavior of a PolyQ Tract

(2016) Bahareh Eftekharzadeh et al.   BIOPHYSICAL JOURNAL

Cancer statistics for African Americans, 2016: Progress and opportunities in reducing racial disparities

(2016) Carol E. DeSantis et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Second-Generation HSP90 Inhibitor Onalespib Blocks mRNA Splicing of Androgen Receptor Variant 7 in Prostate Cancer Cells

(2016) R. Ferraldeschi et al.   CANCER RESEARCH

No effect ofARpolyG polymorphism on spinal and bulbar muscular atrophy phenotype

(2016) C. Bertolin et al.   EUROPEAN JOURNAL OF NEUROLOGY

Permanent inactivation of Huntington's disease mutation by personalized allele-specific CRISPR/Cas9

(2016) Jun Wan Shin et al.   HUMAN MOLECULAR GENETICS

Refinement of the androgen response element based on ChIP-Seq in androgen-insensitive and androgen-responsive prostate cancer cell lines

(2016) Stephen Wilson et al.   Scientific Reports

The lncRNA SLNCR1 Mediates Melanoma Invasion through a Conserved SRA1-like Region

(2016) Karyn Schmidt et al.   Cell Reports

Variation in CAG and GGN repeat lengths and CAG/GGN haplotype in androgen receptor gene polymorphism and prostate carcinoma in Nigerians

(2016) O. Akinloye et al.   BRITISH JOURNAL OF BIOMEDICAL SCIENCE

DisCons: a novel tool to quantify and classify evolutionary conservation of intrinsic protein disorder

(2015) Mihaly Varadi et al.   BMC BIOINFORMATICS

Integrative Clinical Genomics of Advanced Prostate Cancer

(2015) Dan Robinson et al.   CELL

Short linear motifs – ex nihilo evolution of protein regulation

(2015) Norman E. Davey et al.   Cell Communication and Signaling

Variable Glutamine-Rich Repeats Modulate Transcription Factor Activity

(2015) Rita Gemayel et al.   MOLECULAR CELL

Identification of a Novel Coregulator, SH3YL1, That Interacts With the Androgen Receptor N-Terminus

(2015) Alicia M. Blessing et al.   MOLECULAR ENDOCRINOLOGY

The landscape of long noncoding RNAs in the human transcriptome

(2015) Matthew K Iyer et al.   NATURE GENETICS

Androgen signaling is a confounding factor for β-catenin-mediated prostate tumorigenesis

(2015) S H Lee et al.   ONCOGENE

Partial androgen insensitivity syndrome with persistent müllerian remnants. A case report

(2015) Francisca Bermejo-Costa et al.   Endocrinologia y Nutricion

Androgen receptor splice variants activating the full-length receptor in mediating resistance to androgen-directed therapy

(2015) Bo Cao et al.   Oncotarget

RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies

(2014) Alexandros Stamatakis   BIOINFORMATICS

Nuclear Receptors, RXR, and the Big Bang

(2014) Ronald M. Evans et al.   CELL

Reversible Amyloid Fiber Formation in the N Terminus of Androgen Receptor

(2014) Julia Asencio-Hernández et al.   CHEMBIOCHEM

The N-terminal domain of the androgen receptor drives its nuclear localization in castration-resistant prostate cancer cells

(2014) Javid A. Dar et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Identification of a new androgen receptor (AR) co-regulator BUD31 and related peptides to suppress wild-type and mutated AR-mediated prostate cancer growth via peptide screening and X-ray structure analysis

(2014) Cheng-Lung Hsu et al.   Molecular Oncology

Polyglutamine-expanded androgen receptor interferes with TFEB to elicit autophagy defects in SBMA

(2014) Constanza J Cortes et al.   NATURE NEUROSCIENCE

Allele-Specific Suppression of Mutant Huntingtin Using Antisense Oligonucleotides: Providing a Therapeutic Option for All Huntington Disease Patients

(2014) Niels H. Skotte et al.   PLoS One

Promoter-Dependent Activity on Androgen Receptor N-Terminal Domain Mutations in Androgen Insensitivity Syndrome

(2014) Rieko Tadokoro-Cuccaro et al.   Sexual Development

Conserved sequence-specific lincRNA–steroid receptor interactions drive transcriptional repression and direct cell fate

(2014) William H. Hudson et al.   Nature Communications

Have androgen receptor gene CAG and GGC repeat polymorphisms an effect on sperm motility in infertile men?

