Drug-Initiated Activity Metabolomics Identifies Myristoylglycine as a Potent Endogenous Metabolite for Human Brown Fat Differentiation

Apoptotic brown adipocytes enhance energy expenditure via extracellular inosine

(2022) Birte Niemann et al.   NATURE

Identification of bioactive metabolites using activity metabolomics

(2019) Markus M. Rinschen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Autonomous METLIN-Guided In-source Fragment Annotation for Untargeted Metabolomics

(2019) Xavier Domingo-Almenara et al.   ANALYTICAL CHEMISTRY

Inosine pranobex enhances human NK cell cytotoxicity by inducing metabolic activation and NKG2D ligand expression

(2019) Michael T. McCarthy et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Discovery of Small Molecules for the Reversal of T Cell Exhaustion

(2019) Brett S. Marro et al.   Cell Reports

METLIN: A Technology Platform for Identifying Knowns and Unknowns

(2018) Carlos Guijas et al.   ANALYTICAL CHEMISTRY

Discovery of Hydrolysis-Resistant Isoindoline N-Acyl Amino Acid Analogues that Stimulate Mitochondrial Respiration

(2018) Hua Lin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Analyses of the genetic diversity and protein expression variation of the acyl: CoA medium-chain ligases, ACSM2A and ACSM2B

(2018) Rencia van der Sluis   MOLECULAR GENETICS AND GENOMICS

Metabolomics activity screening for identifying metabolites that modulate phenotype

(2018) Carlos Guijas et al.   NATURE BIOTECHNOLOGY

Ablation of PM20D1 revealsN-acyl amino acid control of metabolism and nociception

(2018) Jonathan Z. Long et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The ReFRAME library as a comprehensive drug repurposing library and its application to the treatment of cryptosporidiosis

(2018) Jeff Janes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New insights into the catalytic mechanism of human glycine N-acyltransferase

(2017) Rencia van der Sluis et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

A relative quantitative positive/negative ion switching method for untargeted lipidomics via high resolution LC-MS/MS from any biological source

(2017) Susanne B. Breitkopf et al.   Metabolomics

Metabolomics-based discovery of a metabolite that enhances oligodendrocyte maturation

(2017) Brittney A Beyer et al.   Nature Chemical Biology

Specific Interaction of the Human Mitochondrial Uncoupling Protein 1 with Free Long-Chain Fatty Acid

(2017) Linlin Zhao et al.   STRUCTURE

Critical role for cytosolic group IVA phospholipase A 2 in early adipocyte differentiation and obesity

(2016) Lucía Peña et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The Secreted Enzyme PM20D1 Regulates Lipidated Amino Acid Uncouplers of Mitochondria

(2016) Jonathan Z. Long et al.   CELL

GlycineN-acyltransferase-like 3 is responsible for long-chainN-acylglycine formation in N18TG2cells

(2016) Kristen A. Jeffries et al.   JOURNAL OF LIPID RESEARCH

Urinary metabolic profile predicts high-fat diet sensitivity in the C57Bl6/J mouse

(2016) Juliette Fedry et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

The Obesity Epidemic — Understanding the Disease and the Treatment

(2016) Caroline M. Apovian   NEW ENGLAND JOURNAL OF MEDICINE

Brown adipose tissue: a potential target in the fight against obesity and the metabolic syndrome

(2015) L. Poekes et al.   CLINICAL SCIENCE

A new perspective on the importance of glycine conjugation in the metabolism of aromatic acids

(2014) Christoffel Petrus Stephanus Badenhorst et al.   DRUG METABOLISM REVIEWS

Taking control over intracellular fatty acid levels is essential for the analysis of thermogenic function in cultured primary brown and brite/beige adipocytes

(2014) Y. Li et al.   EMBO REPORTS

Brown adipose tissue and its therapeutic potential

(2014) M. E. Lidell et al.   JOURNAL OF INTERNAL MEDICINE

LPA receptor signaling: pharmacology, physiology, and pathophysiology

(2014) Yun C. Yung et al.   JOURNAL OF LIPID RESEARCH

Cysteinyl Leukotriene Receptor-1 Antagonists as Modulators of Innate Immune Cell Function