(2013) N. delli Muti et al.   ANDROLOGIA

Integrative Genomic Analyses Reveal an Androgen-Driven Somatic Alteration Landscape in Early-Onset Prostate Cancer

(2013) Joachim Weischenfeldt et al.   CANCER CELL

Phylogenomic Analyses Elucidate the Evolutionary Relationships of Bats

(2013) Georgia Tsagkogeorga et al.   CURRENT BIOLOGY

Long Non-Coding RNAs and Complex Human Diseases

(2013) Jing Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Enhanced Aggregation of Androgen Receptor in Induced Pluripotent Stem Cell-derived Neurons from Spinal and Bulbar Muscular Atrophy

(2013) Yoshihiro Nihei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Non-linear association between androgen receptor CAG and GGN repeat lengths and reproductive parameters in fertile European and Inuit men

(2013) L.J.S. Brokken et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Unmasking the roles of N- and C-terminal flanking sequences from exon 1 of huntingtin as modulators of polyglutamine aggregation

(2013) S. L. Crick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Androgen receptor splice variants are resistant to inhibitors of Hsp90 and FKBP52, which alter androgen receptor activity and expression

(2013) Ayesha A. Shafi et al.   STEROIDS

Two new graphical methods for mapping trait evolution on phylogenies

(2013) Liam J. Revell   Methods in Ecology and Evolution

Toxic and non-toxic aggregates from the SBMA and normal forms of androgen receptor have distinct oligomeric structures

(2012) Tobias Jochum et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Cell-free Formation of RNA Granules: Low Complexity Sequence Domains Form Dynamic Fibers within Hydrogels

(2012) Masato Kato et al.   CELL

Evaluation of the effects of androgen receptor gene trinucleotide repeats and prostate-specific antigen gene polymorphisms on prostate cancer

(2012) D. Alptekin et al.   GENETICS AND MOLECULAR RESEARCH

Potent activity of the Hsp90 inhibitor ganetespib in prostate cancer cells irrespective of androgen receptor status or variant receptor expression

(2012) SUQIN HE et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Ethnic Variation in Allele Distribution of the Androgen Receptor (AR) (CAG)n Repeat

(2012) C. M. Ackerman et al.   JOURNAL OF ANDROLOGY

Androgen Receptor Splice Variants Activate Androgen Receptor Target Genes and Support Aberrant Prostate Cancer Cell Growth Independent of Canonical Androgen Receptor Nuclear Localization Signal

(2012) Siu Chiu Chan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Stress Response Mediator ATF3 Represses Androgen Signaling by Binding the Androgen Receptor

(2012) H. Wang et al.   MOLECULAR AND CELLULAR BIOLOGY

Resolving conflict in eutherian mammal phylogeny using phylogenomics and the multispecies coalescent model

(2012) S. Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of the androgen receptor CAG repeat polymorphism in prostate cancer, and spinal and bulbar muscular atrophy

(2011) R. Kumar et al.   LIFE SCIENCES

Structural basis for nuclear hormone receptor DNA binding

(2011) Christine Helsen et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Is G→T substitution in the sequence of CAG repeats within the androgen receptor gene associated with aggressive behaviour in the red foxVulpes vulpes?

(2010) Piotr Gronek et al.   ACTA THERIOLOGICA

Novel (60%) and Recurrent (40%) Androgen Receptor Gene Mutations in a Series of 59 Patients with a 46,XY Disorder of Sex Development

(2010) L. Audi et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Castration resistance in human prostate cancer is conferred by a frequently occurring androgen receptor splice variant

(2010) Shihua Sun et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanism of Cis-Inhibition of PolyQ Fibrillation by PolyP: PPII Oligomers and the Hydrophobic Effect

(2009) Gregory D. Darnell et al.   BIOPHYSICAL JOURNAL

Evolutionary History and Functional Characterization of Androgen Receptor Genes in Jawed Vertebrates

(2009) Yukiko Ogino et al.   ENDOCRINOLOGY

Androgen Receptor CAG Repeat Polymorphisms in Canine Prostate Cancer

(2009) C.-L. Lai et al.   JOURNAL OF VETERINARY INTERNAL MEDICINE

Comparing Models of Evolution for Ordered and Disordered Proteins

(2009) C. J. Brown et al.   MOLECULAR BIOLOGY AND EVOLUTION

The androgen receptor gene polyglycine repeat polymorphism is associated with memory performance in healthy Chinese individuals

(2009) Denes Kovacs et al.   PSYCHONEUROENDOCRINOLOGY

Functional Characterization of the Native NH2-Terminal Transactivation Domain of the Human Androgen Receptor: Binding Kinetics for Interactions with TFIIF and SRC-1a†

(2008) Derek N. Lavery et al.   BIOCHEMISTRY

Ligand-Independent Androgen Receptor Variants Derived from Splicing of Cryptic Exons Signify Hormone-Refractory Prostate Cancer

(2008) R. Hu et al.   CANCER RESEARCH

Androgen receptor and Kennedy disease/spinal bulbar muscular atrophy

(2008) Douglas Ashley Monks et al.   HORMONES AND BEHAVIOR

The androgen receptor CAG and GGN repeat polymorphisms and prostate cancer susceptibility in African-American men: results from the Flint Men’s Health Study

(2008) Ethan M. Lange et al.   JOURNAL OF HUMAN GENETICS

Consequences of poly-glutamine repeat length for the conformation and folding of the androgen receptor amino-terminal domain

(2008) Philippa Davies et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Short alleles of both GGN and CAG repeats at the exon-1 of the androgen receptor gene are associated to increased PSA staining and a higher Gleason score in human prostatic cancer

(2008) Germán Rodríguez-González et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Does Race Affect Postoperative Outcomes in Patients With Low-Risk Prostate Cancer Who Undergo Radical Prostatectomy?

(2008) M.J. Resnick et al.   UROLOGY