(2014) A. J. Theron et al.   Journal of Immunology Research

Toward ‘Omic Scale Metabolite Profiling: A Dual Separation–Mass Spectrometry Approach for Coverage of Lipid and Central Carbon Metabolism

(2013) Julijana Ivanisevic et al.   ANALYTICAL CHEMISTRY

Brown adipose tissue: development, metabolism and beyond

(2013) Tim J. Schulz et al.   BIOCHEMICAL JOURNAL

Adipose tissue plasticity from WAT to BAT and in between

(2013) Yun-Hee Lee et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Early Metabolic Adaptation in C57BL/6 Mice Resistant to High Fat Diet Induced Weight Gain Involves an Activation of Mitochondrial Oxidative Pathways

(2013) Claire L. Boulangé et al.   JOURNAL OF PROTEOME RESEARCH

Analysis of the Human Tissue-specific Expression by Genome-wide Integration of Transcriptomics and Antibody-based Proteomics

(2013) Linn Fagerberg et al.   MOLECULAR & CELLULAR PROTEOMICS

Brown and beige fat: development, function and therapeutic potential

(2013) Matthew Harms et al.   NATURE MEDICINE

Adipose tissue browning and metabolic health

(2013) Alexander Bartelt et al.   Nature Reviews Endocrinology

Lysophosphatidylcholine Triggers TLR2- and TLR4-Mediated Signaling Pathways but Counteracts LPS-Induced NO Synthesis in Peritoneal Macrophages by Inhibiting NF-κB Translocation and MAPK/ERK Phosphorylation

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XCMS Online: A Web-Based Platform to Process Untargeted Metabolomic Data

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Designation of enzyme activity of glycine-N-acyltransferase family genes and depression of glycine-N-acyltransferase in human hepatocellular carcinoma

(2012) Moe Matsuo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Fatty acid binding protein 4 expression marks a population of adipocyte progenitors in white and brown adipose tissues

(2012) Tizhong Shan et al.   FASEB JOURNAL

Lipolytic Products Activate Peroxisome Proliferator-activated Receptor (PPAR) α and δ in Brown Adipocytes to Match Fatty Acid Oxidation with Supply

(2012) Emilio P. Mottillo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human BAT Possesses Molecular Signatures That Resemble Beige/Brite Cells

(2012) Louis Z. Sharp et al.   PLoS One

Human Prostate Cancer Harbors the Stem Cell Properties of Bone Marrow Mesenchymal Stem Cells

(2011) H. E. Zhau et al.   CLINICAL CANCER RESEARCH

Identification of glycine N-acyltransferase-like 2 (GLYATL2) as a transferase that produces N-acyl glycines in humans

(2010) Dominik P. Waluk et al.   FASEB JOURNAL

Effect of epinephrine deficiency on cold tolerance and on brown adipose tissue

(2010) Rana I. Sharara-Chami et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Brown adipose tissue—a new role in humans?

(2010) Martin E. Lidell et al.   Nature Reviews Endocrinology

Identification and Importance of Brown Adipose Tissue in Adult Humans

(2009) Aaron M. Cypess et al.   NEW ENGLAND JOURNAL OF MEDICINE

Emerging lysophospholipid mediators, lysophosphatidylserine, lysophosphatidylthreonine, lysophosphatidylethanolamine and lysophosphatidylglycerol

(2009) Kumiko Makide et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Human Multipotent Adipose-Derived Stem Cells Differentiate into Functional Brown Adipocytes

(2009) Christian Elabd et al.   STEM CELLS

Within brown-fat cells, UCP1-mediated fatty acid-induced uncoupling is independent of fatty acid metabolism

(2008) Irina G. Shabalina et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

ProteoWizard: open source software for rapid proteomics tools development

(2008) Darren Kessner et al.   BIOINFORMATICS

Human SGBS Cells – a Unique Tool for Studies of Human Fat Cell Biology

(2008) Pamela Fischer-Posovszky et al.   Obesity Facts